Clinical trials: Essential Tremor, Movement Disorders
Essential Tremor, Deep Brain Stimulation
Multicentre RCT of Awake Versus Asleep Tractography Based DBS for ET
Rationale: Deep brain stimulation (DBS) of the thalamus is an effective surgical treatment for patients with disabling essential tremor, despite optimal pharmacological treatment.
- Conditions
- Essential Tremor, Deep Brain Stimulation, Diffusion Tensor Imaging, Magnetic Resonance
- Trial name
- TREMBLE (NCT05968976)
- Testing
- Awake DBS, Asleep DBS
- Where
- Netherlands
- Volunteers
- 110 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Essential Tremor
Temporal Interference for Essential Tremor
This single-center prospective study aims to investigate the treatment efficacy of temporal interference (TI) in essential tremor patients aged 30-70.
- Trial name
- NCT07016425
- Testing
- Temporal Interference
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Liankun_Ren
Dystonia, Parkinson Disease
Impact of a Standardized Music Therapy Protocol on the Quality of Life of Patients With Abnormal Movements Treated With Continuous Electrical Neuromodulation
The study of the impact of music on emotional, motor and cognitive aspects remains recent. Music therapy has experienced a major boom over the last half century thanks to neuroradiological techniques for investigating the brain…
- Conditions
- Dystonia, Parkinson Disease, Essential Tremor
- Trial name
- Music-QOL (NCT05214313)
- Testing
- Music Therapy
- Where
- France
- Volunteers
- 21 people
- Sponsor
- University Hospital, Montpellier
Essential Tremor
A Study of Wearable Device in Essential Tremor Patients
The purpose of this research is to observe the daily loss of benefit from DBS therapy by performing a standardized set of tasks throughout the day while wearing an Apple Watch to collect movement and other physiological data.
- Trial name
- NCT05976074
- Testing
- Apple Watch, BrainRISE app
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Essential Tremor, Transcranial Direct Current Stimulation
Transcranial Direct Current Stimulation of the Motor Cortex in Essential Tremor
The current research is aimed at using Transcranial Direct Current Stimulation (tDCS) as complementary therapeutic tool in the treatment of essential tremor. Patients will be randomized into two groups (tDCS-cathode vs.
- Trial name
- NCT03952117
- Testing
- transcranial direct current stimulation
- Where
- Lebanon
- Volunteers
- 40 people
- Sponsor
- Lebanese American University
Parkinson's Disease (PD), Essential Tremor
Investigating Subcortical Contributions to Speech Sequencing in Deep Brain Stimulator Recipients
This study will examine how two important brain circuits - one involving the subthalamic nucleus (STN) and one involving the ventral intermediate nucleus of the thalamus (VIM) - contribute to learning and producing speech…
- Trial name
- NCT07455760
- Testing
- Phoneme sequence learning, Cessation and re-enabling of stimulation of the STN, Cessation and re-enabling of stimulation of the VIM thalamic nucleus
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Boston University Charles River Campus
Essential Tremor
GyroGlove Use in Essential Tremor Patients
This is a multi-centre, single-blind, placebo-controlled trial with an open label follow up. After the baseline assessment, all participants will receive the GyroGlove for two weeks during the open label follow up part of the…
- Trial name
- NCT05958030
- Testing
- GyroGlove
- Where
- 7 sites in United States, United Kingdom
- Volunteers
- 30 people
- Sponsor
- GyroGear Ltd
Parkinson Disease, Epilepsy
Neurofeedback Using Implanted Deep Brain Stimulation Electrodes
Deep brain stimulation (DBS) has become a gold-standard symptomatic treatment option for Parkinson's disease (PD) and is also explored for a variety of other neurological disorders.
- Conditions
- Parkinson Disease, Epilepsy, Essential Tremor
- Trial name
- NCT05101161
- Testing
- Neurofeedback
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- ETH Zurich
Essential Tremor
Gamma Knife Radiosurgery for Treatment of Essential Tremor
The purpose of this study is to examine effects (good and bad) of gamma knife radiosurgery for essential tremor. The gamma knife places a small lesion in the brain to suppress tremors.
- Trial name
- NCT02255929
- Testing
- Gamma Knife Radiosurgery
- Where
- United States
- Volunteers
- 183 people
- Sponsor
- Swedish Medical Center
Parkinson's Disease, Essential Tremor
Dexmedetomidine Effects on Microelectrode Recording in Deep Brain Stimulation
To test the hypothesis that sedation induced by Dexmedetomidine at levels appropriate for awake, DBS surgery has no significant effect on electrophysiological parameters of DBS micro-electrode recordings
- Conditions
- Parkinson's Disease, Essential Tremor, Dystonia
- Trial name
- NCT00608231
- Testing
- Dexmedetomidine Hydrochloride Infusion, Normal Saline
- Where
- United States
- Sponsor
- Vanderbilt University
Tremor, Parkinson Disease
Open Label Study for the Use of Transcranial Ultrasound Treatment of Tremor
The purpose of this Phase I open label study is to evaluate longer term tolerability and potential effectiveness of transcranial ultrasound in people with tremor as a results of Parkinson's Disease or Essential Tremor.
