Clinical trials: Etomidate
Hemodynamics, Oxidative Stress
Effect of Induction and Maintenance of Anesthesia With Etomidate on Hemodynamics and Oxidative Stress in Diabetic Patients
To explore the effect of induction and maintenance of anesthesia with etomidate on hemodynamics and oxidative stress in diabetic patients.
- Conditions
- Hemodynamics, Oxidative Stress, Anesthesia
- Trial name
- NCT02202239
- Testing
- midazolam, Penehyclidine Hydrochloride Injection, Etomidate
- Volunteers
- 60 people
- Sponsor
- Zhujiang Hospital
Etomidate is Mixed With Propofol
Etomidate/Propofol Mixture or Propofol Monotherapy Use in Patients Undergoing General Anesthesia
The purpose of this study was to investigate the effects of different proportions of etomidate/propofol mixture and propofol alone intravenous anesthesia on intraoperative and postoperative physiological indicators and…
- Trial name
- NCT03855267
- Testing
- Propofol 20 MG/ML, Propofol 20 mg/ml , etomidate 2 mg/ml
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Guolin Wang
Intubation Complication
Evaluating the Hemodynamic Effects of Ketamine Versus Etomidate During Rapid Sequence Intubation
The purpose of this study is to compare the hemodynamic effects of ketamine v etomidate during rapid sequence intubation (RSI) in the pre-hospital and emergency department setting.
- Trial name
- Ket-RSI (NCT03545503)
- Testing
- Etomidate, Ketamine
- Where
- United States
- Volunteers
- 428 people
- Sponsor
- South East Area Health Education Center, Wilmington, NC
Major Surgery
The GUARDIAN Trial - Induction Agent Sub-Study
This is a sub-study of the overall GUARDIAN trial (NCT04884802) in which some GUARDIAN trial participants will be additionally randomized to etomidate vs propofol for anesthetic induction.
- Trial name
- NCT04934683
- Testing
- Routine Blood Pressure Management, Tight Blood Pressure Management, Etomidate Induction
- Where
- 11 sites in United States, China and 2 more
- Volunteers
- 6,254 people
- Sponsor
- The University of Texas Health Science Center, Houston
Anesthesia
Duration and Depth of Anesthesia Induced by a Bolus of Etomidate
Induction of general anesthesia requires to be safe and to ensure a proper level of anesthesia. A proper anesthesia is sufficient to guarantee loss of consciousness and amnesia and without being too depth leading to a…
- Trial name
- NCT05862753
- Testing
- induction by Etomidate bolus
- Where
- Belgium
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Insomnia, Digestive Endoscopy
Changes in Etomidate Dosage in Patients With Insomnia Undergoing Intravenous Anesthesia
To compare the dosage requirement of etomidate under intravenous anesthesia between patients with insomnia and those with normal sleep pattern.
- Trial name
- NCT07028177
- Testing
- No interventions, it is a observational study
- Where
- China
- Volunteers
- 840 people
- Sponsor
- Beijing Tiantan Hospital
Complication of Gastrostomy
Etomidate Emulsion for Sedation in Patients Scheduled for Upper Gastrointestinal (GI) Endoscopy
The study is designed to explore and compare the efficacy and safety of etomidate and propofol with or without analgesic for painless gastroscopy, and to provide more reliant support for implementation and promotion of comfort…
- Trial name
- NCT01729897
- Testing
- Etomidate, Fentanyl, Propofol
- Volunteers
- 328 people
- Sponsor
- Jiangsu Nhwa Pharmaceutical Co., Ltd.
Safety of Gastroscopy
Combined Use of Etomidate and Propofol in Painless Gastroscopy.
Gastroscopy, as a conventional examination for gastrointestinal tract disease, plays a very important role especially in early diagnosis and differential diagnosis of esophageal and gastric carcinoma.
- Trial name
- NCT01913054
- Testing
- Fentanyl Injection, Etomidate Fat Emulsion Injection, Propofol Injection
- Where
- 6 sites in China
- Volunteers
- 2,450 people
- Sponsor
- Jiangsu Nhwa Pharmaceutical Co., Ltd.
General Anesthesia
Effect of Pre-injection of Lidocaine on Myoclonus Induced by Induction With Etomidate in Elderly Patients During General Anesthesia
To evaluate the effect of pre-injection of lidocaine on myoclonus induced by induction with etomidate during general anesthesia in elderly patients
- Trial name
- NCT02141737
- Testing
- Lidocaine Hydrochloride Injection, Etomidate Fat Emulsion Injection, normal saline
- Where
- China
- Volunteers
- 272 people
- Sponsor
- Tang-Du Hospital
Etomidate, Myoclonus
Median Effective Dose of Remifentanil for the Prevention of Myoclonus Induced by Etomidate Injection
Since its introduction in 1973, etomidate has been widely used in clinical anaesthesia, especially in haemodynamically unstable patients, as a new anaesthetic induction drug with the advantage of low circulatory and respiratory…
- Trial name
- NCT05754762
- Testing
- Remifentanil
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Yangzhou University
Acute Respiratory Failure
Randomized Trial of Sedative Choice for Intubation
Among critically ill adults undergoing emergency tracheal intubation, one in five experience hypotension, cardiac arrest, or death.
