Clinical trials: Excision Margin
Gummy Smile
Clinical Evaluation of Conventional Versus Microsurgical Techniques of Esthetic Crown Lengthening
the study compare gingival margin stability following conventional approach versus microsurgical approach of esthetic crown lengthening in management of patients with short clinical crowns in the upper anterior region.In…
- Trial name
- NCT03804281
- Testing
- Test group, Control group
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Hepato Cellular Carcinoma, Intrahepatic Bile Duct Carcinoma
Peritumoral MRE Stiffness for Predicting Resection Margin Status and Recurrence in Liver Cancer
Microscopic residual tumor at the resection margin is a critical risk factor for recurrence in patients undergoing hepatectomy for liver cancer, yet current detection relies solely on postoperative pathological examination of the…
- Conditions
- Hepato Cellular Carcinoma, Intrahepatic Bile Duct Carcinoma, Metastatic Hepatocellular Carcinoma
- Trial name
- NCT07704216
- Testing
- Three-Dimensional Magnetic Resonance Elastography
- Volunteers
- 150 people
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Stomach Neoplasms, Siewert Type II Adenocarcinoma of Esophagogastric Junction
Length of the Proximal Resection Margin for Siewert-II/Siewert-III Tumors
The incidence of adenocarcinomas of the esophagogastric junction (AEJ) has increased rapidly during the past decades. By the Siewert classification, the AEJ is the tumor center located 5 cm above the anatomic cardia and 5 cm…
- Conditions
- Stomach Neoplasms, Siewert Type II Adenocarcinoma of Esophagogastric Junction, Recurrence, Siewert Type III Adenocarcinoma of Esophagogastric Junction
- Trial name
- NCT02313688
- Testing
- gastrectomy
- Where
- China
- Volunteers
- 320 people
- Sponsor
- West China Hospital
Patient Satisfaction, Bleaching Efficacy
Patient Satisfaction With At-home Dental Bleaching Using Orthodontic Retainers With Different Margin Designs
This randomized single-blind, split-mouth clinical trial evaluated patient satisfaction with at-home dental bleaching using orthodontic retainers with different margin designs, as well as bleaching efficacy, tooth sensitivity…
- Conditions
- Patient Satisfaction, Bleaching Efficacy, Tooth Sensitivity, Gingival Irritation
- Trial name
- NCT07208708
- Testing
- Scalloped margin retainer, Straight orthodontic retainer
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Universidad Rey Juan Carlos
High-grade Squamous Intraepithelial Lesions (HSIL), Cervical Conization
Predicting Treatment Failure in HSIL Patients with Positive Margins After Conization Via Detection of PAX1 Methylation
The goal of this multicenter, observational study is to evaluate whether methylation testing of paired box gene 1 (PAX1) can better predict and diagnose recurrence or persistent disease in patients with positive margins after…
- Trial name
- NCT06713655
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Lip, Lip Cancer
T1 Squamous Cell Carcinomas of the Lip
The purpose of this study is to investigate the risk of recurrence and metastasis in patients treated with different surgical margins (5mm vs 10mm) for a T1 squamous cell carcinoma of the lip.
- Conditions
- Lip, Lip Cancer, Lip SCC, Squamous Cell Carcinoma
- Trial name
- NCT05610293
- Where
- 3 sites in Netherlands
- Volunteers
- 300 people
- Sponsor
- Maastricht University Medical Center
Nasopharyngeal Carcinoma
Online Adaptive Radiotherapy for Nasopharyngeal Carcinoma
In this multicenter, prospective, randomized, controlled, non-inferiority Phase III clinical trial, treatment-naïve patients with nasopharyngeal carcinoma (NPC) without metastasis will be enrolled for curative radiotherapy.
- Trial name
- OART (NCT06516133)
- Testing
- Intensity modulated radiation therapy (IMRT) with conventional planning target volume (PTV) margin and without online adaptive radiotherapy, Chemotherapy, Intensity modulated radiation therapy (IMRT) with smaller planning target volume (PTV) margin and online adaptive radiotherapy
- Where
- China
- Volunteers
- 494 people
- Sponsor
- Sun Yat-sen University
Cervical Intraepithelial Neoplasia
Recurrence in High-grade Lesions After Conization
Objectives: To identify factors associated with disease recurrence in patients with high-grade cervical intra-epithelial neoplasia (CIN) undergoing large loop excision of the transformation zone (LLETZ).
- Trial name
- NCT02540421
- Where
- Brazil
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Faculdade de Medicina do ABC
Deep Marginal Elevation
The Effect of Material Choice on Clinical Outcomes in Deep Margin Elevation
In dentistry, particularly in posterior teeth with extensive caries or old restorations, the extension of restoration margins below the gingival level presents a significant clinical challenge.
- Trial name
- NCT07234266
- Testing
- 3d printed resin restoration with deep margin elevation
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Mersin University
Breast Cancer
Assessment of Lumpectomy Margins With the Histolog Scanner in Comparison With Intraoperative Imaging Techniques
Study to assess the capability of using the Histolog Scanner, a recent large field-of-view confocal laser scanning medical imaging device for the breast cancer detection in fresh lumpectomy margins.
