Clinical trials: Essential Tremor, open to volunteers
Action Tremor, Stigma, Social
ET Stigma Response to Tremor Suppression
Essential Tremor (ET) is prevalent, affecting approximately 3% of the adult population. Involuntary shaking of the hands during action is a prominent feature, interfering with feeding and writing and other manual tasks.
- Trial name
- NCT07430761
- Testing
- stereotactic thalamotomy with focused ultrasound
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- University of Texas Southwestern Medical Center
Essential Tremor
3-D Tractography FUS Ablation for Essential Tremor
The investigators propose to advance Vim-FUSA (Ventral Intermediate Nucleus - Focused Ultrasound Ablation) with the support of 3-D tractography, a neuroimaging technique to visually represent nerve tracts within the brain.
- Trial name
- NCT06331052
- Testing
- MR-guided Focused Ultrasound Ablation
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of North Carolina, Chapel Hill
PARKINSON DISEASE (Disorder)
Wearable for Assessing Tremor and Continuous Health in Parkinson's Disease and Essential Tremor
This prospective observational study will examine tremor and upper-limb movement in adults with Parkinson's disease or essential tremor using non-invasive wearable sensors.
- Trial name
- PD-WATCH (NCT07787299)
- Testing
- Device exposure: Wearable inertial sensor monitoring
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Heriot-Watt University
Movement Disorders, Parkinson Disease
Abbott DBS Post-Market Study of Outcomes for Indications Over Time
The purpose of this international study is to evaluate long-term safety and effectiveness of Abbott deep brain stimulation (DBS) systems for all indications, including Parkinson's disease, essential tremor or other disabling…
- Conditions
- Movement Disorders, Parkinson Disease, Essential Tremor, Tremor
- Trial name
- ADROIT (NCT04071847)
- Testing
- Deep Brain Stimulation (DBS)
- Where
- 48 sites in United States, Australia and 7 more
- Volunteers
- 1,000 people
- Sponsor
- Abbott Medical Devices
Essential Tremor
Stereotactic Radiosurgery in the Treatment of Essential Tremor
The goal of this interventional study is to evaluate the effectiveness of treatment using stereotactic radiosurgery in the treatment of essential tremor in adult patients
- Trial name
- EASIER (NCT06821906)
- Testing
- Stereotactic Radiosurgery
- Where
- Poland
- Volunteers
- 42 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Essential Tremor
Non-Invasive Neuromodulation for Essential Tremor: Long-Term Safety and Effectiveness Study
This is a prospective, single-center, single-arm, open-label clinical study designed to evaluate the long-term efficacy and safety of non-invasive neuromodulation using transcutaneous afferent patterned stimulation (TAPS) in…
- Trial name
- NCT07774598
- Testing
- Transcutaneous Afferent Patterned Stimulation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Ruijin Hospital
Essential Tremor
Directional Versus Nondirectional DBS for ET
This will be a single center (OHSU) proof of concept trial to demonstrate that directional deep brain stimulation (DBS) creates a larger therapeutic window for the treatment of essential tremor (ET), effectively treats ET, and…
- Trial name
- NCT04828798
- Testing
- Deep brain stimulation of the VIM Thalamic nuclei
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Oregon Health and Science University
Parkinson Disease, Essential Tremor
Effects of Stimulation Patterns of Deep Brain Stimulation
The purpose of this study is to measure the effects of non-regular temporal patterns of deep brain stimulation (DBS) on motor symptoms and neural activity in persons with Parkinson's disease (PD), essential tremor (ET), dystonia…
- Conditions
- Parkinson Disease, Essential Tremor, Multiple Sclerosis, Dystonia
- Trial name
- NCT02553525
- Testing
- Therapeutic Stimulation Patterns, Symptogenic Stimulation Patterns
- Where
- 3 sites in United States
- Volunteers
- 180 people
- Sponsor
- Duke University
Parkinson Disease, Essential Tremor
24-months Study to Evaluate Safety and Efficacy of Peroneal Transcutaneous NeuroModulation in Subjects With Parkinson's Disease and Essential Tremor
This study investigates the long-term safety and tolerability of home peroneal eTNM® therapy using the URIS I™ device in subjects with Parkinson's disease (PD) or Essential Tremor (ET).
- Trial name
- NCT06570421
- Testing
- Peroneal electrical transcutaneous neuromodulation (peroneal eTNM®)
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- Stimvia s.r.o.
Parkinson Disease, Essential Tremor
Cortical-Basal Ganglia Speech Networks
In this research study the researchers want to learn more about brain activity related to speech perception and production.
- Conditions
- Parkinson Disease, Essential Tremor, Dystonia
- Trial name
- NCT04286308
- Testing
- electrophysiological data collection
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Movement Disorder
Phenotype/Genotype Correlations in Movement Disorders
The goal of this protocol is to identify families with inherited movement disorders and evaluate disease manifestations to establish an accurate clinical diagnosis by using newest technological advances and investigate the…
- Trial name
- NCT00018889
- Where
- United States
- Volunteers
- 2,500 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson's Disease, Essential Tremor
Deep Brain Stimulation Surgery for Movement Disorders
Background: Deep brain stimulation (DBS) is an approved surgery for certain movement disorders, like Parkinson's disease, that do not respond well to other treatments.
