Clinical trials: Essential Tremor
Essential Tremor
Atlas Predicted DBS Settings in Essential Tremor
Programming Deep Brain Stimulation for the treatment of Essential Tremor can be a time intensive process. Using an atlas created using functional tremor responses in the operating room to determine the optimal settings would lead…
- Trial name
- NCT02678429
- Testing
- Change DBS programming
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Vanderbilt University
Essential Tremor
Trial of Cannabis for Essential Tremor
This is a pilot trial to evaluate the safety and efficacy of a combined oral formulation of THC and CBD in patients with Essential Tremor.
- Trial name
- NCT03805750
- Testing
- CBD/THC
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of California, San Diego
Essential Tremor
Evaluate SAGE-547 in Participants With Essential Tremor
Stage 1 is a double-blind, proof-of-concept study designed to evaluate the safety, tolerability, pharmacokinetics (PK), and efficacy of SAGE-547 Injection in male and female participants with essential tremor in the upper limb.
- Trial name
- NCT02277106
- Testing
- SAGE-547
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Sage Therapeutics
Essential Tremor, Parkinson's Disease
Evaluation of the Infinity Deep Brain Stimulation Electrode Screening Mode Tool
The objective of this clinical investigation is to characterize the clinical performance of Abbott's Clinician Programmer Electrode Screening Mode tool (InformityTM tool) in programming InfinityTM deep brain stimulation (DBS)…
- Trial name
- EVIDENT (NCT03794661)
- Testing
- Clinician programmer electrode screening mode tool
- Where
- 3 sites in United States
- Volunteers
- 8 people
- Sponsor
- Abbott Medical Devices
Essential Tremor
A Phase 2 RCT Study of CX-8998 for Essential Tremor
This is a multicenter, double-blind, placebo-controlled, parallel-group study consisting of a screening period of up to 4 weeks (with the exception of participants on primidone at baseline who will be allowed 6 weeks of screening…
- Trial name
- NCT03101241
- Testing
- CX-8998
- Where
- 22 sites in United States
- Volunteers
- 95 people
- Sponsor
- Jazz Pharmaceuticals
Essential Tremor
A Clinical Study to Evaluate CAD-1883 in Essential Tremor
This is an open-label study designed to evaluate the safety, tolerability and efficacy of CAD-1883, a positive allosteric modulator of the SK channel, administered twice daily orally to adult patients with ET.
- Trial name
- NCT03688685
- Testing
- CAD-1883
- Where
- 7 sites in United States
- Volunteers
- 25 people
- Sponsor
- Cadent Therapeutics
Essential Tremor
Pregabalin in the Treatment of Essential Tremor
Pregabalin is approved for the treatment of nerve pain as well as an additional therapy in the treatment of seizures. In December 2004, Pfizer gained Food and Drug Administration (FDA) approval for use of pregabalin in nerve pain…
- Trial name
- NCT00646451
- Testing
- pregabalin (Lyrica)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Baylor College of Medicine
Essential Tremor of the Upper Limbs
Botulinum Toxin A to Treat Arm Tremor
The objective of this study is to assess the efficacy and safety of a single, kinematic-analysis-based intramuscular injection of NT 201, compared with placebo, in moderate to marked essential tremor of the upper limb.
- Trial name
- NCT02207946
- Testing
- IncobotulinumtoxinA
- Where
- 6 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- Merz Pharmaceuticals GmbH
Essential Tremor, Tremor
Functional Imaging of Tremor Circuits and Mechanisms of Treatment Response
Essential Tremor (ET) is the most common tremor disorder, currently affecting an estimated 2.9 million Americans and leading to disability and decreased quality of life in 75% of cases.
- Trial name
- NCT02495883
- Testing
- Ethanol, Propranolol
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Essential Tremor
Comparison of Botulinum Toxin Injections in Forearm FLexor Plus EXtensor Muscles vs. Flexor Muscles Alone for Treatment of Essential Hand Tremor(FLEX-D ET)
To compare the efficacy of botulinum toxin (BoNT) injections in forearm flexors plus extensor muscles versus flexors alone for the treatment of essential hand tremor (ET).
- Trial name
- FLEX-D ET (NCT02909907)
- Testing
- Botulinum toxin
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- The Cleveland Clinic
Essential Tremor
A Pilot Study of the Cala ONE Device for Essential Tremor
Prospective, multi-center, randomized, controlled study designed to evaluate safety and repeatable effectiveness. Subjects will be randomized 2:1:1 to transcutaneous afferent patterned stimulation (TAPS), sham, or 'no…
- Trial name
- EXCITE (NCT03152136)
- Testing
- Cala ONE device
- Where
- 4 sites in United States
- Volunteers
- 62 people
- Sponsor
- Cala Health, Inc.
