Clinical trials: Essential Hypertension.
Hypertension
A Clinical Study to Compare Long-term Efficacy and Safety of an Aliskiren Based Regimen to a Hydrochlorothiazidebased Treatment Regimen With Optional Addition of Amlodipine
This study is designed to compare the long-term efficacy and safety of an aliskiren based regimen to an HCTZ based treatment regimen with optional addition of amlodipine in patients with essential hypertension.
- Trial name
- NCT00219154
- Testing
- aliskiren
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 1,125 people
- Sponsor
- Novartis
Essential Hypertension
Imidapril and Candesartan on Fibrinolysis and Insulin-Sensitivity in Patients With Mild to Moderate Hypertension
BACKGROUND The effects of ACE-inhibitors on fibrinolysis are well documented. Experimental and clinical studies have shown that ACE inhibitors induce a reduction in plasma PAI-1 levels in many cardiovascular diseases, like…
- Trial name
- NCT00644475
- Testing
- Imidapril, Candesartan
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Pavia
Hypertension,Essential
Brain BOLD fMRI in Hypertensive and Normotensive Participants
This study will explore the brainstem activity in response to stress in hypertensive patients and normotensive subjects. In addition, it will evaluate if the response in hypertensive patients can be modulated by blocking the…
- Trial name
- BRAIrdN (NCT03473275)
- Testing
- Cold Pressor test, PinPrick test
- Where
- Switzerland
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Hypertension, Essential
A Study to Evaluate the Efficacy and Safety of AD-209
The purpose of this study is to evaluate the efficacy and safety of AD-209
- Trial name
- NCT05631990
- Testing
- AD-209, AD-209-1A, AD-209-1B
- Where
- South Korea
- Volunteers
- 221 people
- Sponsor
- Addpharma Inc.
Pediatric Hypertension, Primary Hypertension
Endothelial Extracellular Vesicles as Biomarkers of Endothelial Activation in Children With Newly Diagnosed Hypertension
Childhood hypertension is associated with early endothelial dysfunction and an increased risk of future cardiovascular disease. Endothelial extracellular vesicles (EEVs) have emerged as promising biomarkers of endothelial…
- Conditions
- Pediatric Hypertension, Primary Hypertension, Endothelial Dysfunction
- Trial name
- HYPER-endoEV-c (NCT07728643)
- Where
- Croatia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Essential Hypertension
The Effect of the Use of BATHE Interview Technique on Treatment Compliance in Hypertension Patients in Primary Care
The research is planned to evaluate the treatment compliance after the BATHE interview technique in hypertension patients.
- Trial name
- NCT05476120
- Testing
- BATHE
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people
- Sponsor
- Dokuz Eylul University
Essential Hypertension
Safety and Tolerability of Azilsartan Medoxomil Plus Chlorthalidone Compared to Olmesartan Medoxomil Plus Hydrochlorothiazide in Participants With Essential Hypertension
The purpose of this study is to compare the safety and tolerability of azilsartan medoxomil plus chlorthalidone, once daily (QD), versus olmesartan medoxomil-hydrochlorothiazide in adults with essential hypertension.
- Trial name
- NCT00996281
- Testing
- Azilsartan medoxomil and chlorthalidone, Olmesartan medoxomil and hydrochlorothiazide
- Where
- 26 sites in Austria, Germany and 3 more
- Volunteers
- 837 people
- Sponsor
- Takeda
Hypertension,Essential
An OS to Evaluate Effectiveness and Safety of Fixed-dose Combinations of FMS/AML or FMS/AML/HCTZ
The main purpose of this observation study is to collect data on the effects and side effects for 12 weeks of the medication administration of the single-pill combinations, which are fimasartan/amlodipine or…
- Trial name
- NCT05413057
- Where
- South Korea
- Volunteers
- 20,000 people
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Hypertension
Antihypertensive Efficacy and Tolerability and Determine the Adequate Antihypertensive Dosage of Fimasartan in Mild to Moderate Essential Hypertension Patients
The purpose of this study is to evaluate the antihypertensive efficacy and tolerability of 8 week treatment with Fimasartan (BR-A-657-K) 20, 60, 120, 240 mg and placebo in patients with mild to moderate essential hypertension and…
- Trial name
- NCT00923611
- Testing
- Fimasartan
- Where
- South Korea
- Volunteers
- 182 people
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Hypertension
TElmisartan and AMlodipine Single Pill sTudy With Patients Not on Goal With Mono rAas Therapy-switch
The general aim of this trial to determine the efficacy as measured by the percentage of patients reaching blood pressure goal at the end of the treatment period at 12 weeks.
