Clinical trials: Excision Margin
Breast Cancer - Ductal Carcinoma in Situ (DCIS), Breast-Conserving Surgery
Reoperation Rate in Breast-Conserving Surgery Using Confocal Histolog® Scanner for Intraoperative Margin Assessment
This PMPF study is proposed to evaluate in real life the reoperation rates (ROR) of breast cancer and/or DCIS surgery when including the use of the HLS in the context of breast lumpectomy margin assessment.
- Trial name
- SHIELD (NCT05946759)
- Testing
- Histolog Scanner
- Where
- Germany
- Volunteers
- 54 people
- Sponsor
- SamanTree Medical SA
Gingival Recession, Localized
Effect of Restoration Margin Level in the Treatment of Gingival Recession Associated With Non-carious Cervical Lesion
The aim of this randomized, parallel-group clinical trial was to compare the 1-year periodontal, root coverage, esthetic, and patient-centered outcomes of the partial restoration placement with different apical margin levels…
- Trial name
- NCT05682274
- Testing
- Partial restoration approach combined with CAF+CTG
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Gazi University
Glioblastoma Multiforme, Adult
UNIty-Based MR-Linac Guided Adaptive RadioThErapy for High GraDe Glioma-3 (UNITED-3)
The goal of this study is to test whether an adaptive radiation therapy (RT), two-phase approach in participants with glioblastoma impacts local control compared to standard non-adaptive RT approach.
- Trial name
- UNITED-3 (NCT05720078)
- Testing
- Adaptive, two-phase RT
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Sunnybrook Health Sciences Centre
Gastric Tumors
Usefulness of Near-focus With Narrow-band Imaging
Near-focus with narrow-band imaging is a novel technique to improve the quality of images of the irregular mucosal structures and microvessels of gastric neoplasms.
- Trial name
- NCT02661945
- Testing
- Near focus with narrow band imaging
- Where
- 7 sites in South Korea
- Volunteers
- 444 people
- Sponsor
- Kyunghee University Medical Center
Vulvar Neoplasm, Dysplasia Vulvar
A Study Evaluating the Effect of Frozen-Section Directed Excision Surgery on Vulvar Dysplasia
The purpose of this study is to compare "Frozen-Section Directed Excision", which has been a proven method of surgery used in dermatology, versus the current, standard method called "Wide Local Excision" to treat high-grade…
- Trial name
- NCT05934851
- Testing
- Frozen-Section Directed Excision, Wide Local Excision
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Wake Forest University Health Sciences
Prostate Cancer
The AIM Study: Assessing the Impact of Margin Reduction
This study will observe patients who receive external beam radiation for prostate cancer. These patients will be localized and tracked (targeted) with the Calypso 4D Localization System.
- Trial name
- AIM (NCT00754000)
- Testing
- Observation
- Where
- 4 sites in United States
- Volunteers
- 82 people
- Sponsor
- Varian, a Siemens Healthineers Company
Non-Small Cell Lung Cancer
Factors Determine the Feasibility and Surgical Margin Quality of Sublobar Resection for Non-small Cell Lung Cancer?
Sublobar resection (SR) has been recognized as non-inferior to lobectomy for small-sized non-small cell lung cancer (NSCLC). This study aimed to systematically identify the potential factors influencing the feasibility and…
- Trial name
- NCT07005401
- Where
- China
- Volunteers
- 1,064 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Transverse Colon Cancer
Resection Margin of Transverse Colon Cancer With Extracorporeal Versus Intracorporeal Anastomosis
The approach of anastomosis in laparoscopic resection of transverse colon cancer (TCC) has rarely been discussed. This study aims to compare the resection margin of TCC with extracorporeal anastomosis (ECA) versus intracorporeal…
- Trial name
- NCT05061199
- Testing
- approach of anastomosis
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Shanghai Minimally Invasive Surgery Center
Breast Cancer Female
Intraoperative Use of an Optical Coherence Tomography (OCT) Imaging System to Guide Additional Margin Cavity Shaves in Breast Conserving Surgery (BCS)
Female patients undergoing a breast conserving procedure will be consented for the excised breast tissue to be imaged on an investigational OCT-based device.
- Trial name
- NCT04314700
- Testing
- OCT- based investigational imaging device
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Perimeter Medical Imaging
Psoriasis
Study of Subcutaneous (Injected Under the Skin) Risankizumab to Assess Change in Disease Symptoms in Adult Participants With Moderate to Severe Plaque Psoriasis With Palmoplantar Involvement
Plaque Psoriasis is a chronic inflammatory disease in which skin cells build up and develop scaly red and white patches on the skin. It is caused by an overactive immune system where the body attacks healthy tissue by mistake.
