Clinical trials: Exercise Pulmonary Hypertension
Pulmonary Hypertension
Acute Exposure of Simulated Hypoxia on Heart Rate and Ventilation During Exercise
Randomized crossover trial in patients with Pulmonary Hypertension (PAH, CTEPH) to assess the acute response to simulated altitude (FIO2: 15.1% = equivalent to 2500m above sea level) on heart rate and Ventilation changes under…
- Trial name
- NCT03592979
- Testing
- Simulated Altitude: (FiO2: 15.1)
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University of Zurich
Mitral Regurgitation, Pulmonary Hypertension
The Right Ventricular Pulmonary Circulation Continuum in Mitral Valve Disease Study
Mitral regurgitation (MR) is a prevalent valvular heart pathology. Indications for surgery include symptoms, impaired left ventricular function or enlarging dimensions, new onset atrial fibrillation, pulmonary hypertension…
- Trial name
- RIPCOM1 (NCT03155373)
- Testing
- Cardiac catheterisation, Cardiopulmonary exercise testing, Pulmonary function tests
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Imperial College London
Pulmonary Arterial Hypertension
Effects of Pulmonary Hypertension Therapy in Atypical Pulmonary Arterial Hypertension
The purpose of this study is to characterize the clinical and hemodynamic response of Pulmonary Arterial Hypertension (PAH) therapy in patients with atypical PAH and risk factors for left heart disease.
- Trial name
- NCT04787445
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Mayo Clinic
Systemic Sclerosis, Scleroderma
Multi-center, Web Based Observational Study of Pulmonary Hypertension in Scleroderma Patients
The purpose of this study is to determine the timeline of progression from pre-pulmonary hypertension to diagnosable pulmonary hypertension based on right heart catheterization.
- Conditions
- Systemic Sclerosis, Scleroderma, Pulmonary Hypertension, Pulmonary Arterial Hypertension
- Trial name
- NCT00377949
- Where
- 25 sites in United States
- Volunteers
- 602 people
- Sponsor
- Georgetown University
Pulmonary Arterial and Chronic Thromboembolic Pulmonary Hypertension, Chronic Cardiorespiratory Disease
Effect of Short-term Oxygen During CPET in Pulmonary Hypertension
In a randomized, sham-controlled trial the investigators will test whether supplemental oxygen given during cardiopulmonary exercise testing will improve exercise performance and physiological parameters in patients with…
- Trial name
- ExOx-CPET (NCT01748474)
- Testing
- Supplemental oxygen via a mask
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Zurich
Alveolitis, Fibrosing, Fibrosis, Pulmonary
Sildenafil Study to Treat Idiopathic Pulmonary Fibrosis
Medicines that decrease blood pressure in the lungs may help idiopathic pulmonary fibrosis (IPF) patients function better. This study will test whether sildenafil improves the ability to exercise in patients with pulmonary…
- Conditions
- Alveolitis, Fibrosing, Fibrosis, Pulmonary, Hypertension, Pulmonary
- Trial name
- NCT00359736
- Testing
- sildenafil
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- VA Office of Research and Development
Pulmonary Arterial Hypertension
Utility of At-home Monitoring of Exercise Capacity by App-based 6-minute Walk Test
Evaluate for accuracy and reproducibility of data collected via the participant-operated Walk.Talk.Track. (WTT) app combined with Apple Watch during in-clinic, technician proctored 6MWT's.
- Trial name
- DynAMITE (NCT03893500)
- Testing
- Home-based 6 minute walk test
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Stanford University
Altitude, Pulmonary Hypertension
Effect of Bosentan on Exercise Capacity at High Altitude
This study is to determine whether bosentan will alter exercise capacity after rapid ascent to high altitude. We hypothesize that bosentan administration will improve arterial oxygenation and exercise capacity.
- Trial name
- NCT00432978
- Testing
- Bosentan administration
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- VA Loma Linda Health Care System
Respiratory Impairment, Elevated Blood Pressure
Walking and Blood Pressure in Older Adults With Respiratory Impairment.
The purpose of this study is to evaluate the effect of an 8-week walking program on blood pressure in inactive older adults with respiratory impairment, a condition where lung function is sub-optimal for a person's age.
- Conditions
- Respiratory Impairment, Elevated Blood Pressure, Physical Inactivity
- Trial name
- NCT06033417
- Testing
- Increased lifestyle walking (intervention), Health education only (control)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Iowa State University
Hypertension, Pulmonary, Hypertension, Pulmonary Arterial
Exercise Hemodynamic, Right Ventricular Coupling and Echocardiography in Pulmonary Hypertension
This study aims to investigate the exercise profile in pulmonary hypertension patients with either pulmonary arterial hypertension, chronic thromboembolic pulmonary hypertension or pulmonary hypertension due to left heart disease…
- Trial name
- EXERTION (NCT04663217)
- Testing
- Exercise
- Where
- 2 sites in Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Giessen
Langerhans Cell Histiocytosis
Evaluation of Exercise Capacity and Exercise Limitation in Patients With Pulmonary Langerhans Cell Histiocytosis
Pulmonary Langerhans Histiocytosis Cells (PLCH) is characterized by infiltration of Langerhans cells and formation of loose granulomas with lymphocytic infiltrate and formation of nodular and cystic lesions on chest CT, and is…
- Trial name
- NCT02665546
- Where
- Brazil
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- InCor Heart Institute
Dyspnea, Chronic Obstructive Pulmonary Disease
The Impact of Udenafil on Exercise Capacity in Severe Chronic Obstructive Pulmonary Disease (COPD) Patients
Pulmonary hypertension (PH) is a serious complication of COPD which is associated with shorter survival, more frequent exacerbation, and increased use of health resources.
- Conditions
- Dyspnea, Chronic Obstructive Pulmonary Disease, Pulmonary Hypertension
- Trial name
- NCT01364181
- Testing
- Udenafil
- Where
- South Korea
- Volunteers
- 23 people
- Sponsor
- Seoul National University Hospital
COPD, Pulmonary Hypertension
Study of Sildenafil Effects in Combination With Rehabilitation in Patients With Chronic Obstructive Pulmonary Disease (COPD) and Associated Pulmonary Hypertension
Sildenafil is a phosphodiesterase-5 inhibitor that has been approved for the treatment of pulmonary arterial hypertension with orphan drug designation. Sildenafil modulates the nitric oxide (NO) pathway in the vessel wall.
- Trial name
- SIL-COPD-02 (NCT01055405)
- Testing
- Sildenafil
- Where
- Spain
- Volunteers
- 65 people
- Sponsor
- Hospital Clinic of Barcelona
Pulmonary Hypertension
Pulmonary Hypertension and Measurement of Exercise Capacity Remotely
Background Hospital-based walking exercise tests are routinely used in patients with pulmonary hypertension to assess functional ability and disease progression over time.
- Trial name
- PERSPIRE (NCT04903704)
- Testing
- 1 Minute Sit to Stand Test
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Pulmonary Hypertension
Inspiratory Muscle Training in Pulmonary Hypertension
The aim of this study is to investigate the effective of inspiratory muscle training on respiratory function, exercise capacity, physical activity and quality of life.
- Trial name
- NCT03385733
- Testing
- inspiratory muscle training
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul University
Pulmonary Hypertension
Early Intervention With Inhaled Treprostinil Among Patients With Exercise-Induced Pulmonary Hypertension (EPIH)
This prospective open-label matched-control pilot study evaluates whether inhaled treprostinil improves exercise pulmonary vascular resistance and functional outcomes in adults with interstitial lung disease or connective tissue…
- Trial name
- EPIH IIT (NCT07837830)
- Testing
- Treprostinil, Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Valley Health System
COPD, Pulmonary Hypertension
Right Ventricular Response to Exercise Among Patients With Chronic Obstructive Pulmonary Disease
This study plans to learn more about heart function among individuals with chronic obstructive pulmonary disease (COPD). In particular, the investigators want to understand the different patterns of right ventricular response…
- Conditions
- COPD, Pulmonary Hypertension, Exercise, Right Ventricular (RV) Dysfunction
- Trial name
- ReV UP COPD (NCT07576894)
- Testing
- Exercise training
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Colorado, Denver
Dyspnea, Lung Diseases
Effects of Automated Oxygen Titration Alone or With High Flow Nasal Therapy on Dyspnea and Exercise Tolerance
The main purpose of this study is to evaluate the effects of automated oxygen administration (FreeO2 system) alone or with high-flow oxygen on dyspnea and exercise tolerance in people with desaturating chronic lung disease…
- Conditions
- Dyspnea, Lung Diseases, Pulmonary Hypertension, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT05267418
- Testing
- Automated nasal O2 titration with FreeO2
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Laval University
Pulmonary Hypertension
Acute Exposure to High Altitude on Pulmonary Artery Pressure and Right Heart Function (Echo)
Randomized crossover Trial in patients with Pulmonary Hypertension (PAH, CTEPH) to assess the acute response to High Altitude ("Säntis"; 2500m above sea level) on pulmonary artery pressure and right heart function (echo)
- Trial name
- NCT03637166
- Testing
- Assessment at Low Altitude (470m above sea level), Exposure to High Altitude (2500m above sea level)
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University of Zurich
Pulmonary Arterial Hypertension
Mobile Health Intervention to Improve Exercise in Pediatric PH
Children and adults with pulmonary arterial hypertension (PAH) have severely reduced daily activity compared to healthy populations.
- Trial name
- MhOVE-PPH (NCT06549452)
- Testing
- mHealth Intervention, Usual Care
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Vanderbilt University Medical Center