Clinical trials: Excision Margin
Glioblastoma Multiforme, Adult
UNIty-Based MR-Linac Guided Adaptive RadioThErapy for High GraDe Glioma-3 (UNITED-3)
The goal of this study is to test whether an adaptive radiation therapy (RT), two-phase approach in participants with glioblastoma impacts local control compared to standard non-adaptive RT approach.
- Trial name
- UNITED-3 (NCT05720078)
- Testing
- Adaptive, two-phase RT
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Sunnybrook Health Sciences Centre
Dry Eye Syndrome
Lid Margin And Conjunctival Microbial Flora Following Punctum Occlusion
To determine if the types and amount of bacteria or other germs change over time after the routine procedure of blockage of tear drainage duct in the treatment of dry eye condition or other condition benefiting from a tear…
- Trial name
- NCT00735865
- Testing
- Punctal plugs, punctal cautery, Punctal Plug, Punctal thermocauterization, Silicone plug or thermodynamic hydrophobic acrylic plug
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- Lahey Clinic
HepatoCellular Carcinoma
Radiotherapy in Hepatocellular Carcinomas After Hepatectomy With Narrow Margin (<1 cm) and / or Microvascular Invasion
Hepatocellular carcinoma is one of ten leading cancer types worldwide and also in Asia, but the five-year relative survival rate is relatively quite low1-3.
- Trial name
- RHCC:BCLC-A (NCT02678806)
- Testing
- Postoperative radiotherapy, Postoperative TACE
- Where
- China
- Volunteers
- 620 people
- Sponsor
- Guangxi Medical University
Gingivitis
Influence of the Restorative Cervical Margin Placement on the Supracrestal Tissue Attachment
The aim of the present study is to understand the influence that marginal/subgingival restorations exert on the surrounding periodontal tissues.
- Trial name
- NCT04299347
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Siena
Rectal Cancer
Intraoperative Assessment of Distal Resection Margins Using Frozen Section in Mid and Low Rectal Cancer Surgery
This study aims to improve the safety of distal surgical margins in patients with middle and low rectal cancer who receive neoadjuvant radiotherapy.
- Trial name
- NCT07398716
- Testing
- Intraoperative Frozen Section Assessment, Standard Surgery Without Frozen Section
- Where
- Turkey (Türkiye)
- Volunteers
- 99 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Squamous Cell Carcinoma Head and Neck Cancer (HNSCC), Margin Assessment
Intraoperative Molecular Imaging Using ICG for Head and Neck Tumors
This study is for adult patients with head and neck cancer who are at risk of recurrence. The purpose of this study is to evaluate whether the use of Indocyanine Green (ICG) dye allows for better identification of tumor tissue…
- Trial name
- NCT07149207
- Testing
- Indocyanine Green (ICG)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Medical University of South Carolina
Hepatocellular Carcinoma (HCC), Radiotherapy, Adjuvant
Adjuvant Radiotherapy of Sintilimab Versus TACE for HCC
This study is an open-label, randomized controlled, multicenter, phase III clinical trial
- Conditions
- Hepatocellular Carcinoma (HCC), Radiotherapy, Adjuvant, Immune Checkpoint Inhibitor, TACE
- Trial name
- NCT07186621
- Testing
- Sintilimab, radiotherapy, TACE
- Where
- China
- Volunteers
- 286 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Dry Eye, Dry Eye Syndromes
Effect of Micropulse Laser on Dry Eye Disease Due to Meibomian Gland Dysfunction
The modern treatment of meibomian gland dysfunction(MGD) is based on anti-inflammatory drops or oral antibiotics for decreasing dry eye disease (DED) associated inflammation, warm compresses for liquefying the thicker meibum, and…
- Conditions
- Dry Eye, Dry Eye Syndromes, Meibomian Gland Dysfunction
- Trial name
- NCT04425551
- Testing
- laser light
- Where
- 2 sites in Greece
- Volunteers
- 30 people
- Sponsor
- Naval Hospital, Athens
Crown Lengthening
Gingival Margin Stability Following Esthetic Crown Lengthening Utilizing a Double Periodontal Surgical Guide
In patients with excessive gingival display, esthetic crown lengthening procedure by means of scalpel, diode laser or electro-surgery could result in the same gingival marginal stability at 3 and 6 months follow up.
- Trial name
- NCT06397521
- Testing
- Crown lengthening
- Where
- Egypt
- Volunteers
- 21 people
- Sponsor
- Ain Shams University
Head and Neck Neoplasms, Thyroid Neoplasm
Peroperative Assessment of Malignancies of the Head and Neck Using High-resolution 18F-FDG-PET/CT
In this study, patients diagnosed with a pathology-proven malignancy of the head and neck will receive a routine clinical activity of 18F-FDG ((18)F-luorodeoxyglucose) before undergoing standard of care surgical resection of the…
- Conditions
- Head and Neck Neoplasms, Thyroid Neoplasm, Skin Neoplasm
- Trial name
- NCT05068687
- Testing
- high-resolution PET-CT specimen imaging.
- Where
- Belgium
- Volunteers
- 9 people
- Sponsor
- University Hospital, Ghent
Breast Cancer
Post-market Evaluation of LumiSystem: Intraoperative Margin Performance and Clinical Utility (IMPACT) Registry
This is a minimal risk post-market registry study conducted at participating clinical institutions that are utilizing LumiSystem consistent with the U.S.