- Trial name
- IMMprint (NCT04713592)
- Testing
- Risankizumab
- Where
- 55 sites in United States, Canada and 2 more
- Volunteers
- 174 people
- Sponsor
- AbbVie
Varicose Veins, Cicatrix
Juvista (Avotermin) in Scars Following Varicose Vein Removal
This trial is being undertaken to investigate the efficacy and safety of Juvista in the improvement of scar appearance when administered to approximated wound margins following varicose vein surgery.
- Trial name
- NCT00430326
- Testing
- Avotermin
- Where
- 21 sites in Belgium, Latvia and 2 more
- Volunteers
- 156 people
- Sponsor
- Renovo
Prostate Cancer
Prostate Margin Reduction to Reduce Acute Rectal Toxicity (PROTRACT)
The objectives of this study are: 1. Retrospectively validate a reduced margin schema for intermediate risk prostate hypofractionated VMAT treatments 2.
- Trial name
- PROTRACT (NCT04004858)
- Testing
- External beam radiation therapy
- Where
- 3 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Southlake Health
Rectal Cancer
Intraoperative Assessment of Distal Resection Margins Using Frozen Section in Mid and Low Rectal Cancer Surgery
This study aims to improve the safety of distal surgical margins in patients with middle and low rectal cancer who receive neoadjuvant radiotherapy.
- Trial name
- NCT07398716
- Testing
- Intraoperative Frozen Section Assessment, Standard Surgery Without Frozen Section
- Where
- Turkey (Türkiye)
- Volunteers
- 99 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
High-grade Squamous Intraepithelial Lesions (HSIL), Cervical Conization
Predicting Treatment Failure in HSIL Patients with Positive Margins After Conization Via Detection of PAX1 Methylation
The goal of this multicenter, observational study is to evaluate whether methylation testing of paired box gene 1 (PAX1) can better predict and diagnose recurrence or persistent disease in patients with positive margins after…
- Trial name
- NCT06713655
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma
Real-time Margin Assessment in Head and Neck Cancer
To investigate if the combination of fresh frozen sectioning based on cetuximab-800CW can enhance tumor-positive margin detection intra-operatively.
- Trial name
- LIGHTNING (NCT05499065)
- Testing
- Fluorescence guided detection of tumor positive margins, Cetuximab-IRDye800
- Where
- Netherlands
- Volunteers
- 23 people
- Sponsor
- University Medical Center Groningen
Customized Healing Abutment Bone Grafts Connective Tissue Graft Immediate Implant Placement
Midfacial Gingival Margin Changes Following Immediate Implants.
Dimensional changes, including the loss of labial soft tissues and midfacial gingival recession, seem to be inevitable following immediate placement.
- Trial name
- NCT05975515
- Testing
- Connective tissue graft /Bone graft/ Customized HA
- Where
- Egypt
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Cairo University
Breast Cancer
Breast Cancer Margin Delineation Using Polarization Subtraction Imaging Technology
This study will evaluate LumaScan, an innovative polarization microscope for real time, intraoperative imaging and evaluation of the surface of excised tissue excised during Breast Conservation Surgery (BCS) for non invasive and…
- Trial name
- NCT02207179
- Testing
- LumaScan Image Guided Surgery
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- LumaMed
Pancreatic Cancer, Diagnosis
The Application of Probe Confocal Laser Endomicroscopy in Pancreatic Tumor Surgery
Aim of the study: To evaluate the value of Probe Confocal Laser Endomicroscopy (PCLE) in surgery for pancreatic tumor. Methods: Patients who are diagnosed with pancreatic tumor based on preoperative radiographic findings and will…
- Conditions
- Pancreatic Cancer, Diagnosis, Pancreatoduodenectomy, Distal Pancreatectomy
- Trial name
- NCT06289803
- Testing
- probe confocal laser endomicroscopy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Fudan University
Prosthesis User, Digitalism
"Clinical Evaluation of Retraction Cord Effectiveness Using Intraoral Scanner
Dental-supported fixed partial dentures (FPDs) have long been a commonly preferred treatment method for the rehabilitation of teeth with excessive substance loss and for addressing existing tooth deficiencies.
- Trial name
- NCT06447389
- Testing
- retraction cordu (SURE-CORD®PLUS)
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Complete Placenta Previa
Efficacy Study of Random Placenta Margin Incision to Treat Complete Placenta Previa
The purpose of this study is to assess the efficacy of random placenta margin incision for hemorrhage control during cesarean section of complete placenta previa pregnancies.
- Trial name
- NCT02695069
- Testing
- Random Placenta Margin Incision
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Maternal and Child Health Hospital of Foshan