Clinical trials: Executive Dysfunction
Mild Cognitive Impairment
Effect of Tablet-Based Games on Executive Functions in Older Adults With Mild Cognitive Impairment
The primary objective of this study is to investigate whether a tablet-based role-playing game is more effective than tablet-based word or image puzzles at improving executive functions in older adults with mild cognitive…
- Trial name
- NCT05468424
- Testing
- tablet (iPad or android) based role-playing game, tablet (iPad or android) based word puzzles and image puzzles
- Where
- 2 sites in Canada
- Volunteers
- 42 people
- Sponsor
- John Puxty
Alzheimer's Disease, Mild Cognitive Impairment
Music Therapy Experiences in Patients With Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD)
This study compares different music therapy (MT) experiences and their impact on memory and language in patients with Alzheimer's disease and Mild Cognitive Impairment.
- Trial name
- NCT04666077
- Testing
- Home-based MT through Supervised, Supported Singing (H3S), Individualized Music Therapy (IMT), Attention Control (AtCon)
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Executive Dysfunction, Parkinson Disease
High-Speed Yoga and Executive Function
The purpose of this research study is to establish if a novel high-speed yoga program which incorporates visual cues can make a positive change in the participant's ability to make decisions and move as measured by several…
- Conditions
- Executive Dysfunction, Parkinson Disease, Quality of Life
- Trial name
- NCT04215900
- Testing
- High-speed yoga multi-directional yoga
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Miami
Mild Cognitive Impairment (MCI)
Creative Dance-Supported CO-OP Approach in Older Adults With Mild Cognitive Impairment
The goal of this clinical trial is to evaluate if the CO-OP (Cognitive Orientation to daily Occupational Performance) approach, supported by creative dance, can improve cognitive functions in older adults with mild cognitive…
- Trial name
- COOP-DANCE (NCT06644690)
- Testing
- CO-OP with Creative Dance, CO-OP Only
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Çankırı Karatekin University
Depression, Executive Dysfunction
The Antidepressant Effect of Intermittent Theta Burst Stimulation (iTBS)
The present study is a randomized placebo-controlled trial examining the effect of intermittent theta burst stimulation (iTBS) on unipolar depression. iTBS is a form of transcranial magnet stimulation.
- Trial name
- NCT05516095
- Testing
- Transcranial magnet stimulation
- Where
- Norway
- Volunteers
- 73 people
- Sponsor
- University Hospital of North Norway
Mild Cognitive Impairment (MCI)
TACS to Engage Theta-Gamma Coupling and Enhance Working Memory in Patients With MCI (tACS-MCI)
This study is looking at a new non-invasive brain stimulation methods called transcranial alternating current stimulation (tACS) to see if it can improve working memory and thinking processes in people with Mild Cognitive…
- Trial name
- tACS-MCI (NCT06783283)
- Testing
- Transcranial Alternating Current Stimulation
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Centre for Addiction and Mental Health
Traumatic Brain Injury, Executive Dysfunction
Online Emotional Regulation Group Treatment
This study will examine the feasibility of online delivery of emotional regulation training to individuals with TBI with emotional dysregulation.
- Conditions
- Traumatic Brain Injury, Executive Dysfunction, Emotional Dysregulation
- Trial name
- NCT01730261
- Testing
- Online Emotional Regulation Treatment
- Where
- United States
- Volunteers
- 147 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cognitive Impairment
AI-Driven Cognitive Digital Therapeutics for Dementia Management
The study would investigate the effect of a cognitive digital therapeutics system. The intervention group would receive three digital therapeutics sessions per week for 8 weeks, while the control group would receive usual care.
- Trial name
- NCT06783465
- Testing
- Digital therapeutics session
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Taipei Medical University WanFang Hospital
Hypertension, Mild Cognitive Impairment
CAndesartan vs LIsinopril Effects on the BRain
The aim of this study is to conduct a 1-year double blind randomized control trial comparing candesartan to lisinopril in 140 individuals with hypertension and executive mild cognitive impairment in their effects on executive…
- Trial name
- CALIBREX (NCT01984164)
- Testing
- Candesartan, Lisinopril
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- Emory University
Executive Dysfunction
Development and Pilot Testing of a Novel Preschool Executive Function Curriculum
Executive function (EF) skills are a set of essential cognitive abilities that enable individuals to demonstrate their knowledge and talents, effectively complete tasks and navigate social interactions through flexible regulation…
- Trial name
- NCT05135728
- Testing
- Unstuck and On Target: Preschool
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Children's National Research Institute
Schizophrenia, Neurocognitive Disorders
Goal Management Training for Patients With Schizophrenia or High Risk for Schizophrenia
About 85% of patients with schizophrenia have cognitive impairments, executive functions being particularly affected. Executive dysfunction, and cognitive deficits in general, are important predictors of functional outcomes…
- Trial name
- NCT03048695
- Testing
- GMT
- Where
- Norway
- Volunteers
- 83 people
- Sponsor
- Sykehuset Innlandet HF
Brain Injuries
Lariboisière Cognitive Assessment: Evaluation of the 1-year Outcomes
Cognitive sequelae are common following acquired brain injuries. However, their detection can be challenging, particularly in acute care units such as neurosurgery.
- Trial name
- ECOG (NCT06171568)
- Testing
- Tests and questionnaires
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Executive Dysfunction, Mild Cognitive Impairment (MCI)
Feasibility Study of Mixed Reality Exergame on Performance and Cortical Outcomes
The executive dysfunctions are a problem in individuals with MCI which predict conversion to dementia and is positively related to physical activity level.
- Trial name
- NCT06843733
- Testing
- Mixed reality exergame, Education
- Where
- Thailand
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Mild Cognitive Impairment (MCI), Depression
Brain Aging and Treatment Response in Geriatric Depression
The proposed project will evaluate the role of neuroimaging biomarkers of brain aging (i.e., neurodegenerative and vascular brain changes) and mild cognitive impairment in the patterns of treatment response to memantine combined…
- Trial name
- NCT01902004
- Testing
- Escitalopram, Memantine
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- University of California, Los Angeles
Brain Injuries
Cognitive Rehabilitation of Executive Dysfunction - Goal Management Training in Patients With Acquired Brain Injury
The main objective of this study is to examine the effect of Goal Management Training for patients with executive difficulties after acquired brain injury in a randomized controlled trial.
- Trial name
- NCT02692352
- Testing
- Goal Management Training, Brain Health Workshop
- Volunteers
- 70 people
- Sponsor
- Sunnaas Rehabilitation Hospital
Parkinson's Disease, Mild Cognitive Impairment
rTMS to Improve Cognition in Parkinson's
The purpose of this study is to examine safety, feasibility, and the behavioral and brain effects of a non-invasive treatment, repetitive transcranial magnetic stimulation (rTMS), for Veterans with Parkinson's disease or atypical…
- Trial name
- TMSCogReP (NCT03836950)
- Testing
- MagVenture MagProX100 stimulator (MagVenture, Falun, Denmark)
- Where
- 2 sites in United States
- Volunteers
- 56 people
- Sponsor
- VA Office of Research and Development
Schizophrenia, Cognitive and Executive Dysfunction
A Pilot Study of Adjunctive Structured Supportive Psychotherapy in Schizophrenia
This pilot randomized controlled trial examined whether adding structured supportive psychotherapy to risperidone treatment is more effective than risperidone alone in improving cognitive function and reducing peripheral…
- Conditions
- Schizophrenia, Cognitive and Executive Dysfunction, Neuroinflammation
- Trial name
- PILOT-SSP-SCZ (NCT07671040)
- Testing
- Structured supportive psychotherapy, Risperidone, Unstructured Supportive Conversation
- Where
- Indonesia
- Volunteers
- 44 people
- Sponsor
- Hasanuddin University
Executive Dysfunction, Cognitive Impairment
Cognitive Training in Stroke Rehabilitation
This is a randomized, controlled pilot study to evaluate the efficacy of "ASCEND-I" (A Strategy and Computer-based intervention to ENhance Daily cognitive functioning after stroke - Inpatient), an inpatient intervention that…
- Trial name
- NCT04472351
- Testing
- ASCEND-I
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Weill Medical College of Cornell University
Acquired Brain Injury, Cognitive Symptom
CBCR for Executive Functions in Patients With ABI in the Chronic Phase
This study examines the effects of computerbased cognitive rehabilitation on executive functions in the chronic phase after acquired brain injury
- Conditions
- Acquired Brain Injury, Cognitive Symptom, Executive Dysfunction
- Trial name
- NCT03558308
- Testing
- Computer based cognitive rehabilitation
- Where
- Denmark
- Volunteers
- 72 people
- Sponsor
- Katrine Sværke
Depression in Old Age, Psychotherapy
Engage for Late-Life Depression and Comorbid Executive Dysfunction
Although there are an increasing number of mental health treatment adaptations for older adults, there are still a number of factors to consider when making these adaptations.
- Conditions
- Depression in Old Age, Psychotherapy, Mild Cognitive Impairment, Executive Dysfunction
- Trial name
- NCT05356611
- Testing
- Engage
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Nevada, Las Vegas