Clinical trials: Etomidate
Depression
Hyperventilation Combined With Etomidate or Ketamine Anesthesia in ECT Treatment of Major Depression
This is a randomized controlled study assessing the effect of pre-emptive hyperventilation on ECT seizure duration, cerebral desaturation and remission of depressive symptoms in patients with Major Depressive Disorder.
- Trial name
- NCT02924090
- Testing
- Etomidate, Ketamine, Hyperventilation
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- University of Manitoba
Anesthesia
The Effect of Propofol or Etomidate on Cognitive Function for 1-3 Years Old Children
Based on China's guangxi guilin for a hernia operation in 1 to 3 years old preschool children propofol and etomidate on behavioral and cognitive function after intravenous anesthesia in according to beta protein in serum and…
- Trial name
- NCT02199990
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Guilin Medical University, China
Dose-Response Relationship, Drug
The Effects of Spinal Anesthesia on ED50 and BIS50 of Etomidate for the Loss of Consciousness
The purpose of this study is to investigate the effect of spinal anesthesia on ED50 and BIS50 of etomidate for the loss of consciousness (LOC) by using up-and-down method.The hypothesis was that spinal anesthesia could…
- Trial name
- LOC (NCT03240055)
- Testing
- spinal anesthesia, etomidate
- Where
- China
- Volunteers
- 54 people
- Sponsor
- General Hospital of Ningxia Medical University
Delirium, Hemodynamic Instability
Target Controlled Infusion of Etomidate or Propofol for Anesthesia of Thoracoscopic Mitral Valve Replacement Surgery
For patients requiring the heart valve replacement surgery, heart function is injured in different degree.Thus, minimizing the impact of the anesthesia drug on the cardiovascular system has important clinical meanings.
- Trial name
- NCT02644980
- Testing
- Propofol, Etomidate, Bispectral Index Monitor
- Volunteers
- 110 people
- Sponsor
- Xijing Hospital
Trauma, Shock, Traumatic
Comparison of Ketamine and Etomidate During Rapid Sequence Intubation in Trauma Patients
In trauma patients with high shock index, the investigators compare the effects on hemodynamics between ketamine and etomidate.
- Trial name
- NCT04120870
- Testing
- Etomidate Injection 0.2 mg/kg, Ketamine injection 2 mg/kg
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Ajou University School of Medicine
Elderly Patients, Gastrointestinal Endoscopy
A Comparative Study of Rimazolam and Propofol Combined With Etomidate in Gastroenteroscopy in Elderly Patients
Studies have shown that etomidate combined with propofol in gastroscopy has high safety and lower incidence of hypoxia and hypotension, suggesting the advantages of etomidate combined with propofol in elderly patients.
- Conditions
- Elderly Patients, Gastrointestinal Endoscopy, Remimazolam Besylate, Etomidate Combined With Propofol
- Trial name
- NCT05103696
- Testing
- Remimazolam Besylate, etomidate combined with propofol
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking University People's Hospital
Etomidate Induced Dose, Hysteroscopic Surgery
Etomidate Induction in Hysteroscopic Surgery
This study intends to study the optimal dose induced by etomidate in outpatients undergoing painless hysteroscopic surgery. At present, the dosage in the user manual is 0.1-0.3mg/kg.
- Trial name
- NCT05520645
- Testing
- etomidate, propofol
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Etomidate Use Disorder, Repetitive Transcranial Magnetic Stimulation (rTMS)
Repetitive Transcranial Magnetic Stimulation for People With Etomidate Addiction (SToP-E-rTMS x Etomidate)
The goal of this clinical trial is to learn if high-frequency rTMS works to treat etomidate addiction in adults. It will also learn about the safety and tolerability of rTMS.
- Trial name
- SToP-E (NCT07736742)
- Testing
- high-frequency Repetitive Transcranial Magnetic Stimulation, Repetitive transcranial magnetic stimulation
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- The University of Hong Kong
Cardiopulmonary Arrest, Respiratory Arrest
Etomidate Versus Ketamine for Emergency Endotracheal Intubation: a Prospective Randomized Clinical Trial
Patients who are having problems breathing sometimes require placement of a breathing tube in their mouth and windpipe. The purpose of this breathing tube is to save the patient's life.
- Trial name
- EvK (NCT02643381)
- Testing
- Etomidate, Ketamine, Emergency Endotracheal Intubation
- Where
- United States
- Volunteers
- 801 people
- Sponsor
- University of Texas Southwestern Medical Center
Anesthesia, ECT
Comparison the Effects of Etomidate and Sevoflurane During Electroconvulsive Therapy
The purpose of the study was to investigate the effects of etomidate or sevoflurane used in electroconvulsive therapy (ECT) on duration of seizure, hemodynamic response and recovery profiles.