- Conditions
- Tremor, Parkinson Disease, Essential Tremor
- Trial name
- NCT05475340
- Testing
- Focused Ultrasound
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Neurological Associates of West Los Angeles
Parkinson Disease, Essential Tremor
[18F] LBT-999 PET Compared to [123I]-FP/CIT SPECT to Distinguish Between Parkinson's Diseases and Essential Tremor
Clinical study to demonstrate an at least equivalent performance of a new PET molecular Imaging radiopharmaceutical named [18F] LBT-999 in brain imaging compared to the SPECT reference method named [123I]-FP-CIT to establish the…
- Trial name
- NCT04265209
- Testing
- SPECT, PET
- Where
- 16 sites in France
- Volunteers
- 152 people
- Sponsor
- GE Healthcare
Essential Tremor
Prospective Study for Symptomatic Relief of ET With Cala Therapy
Prospective, multi-center, single-arm, non-significant risk study designed to evaluate the Cala TWO device. Subjects will be screened for eligibility and fitted with a Cala TWO device.
- Trial name
- PROSPECT (NCT03597100)
- Testing
- Cala TWO
- Where
- 32 sites in United States
- Volunteers
- 263 people
- Sponsor
- Cala Health, Inc.
Essential Tremor, Parkinson Disease
Using Wearable and Mobile Data to Diagnose and Monitor Movement Disorders
The purpose of the research is to better understand the motor behavior of individuals in health and disease. The specific purpose of this project is to identify if we can utilize a smartphone to diagnose different movement…
- Conditions
- Essential Tremor, Parkinson Disease, Huntington Disease, Dystonia, Primary
- Trial name
- NCT04231487
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- Rutgers, The State University of New Jersey
Essential Tremor, Essential Tremor (ET)
Circadian Adaptive DBS in Essential Tremor
Deep brain stimulation (DBS) of the thalamus is an effective treatment for medically refractory essential tremor (ET). DBS involves delivering continuous stimulation to the brain through electrodes permanently implanted in the…
- Conditions
- Essential Tremor, Essential Tremor (ET), Essential Tremor, Movement Disorders
- Trial name
- NCT06635811
- Testing
- Circadian Adaptive DBS, Conventional DBS
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Florida
Essential Tremor
Neurophysiologic Assessment of ET Patients Treated by Vim DBS
Essential tremor is a chronic and progressive neurological disease characterized by upper limb tremor. This is one of the most frequent movement disorders.
- Trial name
- NCT05362448
- Testing
- Frequency
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University College London Hospitals
Traumatic Brain Injury, Stroke
Long-term Brain Stimulation of the Motor Ventral Thalamus (VOP/VIM) to Improve Motor Function
This study aims to recruit patients already implanted with Deep Brain Stimulation (DBS) for movement disorders to complete tasks assessing parameters of motor output, speech, and swallowing functions, both with and without…
- Conditions
- Traumatic Brain Injury, Stroke, Brain Disease, Movement Disorders (Incl Parkinsonism)
- Trial name
- NCT07056348
- Testing
- Deep Brain Stimulation (DBS) of the Motor Thalamus
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jorge Gonzalez-Martinez
Parkinson Disease, Essential Tremor
24-months Study to Evaluate Safety and Efficacy of Peroneal Transcutaneous NeuroModulation in Subjects With Parkinson's Disease and Essential Tremor
This study investigates the long-term safety and tolerability of home peroneal eTNM® therapy using the URIS I™ device in subjects with Parkinson's disease (PD) or Essential Tremor (ET).
- Trial name
- NCT06570421
- Testing
- Peroneal electrical transcutaneous neuromodulation (peroneal eTNM®)
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- Stimvia s.r.o.
Essential Tremor
Interphase Gap in Biphasic Stimulation in DBS for ET
Deep Brain Stimulation (DBS) is a well established therapy in medication-refractory essential tremor (ET). Since the inception of DBS, cathodic pulses are used.
- Trial name
- NCT05177900
- Testing
- Study Tool Computer
- Where
- Belgium
- Volunteers
- 9 people
- Sponsor
- Myles Mc Laughlin
Essential Tremor
A Clinical Study to Evaluate CAD-1883 in Essential Tremor
This is an open-label study designed to evaluate the safety, tolerability and efficacy of CAD-1883, a positive allosteric modulator of the SK channel, administered twice daily orally to adult patients with ET.
- Trial name
- NCT03688685
- Testing
- CAD-1883
- Where
- 7 sites in United States
- Volunteers
- 25 people
- Sponsor
- Cadent Therapeutics