- Trial name
- NCT01134393
- Testing
- telmisartan/amlodipine
- Where
- 47 sites in Germany, Italy and 3 more
- Volunteers
- 502 people
- Sponsor
- Boehringer Ingelheim
Hypertension
A Long Term Study of SPP100 in Patients With Essential Hypertension (Trial is Not Recruiting in the US)
This study will evaluate the safety and efficacy of long term treatment of SPP100 in patients with essential hypertension. (Trial is not recruiting in the US)
- Trial name
- NCT00246584
- Testing
- SPP100
- Where
- Switzerland
- Volunteers
- 300 people
- Sponsor
- Novartis
Hypertension
Antihypertensive Efficacy of Fixed Combination Drug
Treatment and control of hypertension is still insufficient. About 50% of the patients remain uncontrolled. Lack of compliance with discontinuation of drug treatment is an important reason for not achieving blood pressure.
- Trial name
- NCT01211314
- Testing
- Lercanidipine/enalapril fixed combination
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Meir Medical Center
Essential Hypertension, Primary Hypercholesterolemia
A Study to Evaluate the Pharmacokinetics and the Safety After Administration of "BR1017-1" and Co-administration of "BR1017-1A" and "BR1017-1B"
The objective of this clinical study is to evaluate the pharmacokinetics and the safety after administration of "BR1017-1" and co-administration of "BR1017-1A" and "BR1017-1B" in healthy volunteers
- Trial name
- NCT06184269
- Testing
- BR1017-1, BR1017-1A, BR1017-1B
- Where
- South Korea
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Hypertension,Essential, Home Blood Pressure
Diagnosis of Hypertension by Home Blood Pressure Monitoring
Home blood pressure measurement has been recommended to use in the diagnosis of hypertension. The investigators have developed diagnostic algorithm of hypertension by using 24-hour and home blood pressure measurement.
- Conditions
- Hypertension,Essential, Home Blood Pressure, Ambulatory Blood Pressure
- Trial name
- NCT03855605
- Where
- South Korea
- Volunteers
- 470 people
- Sponsor
- DongGuk University
Essential Hypertension
Efficacy and Safety of Azilsartan Medoxomil and Chlorthalidone in Participants With Moderate to Severe Hypertension
The purpose of this study is to compare the antihypertensive effect of chlorthalidone vs hydrochlorothiazide when each is used with azilsartan medoxomil, once daily (QD), in participants with moderate to severe essential…
- Trial name
- NCT00818883
- Testing
- Azilsartan medoxomil and chlorthalidone, Azilsartan medoxomil and hydrochlorothiazide
- Where
- 53 sites in United States, Russia
- Volunteers
- 609 people
- Sponsor
- Takeda
Hypertension, Essential Hypertension
Efficacy and Safety of DWC202404 and DWC202314 in Patients With Hypertension
A Multicenter, Randomized, Double-blind, Phase III Study to Evaluate the Efficacy and Safety of DWC202404 and DWC202314 Combination Therapy in Patients with Essential Hypertension Inadequately Controlled on DWC202404 Monotherapy
- Trial name
- NCT06682000
- Testing
- DWC202404, DWC202314, DWC202404, DWC202314P
- Where
- South Korea
- Volunteers
- 192 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Hypertension
One-Year Safety and Tolerability Study of Azilsartan Medoxomil in Participants With Essential Hypertension
This purpose of this study is to evaluate the long-term safety and tolerability of azilsartan medoxomil in individuals with essential hypertension.
- Trial name
- NCT00695955
- Testing
- Azilsartan medoxomil with or without add-on chlorthalidone, Azilsartan medoxomil with or without add-on hydrochlorothiazide
- Where
- 41 sites in United States, Chile and 1 more
- Volunteers
- 669 people
- Sponsor
- Takeda
Hypertension
Effect of Probiotics on Primary Hypertension
Gut microbiota was found to play a causal role in the pathogenesis of hypertension. Probiotics were shown to have a potential anti-hypertensive effect in human/rodent studies.
- Trial name
- NCT05095350
- Testing
- Probiotic powder
- Where
- 6 sites in China
- Volunteers
- 115 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Hypertension
Effectiveness of a Digital Health Application for Primary Hypertension (Liebria)
This clinical trial with 328 patients with primary hypertension aims to investigate the effectiveness of the self-guided digital application liebria for patients with primary hypertension.
- Trial name
- NCT06243978
- Testing
- liebria, information brochure on hypertension
- Where
- Germany
- Volunteers
- 328 people
- Sponsor
- Gaia AG
Hypertension,Essential
Peripheral Vascular Effects of Sulfhydryl-containing Antihypertensive Pharmacotherapy on Microvessels in Humans
High blood pressure can cause physical changes to the blood vessels of the body (remodeling). If a person who has high blood pressure also has a lot of blood vessel remodeling with their condition, they are more likely to have…
- Trial name
- H2SPharm (NCT03179163)
- Testing
- Captopril Pill, Enalapril Pill, Hydrochlorothiazide
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Penn State University