- Trial name
- IMPACT (NCT07616856)
- Where
- 2 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- Lumicell, Inc.
Non-Small Cell Lung Cancer
Factors Determine the Feasibility and Surgical Margin Quality of Sublobar Resection for Non-small Cell Lung Cancer?
Sublobar resection (SR) has been recognized as non-inferior to lobectomy for small-sized non-small cell lung cancer (NSCLC). This study aimed to systematically identify the potential factors influencing the feasibility and…
- Trial name
- NCT07005401
- Where
- China
- Volunteers
- 1,064 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Rectal Cancer, Treatment
Safety and Efficacy Study of Cylindrical Abdominoperineal Resection to Treat Rectal Cancer
The purpose of this study is to determine whether cylindrical abdominoperineal resection is effective in the treatment of advanced very low rectal cancer
- Conditions
- Rectal Cancer, Treatment, Postoperative Complications, Neoplasm Recurrence, Local
- Trial name
- NCT00949273
- Testing
- cylindrical abdominoperineal resection
- Where
- 7 sites in China
- Volunteers
- 300 people
- Sponsor
- Beijing Chao Yang Hospital
Breast-Conserving Surgery
A Novel Intraoperative Fluorescence-guided System for Evaluating Margins During Breast-conserving Surgery for Breast Cancer
The goal of this clinical trial is to learn if a novel intraoperative fluorescence-guided system (EndoSCell Scanner) can help surgeons more accurately remove all cancerous tissue during breast-conserving surgery in female…
- Trial name
- NCT07352930
- Testing
- EndoSCell Scanner (ES Scanner) System
- Where
- China
- Volunteers
- 172 people
- Sponsor
- Guangdong Provincial People's Hospital
Solid Tumor, Adult
Ex Vivo Tumor Visualization and Resection Margin Assessment Using Topically Applied Fluorescent Imaging Agents
This is a proof-of-principle study, that uses freshly resected human solid tumor specimens to assess the performance of topically applied fluorescent imaging agents for the detection of tumor tissue and close / tumor-positive…
- Trial name
- SprayDye (NCT06292845)
- Testing
- Topical application of a fluorescent imaging agent
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Erasmus Medical Center
Dental Restoration Failure of Marginal Integrity
Clinical Evaluation of Subgingival Open Sandwich Restorations
This study was designed to evaluate and compare the 3-year periodontal responses and clinical performance of proximal subgingival open sandwich restorations using three different glass ionomer-based restorative materials and…
- Trial name
- NCT05125900
- Testing
- Proximal box elevation using one of the tested materials
- Where
- Egypt
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Altered Passive Eruption of Teeth
The Effect of Using Two Different Suturing Techniques on Free Gingival Marginal Stability
Gummy smile is one of the major esthetic problems nowadays; it is due to several causes that either dental or skeletal. Etiology of the gummy smile is altered passive eruption, vertical maxillary excess, different gingival…
- Trial name
- NCT04219436
- Testing
- vertical mattress suturing technique, figure of eight suturing technique
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Anal Basaloid Carcinoma, Anal Canal Cloacogenic Carcinoma
Nivolumab After Combined Modality Therapy in Treating Patients With High Risk Stage II-IIIB Anal Cancer
This phase III trial investigates how well nivolumab after combined modality therapy works in treating patients with high risk stage II-IIIB anal cancer.
- Conditions
- Anal Basaloid Carcinoma, Anal Canal Cloacogenic Carcinoma, Anal Margin Squamous Cell Carcinoma, Stage IIB Anal Cancer AJCC v8
- Trial name
- NCT03233711
- Testing
- Biopsy Procedure, Biospecimen Collection, Colonoscopy
- Where
- 896 sites in United States, Canada
- Volunteers
- 344 people
- Sponsor
- National Cancer Institute (NCI)
Circumferential Resection Margin, Intraoperative Perforation of Rectum
Surgery Without Neoadjuvant Chemoradiotherapy Compared With Neoadjuvant Chemoradiotherapy for Rectal Cancer With Negative Circumferential Resection Margin Based on MRI Assessment, a Perspective Multicenter Randomized Controlled Trial
For now, neoadjuvant chemoradiotherapy is routinely performed for T3N1-2M0 rectal cancer. However, there are lots of complications following neoadjuvant chemoradiotherapy, such as Wound-related complications, anastomotic leakage…
- Conditions
- Circumferential Resection Margin, Intraoperative Perforation of Rectum, Local Recurrence of Malignant Tumor of Rectum, Disease-free Survival
- Trial name
- SCRM-01 (NCT03504449)
- Testing
- neoadjuvant chemoradiotherapy
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Beijing Chao Yang Hospital
Breast Cancer
Intraoperative Margin Assessment in Breast Cancer With HSI-Raman
Breast-conserving surgery (lumpectomy) aims to remove cancer while preserving healthy tissue, but up to 20% of patients require a second operation because cancer cells remain at the edge (margin) of the removed tissue.
- Trial name
- Spectra-BREAST (NCT07111728)
- Testing
- Spectra-BREAST system in Invasive Breast Cancer, Spectra-BREAST system in DCIS Breast Cancer
- Where
- Italy
- Volunteers
- 104 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA