Clinical trials: Essential Tremor, open to volunteers
Parkinson's Disease, Essential Tremor
Deep Brain Stimulation Surgery for Movement Disorders
Background: Deep brain stimulation (DBS) is an approved surgery for certain movement disorders, like Parkinson's disease, that do not respond well to other treatments.
- Conditions
- Parkinson's Disease, Essential Tremor, Dystonia
- Trial name
- NCT01581580
- Testing
- Medtronic Activa Tremor Control System, Deep Brain Stimulation
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Essential Tremor, Movement Disorders, Essential Tremor
Analysis of Cutaneous Phosphorylated Alpha-Synuclein to Identify Patients at Risk of Progressing From Essential Tremor to Parkinson's Disease
Background and Rationale Essential tremor (ET) affects over 6 million Americans and approximately 5% of adults over age 60. Patients with ET have a 10-20 times higher risk of developing Parkinson's disease (PD) compared to…
- Conditions
- Essential Tremor, Movement Disorders, Essential Tremor, Essential Tremor-plus
- Trial name
- Syn-T (NCT07428447)
- Where
- 8 sites in United States
- Volunteers
- 300 people
- Sponsor
- CND Life Sciences
Essential Tremor
Stereotactic Radiosurgery in the Treatment of Essential Tremor
The goal of this interventional study is to evaluate the effectiveness of treatment using stereotactic radiosurgery in the treatment of essential tremor in adult patients
- Trial name
- EASIER (NCT06821906)
- Testing
- Stereotactic Radiosurgery
- Where
- Poland
- Volunteers
- 42 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Essential Tremor
Non-Invasive Neuromodulation for Essential Tremor: Long-Term Safety and Effectiveness Study
This is a prospective, single-center, single-arm, open-label clinical study designed to evaluate the long-term efficacy and safety of non-invasive neuromodulation using transcutaneous afferent patterned stimulation (TAPS) in…
- Trial name
- NCT07774598
- Testing
- Transcutaneous Afferent Patterned Stimulation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Ruijin Hospital
Essential Tremor
Transcranial Temporal Interference Stimulation (tTIS) To Modulate Essential Tremor
The goal of this proof-of-concept study is to examine the effects of a relatively new, non-invasive electrical current-based technique, transcranial temporal interference stimulation (tTIS), in patients with Essential Tremor…
- Trial name
- TremorTIS (NCT07531238)
- Testing
- Transcranial temporal interference stimulation, Tremor monitoring through Inertial Measurement Units (IMUs)
- Where
- Switzerland
- Volunteers
- 6 people
- Sponsor
- University Hospital, Geneva
Essential Tremor, Deep Brain Stimulation
Multicentre RCT of Awake Versus Asleep Tractography Based DBS for ET
Rationale: Deep brain stimulation (DBS) of the thalamus is an effective surgical treatment for patients with disabling essential tremor, despite optimal pharmacological treatment.
- Conditions
- Essential Tremor, Deep Brain Stimulation, Diffusion Tensor Imaging, Magnetic Resonance
- Trial name
- TREMBLE (NCT05968976)
- Testing
- Awake DBS, Asleep DBS
- Where
- Netherlands
- Volunteers
- 110 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Essential Tremor, Parkinson's Disease
Intraoperative Microelectrode Recordings Using MAVEN Compared to Standard Recording Apparatuses
The purpose of this research is to determine if the electrophysiologic data collected from standard-of-care microelectrode recordings during human deep brain stimulation (DBS) surgery will be the same using the MAVEN device…
- Conditions
- Essential Tremor, Parkinson's Disease, Dystonia
- Trial name
- NCT07868614
- Testing
- Multifunctional Apparatus for Voltammetry, Electrophysiology, and Neuromodulation (MAVEN)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Essential Tremor
The Swedish Essential Tremor (SWEET) Trial
To evaluate the effect of deep brain stimulation (DBS) vs best medical treatment in essential tremor (ET) in a randomized, single-blinded controlled trial.
- Trial name
- SWEET (NCT03832712)
- Testing
- Deep Brain Stimulation, Best Medical Treatment
- Where
- 6 sites in Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska Institutet
Essential Tremor
Functional Brain Network Changes in Patients Undergoing Deep Brain Stimulation for Essential Tremor
The purpose of this study is to collect electrophysiological data related to functional brain network changes in patients undergoing deep brain stimulation for the treatment of essential tremor.
- Trial name
- TRaNCE (NCT06293638)
- Testing
- Alcohol, Alprazolam, Cold Therapy
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Essential Tremor
The Encora X1™ in a Real World Observational Study
This research is a post-market study designed to evaluate the long-term, real-world impact of the Encora X1™ on your daily life.
- Trial name
- NCT07911488
- Testing
- Encora X1
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Encora, Inc.
Movement Disorder
Phenotype/Genotype Correlations in Movement Disorders
The goal of this protocol is to identify families with inherited movement disorders and evaluate disease manifestations to establish an accurate clinical diagnosis by using newest technological advances and investigate the…
- Trial name
- NCT00018889
- Where
- United States
- Volunteers
- 2,500 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Essential Tremor
Dual Lead Thalamic Deep Brain Recording (DBR)-DBS Interface for Closed Loop Control of Severe Essential Tremor
This is a feasibility study based on physician-initiated Investigational Device Exemption (IDE) including intraoperative experiments and chronic testing of implanted dual thalamic DBS lead systems.
- Trial name
- NCT04212780
- Testing
- Medtronic Summit Rechargable (RC)+S, ipsilateral thalamic (VIM+VO) DBS, standard ET DBS
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Florida
Movement Disorders, Parkinson Disease
Abbott DBS Post-Market Study of Outcomes for Indications Over Time
The purpose of this international study is to evaluate long-term safety and effectiveness of Abbott deep brain stimulation (DBS) systems for all indications, including Parkinson's disease, essential tremor or other disabling…
- Conditions
- Movement Disorders, Parkinson Disease, Essential Tremor, Tremor
- Trial name
- ADROIT (NCT04071847)
- Testing
- Deep Brain Stimulation (DBS)
- Where
- 48 sites in United States, Australia and 7 more
- Volunteers
- 1,000 people
- Sponsor
- Abbott Medical Devices
Essential Tremor
Magnetoencephalography (MEG) Pilot Study
The purpose of this research is to learn more about how the brain works in people with essential tremor, and how it changes after treatment with High-Intensity Focused Ultrasound (HiFU).
- Trial name
- MEG (NCT07446192)
- Testing
- MRI and fMRI scans, MEG, Sensor-based motor assessments
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Florida
Essential Tremor, Parkinson's Disease (PD)
Closed-loop TMS for Tremor
This study investigates the potential of phase-locked transcranial magnetic stimulation (TMS) as a non-invasive intervention for tremor in patients with Essential Tremor (ET) and Parkinson's Disease (PD).
- Trial name
- NCT07574164
- Testing
- TMS
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Oxford
Essential Tremor
Repetitive Transcranial Magnetic Stimulation Therapy in Essential Tremor
The purpose of this study is to evaluate the efficacy and electrophysiology of repetitive transcranial magnetic stimulation in the treatment of essential tremor.
- Trial name
- rTMS (NCT06145932)
- Testing
- real rTMS
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital of Soochow University
Essential Tremor
Simultaneous Bilateral Radiofrequency Thalamotomy for Medication-Refractory Essential Tremor
This study aims to evaluate the safety and effectiveness of simultaneous bilateral radiofrequency thalamotomy for patients with medication-refractory essential tremor (ET).
- Trial name
- NCT07066358
- Testing
- Simultaneous Bilateral RF Thalamotomy
- Where
- Japan
- Volunteers
- 5 people
- Sponsor
- Tokyo Women's Medical University
Essential Tremor
EMBRACE Tremor BiFUS
This is a post-market (Phase IV) randomized, controlled, blinded, multicenter study with the aim to determine the added value of staged bilateral Exablate thalamotomy compared to a group of patients on previous unilateral…
- Trial name
- NCT06974916
- Testing
- Staged bilateral Exablate thalamotomy, Local standard medical treatment after previous Exablate unilateral thalamotomy.
- Where
- 13 sites in Finland, Germany and 5 more
- Volunteers
- 100 people
- Sponsor
- InSightec
Dystonia, Parkinson Disease
Lesioning Procedures for Movement Disorders
Dystonia is a rare syndrome with varying etiologies. Similarly, tremor conditions refractory to medical management and disabling that they need surgical interventions are rare in our setting.
- Conditions
- Dystonia, Parkinson Disease, Essential Tremor
- Trial name
- NCT06352268
- Testing
- Pallidal, subthalamic or thalamic lesioning
- Where
- India
- Volunteers
- 250 people
- Sponsor
- All India Institute of Medical Sciences
Parkinson Disease, Essential Tremor
Clinical Outcomes for Deep Brain Stimulation
The object of this study is to longitudinally collect clinical outcomes of patients receiving deep brain stimulation for movement disorders with the objective of making retrospective comparisons and tracking of risks, benefits…
- Conditions
- Parkinson Disease, Essential Tremor, Dystonia
- Trial name
- NCT03992625
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Washington University School of Medicine