- Trial name
- Polarhis (NCT05118568)
- Testing
- Histolog Scanner
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- SamanTree Medical SA
Squamous Cell Carcinoma of Head and Neck, Neoadjuvant Therapy
Reducing Excision Margins After Neoadjuvant Chemoimmunotherapy for HPV Negative Resectable Locally Advanced HNSCC
This study aims to explore the 2-year DFS (disease-free survival) rate and organ retention rate and to explore the ORR, PCR rate, 2y-OS， and quality of life of patients.
- Conditions
- Squamous Cell Carcinoma of Head and Neck, Neoadjuvant Therapy, Resection Margin
- Trial name
- NCT05459415
- Testing
- Reducing Excision Margins
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Ameloblastoma
Virtual Lesion Segmentation and Mandibular Ameloblastoma Radiographic Safety Margin
Reconstruction of segmental mandibular defects is in a continuous state of evolution utilizing the recent advances in Computer-Aided Designing (CAD) and preoperative Virtual Surgical Planning (VSP).
- Trial name
- NCT07306962
- Testing
- Virtual lesion segmentation for mandibular ameloblastoma
- Where
- Egypt
- Volunteers
- 10 people
- Sponsor
- Alexandria University
Pancreatic Cancer
Margin-Intense Combo Therapy in Pts w/Potentially Resectable Pancreatic Cancer
RATIONALE: Stereotactic body radiation therapy may be able to send x-rays directly to the tumor and cause less damage to normal tissue.
- Trial name
- NCT01025882
- Testing
- gemcitabine hydrochloride, stereotactic body radiation therapy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Texas Southwestern Medical Center
Early Stage Breast Cancer
Shaving as an Safe Alternative to Frozen Section Analysis
Evaluation of Tumor Bed Cavity Shaving as an Oncologically Safe Alternative to Frozen Section Analysis in Breast-Conserving Surgery and aim of study To assess the oncological safety and practicality of tumor bed cavity shaving…
- Trial name
- NCT07244588
- Testing
- Tumor bed cavity shaving
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Mark Ezzat Gerges
Intraventricular Hemorrhage, Periventricular Leukomalacia
Prediction of Brain Injury in Premature Infants
Extremely low birth weight (ELBW), birth weight less than or equal to 1000 g, infants are at high risk for developing brain injury in the first week of life.
- Conditions
- Intraventricular Hemorrhage, Periventricular Leukomalacia, Brain Injury, Extreme Prematurity
- Trial name
- NCT02814383
- Testing
- Brain Monitoring Platform
- Where
- 3 sites in United States
- Volunteers
- 70 people
- Sponsor
- Baylor College of Medicine
Penile Cancer, Margin Assessment
Image Guided Penile Cancer Surgery
The main treatment modality for Penile Squamous Cell Carcinoma (PSCC) is surgery with curative intent. In organ sparing surgery a tumor-positive margin of up to 36% exist.
- Trial name
- GLANS (NCT05376202)
- Testing
- Cetuximab-IRDye800CW
- Where
- Netherlands
- Volunteers
- 11 people
- Sponsor
- University Medical Center Groningen
Deep Margin Elevation
Rct Deep Margin Elevation by Self Adhesive Composite
This study intend to study the development and introduction of new efficient approaches to overcome the problems of technique sensitivity of deep margin elevation by conventional flowable composite.
- Trial name
- NCT06899412
- Testing
- self adhesive flowable composite, Conventional flowable composite
- Volunteers
- 50 people
- Sponsor
- Cairo University
Breast Cancer
MarginProbe, a Device for Intraoperative Assessment of Margin Status in Breast Conservation Surgery
The purpose of this study is to show that addition of device use to a routine breast cancer tumor excision procedure is beneficial and assists the surgeon in correctly determining the extent of excision.
- Trial name
- Pivotal (NCT00749931)
- Testing
- MarginProbe, Lumpectomy
- Where
- 21 sites in United States, Israel
- Volunteers
- 664 people
- Sponsor
- Dune Medical Devices
Pancreatic Cancer, Adenocarcinoma
Slide Interpretation or Standard Surgical Pathology in Assessing Margin Status in Patients With Pancreatic Cancer Undergoing Surgery
This study is being done to investigate another way of evaluating margin status after pancreatectomy by using cytopathology (slide interpretation) as compared to the traditional method of surgical pathology
- Trial name
- NCT01646697
- Testing
- cytology specimen collection procedure
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Breast Cancer
Evaluation of Breast Cancer Surgical Margins Using Optical Spectroscopy
This study will apply optical spectroscopy to intraoperative margin assessment during surgery for breast cancer. We hypothesize that a combination of fluorescence spectroscopy and diffuse reflectance spectroscopy will reliably…
- Trial name
- NCT00214292
- Testing
- fluorescence spectroscopy and diffuse spectroscopy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Wisconsin, Madison