Clinical trials: Estradiol
Menopause
Efficacy and Safety of Estradiol and Progesterone Microspheres for the Treatment of Climacteric Symptoms.
During menopause a woman's body slowly produces less of the hormones estrogen and progesterone. Lower hormone levels in menopause may lead to hot flashes, vaginal dryness and osteoporosis.
- Trial name
- NCT00775242
- Testing
- Estradiol and Progesterone
- Where
- Mexico
- Volunteers
- 103 people
- Sponsor
- Centro A.F. de Estudios Tecnologicos, S.A.
Hepatitis C
Drug Interaction Study of an OCP (Norethindrone (ND) Acetate and Ethinyl Estradiol (EE))With a Combination of Daclatasvir (DCV) Asunaprevir (ASV) and BMS-791325
The purpose of this study is to assess the effect of DCV/ASV/BMS-791325 fixed dose combination (FDC) + 75mg BMS-791325 on the Pharmacokinetics (PK) of the oral contraceptive agent.
- Trial name
- NCT02103569
- Testing
- FDC of Daclatasvir, Asunaprevir and BMS-791325, FDC of Norethindrone and Ethinyl Estradiol, BMS-791325
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Vulvovaginal Atrophy
Study to Evaluate Estradiol Vaginal Tablets vs Promestriene Vaginal Cream
This is a study to evaluate the acceptability, efficacy and preferences of 10 of estradiol vaginal tablets vs promestriene vaginal cream
- Trial name
- NCT03385551
- Testing
- Estradiol
- Where
- 2 sites in Italy, Spain
- Volunteers
- 120 people
- Sponsor
- Instituto Palacios
Bioequivalence
Bioavailability of Levonorgestrel and Ethinyl Estradiol Tablets 15.0 mg/0.03 mg With Regards to Reference Product
This Pivotal study will investigate the bioavailability in women of 2 tablet formulations containing Levonorgestrel 15.0 mg and Ethinyl estradiol 0.03 mg. The Pivotal study will be performed at a single site with 30 subjects.
- Trial name
- NCT04230070
- Testing
- Levonorgestrel 15.0 mg and Ethinyl estradiol 0.03 mg Test Drug, Levonorgestrel 15.0 mg and Ethinyl estradiol 0.03 mg Reference Product
- Where
- Chile
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Laboratorios Andromaco S.A.
Osteoporosis
Effects of Continuous Combined Hormone Replacement Therapy and Clodronate on Bone Mineral Density (BMD) in Osteoporotic Women
Recent studies suggest that the combination of two inhibitors of bone resorption may induce a greater increase in bone mineral density (BMD) than either agent alone.
- Trial name
- Osteo (NCT00877097)
- Testing
- Klodronate and Kliogest, Bonefos
- Volunteers
- 167 people
- Sponsor
- Kuopio University Hospital
Metrorrhagia
An Open-Label Study to Compare the Bleeding Profile of Norelgestromin/Ethinyl Estradiol in an Extended Regimen to Norelgestromin/Ethinyl Estradiol Given in a Traditional Regimen
The purpose of this study is to compare the bleeding profile of norelgestromin/ethinyl estradiol given in an extended continuous regimen to norelgestromin/ethinyl estradiol given in a traditional cyclic regimen
- Trial name
- NCT00320580
- Testing
- norelgestromin/ethinyl estradiol
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.
Cardiovascular Diseases
Effect of Estradiol+Drospirenone Versus Estradiol+MPA on Endothelial Function
This study compares the effects of two common hormone medications on the heart and blood vessels of healthy post-menopausal women over the age of 45. The study will take place over the course of about 5 months.
- Trial name
- NCT01109979
- Testing
- Estradiol+MPA, Estradiol+Drospirenone
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Hyperandrogenemia, Polycystic Ovary Syndrome (PCOS)
Assessment of the Sensitivity of the Hypothalamic GnRH Pulse Generator to Estradiol and Progesterone Inhibition
Girls with high levels of the male hormone testosterone often develop polycystic ovary syndrome (PCOS) as adults. Women with PCOS often have irregular menstrual periods, excess facial and body hair, and weight gain.
- Trial name
- NCT01425541
- Testing
- estrace, Progesterone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Virginia
Infertility
NATural Ovarian Stimulation
To overcome unsuitable effects of controlled ovarian hyperstimulation (COH )while maintaining large oocyte availability, investigators elaborated an innovative protocol (NATural Ovarian Stimulation) that dissociates E2 production…
- Trial name
- NATOS (NCT02892942)
- Testing
- Gonal-F®, Cetrotide®
- Where
- France
- Volunteers
- 129 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Breast Cancer
Correlation of 16α-[18F]Fluoro-17β-estradiol PET Imaging With ESR1 Mutation
The propose of this prospective study focuses on the role of [18F]FES PET imaging in patients with breast cancer who might receive or are receiving hormone therapy.
- Trial name
- breast (NCT03544762)
- Testing
- 18F-FES PET
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Contraception
The Effects of Annovera™ and Tampon Co-Usage on the Pharmacokinetics of Segesterone Acetate and Ethinyl Estradiol
This study will evaluate the effect of Annovera and tampon co-usage on the pharmacokinetics (PK) of segesterone acetate (SA) and ethinyl estradiol (EE).
- Trial name
- NCT04272008
- Testing
- Segesterone Acetate and Ethinyl Estradiol, Tampon
- Where
- 2 sites in United States, Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- TherapeuticsMD