Clinical trials: Essential Hypertension.
Hypertension, Primary Hypertension
Effectiveness of SMS Reminders of Blood Pressure-lowering Drugs Intake
By conducting the SPPA trial we try to find out, whether personalized Short Message Service (SMS) reminders of blood pressure-lowering medication can effectively increase patients' adherence to blood pressure-lowering medication.
- Conditions
- Hypertension, Primary Hypertension, Non-Adherence, Medication, Non-Adherence, Patient
- Trial name
- SPPA (NCT03105687)
- Testing
- SMS reminders of medicines intake
- Where
- 24 sites in Slovakia
- Volunteers
- 300 people
- Sponsor
- Comenius University
Hypertension
Efficacy and Safety of Metoprolol Succinate Prolonged-Release Tablet in Patients With Mild to Moderate Hypertension
This is an open-label, non-comparative, multi-centre clinical study to evaluate the Efficacy and safety of Metoprolol Succinate prolonged-release tablet (Betaloc Zok) in patients with mild to moderate essential hypertension.
- Trial name
- NCT00861016
- Testing
- metoprolol succinate prolonged-release tablet and felodipine
- Volunteers
- 310 people
- Sponsor
- AstraZeneca
Cardiovascular Diseases, Cerebral Infarction
Screening, Early Referral and Lifestyle Tailored E_prescription for Cardiovascular Prevention
We will evaluate an e_Prescription intervention can be integrated into an electronic screening program, which together exploit: (i) reach - the adult population has 100% mobile phone ownership and 92% internet national coverage…
- Conditions
- Cardiovascular Diseases, Cerebral Infarction, Type2 Diabetes Mellitus, Hypertension,Essential
- Trial name
- SELECT (NCT04082091)
- Testing
- SELECT mHealth Program
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Anxiety Disorders and Symptoms, Fibromyalgia
The Benefits of Natural Medicine, Vitamin IV Therapy and Supplements: Maintaining Good Health Through Nature
Herbal Medicine is known as the medicinal use of herbal substances as a means of treating different conditions in the human body to ensure that the body remains in optimal health and wellness.
- Conditions
- Anxiety Disorders and Symptoms, Fibromyalgia, Arthritis, Chronic Pain
- Trial name
- NCT05067998
- Testing
- IV Vitamin Infused Therapy Treatment, Herbal medicine
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Faith A. Richardson
Bradycardia, Hypertension, Systolic
Preload and Autonomic Responses With Cardiac Neuromodulation Therapy (CNT) (CS-06)
This investigation will evaluate the effect of RV pacing lead position on cardiac function and the modulation of the autonomic nervous system with Cardiac Neuromodulation Therapy (CNT) pacing signals.
- Trial name
- CS-06 (NCT04463121)
- Testing
- Moderato IPG's CNT pacing signals, CD Leycom Pressure/Volume Combination Catheters
- Where
- Czechia
- Volunteers
- 22 people
- Sponsor
- BackBeat Medical Inc
Hypertension, Pharmacogenetics
A Study on Molecular Genetics of Drug Responsiveness in Essential Hypertension
Blood pressure variation and the risk of essential hypertension have an important genetic component. In most cases susceptibility to essential hypertension is likely determined by the action of more than one gene.
- Trial name
- GENRES (NCT03276598)
- Testing
- Amlodipine, Bisoprolol, Hydrochlorothiazide
- Where
- Finland
- Volunteers
- 233 people
- Sponsor
- Helsinki University Central Hospital
Essential Hypertension
Study of the Product QGC001 as a Single Dose and Multiple Doses Administered Orally to Healthy Adult Subjects
1QG2 is a Phase 1 study aiming to assess the safety and tolerability of ascending single/multiple oral doses (SAD \& MAD) in healthy young subjects, the preliminary food interaction and the effect of QGC001 on blood pressure and…
- Trial name
- NCT01900184
- Testing
- QGC001 [(3S,3'S)-4,4'-dithiobis (3-aminobutane-1-sulfonic acid)]
- Where
- France
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Quantum Genomics SA
Hypertension
Salt Reduction on Blood Pressure and Cardiovascular Organ Damage
The purpose of this study is to determine the effect of a modest reduction in salt intake on blood pressure in white, black and Asian individuals with hypertension or prehypertension, and also to determine whether a modest…
- Trial name
- NCT00152074
- Testing
- Reduce salt intake
- Where
- United Kingdom
- Volunteers
- 210 people
- Sponsor
- St George's, University of London
Essential (Primary) Hypertension, Hypertensive Heart Disease With (Congestive) Heart Failure
Positive Care Effect of the Digital Health Assistant ADELE Blood Pressure for Hypertension Patients
High blood pressure (hypertension) can cause damage to vital organs such as the heart, kidneys, eyes, brain and blood vessels. The risk of developing high blood pressure increases with age.