- Trial name
- NCT02500225
- Testing
- Etomidate, Sevoflurane
- Volunteers
- 25 people
- Sponsor
- Inonu University
Congenital Hydronephrosis, Congenital Choledochal Cyst
Effects of Etomidate on Postoperative Circadian Rhythm Changes of Salivary Cortisol in Children
Etomidate is an unique drug used for induction of general anesthesia and sedation. Adrenal cortical inhibition by etomidate has received much attention.
- Conditions
- Congenital Hydronephrosis, Congenital Choledochal Cyst, Fracture
- Trial name
- NCT02013986
- Testing
- etomidate, midazolam, propofol
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Du yi
Sedation Complication, Endoscopic Submucosal Dissection
Efficacy and Safety of Etomidate Sedation in Gastric Endoscopic Submucosal Dissection
During endoscopy, the patient is sedated to relieve pain and improve the ease of the procedure. Sedation endoscopy using propofol is effective, but has the disadvantage that cardiopulmonary side effects are frequently observed.
- Conditions
- Sedation Complication, Endoscopic Submucosal Dissection, Esophagogastroduodenoscopy
- Trial name
- NCT05407870
- Testing
- Etomidate Injection, Propofol Injection
- Where
- South Korea
- Volunteers
- 138 people
- Sponsor
- Korea University Anam Hospital
Patient Admitted in Reanimation
Hydrocortisone Use After Etomidate in Intensive Care
the objective of the study is to assess the value of substitution with 200mg/24h of hydrocortisone for 48 hours for patients in intensive care who have received a single injection of etomidate
- Trial name
- NCT00862381
- Testing
- Hydrocortisone
- Where
- 2 sites in France
- Volunteers
- 106 people
- Sponsor
- University Hospital, Grenoble
Intubation; Difficult
Ketamine Versus Etomidate During Rapid Sequence Intubation: Consequences on Hospital Morbidity
The expected benefit is a reduction of the morbidity of patients admitted in the intensive care unit having received ketamine for intubation.
- Trial name
- KETASED (NCT00440102)
- Testing
- Ketamine, Etomidate
- Where
- France
- Volunteers
- 655 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hemodynamics, Side Effects
Etomidate vs Propofol-Induction Characteristics
The ideal induction agent for day care surgery should have properties of rapid, smooth induction, better haemodynamic profile, faster recovery and devoid of side effects in the form of pain on injection, involuntary movements…
- Trial name
- Induction (NCT02807610)
- Testing
- Inj Etomidate, Injection Propofol
- Volunteers
- 100 people
- Sponsor
- Maharashtra University of Health Sciences
Airway Control, Anesthesia
Ketamine Versus Etomidate for Rapid Sequence Intubation
The purpose of this study is to compare the effectiveness and safety of ketamine and etomidate during rapid sequence intubation (RSI).
- Conditions
- Airway Control, Anesthesia, Intubation, Complication
- Trial name
- NCT01823328
- Testing
- Ketamine, Etomidate
- Where
- United States
- Volunteers
- 143 people
- Sponsor
- Hennepin Healthcare Research Institute
Coronary Artery Bypass Surgery
A Comparison of Etomidate and Ketamine for Anesthesia Induction in Coronary Artery Bypass Graft Surgery
The aim of this study is to determine whether ketamine is an acceptable alternative to etomidate for anesthesia induction in coronary artery bypass graft surgery in terms of hemodynamic stability and also to compare these agents…
- Trial name
- NCT01386229
- Testing
- Ketamine, Etomidate
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Baskent University
Pharmacokinetics
Substance Balance Trial of Methoxyethyl Etomidate Hydrochloride
This study was a single-center, single-dose, open-label design with 6-8 healthy adult male subjects to evaluate the body material balance of [14C]ET-26.
- Trial name
- NCT06822114
- Testing
- Methoxyethyl Etomidate Hydrochloride
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Ahon Pharmaceutical Co., Ltd.
Gastrointestinal Endoscopy
Etomidate Combined With Propofol Versus Propofol for Sedation in High-Altitude Patients During Gastroscopy: a Randomized Multicenter Clinical Trial
One of the most common adverse events during sedated gastrointestinal endoscopy is hypoxemia, which can lead to serious consequences.
- Trial name
- NCT07079176
- Testing
- etomidate combined with propofol, propofol
- Volunteers
- 732 people
- Sponsor
- RenJi Hospital
QT Interval, Variation in
Clinical Trial of the Effect of Methoxyethyl Etomidate Hydrochloride on the QT Interval of the Heart
A single intravenous injection of 0.8mg/kg or 2.8mg/kg Et-26-hcl was given to 18 subjects. The effect of plasma concentration on QT interval was evaluated by C-QTc effect model, and the pharmacokinetic characteristics and safety…
- Trial name
- NCT06822153
- Testing
- ET-26 0.8mg/kg(low-dose) group, ET-26 2.8mg/kg(high dose) group
- Where
- China
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Ahon Pharmaceutical Co., Ltd.