- Conditions
- Parkinson's Disease, Essential Tremor, Dystonia
- Trial name
- NCT01581580
- Testing
- Medtronic Activa Tremor Control System, Deep Brain Stimulation
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Preoperative Anxiety
Evaluating the Impact of Virtual Reality on Mood in Patients Undergoing Magnetic Resonance-Guided Focused Ultrasound for Medication-Refractory Essential Tremor
The primary objective of this randomized study is to evaluate the effect of a virtual reality (VR) video on pre-treatment anxiety levels in individuals undergoing magnetic resonance-guided focused ultrasound (MRgFUS) treatment…
- Trial name
- NCT07287605
- Testing
- VR headset: video number 1, VR headset: video number 2
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Sunnybrook Health Sciences Centre
Parkinson's Disease and Parkinsonism, Progressive Supranuclear Palsy
The Use of the CUE1/CUE1+ in People With Parkinson's Disease and Related Disorders
People with Parkinson's disease (PD) commonly experience a range of both motor (e.g., bradykinesia, rigidity, tremor, and postural instability) and non-motor (e.g., fatigue, psychiatric and behavioural disturbances, autonomic…
- Conditions
- Parkinson's Disease and Parkinsonism, Progressive Supranuclear Palsy, Different Types of Tremor Including Essential Tremor, Dystonia
- Trial name
- NCT06174948
- Testing
- CUE1 non-invasive device
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Queen Mary University of London
Essential Tremor
Essential 3 - Decentralized, Phase 3 Study Evaluating the Safety and Efficacy of Ulixacaltamide in Essential Tremor (ET)
The goal of this clinical study is to compare ulixacaltamide and placebo treatment in essential tremor. The main question it aims to answer is: Is ulixacaltamide a safe and efficacious treatment for patients with essential…
- Trial name
- NCT06087276
- Testing
- 60 mg ulixacaltamide
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Praxis Precision Medicines
Essential Tremor, Parkinson's Disease
Intraoperative Microelectrode Recordings Using MAVEN Compared to Standard Recording Apparatuses
The purpose of this research is to determine if the electrophysiologic data collected from standard-of-care microelectrode recordings during human deep brain stimulation (DBS) surgery will be the same using the MAVEN device…
- Conditions
- Essential Tremor, Parkinson's Disease, Dystonia
- Trial name
- NCT07868614
- Testing
- Multifunctional Apparatus for Voltammetry, Electrophysiology, and Neuromodulation (MAVEN)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Essential Tremor
Dual-Site Transcranial Magnetic Stimulation of the Supplementary Motor Area and Cerebellum for the Treatment of Essential Tremor.
Essential tremor is a common movement disorder that causes involuntary shaking, mainly during voluntary actions such as writing or holding objects.
- Trial name
- NCT07344194
- Testing
- Dual-site repetitive transcranial magnetic stimulation (rTMS) of the supplementary motor area and cerebellum
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- São Paulo State University
Epilepsy, Essential Tremor
Human Cognition During Surgery: Stimulation-based and Cholinergic Modulation
This is a research study to determine how COBENFY KarXT (FDA approved), a drug which has been approved for treatment of certain disorders, affects brain activity and cognitive tasks which may be regulated by the cholinergic…
- Conditions
- Epilepsy, Essential Tremor, Seizures, Memory Consolidation
- Trial name
- NCT07721272
- Testing
- Cobenfy KarXT pill (50/20 mg)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Texas Southwestern Medical Center
Parkinson Disease (PD), Essential Tremor
Modulate Tremor Severity With Low-intensity Focused Ultrasound Stimulation Targeting the Deep Nucleus of Patients With Refractory Hand Tremor.
The study plans to recruit 12 patients with Parkinsonian tremor, essential tremor, or dystonic tremor. After receiving NaviFUS-ctbTUS stimulation, the improvement in their tremor will be recorded.
- Conditions
- Parkinson Disease (PD), Essential Tremor, Dystonic Tremor, Continuous Theta Burst Stimulation Transcranial Focused Ultrasound
- Trial name
- NCT07172295
- Testing
- Accelerated NaviFUS-ctbFUS stimulation
- Where
- Taiwan
- Volunteers
- 12 people
- Sponsor
- National Taiwan University Hospital
Essential Tremor, Neuromodulation
Ultrasound Neuromodulation in Essential Tremor
This study is being done to test whether low-intensity focused ultrasound (LIFU) (low energy sound waves) cause temporary changes in brain activity and behavior when directed at particular parts of the brain.
- Trial name
- UNMET (NCT06610877)
- Testing
- Focused ultrasound neuromodulation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Francisco