Clinical trials: Exanimation
Traumatic Brain Injury, Intracerebral Haemorrhage
The EBC Recovery Study
The purpose of this research study to find out if clinically unconscious acute brain injury patients that show brain activation to music and language on electroencephalogram (EEG) (bedside test) have better outcomes and wake up…
- Conditions
- Traumatic Brain Injury, Intracerebral Haemorrhage, Subarachnoid Haemorrhagic Stroke
- Trial name
- NCT04712591
- Testing
- Auditory stimuli
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Miami
Coma
Comparison Between GCS and FOUR Scores
The goal of this observational study is to compare the predictive utility of the Full Outline of Unresponsiveness (FOUR) Score and the Glasgow Coma Scale (GCS) Score in determining outcomes among patients with altered mental…
- Trial name
- GCS/FOUR (NCT06703619)
- Where
- Iraq
- Volunteers
- 240 people
- Sponsor
- Al-Nahrain University
Epilepsy, Coma
Feasibility of Mini-EEG in the Prehospital Setting
The EEG is widely used in the diagnosis of central nervous system pathology, including epileptic seizures and epilepsy. Presently, EEG is available only during office hours in most hospitals, pending on the availability of a…
- Trial name
- NCT02329028
- Testing
- Prehospital mini-EEG
- Where
- Finland
- Volunteers
- 23 people
- Sponsor
- Helsinki University Central Hospital
Coma, Cardiac Arrest
Combined Whole-brain Structural and Functional MRI for the Prediction of Neurological Recovery After Cardiac Arrest
To assess the performance of a predictive model resulting from the analysis of sMRI/fMRI/contrast-enhanced MRI-derived personalized connectomic data, as compared with standard predictors (clinical examination, electrophysiology…
- Conditions
- Coma, Cardiac Arrest, Disorder of Consciousness, Neurologic Disorder
- Trial name
- ARISE (NCT06617377)
- Testing
- advanced whole-brain sMRI/fMRI/contrast-enhanced MRI scan
- Where
- France
- Volunteers
- 263 people
- Sponsor
- University Hospital, Toulouse
Traumatic Brain Injury
Music Therapy for Comatose Brain Injured Patients
The goal of this single-arm observational study is to determine whether alpha music therapy, initiated early in the recovery period, can improve cognitive function for severe traumatic brain injury patients when compared to…
- Trial name
- NCT07544602
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- Mercy Health Ohio
Cardiac Arrest, Coma
GLP-1 Analogs for Neuroprotection After Cardiac Arrest
Experimental studies and previous clinical trials suggest neuroprotective effects of GLP-1 analogs in various degenerative neurological diseases, and in hypoxic brain injuries in experimental designs.
- Trial name
- GLIP1 (NCT02442791)
- Testing
- Byetta (Lilly, Exenatide), 20% Human Albumin
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Jesper Kjaergaard
Brain Death
Incidence of Complications of Brain Death
The purpose of the study is to describe the incidence of complications in brain death adult organ donors.
- Trial name
- NCT04404972
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- Brno University Hospital
Organ Donation
Organ Procurement : Usefulness of a Guide for Meeting With the Next of Kin
A dedicated guide for physicians and organ procurement nurses meeting with the next of kin could be associated with a reduction in organ donation refusal rate, and in anxiety of professionals involved in such meetings
- Trial name
- CANEVAS (NCT02854267)
- Where
- France
- Volunteers
- 322 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiac Arrest
Continuous Jugular Venous Oxygen Saturation (SjO2) Measurement After Cardiac Arrest
Patients successfully resuscitated from sudden cardiac arrest are often comatose, having suffered a period of low blood flow and oxygen delivery to the brain.
- Trial name
- NCT06511999
- Testing
- Continuous SjO2 monitoring with a PediaSat Oximetry Catheter, Intermittent SjO2 monitoring with a PediaSat Oximetry Catheter
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Byron Drumheller
Out-Of-Hospital Cardiac Arrest, Myocardial Infarction
Factors Associated With CPC 1-2 in 110 Patients Admitted in French ICU for a Myocardial Infarction Complicated by an OHCA.
This study evaluate the association of some in-ICU factors with the neurological prognosis of patients admitted for an out-of-hospital cardiac arrest due to a myocardial infarction.
- Conditions
- Out-Of-Hospital Cardiac Arrest, Myocardial Infarction, Coma, Outcome, Fatal
- Trial name
- ACR-MI (NCT04584463)
- Volunteers
- 110 people
- Sponsor
- Central Hospital, Nancy, France
Dyspnea, Coma
The Use of a Point-of-care Thoracic Ultrasound Protocol for Hospital Medical Emergency Teams
Study to assess the possible effects of the use of a point-of-care thoracic ultrasound protocol for hospital medical emergency teams (MET)
- Conditions
- Dyspnea, Coma, Hypotension and Shock
- Trial name
- METUS (NCT03214809)
- Testing
- ultrasound protocol
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Rijnstate Hospital
Sepsis, Asthma
Evaluation of Essential Surgical Skills-Emergency Maternal and Child Health Training
The aim of the proposed study is to determine if specific training in management of general, obstetric, neonatal and pediatric emergencies results in a change in practice of doctors working in emergency departments of public…
- Conditions
- Sepsis, Asthma, Heart Failure, Seizure
- Trial name
- NCT00880204
- Testing
- ESS-EMCH training
- Where
- 2 sites in Pakistan
- Volunteers
- 36 people
- Sponsor
- Child Advocacy International
Consciousness Disorders, Communication
Analysis of Vital, Facial and Muscular Responses Front to Music or Message in Coma, Vegetative State or Sedated Patients
Objectives: (1) To check music or voice message influence on vital signs, facial expressions or muscular tonus of coma, vegetative or sedated patients; (2) To connect the existence of patient's responsiveness with the Glasgow…
- Conditions
- Consciousness Disorders, Communication, Intensive Care
- Trial name
- NCT01141790
- Testing
- Music and voice message
- Where
- Brazil
- Sponsor
- University of Sao Paulo
Critical Illness, Respiratory Failure
International Observational Study on Airway Management in Critically Ill Patients
Endotracheal intubation (ETI) is a potentially life-threatening procedure for critically ill patients and major severe complications such as severe hypoxia, cardiovascular collapse and cardiac arrest are common.
- Conditions
- Critical Illness, Respiratory Failure, Hemodynamic Instability, Coma
- Trial name
- INTUBE (NCT03616054)
- Where
- Italy
- Volunteers
- 3,600 people
- Sponsor
- Azienda Ospedaliera San Gerardo di Monza
Comatose
A Study of Transcutaneous Electrical Stimulation As a Noxious Stimulus for the Glasgow Coma Scale
The purpose of this study is to determine whether electrical stimulation can be used to replace physical stimulation to test awareness of patients with impaired consciousness.
- Trial name
- GCS02 (NCT06681779)
- Testing
- Transcutaneous electrical stimulation, Standard of Care (SOC)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Markey Olson
Traumatic Brain Injury
Comparison of Effectiveness of Pentobarbital and Thiopental in Patients With Refractory Intracranial Hypertension
Objective: to assess the effectiveness of pentobarbital and thiopental to control raised intracranial pressure (ICP), refractory to first level measures, in patients with severe traumatic brain injury.
- Trial name
- NCT00622570
- Testing
- Pentobarbital, thiopental
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Hospital Universitari Son Dureta
Coma
Using EEG to Study Coma in the Neurocritical Care Unit
Despite its clinical significance, the pathophysiology of coma is still under investigation and the physiology of emergence from coma remains a mystery.
- Trial name
- NCT01897194
- Volunteers
- 1 people
- Sponsor
- University of Utah
Coma, Traumatic Brain Injury
Continuous Quantified EEG in NeuroIntensive Care
To evaluate the ability of NICU (NeuroIntensive Care Unit) staff to interpret, before and after a training period, symmetry, sedation level, seizures activities and artefact on continuous cEEG/qEEG (continuous…
- Conditions
- Coma, Traumatic Brain Injury, Subarachnoid Hemorrhage, Ischemic Stroke
- Trial name
- CrazyEEG (NCT02901262)
- Where
- 2 sites in Italy
- Volunteers
- 30 people
- Sponsor
- Azienda Ospedaliera San Gerardo di Monza
Disorder of Consciousness, Minimally Conscious State
Diagnostic Accuracy of the Vegetative and Minimally Conscious State
The aim of this study was to investigate diagnostic accuracy of the vegetative and minimally conscious state: Clinical consensus versus standardized neurobehavioral assessment
- Trial name
- NCT04139239
- Testing
- Coma Recovery Scale-revision
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Hangzhou Normal University
Brain Death
The Use of Liraglutide in Brain Death
There is evidence of the association of brain death and inflammation, affecting outcomes of transplanted organs, but in a way not fully understood.
- Trial name
- NCT03672812
- Testing
- Liraglutide
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Hospital de Clinicas de Porto Alegre