- Conditions
- Essential (Primary) Hypertension, Hypertensive Heart Disease With (Congestive) Heart Failure, Hypertensive Heart Disease Without (Congestive) Heart Failure, Other Secondary Hypertension
- Trial name
- A0007 (NCT06663280)
- Testing
- Digital health assistant ADELE
- Where
- 2 sites in Germany
- Volunteers
- 108 people
- Sponsor
- Alma Phil Gmbh
Hypertension
Clinical Study to Evaluate the Antihypertensive Efficacy and Changes of Neurohormonal Markers of Fimasartan and Atenolol With Exaggerated Blood Pressure Response During Exercise in Essential Hypertensive Patients
The purpose of this study is to evaluate the antihypertensive efficacy and changes of neurohormonal markers of fimasartan and atenolol with exaggerated blood pressure response during exercise in essential hypertensive patients.
- Trial name
- NCT01736488
- Testing
- Fimasartan, Atenolol
- Where
- 4 sites in South Korea
- Volunteers
- 25 people
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Essential Hypertension
Effects of Isometric Wall Squat Training on Blood Pressure in Adults With Hypertension
This randomized controlled trial aims to evaluate whether 12 weeks of isometric wall squat (IWS) exercise can improve blood pressure control and blood pressure variability in adults with essential hypertension.
- Trial name
- ISO-BP (NCT07868822)
- Testing
- Isometric Wall Squat (IWS) Exercise, Standard Hypertension Care
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Korea University Guro Hospital
Essential Hypertension
Effects of Remote Ischemic Conditioning on Blood Pressure in Older Patients With Hypertension
The purpose of this study is to learn about effects of remote ischemic conditioning on blood pressure in older patients with essential hypertension.
- Trial name
- NCT05845905
- Testing
- Remote ischemic conditioning
- Where
- China
- Volunteers
- 158 people
- Sponsor
- Yi Yang
Hypertension,Essential, Hypertension, Masked
Wearable Blood Pressure Devices to Identify Masked Uncontrolled Hypertension.
Uncontrolled out-of-office blood pressure (BP), measured by either home BP monitoring (HBPM) or ambulatory BP monitoring, has been shown to predict higher cardiovascular risk.
- Trial name
- NCT04863508
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- National Taiwan University Hospital Hsin-Chu Branch
Essential Hypertension
Study of CS-3150 Compared to Olmesartan in Patients With Essential Hypertension
Phase 3 study to examine the relation between antihypertensive effect and baseline factors exploratively, compared to olmesartan medoxomil in patients with essential hypertension.
- Trial name
- NCT02848170
- Testing
- CS-3150, olmesartan medoxomil
- Where
- Japan
- Volunteers
- 40 people
- Sponsor
- Daiichi Sankyo Co., Ltd.
Essential Hypertension
A Study to Evaluate the Pharmacokinetic Drug Interaction After Oral Concurrent Administration of Fimasartan and Amlodipine in Healthy Male Volunteers
To evaluate the pharmacokinetic drug interaction after oral concurrent administration of fimasartan and amlodipine in healthy male volunteers
- Trial name
- NCT00938197
- Testing
- Fimasartan, Amlodipine
- Where
- South Korea
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Hypertension
Changes After Angiotensin Converting Enzyme (ACE) Inhibitor Replacement by Angiotensin II Receptor Type I (AT1) Blocker
It is supposed that the significant metabolic effects (improvement of insulin sensitivity) of hypertension therapy with renin-angiotensin system (RAS) blockers in humans are mediated mainly via changes in abdominal adipose…
- Trial name
- ADIRAS (NCT01444833)
- Testing
- Candesartan
- Where
- Slovakia
- Volunteers
- 35 people
- Sponsor
- Slovak Academy of Sciences
Hypertension
A Clinical Trial to Evaluate Efficacy, Tolerability, and Pharmacokinetic-Pharmacodynamic Relationship of Fimasartan/Hydrochlorothiazide
A 2-Week, Randomized, Double-Blind, Parallel, Placebo-Controlled Study to Evaluate the Efficacy, Tolerability, and Pharmacokinetic-Pharmacodynamic Relationship of Fimasartan in Combination with Hydrochlorothiazide in Patients…
- Trial name
- NCT02222480
- Testing
- Fimasartan, Hydrochlorothiazide
- Where
- South Korea
- Volunteers
- 103 people
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Pediatric Disorder, Pediatric Obesity
Pediatric Primary Hypertension and the Renin-Angiotensin System (PHRAS)
Pediatric primary hypertension is increasingly common, occurring in 5-10% of normal-weight children and up to 25% of children with obesity. It is a risk factor for adult cardiovascular and renal disease.
- Conditions
- Pediatric Disorder, Pediatric Obesity, Primary Hypertension
- Trial name
- PHRAS (NCT03310684)
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Hypertension
Effect of Lacidipine and Losartan on 24 Hour Systolic Blood Pressure Variability in Elderly Hypertensive Patients
The aim of this study is to evaluate the effect of lacidipine and losartan in elderly hypertensive patients on reducing the 24 hour systolic BP variability, which is one of the potential parameter to consider in treating elderly…
- Trial name
- NCT00533858
- Testing
- lacidipine (4 mg) or losartan (50 mg)
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Seoul National University Hospital
Hypertension
Effect of Gene Variants on Dopamine Receptor Natriuretic Responses
Hypothesis to be tested: Dopamine D1-like receptor-induced natriuresis is impaired in humans with G protein-related kinase 4 gene variants.
- Trial name
- NCT00592150
- Testing
- fenoldopam
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Virginia