Clinical trials: Etomidate
Adrenocortical Abnormality
Cortisol Level After Repeated Doses of Etomidate
The aim of this study is to investigate the effect of repeated doses of etomidate on the adrenocortical synthesis of corticosteroids in patients aged 18 to 65, ASA status I to III scheduled to electroconvulsive therapy every 2…
- Trial name
- NCT03188029
- Testing
- adrenocortical function
- Where
- Tunisia
- Volunteers
- 30 people
- Sponsor
- University Tunis El Manar
Adrenocortical Deficiency, Hemodynamic Instability
Single Dose of Etomidate and Adrenal Cortex
we aim to evaluate the effects of single dose of etomidate or use of steroid prior to etomidate during emergency intubation on hemodynamics and adrenal cortex.
- Trial name
- NCT01792037
- Testing
- Etomidate, Midazolam, methylprednisolone
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Istanbul University
Hepatic Insufficiency
Phase 1 Hepatic Insufficiency Trial of Methoxyethyl Etomidate Hydrochloride
A Phase I clinical study to compare the pharmacokinetics, pharmacokinetics, and safety of intravenous administration of methoxyetomidate hydrochloride for injection in subjects with mild hepatic insufficiency (Child-pugh A)…
- Trial name
- NCT06176716
- Testing
- ET-26
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ahon Pharmaceutical Co., Ltd.
Cardiac Surgery
Post Operative Hemodynamic Function After Anesthetic Induction With Etomidate for Cardiac Surgery With ECC
Because of its hemodynamic safety, etomidate is widely used for anaesthesia induction of cardiac surgery. It can also cause adrenal insufficiency during the following 48 hours ( 11 betahydroxylase inhibition ).
- Trial name
- NCT00451776
- Testing
- etomidate, propofol
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Adrenal Insufficiency
Evaluation of Etomidate on Adrenal Function in Trauma Patients
Trauma patients are at increased risk for adrenal function insufficiency. A commonly used agent for rapid sequence intubation (RSI) is known to decrease adrenal function.
- Trial name
- NCT00462644
- Testing
- RSI sedation with etomidate/succinylcholine, RSI sedation with fentanyl/midazolam/succinylcholine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Tennessee
Cardiopulmonary Arrest, Respiratory Arrest
Etomidate Versus Ketamine for Emergency Endotracheal Intubation: a Prospective Randomized Clinical Trial
Patients who are having problems breathing sometimes require placement of a breathing tube in their mouth and windpipe. The purpose of this breathing tube is to save the patient's life.
- Trial name
- EvK (NCT02643381)
- Testing
- Etomidate, Ketamine, Emergency Endotracheal Intubation
- Where
- United States
- Volunteers
- 801 people
- Sponsor
- University of Texas Southwestern Medical Center
Elderly Patients, Ambulatory Surgery
Effect of Remimazolam on the Recovery Quality After Day Surgery
The goal of this clinical trial is to compare remimazolam and etomidate in inducing quality of recovery after day surgery for laryngeal mask general anesthesia in elderly patients.
- Trial name
- NCT05748665
- Testing
- Remimazolam besylate, etomidate
- Where
- 3 sites in China
- Volunteers
- 118 people
- Sponsor
- Xijing Hospital
Anesthesia Induction
A Trial to Evaluate the Efficacy and Safety of Methoxyetomidate Hydrochloride for Injection (ET-26) for the Induction of General Anesthesia in Elective Surgery Subjects
This is a multicenter, randomized, double-blind, etomidate-controlled phase III clinical trial. The primary objective is to compare the efficacy and safety between ET-26 and etomidate in the induction of general anesthesia in…
- Trial name
- NCT06203431
- Testing
- ET-26, Etomidate Injectable Emulsion
- Where
- China
- Volunteers
- 270 people
- Sponsor
- Ahon Pharmaceutical Co., Ltd.
Airway Control, Anesthesia
Ketamine Versus Etomidate for Rapid Sequence Intubation
The purpose of this study is to compare the effectiveness and safety of ketamine and etomidate during rapid sequence intubation (RSI).
- Conditions
- Airway Control, Anesthesia, Intubation, Complication
- Trial name
- NCT01823328
- Testing
- Ketamine, Etomidate
- Where
- United States
- Volunteers
- 143 people
- Sponsor
- Hennepin Healthcare Research Institute
Schizophenia Disorder, Major Depression Disorders
Comparison of Remimazolam and Etomidate As Induction Agents for Electroconvulsive Treatment
The goal of this clinical trial is to find if patients would awaken quickly after electroconvulsive treatment when remimazolam is used compared to etomidate. It will also learn about the efficacy of remimazolam.
