Clinical trials: Excretion
Carcinoid Tumors, Neuroendocrine Tumors
Effect of Oral 5-HTP Intake on Urinary 5-HIAA Excretion
This is a research study looking at the effect of 5-Hydroxy Tryptophan (5-HTP) on urine excretion of 5-Hydroxyindolacetic acid (5-HIAA).
- Trial name
- NCT00227136
- Testing
- 5-Hydroxy-Tryptamine
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Western Ontario, Canada
Tuberculosis
Phase 2a Study of PBTZ169
Multicenter, open, randomized study with active control (isoniazid) to evaluate the early antibacterial activity, safety and pharmacokinetics of the drug PBTZ169 (capsules 80 mg) when used in patients with first-diagnosed…
- Trial name
- NCT03334734
- Testing
- PBTZ169, Isoniazid
- Volunteers
- 16 people
- Sponsor
- Nearmedic Plus LLC
Urinary Incontinence, Anal Incontinence
Pelvic Floor Muscle Training During Pregnancy
The project seeks to investigate effectiveness of PFMT during pregnancy.
- Conditions
- Urinary Incontinence, Anal Incontinence, Pelvic Organ Prolapse, Sexual Dysfunction
- Trial name
- NCT07104292
- Testing
- PFMT, Standard care
- Where
- Denmark
- Volunteers
- 804 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Autistic Disorder, Enuresis
Investigation of Teacher-Mediated Toilet Training Using a Manualized Moisture Alarm Intervention
The purpose of this pilot study is to compare an innovative toilet training strategy with a standard behavioral intervention in children with autism spectrum disorder (ASD), as implemented by teachers in the school setting.
- Trial name
- NCT02369445
- Testing
- Moisture Pager Intervention for Toilet Training, Standard of Care
- Where
- 3 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Breast Cancer
Monoclonal Antibodies Elimination in Breast Cancer Patient
This Study evaluates covariables being able to potentially influence the elimination of the monoclonal antibodies (trastuzumab, bevacizumab and denosumab).
- Trial name
- PK-MAB (NCT02855775)
- Testing
- additional blood sample
- Where
- France
- Volunteers
- 76 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Anal Incontinence, Fecal Incontinence
Treatment of Anal Incontinence With Intersphincteric Implants
The purpose of this study is to determine whether treatment with intersphincteric implants is an effective and safe treatment option for patients with anal incontinence
- Trial name
- NCT03080753
- Testing
- Sphinkeeper
- Where
- Sweden
- Volunteers
- 10 people
- Sponsor
- Region Skane
Urinary Sodium Excretion, Salt Intakes
Sodium Sources and Sodium Intake in a Representative Sample of Spanish Children
Previous evidence shows that sodium intake in Spanish adult population is over the recommended limits and this high sodium intake is related with difficulties in body weight control and blood pressure control.
- Conditions
- Urinary Sodium Excretion, Salt Intakes, Body Weight
- Trial name
- NCT03465657
- Where
- Spain
- Volunteers
- 400 people
- Sponsor
- Universidad Complutense de Madrid
Atopic Dermatitis
Targeted Investigation of Microbiome Elimination
The purpose of this study is to examine the pharmacokinetics or survival of new product containing commensal infection fighting bacteria, on the skin of patients with Atopic Dermatitis (AD), after a single application.
- Trial name
- TIME-1 (NCT05177328)
- Testing
- S. hominis A 9 Product
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Atrial Fibrillation, Arrhythmia
Inhibition of Atrial Fibrillation by Elimination of Transitional Mechanisms
There is growing awareness of the importance of electrical rotors to the maintenance of atrial fibrillation (AF). Recent work in our laboratory has found that AF evolves over time, from rapid, focal activation, next to…
- Trial name
- TRANS AF (NCT02758002)
- Testing
- Firm ablation for transitional AF rotors
- Where
- United States
- Sponsor
- University of California, San Diego
Healthy Volunteer
Phase 1 Absorption Distribution Metabolism and Excretion of AQX-1125
This study is conducted to evaluate the absolute bioavailability, metabolism and elimination pathways of AQX-1125 in healthy male and female subjects.
- Trial name
- ADME (NCT03185195)
- Testing
- AQX-1125 Oral Tablet, [14C]-AQX-1125 IV, [14C]-AQX-1125 Oral Solution
- Where
- United Kingdom
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Aquinox Pharmaceuticals (Canada) Inc.
Refractive Error
A PHASED, PROSPECTIVE, MULTI-CENTER STUDY OF THE ELITA SYSTEM
This study will be a 2-phase, prospective, multicenter, open-label, non-comparative, non-randomized clinical investigation to confirm the safety and effectiveness of the ELITA system.
- Trial name
- NCT05713253
- Testing
- ELITA System
- Where
- 2 sites in United States
- Volunteers
- 96 people
- Sponsor
- Johnson & Johnson Surgical Vision, Inc.
Kidney Transplant Dysfunction
Urinary Kidney Injury Molecule-1 (KIM-1) Excretion As Biomarker for Injury in Kidney Transplant Recipients
The purpose of this study is to determine if measuring the level of a protein called Kidney Injury Molecule-1 (KIM-1) in the urine will help healthcare providers detect any problems with the transplanted kidney before the…
- Trial name
- NCT00805571
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Northwell Health
Healthy
A Study to Learn Safety and Blood Levels of PF-07817883 in Healthy People
The purpose of this clinical trial is to learn if the study medicine (called PF-07817883) is safe and how it goes in and out of the body in healthy people. PF-07817883 is for the potential treatment of COVID-19.
- Trial name
- NCT05580003
- Testing
- PF-07817883, Midazolam, Moxifloxacin
- Where
- 2 sites in United States, Belgium
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Pfizer
Neurocognitive Outcome After Aortic Valve Replacement
Elimination of Microemboli During Aortic Valve Replacement
In a randomized controlled trial patients undergoing aortic valve replacement are recruited into 3 groups. Patients receive either an intra-aortic filter (Embol-X), designed to reduce solid microemboli during mechanical surgical…
- Trial name
- ELMAR (NCT01128751)
- Testing
- Embol-X intra-aortic emboli filter, DBT dynamic bubble trap, Control group
- Where
- 3 sites in Germany
- Volunteers
- 150 people
- Sponsor
- University of Giessen
Nasopharyngeal Cancer
Elimination of Adjuvant Chemotherapy for Selected Stage II and III Nasopharyngeal Carcinoma
This study evaluates whether some patients with nasopharyngeal carcinoma but with low risk of distant metastasis can be treated with only radiotherapy and concomitant chemotherapy but without additional adjuvant chemotherapy.
- Trial name
- NCT03175939
- Testing
- Radiotherapy, Cisplatin, 5-FU
- Volunteers
- 263 people
- Sponsor
- Sun Yat-sen University
Healthy Volunteers
A Study to Evaluate the Absorption, Metabolism, and Excretion (ADME) of BMS-986435
The purpose of this study is to determine the absorption, metabolism, excretion; and to evaluate the safety and tolerability of BMS-986435 in healthy male participants Participants will be admitted to the study site for 3 weeks.
- Trial name
- NCT05686096
- Testing
- MYK-224
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Hiv, Syphilis
MENJAGA: Continuous Quality Improvement for Antenatal HIV, Syphilis and Hepatitis B Testing in Indonesia
Elimination of mother-to-child-transmission (EMTCT) of HIV, syphilis and hepatitis B are key priorities in Indonesia, the fourth most populous country in the world.
- Conditions
- Hiv, Syphilis, Hepatitis B
- Trial name
- MENJAGA (NCT06058286)
- Testing
- Continuous quality improvement
- Where
- Indonesia
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Yanri Wijayanti Subronto, MD, PhD,
Healthy
Oat Phenolics Bioavailability
A diet rich in whole grain is inversely associated with cardiovascular disease risk and this benefit could be partly attributed to the phenolic acid content of whole grains.
- Trial name
- NCT02574039
- Testing
- Oat bran, refined grain
- Where
- United Kingdom
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Reading
Atrial Fibrillation, Catheter Ablation
Benefit of Complex Fractionated Atrial Electrograms Elimination in Atrial Fibrillation Ablation
The aim of this study is to evaluate whether performing complex fractionated atrial electrograms ablation improves outcomes in persistent or atrial fibrillation ablation.
- Trial name
- NCT00873067
- Testing
- Additional Complex Fractionated Electrograms ablation, Standard atrial fibrillation ablation procedure
- Where
- Spain
- Volunteers
- 142 people
- Sponsor
- Hospital Clinic of Barcelona
Food Allergies
Master Allergen Child Nutrition. Reintroduction of Small Doses
Reintroduction of small doses of food in allergic children to lightening the elimination diet.
- Trial name
- MANOE (NCT02384707)
- Testing
- allegic food
- Where
- France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Angers