Clinical trials: Exfoliation Glaucoma
Glaucoma Capsulare, Genetic Predisposition to Disease
Genetic and Risk Factors in Exfoliation Glaucoma Patients
Prospective non-randomised cohort study enrolling patients with exfoliation glaucoma. All patients were ophthalmological examined at inclusion. Blood samples were taken for genetic analysis.
- Conditions
- Glaucoma Capsulare, Genetic Predisposition to Disease, Risk Reduction
- Trial name
- NCT06237764
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 130 people
- Sponsor
- Göteborg University
Exfoliation Syndrome, Glaucoma
The International Collaborative Exfoliation Syndrome Treatment Study
Purpose: To determine the efficacy of treatment with latanoprost in combination with pilocarpine versus timolol or timolol/dorzolamide fixed combination (Timoptic or Cosopt) in eyes with XFS and elevated intraocular pressure…
- Conditions
- Exfoliation Syndrome, Glaucoma, Ocular Hypertension
- Trial name
- NCT00804115
- Testing
- Latanoprost with Pilocarpine vs Timolol or Cosopt
- Where
- United States
- Volunteers
- 277 people, healthy volunteers welcome
- Sponsor
- The New York Eye & Ear Infirmary
Open Angle Glaucoma, Pseudoexfoliation Glaucoma
Trabeculopuncture as Predictive Test for the Success of Ab Interno Trabeculectomy
The purpose of this study is to perform trabeculopuncture a test to determine the distal outflow tract function to predict the success of ab interno trabeculectomy.
- Trial name
- NCT06523751
- Testing
- Trabeculopuncture
- Where
- Germany
- Volunteers
- 55 people
- Sponsor
- Wuerzburg University Hospital
Exfoliation Syndrome, Primary Open Angle Glaucoma
Imaging Lens Deposits in Exfoliation Syndrome
The purpose of this study is to use a special eye imaging technique, anterior segment optical coherence tomography (AS-OCT), to image the lens (the curved, transparent part of the eye that helps you to see clearly by directing…
- Conditions
- Exfoliation Syndrome, Primary Open Angle Glaucoma, Cataracts
- Trial name
- NCT02042703
- Testing
- anterior segment OCT
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Duke University
Pseudo Exfoliation Syndrome
Natural History of IOL in Pseudo Exfoliation Syndrome
The purpose of this study is to determine the natural course of IOL in PXF, To demonstrate use of a clinical grading system for PXF, To strategize a way to prevent IOL dislocation, subluxation post operatively, To demonstrate…
- Trial name
- PXF (NCT01255995)
- Testing
- Capsular Tension Ring
- Where
- 4 sites in India
- Volunteers
- 1,500 people
- Sponsor
- Aurolab
Glaucoma Eye, Open-angle Glaucoma
Quality of Life After Glaucoma Surgery: Evaluating the Patient Perspective Across Surgical Options
Glaucoma surgery currently relies on a wide therapeutic arsenal, ranging from conventional filtering surgeries to minimally invasive glaucoma surgery (MIGS).
- Conditions
- Glaucoma Eye, Open-angle Glaucoma, Closed-Angle Glaucoma, Pseudo Exfoliative Syndrome
- Trial name
- G-SCOPE (NCT07303257)
- Testing
- NEI-VFQ-25 (National Eye Institute Visual Function Questionnaire-25).
- Where
- France
- Volunteers
- 132 people
- Sponsor
- Hospices Civils de Lyon
Glaucoma, Primary Open Angle Glaucoma
Transcorneal Electrical Stimulation for the Treatment of Visual Field Defects in Patients With Open-Angle Glaucoma
Glaucoma is a progressive optic neuropathy with retinal ganglion cell loss which leads to visual field loss. Open-angle glaucoma is the most common form of glaucoma.
- Conditions
- Glaucoma, Primary Open Angle Glaucoma, Pseudoexfoliation Glaucoma, Pigment Dispersion Glaucoma
- Trial name
- TES-GPS (NCT06682962)
- Testing
- Transcorneal electrical stimulation (TES) with the OkuStim 2 System
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Okuvision GmbH
Pseudoexfoliation Syndrome
The Endothelial Count in Pxf
Pseudoexfoliation Syndrome Is a common disorder in Egypt. IT is one of the common causes of coexisting cataract and glaucoma. It may be associated with a less than normal endothelial count.
