Clinical trials: Excretion
Hyperoxaluria, Nephrolithiasis
Evaluating ALLN-177 for Reducing Urinary Oxalate Excretion in Calcium Oxalate Kidney Stone Formers With Hyperoxaluria
The purpose of this study is to evaluate the effect of ALLN-177 to reduce urinary oxalate excretion in patients with recurring kidney stones and enteric or idiopathic hyperoxaluria.
- Trial name
- NCT02289755
- Testing
- ALLN-177
- Where
- 4 sites in United States
- Volunteers
- 16 people
- Sponsor
- Allena Pharmaceuticals
Wilson Disease
Off Treatment Urinary Copper Excretion in Wilson Disease, Pilot Study
This is a prospective study that will determine the optimal timing for 24-hour urinary copper excretion (UCE) measurement after temporary discontinuation of standard therapies in Wilson Disease (WD) patients.
- Trial name
- NCT07301216
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Yale University
Bacterial Infections, Wounds
Effects of MRSA Bactericidal Gel To Promote Healing and Eliminate MRSA in cSSTI Vancogel(TM)
Based on personal experience and the literature it is reasonable expectation that Vancomycin is a viable treatment in a direct contact form to eliminate MRSA from open wounds in order to heal the wounds by conventional means.
- Trial name
- Vancogel(R) (NCT00945152)
- Testing
- Vancomycin 1.25-1.50% in a complex gel formulation trademarked Vancogel(R)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Robert S Berman MD
Heart Failure, Edema
Comparing Natriuretic Effects of ER Torsemide to IR Torsemide in Patients With Heart Failure
The primary objective of this study is to learn whether a morning dose of extended-release torsemide enhances renal sodium excretion after lunch (4-8 hours after dosing) compared to immediate-release torsemide.
- Conditions
- Heart Failure, Edema, Pulmonary Congestion, Fluid Overload
- Trial name
- NEXT-HF (NCT06995144)
- Testing
- Extended Release Torsemide Tablets, Immedate Release Torsemide Tablets
- Where
- United States
- Sponsor
- Sarfez Pharmaceuticals, Inc.
Carbon Dioxide
Validation of Continuous Transcutaneous Carbon Dioxide Monitoring in VA-ECMO Patients
Carbon dioxide in patients on veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is eliminated via respirator as well as via the oxygenator's membrane of the ECMO machine.
- Trial name
- NCT04445909
- Testing
- VA-ECMO
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Healthy
Effect of Ketoconazole on Biliary Excretion of AZD0837
This is an explorative study and the scientific question to be investigated is if the biliary excretion of AZD0837 and its metabolites AR-H069927XX and AR-H067637XX are affected by co-administration with ketoconazole
- Trial name
- NCT00812344
- Testing
- AZD0837, Ketoconazole
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Nocturnal Enuresis
Mirabegron 25 mg for Treatment of Primary Nocturnal Enuresis
Investigators will study the efficacy and safety of mirabegron25 in treatment of primary nocturnal enuresis in comparison to oral desmopressin 120 mcg and behavioral therapy
- Trial name
- NCT05617664
- Testing
- desmopressin 120 mcg oral tablets, Mirabegron 25 MG Oral Tablet, Extended Release, behavioral therapy alone
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Benha University
Faecal Incontinence, Asymptomatic Condition
Anal Canal Functional Assessment Using EndoFLIP
Faecal incontinence (FI) is characterized by involuntary loss of rectal content through the anal canal. FI is psychologically and socially debilitating problem that can dramatically affect patient's quality of life, often in…
- Trial name
- NCT04741893
- Testing
- EndoFLIP
- Where
- Hong Kong
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Healthy Volunteers
A Study To Investigate The Elimination Of PF-06273588 From The Body Following A Single Low Dose.
To investigate the pharmacokinetics of PF-06273588 following administration of a micro-dose via both intravenous and oral routes.
- Trial name
- NCT01408355
- Testing
- PF-06273588
- Where
- United Kingdom
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Pfizer
Doping in Sport, Glucocorticoids
SporTRIA Study: A Multicentre Trial for Excretion Kinetics of Triamcinolone Acetonide Following Sport Related Intra-articular Injections in Knees; Definitions of the Washout Periods
Intra-articular and peri-articular glucocorticoid (GC) injections are common in sports medicine. However, from 1st January 2022, all injectable GC routes (including intra-articular administration (IA)) will be prohibited…
- Trial name
- SporTRIA (NCT04574232)
- Testing
- knee intra-articular infiltration with Triamcinolone acetonide
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Central Hospital, Nancy, France
Osteosarcoma, Leukemia
Open-label Leucovorin Pharmacokinetic Study in Patients Receiving High Dose Methotrexate With or Without Voraxaze
The purpose of this study is to investigate whether the administration of Voraxaze reduces exposure to leucovorin and its active metabolite to below the level achieved in patients who have not received Voraxaze.
- Conditions
- Osteosarcoma, Leukemia, Lymphoma
- Trial name
- LVPK (NCT00634504)
- Testing
- glucarpidase, high-dose methotrexate, leucovorin, high-dose methotrexate, leucovorin
- Where
- 25 sites in United States
- Volunteers
- 20 people
- Sponsor
- BTG International Inc.
