Clinical trials: Evaporative Dry Eye
Evaporative Dry Eye Disease
Comparative Efficacy Study to Demonstrate the Non-inferiority of I-DROP® MGD Versus 2 Competitor Eye Drops in Managing Evaporative Dry Eye
A Pilot Comparative study between I-DROP MGD vs two commercially available lubricant eye drops for the management of evaporative dry eye
- Trial name
- NCT06686368
- Testing
- I-DROP MGD, Theloze Duo, Systane Complete PF
- Volunteers
- 60 people
- Sponsor
- I-MED Pharma
Meibomian Gland Dysfunction, Dry Eye
A Multicenter Study Evaluating AZR-MD-001 in Patients With Meibomian Gland Dysfunction and Evaporative Dry Eye Disease (DED)
AZ201801 is a multicenter study of AZR-MD-001 ointment and AZR-MD-001 vehicle in patients with Meibomian Gland Dysfunction (MGD) and evaporative Dry Eye Disease (DED)
- Trial name
- NCT03652051
- Testing
- AZR-MD-001 Low Dose, AZR-MD-001 Mid Dose, AZR-MD-001 High Dose
- Where
- 30 sites in Australia, Canada and 1 more
- Volunteers
- 321 people
- Sponsor
- Azura Ophthalmics
Evaporative Loss Dry Eye Disease
Study for Remote Investigation of Evaporative Dry Eye Disease
Dry eye disease is a common problem that can make your eyes feel uncomfortable and affect your vision, making daily tasks harder.
- Trial name
- I CRIED (NCT06976515)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of California, San Francisco
Dry Eye Disease
Diamond Bur Microblepharoexfoliation, Intense Pulse Light and Meibomian Gland Expression for Evaporative Dry Eye
The goal of this clinical trial is to assess the efficacy and safety of microblepharoeexfoliation (MBE), intense pulse light (IPL) and meibomian gland expression (MGX) combination in patients with meibomian gland dysfunction…
- Trial name
- NCT05857579
- Testing
- Microblepharoexfoliation, Intense pulse light, Meibomian gland expression
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- University of Seville
Evaporative Dry Eye
Quality of Life Improvement in Dry Eye Patients After Intense Pulsed Light Therapy Compared to Punctal Plugs
Dry eye disease (DED) is a widely spread disorder of tears and ocular surface affecting hundreds of millions around the world. Manifestations resulting from moderate to severe DED have significant effects on the patient's quality…
- Trial name
- NCT05331924
- Testing
- IPL therapy, Punctal plugs
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Tanta University
Meibomian Gland Dysfunction
EyeBag Effectiveness in Meibomian Gland Dysfunction
Meibomian gland dysfunction (MGD) is a common condition that causes the secretion from meibomian glands in the eyelids to become blocked. Normally, the secretion helps to maintain a healthy tear film.
- Trial name
- MGD (NCT01870180)
- Testing
- EyeBag
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- Aston University
Dry Eye Syndromes
Topical Ophthalmic AGN-195263 for the Treatment of Evaporative Dry Eye
The objectives of this study are twofold To evaluate the safety and efficacy of 0.1% AGN-195263 administered twice daily compared to its vehicle in patients with evaporative dry eye (EDE) To evaluate the systemic pharmacokinetics…
- Trial name
- NCT02815293
- Testing
- AGN-195263, Vehicle
- Where
- 29 sites in United States
- Volunteers
- 36 people
- Sponsor
- Allergan
Meibomian Gland Dysfunction, Dry Eye
Treatment of Meibomian Gland Dysfunction and Dry Eye in Contact Lens Wearers
The pilot study objective is to evaluate the potential benefits of LipiFlow® System treatment of contact lens wearers with meibomian gland dysfunction and evaporative dry eye by assessing for improvement in meibomian gland…
- Trial name
- NCT02102464
- Testing
- LipiFlow treatment
- Where
- 6 sites in United States, Canada
- Volunteers
- 55 people
- Sponsor
- TearScience, Inc.
Dry Eye Syndrome, Keratoconjunctivitis Sicca
Treatment of Dry Eye Disease Using Pro-ocular™ - A Proof of Concept, Safety, and Efficacy Study
To evaluate the safety and efficacy of 1% Pro-ocular topical gel administered twice daily for 12 weeks in treatment of Dry Eye Disease
- Trial name
- NCT04884217
- Testing
- Pro-ocular™ Topical Gel
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- PharmaDax Inc.
Evaporative Dry Eye
Comparison of Tear Evaporation Rate With Systane Complete in Dry Eye and Non-Dry Eye
The objective of the study is to compare the rate of tear evaporation, measured with a novel evaporimeter, before and for one hour after an eye drop containing nano-sized oil droplets has been instilled.
- Trial name
- BULLDOG (NCT04091581)
- Testing
- Systane Complete
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Evaporative Dry Eye
Comparative Efficacy of Lipid Based Artificial Tears vs Aqueous Based Artificial Tears in Managing EDE
This research aimed to compare the effectiveness of a lipid-based artificial tear (Recuro) against an aqueous-based artificial tear (Softeal) in managing EDE symptoms and signs.
- Trial name
- NCT06913387
- Testing
- Lipid Based Artificial Tears, Aqueous Based Artificial Tears
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Superior University
Dry Eye
Efficacy of 0.38% and 0.18% Sodium Hyaluronate Ocular Lubricants for Dry Eye in Adult Gazan Participants
The goal of this completed clinical trial was to determine if 0.38% and 0.18% sodium hyaluronate (SH) lubricant eye drops improve symptoms of moderate to severe dry eye disease (DED) in adult Gazan participants.
- Trial name
- NCT06851364
- Testing
- 0.38% Sodium Hyaluronate (SH) Eye Drops, 0.18% Sodium Hyaluronate Eye Drops, Normal Saline Eye Drops
- Where
- Palestinian Territories
- Volunteers
- 45 people
- Sponsor
- International Islamic University Malaysia
Dry Eye Syndromes
Lipiflow Treatment Alone vs. Lipiflow + Dextenza Treatment for Dry Eye Disease
To evaluate the benefit of treatment with a physician administered intracanalicular dexamethasone insert in evaporative dry eye disease (DED) patients with meibomian gland disfunction (MGD) and underlying inflammation undergoing…
- Trial name
- NCT04413279
- Testing
- LipiFlow Thermal Pulsation, Dexamethasone Intracanalicular Insert, 0.4mg with LipiFlow Thermal Pulsation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Eye Surgeons of Indiana
Meibomian Gland Dysfunction, Dry Eye Disease
Refractory Meibomian Gland Dysfunction and Plasma Jet
PURPOSE: The investigators propose a new treatment for refractory Meibomian Gland Dysfunction (MGD) patients with plasma jet to remove the hyperkeratinization layer from the lid margin to unblock terminal gland ducts and use…
- Conditions
- Meibomian Gland Dysfunction, Dry Eye Disease, Evaporative Dry Eye, Inflammation
- Trial name
- NCT04608942
- Testing
- Jett Plasma Medical Lift, Mechanical Debridement
- Where
- 2 sites in Brazil
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Evaporative Dry Eye Disease
Safety and Efficacy of NovaTears® + Omega-3 (0.2%) Eye Drops on Signs and Symptoms of Dry Eye
This PMCF study is carried out following successful CE marking of NovaTears® + Omega-3 and is intended to generate systematic clinical data on the safety and performance of the device when used in accordance with the intended…
- Trial name
- NCT04521465
- Testing
- NovaTears® + Omega-3 (Perfluorohexyloctane with 0.2% w/w Omega-3 fatty acid ethyl esters)
- Where
- 2 sites in Germany
- Volunteers
- 36 people
- Sponsor
- Novaliq GmbH
Evaporative Dry Eye
Comparison of Tear Evaporation Rate With DAILIES TOTAL1 and Biotrue ONEday
The purpose of this pilot study is to compare the effect of DAILIES TOTAL1, a low water content silicone hydrogel lens, and Biotrue ONEday, a high water content hydrogel lens, on the rate of tear evaporation.
- Trial name
- MALTESE (NCT04037969)
- Testing
- Nesofilcon A, Delefilcon A
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Dry Eye
Temperature on Evaporative Dry Eye
Ocular surface temperature of a normal person is around 34.6 degree centigrade. After instilling the eye drop, depending on the temperature of the eye drop and the ocular surface, the ocular surface temperature will temporally…
- Trial name
- NCT05720754
- Testing
- Diquafosol tetrasodium, Heated eye mask
- Where
- China
- Volunteers
- 45 people
- Sponsor
- He Eye Hospital
Dry Eye Disease
Study of Efficacy and Tolerability of SYSTANE Complete in Patients With Dry Eye Disease
The purpose of this study is to evaluate the clinical effectiveness and tolerability of SYSTANE® Complete in adult patients with dry eye disease.
- Trial name
- NCT03492541
- Testing
- Propylene glycol-based eye drops
- Where
- 5 sites in United States, Spain and 1 more
- Volunteers
- 134 people
- Sponsor
- Alcon Research
Dry Eye Disease
Vizol S Lipid Balance Efficacy and Safety Study in Patients With Dry Eye
The clinical investigation was intended to investigate the efficacy, ocular tolerability and safety of Vizol S Lipid Balance, a new eye drops, emulsion developed by JADRAN - GALENSKI LABORATORIJ d.d., in patients with moderate to…
- Trial name
- NCT06323395
- Testing
- Vizol S LIPID BALANCE eye drops, ophthalmic saline eye drops
- Where
- 2 sites in Serbia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Jadran Galenski laboratorij d.d.
Primary Sjogren Syndrome, Secondary Sjogren Syndrome
Safety Study of the Use of Topical Cyclosporine in the Treatment of Dry Eye Disease
In the present study the investigators aim to determine the efficacy of an immunomodulating topical medication, compared with a topical lubricant, on the treatment of dry eye disease (DED) due to primary or secondary Sjögren's…
- Conditions
- Primary Sjogren Syndrome, Secondary Sjogren Syndrome, Aqueous Deficient Dry Eye Disease, Evaporative Dry Eye Disease
- Trial name
- NCT02004067
- Testing
- Restasis, Refresh Endura
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Federal University of São Paulo