Clinical trials: Excision Margin
Side-by-side Contrast-enhanced Ultrasound, Hepatocellular Carcinoma (HCC)
Contrast-Enhanced Ultrasound for Early Assessment of Microwave Ablation in HCC
Hepatocellular carcinoma (HCC) is the sixth most common malignancy and the fourth leading cause of cancer-related deaths worldwide [1].
- Trial name
- SBS-CEUS (NCT07598331)
- Testing
- Side-by-Side Contrast-Enhanced Ultrasound
- Where
- China
- Volunteers
- 106 people
- Sponsor
- The First Hospital of Jilin University
Dental Caries, Dental Diseases
Bioactive Versus Non-Bioactive Restorative System in Deep Carious Molars
This research study delves into the effectiveness of bioactive and non-bioactive restorative systems in deep carious permanent molars treated with selective caries removal.
- Conditions
- Dental Caries, Dental Diseases, Deep Caries, Tooth Diseases
- Trial name
- NCT06348953
- Testing
- selective caries removal and conventional non-bioactive restorative system, selective caries removal and bioactive restorative system
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
TNF Alpha
The Effect of Functional Crown Lengthening Versus Deep Margin Elevation on Periodontal Tissues
The present study will evaluate and compare the effect of functional CL and DME in the treatment of posterior teeth with class II caries clinically and on the level of TNF-α in the GCF of treated teeth.
- Trial name
- NCT07380126
- Testing
- Functional Crown lengthening, Deep Margin Elevation
- Volunteers
- 20 people
- Sponsor
- Ain Shams University
Breast Cancer
Margin Optimisation Using Z-axis Assessment With Real-time Tomosynthesis (MOZART Study).
Breast-conserving surgery is commonly performed to remove early-stage breast cancer or ductal carcinoma in situ (DCIS). During surgery, the goal is to completely remove the tumour with a clear margin of normal tissue around it.
- Trial name
- MOZART (NCT07426809)
- Testing
- Standard 2D Specimen Mammography, Mozart 3D Specimen Radiography System
- Where
- Ireland
- Volunteers
- 314 people, healthy volunteers welcome
- Sponsor
- Royal College of Surgeons, Ireland
Retroperitoneal Sarcoma
Proton or Photon RT for Retroperitoneal Sarcomas
This research study is a Phase I clinical trial. Phase I clinical trials test the safety of an investigational intervention. Phase I studies also try to define the appropriate dose of the investigational therapy to use for…
- Trial name
- NCT01659203
- Testing
- IG-IMPT, IG IMRT
- Where
- 10 sites in United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Deep Margin Elevation, Pulpal and Periodontal Health
Impact of DME on Pulpal and Periodontal Health at Varying Gingival Seat Level
The classical idea was to keep the biologic width untouched in order to maintain periodontal health but the newer case reports have given a new dimension to this concept, stating that a limited extension into STA can be used as…
- Trial name
- NCT07169305
- Testing
- Deep Margin Elevation
- Where
- India
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Breast Cancer
Study of the Outcomes of Intraoperative Margin Assessment With MarginProbe
The combination of breast conserving surgery (lumpectomy) with radiation therapy has been shown to result in equivalent overall survival rates compared to mastectomy for the local treatment of breast cancer.
- Trial name
- MarginProbe (NCT02456649)
- Testing
- MarginProbe
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Huntington Memorial Hospital
Prostatic Neoplasms
PRIME - PRostate Imaging for Margin Evaluation
This study will evaluate the feasibility of using intra-operative Cerenkov Luminescence Imaging (CLI) of prostatectomy specimens to determine tumour margin status.
- Trial name
- PRIME (NCT02151097)
- Where
- United Kingdom
- Volunteers
- 7 people
- Sponsor
- Lightpoint Medical Limited
Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma
Real-time Margin Assessment in Head and Neck Cancer
To investigate if the combination of fresh frozen sectioning based on cetuximab-800CW can enhance tumor-positive margin detection intra-operatively.
- Trial name
- LIGHTNING (NCT05499065)
- Testing
- Fluorescence guided detection of tumor positive margins, Cetuximab-IRDye800
- Where
- Netherlands
- Volunteers
- 23 people
- Sponsor
- University Medical Center Groningen
Soft Tissue Sarcoma (STS)
5-AminoLevulinic Acid Aided Resection Margins in Sarcoma
The goal of this study is to learn if the intervention using a fluorescent agent 5-Aminolevulinic acid (5-ALA) to aid in the surgical approach to visualize the soft-tissue sarcoma (STS) during surgical resection.
- Trial name
- 5-ALARMS (NCT07038278)
- Testing
- 5-ALA
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Colorado, Denver
Sentinel Lymph Node, Breast Cancers
EpCAM-Targeted Surface-Enhanced Raman Spectroscopy Nanotags for Rapid Evaluation of Surgical Margins and Sentinel Lymph Node Metastasis Status in Breast Cancers
For early breast cancer patients, breast-conserving surgery and sentinel lymph node biopsy have emerged as the cornerstone of precision oncology, harmonizing oncologic efficacy with the preservation of breast cosmetics and…
- Conditions
- Sentinel Lymph Node, Breast Cancers, Metastases, Margin Assessment
- Trial name
- NCT07018505
- Testing
- SERS detection
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Yunnan Cancer Hospital
Pancreatic Cancer, Cholangiocarcinoma
Margin Status After Pancreaticoduodenectomy for Cancer
This multicentric prospective randomized controlled trial (RCT) compares the Leeds Pathology Protocol (LEEPP) with other "conventional" pathological protocol of PD specimen for periampullary cancer.
- Conditions
- Pancreatic Cancer, Cholangiocarcinoma, Ampullary Cancer
- Trial name
- NCT03267966
- Testing
- Leeds Pathology Protocol (LEEPP)
- Volunteers
- 168 people
- Sponsor
- Campus Bio-Medico University
Oral Cavity Cancer
Gross Examinations Versus Frozen Section for Assessment of Surgical Margins in Oral Cancers
Surgical margin is a significant prognostic factor in oral cavity squamous cell carcinoma (OCSCC)[1,2,3]. Intra-operative frozen section (FS) has been routinely used by the surgeons to achieve adequate surgical margins.
- Trial name
- NCT04809324
- Testing
- Gross examination of the resection specimen, Frozen section
- Where
- 3 sites in India
- Volunteers
- 1,206 people
- Sponsor
- Dr.Pankaj Chaturvedi
Varicose Veins, Cicatrix
Juvista (Avotermin) in Scars Following Varicose Vein Removal
This trial is being undertaken to investigate the efficacy and safety of Juvista in the improvement of scar appearance when administered to approximated wound margins following varicose vein surgery.
- Trial name
- NCT00430326
- Testing
- Avotermin
- Where
- 21 sites in Belgium, Latvia and 2 more
- Volunteers
- 156 people
- Sponsor
- Renovo
Oral Cancer, Osteosarcoma
Quantitative Margin Assessment Using High-resolution Positron Emission Tomography - Computed Tomograhy
The primary endpoint is the assessment of the clinical value of a novel high-resolution mobile PET-CT scanner for intraoperative margin assessment in oral squamous cell carcinoma, soft tissue sarcoma and osteosarcoma surgery.
- Conditions
- Oral Cancer, Osteosarcoma, Soft Tissue Sarcoma, Oral Squamous Cell Carcinoma (OSCC)
- Trial name
- qMAP (NCT06726512)
- Testing
- XEOS AURA 10
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- University Medical Center Groningen
Breast-Conserving Surgery, Negative Surgical Margins
Endoscopic Breast Conserving Surgery With Intra-operative Navigation System
A growing number of Chinese breast cancer patients are diagnosed at a young age. The quality of life of young breast cancer patients has been a critical issue.
- Conditions
- Breast-Conserving Surgery, Negative Surgical Margins, Endoscopy, Esthetics
- Trial name
- NCT05458414
- Testing
- Intra-operative Navigation System
- Where
- China
- Volunteers
- 41 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Cervical Lesions
Clinical Evaluation of a Universal Adhesive in Noncarious Cervical Lesions
The purpose of this prospective clinical trial will be to evaluate the efficacy of an FDA approved and marketed universal dental adhesive formulation in adult noncarious cervical lesions using self-etch and selective etch…
- Trial name
- NCT02172664
- Testing
- Self etch enamel etching, selective etch protocol, Adhese Universal
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Indiana University
Oropharyngeal Squamous Cell Carcinoma
Ex Vivo 3D-ultrasound for Oropharyngeal Cancer
Patients with biopsy-verified oropharyngeal squamous cell carcinomas treated with transoral robotic surgery are included. Immediately post-operatively, freshly resected specimens are examined with ex vivo 3D ultrasound (US).
- Trial name
- NCT06314711
- Testing
- Ultrasound
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Uterine Cancer, Cervical Cancer
Intensity Modulated Radiotherapy (IMRT) for the Pelvis Post-Hysterectomy
The goal of this clinical research study is to use CT scans to find any changes in position of the vagina and pelvic lymph node areas during the course of IMRT radiation therapy.
- Conditions
- Uterine Cancer, Cervical Cancer, Endometrial Cancer
- Trial name
- NCT00508703
- Testing
- Intensity Modulated Radiotherapy (IMRT), CT Scan
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- M.D. Anderson Cancer Center
Sinus Floor Elevation
Influence of the Sinus Floor-to-lower Window Margin Distance on Outcomes of Bone Window Repositioning in Lateral Sinus Floor Elevation With Simultaneous Implant Placement
The goal of this observational study is to evaluate how the vertical distance from the sinus floor to the lower margin of the lateral window affects bone regeneration and implant outcomes after lateral sinus floor elevation with…
- Trial name
- NCT07045389
- Where
- China
- Volunteers
- 47 people
- Sponsor
- Guoli Yang