Human African Trypanosomiasis, Sleeping Sickness
Diagnostic Tools for Human African Trypanosomiasis Elimination and Clinical Trials: WP3 Post Elimination Monitoring
This study determines the feasibility, diagnostic performance and cost for monitoring of eliminated human African trypanosomiasis (HAT) foci using diagnostic algorithms of serological and molecular high throughput tests with and…
- Conditions
- Human African Trypanosomiasis, Sleeping Sickness, Trypanosoma Brucei Gambiense; Infection, West African Sleeping Sickness
- Trial name
- DiTECT-HAT-WP3 (NCT04099628)
- Testing
- Rapid diagnostic test (RDT); Serological and molecular tests on DBS
- Where
- 3 sites in Burkina Faso, Côte d’Ivoire and 1 more
- Volunteers
- 13,747 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche pour le Developpement
Nocturnal Enuresis
A Double-blind Randomized Clinical Trial on the Efficacy of Magnetic Sacral Roots Stimulation for the Treatment of NE
The purpose of this study is to assess the efficacy of daily sacral root magnetic stimulation for 10 sessions in patients with nocturnal enuresis.Eligible patients were randomized to receive either real or sham repetitive sacral…
- Trial name
- NCT02328092
- Testing
- rSMS in treatment of Nocturnal Enuresis
- Volunteers
- 41 people
- Sponsor
- Assiut University
Nutrition, Absorption, Metabolism and Excretion in Healthy Volunteers
Bioavailability of Omega-3 Fatty Acids From Fish Oil Supplements
This study is investigating whether a new type of fish oil supplement, in the form of soft chews, leads to better absorption of omega-3s in the body compared to traditional fish oil capsules.
- Conditions
- Nutrition, Absorption, Metabolism and Excretion in Healthy Volunteers, Fish Oils, Omega 3 Fatty Acids
- Trial name
- Ocean's O3 (NCT06665464)
- Testing
- Fish oil supplement 1, Fish oil supplement 2
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Wageningen University and Research
Healthy Volunteers
A Trial to Study the Absorption, Metabolism, and Excretion of [14C]-Olinciguat in Healthy Male Volunteers
The primary objective is to characterize the pharmacokinetics (PK) of olinciguat and total radioactivity and to assess the elimination of total radioactivity from a single oral dose of [14C]-olinciguat.
- Trial name
- NCT03795519
- Testing
- [14C]-olinciguat
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Cyclerion Therapeutics
Calculi, Urinary
Study of the Benefits of a Short Spa Treatment on the Elimination of Residual Lithic Fragments After Treatment
Current urological therapeutic modalities are represented by extracorporeal lithotripsy (ECL), rigid (URS) or flexible (URSsple) uretero-renoscopy and percutaneous nephrolithotomy (PCNL).
- Trial name
- LITHUTHERM (NCT04031911)
- Testing
- Hydroposturotherapy, Standard support in urology
- Where
- France
- Volunteers
- 1 people
- Sponsor
- GUILLEMIN Francis, MD
HPV Infection, Cervix Cancer
Prevention and Screening Towards Elimination of Cervical Cancer
The research project applies the protocol of the World Health Organisation for screening of cervical cancer, with testing of hrHPV as first screening, followed by Visual Inspection of the cervix with Acetic Acid for…
- Conditions
- HPV Infection, Cervix Cancer, Cervical Dysplasia
- Trial name
- PRESCRIP-TEC (NCT05234112)
- Testing
- Community mobilisation for hrHPV self-testing, hrHPV self-testing, Follow-up after testing
- Where
- Uganda
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Cytokine Hemadsorption Therapy in Critically Ill Patients Who Have no Microbiological Findings and Develop Vasoplegic Shock
EFFECTS OF EXTRACORPOREAL CYTOKINE ELIMINATION ON HEMODYNAMIA AND MORTALITY IN CRITICAL PATIENTS
Observation of the effects of cytokine adsorbent hemadsorption therapy on hemodynamics and mortality in critically ill patients who developed vasoplegic shock due to hyperinflammation without microbiological findings in the…
- Trial name
- NCT05984407
- Testing
- cytokine hemadsorption therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Hakan Küçükkepeci
Restless Legs Syndrome
Restless Legs Patient Study On Absorption, Distribution, Metabolism And Excretion Of Ropinirole And The Effect Of Food
This study in RLS patients is designed to assess the affect food has on the absorption, distribution, metabolism and excretion of ropinirole (by dosing some patients in the fasted state and other patients following a high-fat…
- Trial name
- NCT00419692
- Testing
- Ropinirole
- Where
- 2 sites in Germany, South Africa
- Volunteers
- 32 people
- Sponsor
- GlaxoSmithKline
IBS - Irritable Bowel Syndrome
Alcat Based Elimination Diet for the Treatment of Irritable Bowel Syndrome; a Randomized Double Blind Sham Control Trial
Irritable bowel syndrome (IBS) is the most common GI condition with global prevalence ranging between 10-20%. Although the exact cause is not known there are increasing insights concerning the possible multifactorial etiology…
- Trial name
- NCT05616429
- Testing
- Alcat based personal diet, Standard balanced diet, usual care
- Where
- Israel
- Volunteers
- 70 people
- Sponsor
- Sheba Medical Center