- Trial name
- RSI (NCT05277896)
- Testing
- Ketamine, Etomidate
- Where
- 6 sites in United States
- Volunteers
- 2,367 people
- Sponsor
- Vanderbilt University Medical Center
Trauma
The Effect of Etomidate on Outcomes of Trauma Patients
Rationale: The drug etomidate causes increased mortality if used for continuous sedation in mechanically ventilated patients; however, etomidate continues to be widely used as a single-bolus induction agent for endotracheal…
- Trial name
- NCT00938990
- Testing
- Etomidate, Midazolam
- Sponsor
- Advocate Hospital System
Depression
Hyperventilation Combined With Etomidate or Ketamine Anesthesia in ECT Treatment of Major Depression
This is a randomized controlled study assessing the effect of pre-emptive hyperventilation on ECT seizure duration, cerebral desaturation and remission of depressive symptoms in patients with Major Depressive Disorder.
- Trial name
- NCT02924090
- Testing
- Etomidate, Ketamine, Hyperventilation
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- University of Manitoba
Etomidate, Hypotension
The Safety of Etomidate - Propofol Mixture vs Propofol in Total Intravenous Anesthesia During Abdominal Surgery
The purpose of this study is to access the safety of etomidate - propofol mixture vs propofol in total intravenous anesthesia during abdominal surgery.
- Trial name
- NCT05810363
- Testing
- Etomidate - propofol mixture, Propofol
- Where
- China
- Volunteers
- 468 people, healthy volunteers welcome
- Sponsor
- Ailin Luo
Congenital Hydronephrosis, Congenital Choledochal Cyst
Effects of Etomidate on Postoperative Circadian Rhythm Changes of Salivary Cortisol in Children
Etomidate is an unique drug used for induction of general anesthesia and sedation. Adrenal cortical inhibition by etomidate has received much attention.
- Conditions
- Congenital Hydronephrosis, Congenital Choledochal Cyst, Fracture
- Trial name
- NCT02013986
- Testing
- etomidate, midazolam, propofol
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Du yi
Anesthesia
The Effect of Propofol or Etomidate on Cognitive Function for 1-3 Years Old Children
Based on China's guangxi guilin for a hernia operation in 1 to 3 years old preschool children propofol and etomidate on behavioral and cognitive function after intravenous anesthesia in according to beta protein in serum and…
- Trial name
- NCT02199990
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Guilin Medical University, China
Coronary Artery Disease, Mitral Valve Regurgitation
Effect of Etomidate on Hemodynamics and Adrenocortical Function After Cardiac Surgery
The purpose of this study is to evaluate the effect of a single dose of etomidate for patients undergoing cardiac surgery with the use of cardiopulmonary bypass (CPB) on post-CPB adrenocortical responsiveness, on requirements of…
- Trial name
- NCT00415701
- Testing
- Etomidate, Propofol, Hydrocortisone
- Where
- Switzerland
- Volunteers
- 130 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Bispectral Index, Pediatric
Bispectral Index Guiding Etomidate Used in Children Aged 3 to 10 for Clinical Anesthesia Induction
This research through using bispectral index to guide the induced dose and speed of etomidate lipid emulsion for pediatric total venous anesthesia,and to provide a reference for clinical anesthesia physician.
- Conditions
- Bispectral Index, Pediatric, Etomidate, Induction
- Trial name
- NCT02182648
- Testing
- etomidate, propofol, sevoflurane
- Volunteers
- 120 people
- Sponsor
- Henan Provincial People's Hospital
Myoclonic Jerk
Effect of Pretreatment of Lignocaine Versus Midazolam in Prevention of Etomidate Induced Myoclonus.
This study is a randomized control trial and it was conducted to compare the effectiveness of pretreatment with lignocaine versus midazolam on the frequency of myoclonus associated with etomidate induction.
- Trial name
- NCT04921046
- Testing
- lignocaine, Midazolam 1 milligram Prefilled Syringe
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Rawalpindi Medical College
Etomidate Combined With Propofol, Hypertension
Safety of Etomidate-propofol Mixture vs. Propofol for Total Intravenous Anesthesia in Elderly Patients Undergoing Abdominal Surgery
The purpose of this study is to access the safety of etomidate - propofol mixture vs propofol for total intravenous anesthesia in elderly patients undergoing abdominal surgery.
- Trial name
- NCT07019246
- Testing
- EP mixture, Propofol
- Where
- China
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital