Clinical trials: Estradiol
Sleep Apnea, Post Menopausal
Impact of Estrogen + Estradiol Receptor Alpha Modulator Therapy on Oxidative Stress in Post-menopausal Women With and Without Sleep Apnea
One of the most likely mechanisms explaining the sleep apnea (SA)-induced increase in metabolic syndrome is the oxidative stress (OS) induced by intermittent hypoxia (IH).
- Conditions
- Sleep Apnea, Post Menopausal, Oxidative Stress
- Trial name
- Alpha MenoX (NCT03981341)
- Testing
- Duavive (0.45 estrogens mg and 20 mg bazedoxifene)
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- Laval University
Menopause, Vulvovaginal Atrophy
TXV13-01 Estradiol Vaginal Softgel Capsules in Treating Postmenopausal Women With Symptoms of Vulvar and Vaginal Atrophy
The study was designed to evaluate the efficacy and safety of TX-12-004-HR 10 μg in treating moderate to severe symptoms of vaginal atrophy associated with menopause after 14 days of treatment, and to estimate the effect size and…
- Conditions
- Menopause, Vulvovaginal Atrophy, Painful Intercourse, Dyspareunia
- Trial name
- NCT02449902
- Testing
- Estradiol
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- TherapeuticsMD
Overactive Bladder
Detrol Long Acting (LA) vs Estrace Vaginal Cream for the Treatment of Overactive Bladder Symptoms
The purpose of this study is to determine if long acting tolterodine confers more benefit than intravaginal low dose estrogen in the treatment of Overactive Bladder Syndrome at 12 weeks post-treatment initiation.
- Trial name
- DRIVE (NCT00465894)
- Testing
- Extended Release Tolterodine LA, Intra Vaginal Estradiol Cream
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Healthy
Norethindrone/Ethinyl Estradiol 0.4 mg/35 Mcg Chewable Tablets Under Non-Fasted Conditions
The purpose of this study was to evaluate the relative bioavailability of a test formulation of norethindrone/ethinyl estradiol 0.4 mg/0.035 mg chewable tablets (Teva Pharmaceuticals, USA) compared to the reference listed…
- Trial name
- NCT01344369
- Testing
- Norethindrone/Ethinyl Estradiol, FEMCON® Fe
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Teva Pharmaceuticals USA
Infertility (IVF Patients), Infertility Assisted Reproductive Technology
Estradiol 8 vs 12 mg for Endometrial Preparation in HRT-FET
The goal of this clinical trial is to learn whether 12 mg or 8 mg of oral estradiol valerate is better for preparing the endometrium in women undergoing hormone replacement frozen embryo transfer (HRT-FET) cycles.
- Conditions
- Infertility (IVF Patients), Infertility Assisted Reproductive Technology, Frozen Embryo Transfer (FET), Endometrial Preparation
- Trial name
- NCT07526207
- Testing
- Progynova®
- Where
- 2 sites in Egypt
- Volunteers
- 850 people
- Sponsor
- Cairo University
In Vitro Fertilization, Estradiol
Impact of Supraphysiological Estradiol on ECG in IVF Patients
This prospective observational study aimed to evaluate the effects of supraphysiological estradiol (E2) levels, induced by gonadotropin therapy during IVF, on cardiac electrophysiological parameters.
- Conditions
- In Vitro Fertilization, Estradiol, Cardiac Electrophysiology, Electrocardiography (ECG)
- Trial name
- NCT07007416
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Konya City Hospital
Female Contraception
An Open-label, Multicentre Study on Preference and Satisfaction of Canadian Women for the Transdermal Contraceptive Patch vs. Previous Primary Contraceptive Method
The purpose of this study is to document the experience of transdermal contraceptive patch over a period of 9 cycles, compared to their previous contraceptive method.
- Trial name
- NCT00653016
- Testing
- norelgestromin; ethinyl estradiol
- Volunteers
- 405 people
- Sponsor
- Janssen-Ortho Inc., Canada
Healthy Volunteer Study
Drug-drug Interaction Study of Bemnifosbuvir/Ruzasvir (BEM/RZR) and Ethinyl Estradiol/Levonorgestrel (EE/LNG)
Drug-drug interaction study between Ethinyl Estradioll/Levonorgestrel and Bemnifosbuvir/Ruzasvir
- Trial name
- NCT07272889
- Testing
- Ethinyl Estradioll/Levonorgestrel (EE/LNG), Bemnifosbuvir/Ruzasvir (BEM/RZR), Bemnifosbuvir/Ruzasvir (BEM/RZR) + Ethinyl Estradioll/Levonorgestrel (EE/LNG)
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Atea Pharmaceuticals, Inc.
Dyspareunia
Study Comparing Estradiol Vaginal Inserts 4mcg To IMVEXXY ® (Estradiol Vaginal Inerts 4 mcg) In The Treatment Of Dyspareunia in Women With Vulvur and Vaginal Atrophy
Randomized, double-blind, placebo-controlled, parallel-designed, multiple-site, bioequivalence study with clinical endpoints.
- Trial name
- NCT05617820
- Testing
- Estradiol, Imvexxy
- Where
- 48 sites in United States, El Salvador and 1 more
- Volunteers
- 1,050 people, healthy volunteers welcome
- Sponsor
- Teva Pharmaceuticals USA
Primary Dysmenorrhea
Treatment Choice in Primary Dysmenorrhea
Our aim is to evaluate and compare the pain relief of estradiol valerate/dienogest and ethinylestradiol/ drospirenone by using doppler indices.
- Trial name
- NCT03124524
- Testing
- estradiol valerate/dienogest, ethinylestradiol and drospirenone
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Adana Numune Training and Research Hospital
Vulvovaginal Atrophy, Menopause
A Safety and Efficacy Study of Estradiol Vaginal Capsule in Postmenopausal Women With Vulvovaginal Atrophy
This study will access the safety and efficacy of three doses of estradiol vaginal capsules in postmenopausal women with vulvovaginal atrophy.
- Conditions
- Vulvovaginal Atrophy, Menopause, Dyspareunia
- Trial name
- NCT02670785
- Testing
- Estradiol Vaginal Capsule (EVC)
- Where
- 20 sites in United States
- Volunteers
- 203 people
- Sponsor
- Warner Chilcott
Low Serum Testosterone Levels in Man
D-chiro-inositol Increases Androgens and Reduces Estrogens in Human Serum
The aim of this pilot study is to test the effect of a 30 day-D-chiro-inositol oral treatment on a set of clinical parameters (mainly sex hormones) in a group of male volunteers selected by their age and BMI to investigate if…
- Trial name
- NCT04615767
- Testing
- D-chiro-inositol
- Where
- Italy
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- AGUNCO Obstetrics and Gynecology Centre
Fertility Disorders
Comparison Between Testosterone and Estradiol Over the Homogenization of Follicular Cohort
In vitro fertilization(IVF) with Gonadotropin-releasing hormone (GnRH) antagonist is one of the most used protocol for the treatment of infertile couples nowadays.
- Trial name
- NCT03238092
- Testing
- Testosterone, Estradiol
- Volunteers
- 26 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Advanced Triple-Negative Breast Carcinoma, Anatomic Stage III Breast Cancer AJCC v8
Estradiol in Treating Patients With ER Beta Positive, Triple Negative Locally Advanced or Metastatic Breast Cancer
This phase II trial studies how well estradiol works in treating patients with estrogen receptor beta (ER beta) positive, triple negative breast cancer that has spread to nearby tissue or lymph nodes (locally advanced) or other…
- Conditions
- Advanced Triple-Negative Breast Carcinoma, Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Triple-Negative Breast Carcinoma
- Trial name
- NCT03941730
- Testing
- Biopsy, Computed Tomography, Magnetic Resonance Imaging
- Where
- 9 sites in United States
- Volunteers
- 8 people
- Sponsor
- Mayo Clinic
Metrorrhagia
Efficacy and Safety Study for the Treatment of Dysfunctional Uterine Bleeding
The purpose of this study is to determine whether the study drug is safe and effective in the treatment of dysfunctional uterine bleeding.
- Trial name
- NCT00307801
- Testing
- Estradiol valerate/Dienogest (Natazia, Qlaira, BAY86-5027)
- Where
- 36 sites in Australia, Czechia and 8 more
- Volunteers
- 231 people
- Sponsor
- Bayer
Coronary Disease, Cardiovascular Diseases
Estrogen Replacement to Reduce Risk of Neurologic Injury After Coronary Artery Bypass Graft Surgery
The purpose of this study is to test whether perioperative estrogen replacement in postmenopausal women reduces the risk for neurologic injury after coronary artery bypass graft (CABG) surgery.
- Conditions
- Coronary Disease, Cardiovascular Diseases, Heart Diseases, Neurologic Manifestations
- Trial name
- NCT00123539
- Testing
- Estrogen Replacement Therapy, Surgery
- Where
- United States
- Volunteers
- 334 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Contraception
Study to Evaluate Cycle Control With Norgestimate/Ethinyl Estradiol and Drospirenone/Ethinyl Estradiol in Healthy Sexually Active Females
The purpose of this study in healthy sexually active females is to evaluate the cycle control with norgestimate/ethinyl estradiol versus drospirenone/ethinyl estradiol.
- Trial name
- NCT00745901
- Testing
- Norgestimate/ethinyl estradiol; Drospirenone/ethinyl estradiol
- Volunteers
- 355 people, healthy volunteers welcome
- Sponsor
- Ortho-McNeil Janssen Scientific Affairs, LLC
Uterine Fibroids (UF)
A Study to Evaluate Changes in Hair in Adult Participants Taking Oral Oriahnn Capsules With Heavy Menstrual Bleeding (HMB) Associated With Uterine Fibroids (UF)
Uterine Fibroids (UF) are benign smooth muscle neoplasms of the uterus that affect women of reproductive age. UFs are one of the leading causes of hospitalizations for gynecological disorders and often lead to hysterectomy.
- Trial name
- Pink Orchid (NCT06058728)
- Where
- United States
- Sponsor
- AbbVie
Contraception
Efficacy and Safety Study of the Combined Oral Contraceptive NOMAC-E2 Compared to a COC Containing DRSP/EE (292002)(P05722)
The primary purpose of this study is to assess contraceptive efficacy, vaginal bleeding patterns (cycle control), general safety and acceptability of the nomegestrol acetate-estradiol (NOMAC-E2) combined oral contraceptive (COC)…
- Trial name
- NCT00413062
- Testing
- NOMAC-E2, DRSP-EE
- Volunteers
- 2,281 people, healthy volunteers welcome
- Sponsor
- Organon and Co
Turner's Syndrome
Initiating Transdermal Estradiol Therapy in Turner's Syndrome
This is a multicenter, randomized, controlled, semi-blinded study to compare two low doses of estradiol administered by recently available transdermal patches for the initiation of puberty in Turner syndrome girls 11.5-13.0 years…
- Trial name
- NCT00870220
- Testing
- Norditropin, Menostar 14mcg patch, Vivelle dot 25mcg patch
- Where
- 3 sites in United States
- Volunteers
- 1 people
- Sponsor
- University of Chicago