- Conditions
- Schizophenia Disorder, Major Depression Disorders, Schizoaffective Disorder, Bipolar
- Trial name
- NCT06664138
- Testing
- Remimazolam, Etomidate
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Yeongseok Yun
Dose-Response Relationship, Drug
The Effects of Spinal Anesthesia on ED50 and BIS50 of Etomidate for the Loss of Consciousness
The purpose of this study is to investigate the effect of spinal anesthesia on ED50 and BIS50 of etomidate for the loss of consciousness (LOC) by using up-and-down method.The hypothesis was that spinal anesthesia could…
- Trial name
- LOC (NCT03240055)
- Testing
- spinal anesthesia, etomidate
- Where
- China
- Volunteers
- 54 people
- Sponsor
- General Hospital of Ningxia Medical University
Etomidate Overdose of Undetermined Intent
A Dose-response Study of Lidocaine and Etomidate
IV lidocaine administration can reduce the minimal amount of Etomidate and time for induction of anesthesia.
- Trial name
- NCT01916642
- Testing
- Lidocaine 1mg/kg, Lidocaine 1.5mg/kg, Lidocaine 2mg/kg
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Hemodynamics
The Effect-site Concentration of Remifentanil Blunting Endotracheal Intubation Responses During Anesthesia Induction With Lidocaine or Sufentanil Combined With Etomidate: A Randomized Controlled Study
The aim of this study was to compare the effect-site target concentration (including EC₅₀ and EC₉₀) of remifentanil required to suppress cardiovascular responses to tracheal intubation during anesthesia induction with etomidate…
- Trial name
- NCT07089173
- Testing
- Intravenous normal saline (NS 0.9), intravenous sufentanil, Intravenous lidocaine
- Where
- China
- Volunteers
- 99 people
- Sponsor
- Peking University Shenzhen Hospital
Primary Aldosteronism
Subtyping Primary Aldosteronism With Para-chloro-2-[18F]Fluoroethyl-etomidate
The goal of this clinical trial is to investigate the uptake characteristics of [18F]CETO in adrenal tissue in patients with two different subtypes of primary aldosteronism.
- Trial name
- SPACE (NCT06616142)
- Testing
- [18F]CETO tracer, Dexamethasone oral, Adrenal vein sampling
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- University Medical Center Groningen
Coronary Artery Bypass Surgery
A Comparison of Etomidate and Ketamine for Anesthesia Induction in Coronary Artery Bypass Graft Surgery
The aim of this study is to determine whether ketamine is an acceptable alternative to etomidate for anesthesia induction in coronary artery bypass graft surgery in terms of hemodynamic stability and also to compare these agents…
- Trial name
- NCT01386229
- Testing
- Ketamine, Etomidate
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Baskent University
Elderly Patients, Gastrointestinal Endoscopy
A Comparative Study of Rimazolam and Propofol Combined With Etomidate in Gastroenteroscopy in Elderly Patients
Studies have shown that etomidate combined with propofol in gastroscopy has high safety and lower incidence of hypoxia and hypotension, suggesting the advantages of etomidate combined with propofol in elderly patients.
- Conditions
- Elderly Patients, Gastrointestinal Endoscopy, Remimazolam Besylate, Etomidate Combined With Propofol
- Trial name
- NCT05103696
- Testing
- Remimazolam Besylate, etomidate combined with propofol
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking University People's Hospital
Gastroscopy, Colonoscopy
A Trial to Evaluate the Efficacy and Safety of Methoxyethyl Etomidate Hydrochloride in Gastroscopy/Colonoscopy
A total of 78 subjects undergoing gastroscopy/colonoscopy were randomly assigned to the methoxetomidate hydrochloride group and the etomidate group according to the ratio of 1:1:1 with etomidate as the control group, 26 cases in…
- Trial name
- NCT06682546
- Testing
- ET-26HCl 0.6mg/kg group, ET-26HCl 0.8mg/kg group, Etomidate Injectable Product 0.3mg/kg group
- Where
- 3 sites in China
- Volunteers
- 78 people
- Sponsor
- Ahon Pharmaceutical Co., Ltd.
Renal Insufficiency
Phase 1 Renal Insufficiency Trial of Methoxyethyl Etomidate Hydrochloride
Twenty-four subjects were divided into three groups: subjects with mild renal insufficiency, subjects with moderate renal insufficiency and subjects with normal renal function, with 8 subjects in each group.Subjects with mild…
- Trial name
- NCT06747520
- Testing
- ET-26HCl
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ahon Pharmaceutical Co., Ltd.
Healthy Elderly Subjects
Safety and Pharmacokinetics/ Pharmacodynamics of Methoxyethyl Etomidate Hydrochloride in Healthy Elderly Subjects
16 subjects were divided into two groups: One group consisted of healthy non-elderly subjects aged 18-64 years (including boundary value).
- Trial name
- NCT06764147
- Testing
- ET-26HCl
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Ahon Pharmaceutical Co., Ltd.
Induction of Anaesthesia
Comparison of Etomidate, Propofol and Etomidate-propofol Combination in Terms of Effects on Haemodynamic Response to Intubation
The purpose of this study is to evaluate the effect of propofol, etomidate and propofol-etomidate combination on hemodynamic responses during laryngoscopy and tracheal intubation and assess the adverse effect related to this…
- Trial name
- NCT02186990
- Testing
- propofol, etomidate, etomidate-propofol
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Ordu University