Clinical trials: Excision Margin
Prostate Cancer
Docetaxel Compared With Observation in Treating Patients Who Have Undergone Radical Prostatectomy for Prostate Cancer
RATIONALE: Drugs used in chemotherapy, such as docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00376792
- Testing
- docetaxel, active surveillance, adjuvant therapy
- Where
- 8 sites in Denmark, Finland and 3 more
- Volunteers
- 396 people
- Sponsor
- Scandinavian Prostate Cancer Group
Hepatocellular Carcinoma
The Influence of Resection Margin on the Recurrence of Early-stage Hepatocellular Carcinoma
Before the surgery, the investigators predict the risk of microvascular invasion (MVI) presence for the early-stage hepatocellular carcinoma according to the nomogram the investigators have created.
- Trial name
- NCT02525965
- Testing
- Wide resection margin >1cm, Narrow resection margin <1cm
- Where
- China
- Volunteers
- 194 people
- Sponsor
- Eastern Hepatobiliary Surgery Hospital
Breast Cancer, Sentinel Lymph Node
Tumor-Targeted-NIR-II Fluorescent Molecular Probes for the Identification of Breast Cancer Tissue and SLN Metastatic Status
Accurate evaluation of tumor boundaries in breast-conserving surgery is closely associated with reducing the second operation of patients.
- Conditions
- Breast Cancer, Sentinel Lymph Node, Metastases, Margin Assessment
- Trial name
- NIR-II (NCT06713161)
- Testing
- NIR-II Probe(i.e ICG-POL6326) incubation solution
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Yunnan Cancer Hospital
Breast Cancer
Excision Followed by Radiofrequency Ablation for Breast Cancer
The purpose of this study will be to evaluate, in a multi-center setting, the ability of radiofrequency ablation (RFA) of breast cancer lumpectomy sites to extend the "final" negative margin and consequently decrease the rates of…
- Trial name
- ABLATE (NCT01153035)
- Testing
- Radiofrequency Ablation
- Where
- 6 sites in United States
- Volunteers
- 104 people
- Sponsor
- University of Arkansas
Solid Tumor, Small Cell Lung Cancer (SCLC)
Dose Determining Study of EXS74539 (REC-4539) in Participants With Select Solid Tumors
The primary purpose of this study is to determine the safety, tolerability, and maximum tolerated dose (MTD) of EXS74539 (REC-4539) in participants with select solid tumors.
- Conditions
- Solid Tumor, Small Cell Lung Cancer (SCLC), High Grade Neuroendocrine Cancer, Small Cell Carcinomas of Non-lung Origin
- Trial name
- NCT07517198
- Testing
- EXS74539
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Exscientia AI Ltd., a wholly owned subsidiary of Recursion Pharmaceuticals, Inc.
Colorectal Polyp
Assessment of Endoscopic Tip Control Using a Novel Score Based on the Snare Tip Soft Coagulation of Polypectomy Margin Defects
Colorectal cancer is the third most common malignancy worldwide and the second leading cause of cancer related death with approximately 880 792 deaths every year (9,2% of the global yearly 9.6 million cancer deaths).
- Trial name
- NCT05660317
- Testing
- Tip control score
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Margin, Tumor-Free, Breast Cancer
Impact of Systematic Shaving on Margins
The objective of this clinical trial is to demonstrate the reduction of positive margins in the definitive pathology of patients undergoing breast-conserving surgery with the systematic shaving technique compared to conventional…
- Conditions
- Margin, Tumor-Free, Breast Cancer, Surgery
- Trial name
- NCT05782686
- Testing
- Margin shaving
- Where
- Spain
- Volunteers
- 234 people
- Sponsor
- Hospital Universitari de Bellvitge
Breast Cancer, Chemotherapy Effect
Simvastatin Effect in Combination With Neoadjuvant Chemotherapy to Clinical Response and Tumor-Free Margin in Locally Advanced Breast Cancer
Introduction: Neoadjuvant chemotherapy (NACT) has been the standard therapy for treating patients with locally advanced breast cancer (LABC). Doxorubicin-based regimen showed a clinical response for 70-80%.
- Trial name
- NCT04418089
- Testing
- Simvastatin 40mg
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Universitas Indonesia
Breast Cancer, Ductal Carcinoma In Situ
HISMAR: Intraoperative Margin Assessment Using the Histolog® Scanner to Reduce Reoperation in Breast-Conserving Surgery
This study evaluates whether systematic intraoperative margin assessment using the Histolog® Scanner - a confocal fluorescence microscopy device - reduces the need for reoperation after breast-conserving surgery (lumpectomy) in…
- Conditions
- Breast Cancer, Ductal Carcinoma In Situ, Invasive Lobular Carcinoma, Breast Neoplasm Female
- Trial name
- HISMAR (NCT07527468)
- Testing
- Histolog® Scanner
- Where
- Switzerland
- Volunteers
- 228 people
- Sponsor
- Hôpital du Valais
Rectal Cancer
Optical Biopsy for Distal Margin in Low Rectal Cancer
This is a multi-center prospective randomized controlled study. In this study, the investigators will use confocal laser endomicroscopy to make real-time in vivo optical biopsy of distal margin in rectal cancer surgery and help…
- Trial name
- NCT04016948
- Testing
- Probe-based confocal laser endomicroscopy optical biopsy, Intra-operative frozen section
- Where
- China
- Volunteers
- 146 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Prostate Cancer
Retrospective Study of Positive Biopsy Specimens on Patients Undergoing a Prostatectomy
This is a review of prostate biopsy specimens which show capsular penetration or positive surgical margins. Patients had surgery performed at William Beaumont Hospital-Royal Oak, Michigan.
- Trial name
- NCT00513721
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Corewell Health East
Skin Cancer
Optical Imaging of Skin Cancers for Margin Delineation of Non-Melanoma Skin Cancers
The goal of this clinical research study is to evaluate an experimental imaging technology, the multispectral digital microscope (MDM), which may help doctors see how far skin cancer extends (widens out) on an area of skin.
- Trial name
- NCT00432471
- Testing
- Optical Imaging
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- M.D. Anderson Cancer Center
Crohn Disease
Intraoperative Ultrasound in Crohn's Disease
To study the role of intraoperative ultrasound of small bowel as a possible tool that can reduce the rate of histologically involved resection margins from Crohn's Disease.
- Trial name
- NCT06388057
- Testing
- Intraoperative Small Bowel Ultrasonography
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Rectal Cancer, Rectal Adenocarcinoma
Evaluation of Rectal Tumor Margin Using Confocal Endomicroscopy and Comparison to Histopathology
This innovative study will involve the use of probe-based confocal laser endomicroscopy, a new medical imaging technology never used for surgical indications to date.
- Trial name
- TRaMA (NCT01887509)
- Testing
- Probe-based confocal laser endomicroscopy, Rectoscopy, EUS
- Where
- France
- Volunteers
- 21 people
- Sponsor
- IHU Strasbourg
Breast Cancer Female
Wide-field Optical Coherence Tomography Imaging of Excised Breast Tissue.
This is a single-arm, multi-center data collection study designed to collect WF-OCT imaging data of excised breast tissue margins with corresponding margin status from histopathology.
- Trial name
- NCT04242277
- Testing
- Investigational WF-OCT device
- Where
- 2 sites in United States
- Volunteers
- 198 people
- Sponsor
- Perimeter Medical Imaging
Squamous Cell Carcinoma (SCC), Basal Cell Carcinoma (BCC)
Intraoperative Margin Assessment During Mohs Surgery
The research team will develop an intraoperative handheld device for assessing surgical margins during Mohs surgery. The device technology is based on multimodal optical spectroscopy (MMS), combining three optical spectroscopy…
- Trial name
- NCT02750033
- Testing
- Multimodal Spectroscopy (MMS)
- Sponsor
- Seton Healthcare Family
Fluorodeoxyglucose F18
Peroperative Assessment of Tumour Resection Margins Using High-resolution 18F-FDG-PET/CT in Pancreatic Adenocarcinoma
One of the main risks for recurrence in patients with pancreatic cancer is incomplete surgery of the primary tumor. During the operation, the surgeon bases himself for this on imaging and peroperative vision.
- Trial name
- IMA-PANC-CA (NCT05023291)
- Testing
- Positron Emissie Tomografie - Computer Tomografie
- Where
- Belgium
- Volunteers
- 5 people
- Sponsor
- University Hospital, Ghent
Astrocytoma, Glioblastoma
Investigational Imaging Technique During Brain Surgery
This early phase I trial tests the safety and reliability of an investigational imaging technique called quantitative oblique back illumination microscopy (qOBM) during brain surgery for detecting brain tumors and brain tumor…
- Conditions
- Astrocytoma, Glioblastoma, Oligodendroglioma
- Trial name
- NCT05513859
- Testing
- Craniotomy, Quantitative Oblique Back-Illumination Microscopy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Emory University
Uterine Cervical Neoplasm, Endometrial Neoplasms
Online Adaptive Radiotherapy for Postoperative Treatment of Endometrial and Cervical Cancer
Online adaptive radiotherapy (oART) has demonstrated to be feasible to reduce planning target volume (PTV) margins for postoperative treatment of endometrial and cervical cancer.
- Trial name
- NCT05869123
- Testing
- Online adaptive radiotherapy
- Where
- China
- Volunteers
- 17 people
- Sponsor
- Peking Union Medical College Hospital
Polyp Resection Adequacy
Colorectal Polyp Resection Adequacy
The purpose of this study is to determine the best way to ensure that polyps are completely removed by evaluating the borders of the removed polyp.
- Trial name
- NCT02217085
- Where
- United States
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center