Essential Tremor
A Pilot Study to Assess the Effects of Pre-SMA LF-rTMS for the Treatment of Essential Tremor
The purpose of this study is to determine the effects of Low Frequency Repetitive Transcranial Magnetic Stimulation (LF r-TMS) of the pre-Supplementary Motor Area (pre-SMA) on tremor as measured by the tremor rating scale (TRS)…
- Trial name
- NCT02763865
- Testing
- MagVenture MagProx100 Stimulator with a Cool-B65 A/P coil
- Volunteers
- 10 people
- Sponsor
- Medical University of South Carolina
Essential Voice Tremor, Vocal Tremor
Effects of Octanoic Acid for Treatment of Essential Voice Tremor
Essential voice tremor is a neurological condition that produces a regular, shaking quality in the voice. One form of drug treatment that produces some improvement in tremor of the hands is octanoic acid, which is a food additive…
- Conditions
- Essential Voice Tremor, Vocal Tremor, Voice Tremor, Essential Tremor of Voice
- Trial name
- NCT01864525
- Testing
- Octanoic acid, Inactive capsule
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Syracuse University
Essential Tremor, Parkinson's Disease
Compare Rates of Agreement Between Clinical Diagnosis and Visual Assessment of DaTscan™ Images in Non-Caucasian and Caucasian Subjects With Parkinson's Disease (PD) or Essential Tremor (ET)
The primary objective of this study is to determine if the diagnostic performance of DaTscan™ single photon emission computed tomography (SPECT) imaging is different in non-Caucasian subjects compared with Caucasian subjects with…
- Trial name
- NCT01952678
- Testing
- DaTscan™ - Non-Caucasian Participants, DaTscan™ - Caucasian Participants
- Where
- United States
- Volunteers
- 204 people
- Sponsor
- GE Healthcare
Essential Tremor
Essential Voice Tremor: A Study of Botulinum Toxin Treatment and Injection Augmentation
Botulinum toxin is the common treatment of choice for patients with Essential Voice Tremor (EVT), but results are not universally beneficial to all patients.
- Trial name
- NCT02711995
- Testing
- RenuGel, Botulinum Toxin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Weill Medical College of Cornell University
Essential Vocal Tremor, Essential Voice Tremor
Propranolol and Botulinum Toxin for Essential Vocal Tremor
Essential tremor is the most common adult-onset movement disorder, and essential voice tremor is the vocal manifestation of essential tremor.
- Conditions
- Essential Vocal Tremor, Essential Voice Tremor, Essential Tremor, Voice Tremor
- Trial name
- NCT02111369
- Testing
- Propranolol, Botulinum Toxin
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Emory University
Parkinson's Disease, Essential Tremor
RECHARGE Sub-Study to the Implantable Systems Performance Registry (ISPR)
The purpose of this study is to assess the recharge feature of the Activa RC System in patients who are receiving Deep Brain Stimulation (DBS) for Parkinson's Disease (PD), Essential Tremor (ET), or dystonia.
- Conditions
- Parkinson's Disease, Essential Tremor, Dystonia
- Trial name
- RECHARGE (NCT00998660)
- Testing
- Activa RC
- Where
- 11 sites in United States, Austria and 4 more
- Volunteers
- 100 people
- Sponsor
- MedtronicNeuro
Essential Tremor
Zonisamide in the Treatment of Essential Tremor
The purpose of this study is to determine if Zonisamide is effective in reducing tremors in patients with Essential Tremor.
- Trial name
- NCT00616343
- Testing
- Zonisamide
- Volunteers
- 9 people
- Sponsor
- Loma Linda University
Essential Tremor
Double-Blind, Placebo Controlled Pilot Study of Octanoic Acid in Essential Tremor
Background: Essential tremor (ET) is a neurological disorder characterized by uncontrollable shaking. Several medications are used to treat ET; however, they are often only partly effective and can have side effects.
- Trial name
- NCT00848172
- Testing
- Octanoic Acid
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Tremor
Electrophysiological Study of the Effects of Limb Cooling on Essential Tremor
To determine the effects of upper limb forearm cooling on Essential Tremor upper limb tremor using a more practical method of limb cooling through a forearm cold pack.
- Trial name
- NCT01093027
- Testing
- 15 - 30, 30 - 15
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic