Clinical trials: Exercise Response
Long QT Syndrome, Cardiac Repolarization
Effect of Beta-blocker Therapy on QTc Response in Exercise and Recovery in Normal Subjects
Background. In congenital long QT syndrome type 1 (LQT1), episodes of ventricular tachycardia are usually triggered by exercise and can be prevented in most patients by beta-blocker therapy.
- Trial name
- NCT00588965
- Testing
- Propranolol LA
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- MetroHealth Medical Center
Transmission, Patient-Professional
The Effects of Filter During CPET on WOB and Aerosol Particle Concentrations
Due to the concerns of virus transmission during COVID-19 pandemic, multiple respiratory societies postpone or limit pulmonary function test, especially cardiopulmonary exercise test (CPET), as patients may generate large amount…
- Trial name
- NCT04526925
- Testing
- Respiratory filter in-line placed with the standard mouthpiece, Standard mouthpiece
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Ozone Exposure During Rest and Exercise
Susceptibility of Cardiorespiratory Responses to Ozone During Cycling Exercise
Ground level ozone (O3) is a common airborne pollutant that is well recognized to cause negative respiratory symptoms and impair pulmonary function.
- Trial name
- NCT05473000
- Testing
- Exercise, Ozone, Room air
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Aging, Physical Fitness
Myogenic and Osteogenic Responses to eXercise and Ibuprofen
The purpose of this study is to determine if the use of ibuprofen blocks the benefits of exercise to build bone and muscle mass.
- Trial name
- MOXI (NCT00462722)
- Testing
- Ibuprofen, musculoskeletal-loading exercise
- Where
- United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Alzheimer Disease 2 Due to Apoe4 Isoform, Healthy Aging
Dementia Risk and Dynamic Response to Exercise
Research suggests that physical exercise supports brain health and cognition as we age. The goal of this project is to examine the specific changes in brain blood flow and biological factors in the blood immediately after…
- Trial name
- DYNAMIC (NCT04009629)
- Testing
- Moderate Intensity Aerobic Exercise
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Osteoporosis
PTH And Calcium Responses to Exercise in Older Adults Experiment 2 (PACE Sr. 2)
Declines in serum calcium during exercise may cause increases in markers of bone resorption. This study will determine if preventing the decline serum ionized calcium experienced at the onset of exercise through the use of a…
- Trial name
- NCT02580604
- Testing
- Calcium Chloride/Calcium Gluconate, Half-Normal Saline
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Physical Activity, Obesity
Feelings About Exercise
This study seeks to investigate why some individuals exercise more than others by focusing on feelings related to exercise. This two part study first examines whether regular exercisers (n=30) and non-exercisers (n=30) differ in…
- Trial name
- NCT03598647
- Testing
- Affect and physical activity, Physical activity information
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Alcohol Intake, Sleep Deprivation
Combined and Isolated Effects of Sleep Deprivation and Alcohol Intake on Exercise Performance in Humans.
Although the effects of acute alcohol intake and sleep deprivation on exercise performance lacks evidence in the literature, in many situations, they occur simultaneously.
- Trial name
- NCT02117193
- Testing
- Alcohol intake, Sleep deprivation
- Where
- Brazil
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Aging
Sex Differences in Vascular Responses to Exercise
A key early event in cardiovascular disease development is endothelial dysfunction, characterized by impaired flow-mediated dilation.
- Trial name
- NCT04128215
- Testing
- Control Period, Exercise Period
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Florida
Knee Injuries
Optimized Loading Response by JOURNEY II BCS Knee Increases Daily Physical Activity and Functions
Smith \& Nephew's first edition of the Journey posterior stabilizing total knee arthroplasty was analyzed by the Center for Musculoskeletal Research in a past research study, and it was determined that subjects experienced more…
- Trial name
- NCT02335710
- Testing
- Journey II BCS TKA
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The University of Tennessee, Knoxville
Type 2 Diabetes Mellitus, Impaired Glucose Tolerance (Prediabetes)
Exercise Training and Glucose Metabolism in Aging
Diabetes and its associated complications affect more than 20 million Americans, and the prevalence of type 2 diabetes and impaired glucose tolerance rises dramatically with age such that 40% of Americans over age 60 are…
- Trial name
- NCT00701051
- Testing
- Aerobic exercise training, Detraining (cessation of exercise)
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Healthy
Genetic Determinants of Response to Beta Blockade
The overall goal of this project is to determine the genetic factors contributing to interindividual differences in response to beta-blockade.
- Trial name
- NCT00837902
- Testing
- Atenolol (β-blocker)
- Where
- United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Exercise Training, Hemodynamic Response
The Impact of Blood Flow Restriction (BFR) on Exercise and Hemodynamic Responses
The impact of blood flow restriction (BFR) on exercise and hemodynamic responses will be studied. The use of BFR will be studied during yoga and low-intensity aerobic exercise in healthy subjects with no history of chronic…
- Trial name
- NCT03540147
- Testing
- Hokanson Cuffs, BStrong Bands
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Eating Disorders
Response to Acute Exercise in Eating Disorders
Individuals with eating disorders (ED) represent a high-priority clinical population, with among the highest mortality rates of any psychiatric disorder, and driven exercise (DEx) is a symptom evidenced in up to 80% of those with…
- Trial name
- NCT06213883
- Testing
- Biobehavioral Response to in-lab exposure to physical activity
- Where
- 2 sites in United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Physical Inactivity, Overweight or Obesity
eMOTION Formative Study
The eMOTION Study is a two-part ORBIT model phase 1 trial. The first part, called the Formative Study, will assess acceptability and feasibility of a novel physical activity intervention in adults at increased risk for cancer due…
- Conditions
- Physical Inactivity, Overweight or Obesity, Cancer
- Trial name
- NCT06125964
- Testing
- Intensity-Based Goals, Affect-Based Goals, TYPE/CONTEXT Enhancement
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Alzheimer's Disease
Dose Response Study of Aerobic Exercise in Older Adults
This is a randomized, 26-week study of supervised exercise assessing three doses of exercise in sedentary individuals 65 years of age and over with age-related cognitive changes.
- Trial name
- NCT01129115
- Testing
- Nonexercise control group, Aerobic Exercise Group 1, Aerobic Exercise Group 2
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Jeff Burns, MD
Healthy Aging, Alzheimer Disease
Acute Exercise and the Cerebral Metabolic Response in Aging and Alzheimer's Disease
The overall goal is to characterize the acute exercise response as it relates to brain glucose metabolism in aging and Alzheimer's Disease (AD).
- Trial name
- AEROBIC (NCT04299308)
- Testing
- Aerobic Exercise
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Healthy Volunteers
Study of GSK2586881 on Acute Hypoxia and Exercise
This study is conducted to examine how GSK2586881, a recombinant human ACE2 peptide, modulates the acute hypoxic pulmonary vasoconstriction (HPV) response in healthy volunteers.
- Trial name
- NCT03000686
- Testing
- GSK2586881
- Where
- Germany
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy, Pre Hypertension
Race, Natriuretic Peptides and Physiological Perturbations
The purpose of the study is to understand the origins of differential response to beta-blockers in African-Americans and may provide insight regarding racial differences in cardiovascular risk.
- Trial name
- NCT03070184
- Testing
- Exercise capacity VO2 max determination, Standardized meals, Exercise challenge
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Sarcopenia
Muscle Capillarization and Sarcopenia
Aging is associated with a loss of muscle mass, termed sarcopenia, that reduces mobility, decreases physical function and accelerates progression of other age-related disorders.
- Trial name
- NCT03984994
- Testing
- Aerobic exercise training, Strength training
- Where
- 2 sites in United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Baltimore VA Medical Center