- Trial name
- NCT03265457
- Testing
- Specular microscopy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Assiut University
Pseudoexfoliation Glaucoma
Phacoemulsification vs SLT as Initial Treatment for Pseudoexfoliation Glaucoma
The Canadian Pseudoexfoliation Glaucoma Study 1 is a randomized clinical trial that aims to compare two initial treatment options - Selective Laser Trabeculoplasty (SLT) and Phacoemulsification (PHACO) - in newly diagnosed…
- Trial name
- CANPEX1 (NCT04416724)
- Testing
- Phacoemulsification, Selective Laser Trabeculoplasty
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Nova Scotia Health Authority
Pseudoexfoliation Syndrome, Glaucoma
Plasma Levels of Matrix Metalloproteinases (MMPs) and Degree of DNA Fragmentation in Pseudoexfoliation (PEX) Glaucoma
Glaucoma is a worldwide leading cause of blindness. The key feature of this ocular neuropathy is characterized by an excavating optic nerve head.
- Trial name
- NCT00327613
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University Hospital, Basel, Switzerland
Exfoliation Syndrome, Ocular Hypertension
Randomized Prospective Study of Selective Laser Trabeculoplasty (SLT) Versus Argon Trabeculoplasty (ALT) in Patients With Pseudoexfoliation Glaucoma and Ocular Hypertension
Multi-center, prospective, randomized, controlled clinical trial to compare selective laser trabeculoplasty (SLT) and Argon laser trabeculoplasty (ALT) in pseudoexfoliation glaucoma and ocular hypertension patients.
- Trial name
- SLT (NCT01126203)
- Testing
- SLT, ALT
- Where
- 5 sites in Canada
- Volunteers
- 25 people
- Sponsor
- University of Calgary
Primary Open-angle Glaucoma, Ocular Hypertension
Adherence With Fixed Versus Unfixed Glaucoma Therapy
A 6-month, parallel, non-interventional trial investigating the level of adherence and the impact of dosing in open-angle glaucoma patients who receive either unfixed therapy with latanoprost once in the evening and timolol twice…
- Conditions
- Primary Open-angle Glaucoma, Ocular Hypertension, Exfoliation Glaucoma
- Trial name
- NCT01281020
- Where
- Greece
- Volunteers
- 132 people
- Sponsor
- Aristotle University Of Thessaloniki
Dry Eye Disease
Exploratory Study Comparing Signs and Symptoms in Patients With Ocular Hypertension or Glaucoma Using Xalatan R® or Travatan Z®
The purpose of this study is to determine if there is a difference in the ocular signs and symptoms of subjects' eyes using Xalatan® 0.005% versus Travatan Z® 0.004% based on the outcome of subject assessment and clinical…
- Trial name
- NCT00799682
- Testing
- Xalatan, Travatan Z
- Where
- 5 sites in United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Ophthalmic Consultants of Long Island
Cataract, Pseudoexfoliation Syndrome
Bromfenac to Reduce Inflammation in Patients With Pseudoexfoliation Syndrome After Cataract Surgery
OBJECTIVE To evaluate the efficacy of bromfenac ophthalmic solution 0.09% for reducing postoperative inflammation in eyes with pseudoexfoliation syndrome (PEX) undergoing cataract surgery and receiving standard postoperative eye…
- Trial name
- REPEX (NCT02137161)
- Testing
- Dexamethasone+Tobramycin eye drop, Bromfenac eye drop
- Where
- Italy
- Volunteers
- 62 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Pseudoexfoliation Syndrome, Cataract
Influence of Cataract Surgery on Corneal Biomechanical Properties in Patients With Pseudoexfoliation Syndrome
Pseudoexfoliation syndrome is associated with alterations in the biomechanical properties of the cornea. This prospective observational cohort study aims to evaluate changes in corneal biomechanical properties after standard…
- Trial name
- NCT07719101
- Where
- Croatia
- Volunteers
- 70 people
- Sponsor
- Kata Culina
Abdominal Aortic Aneurysms, Pseudoexfoliation Syndrome
Abdominal Aortic Aneurysms and Pseudoexfoliation Syndrome
Conflicting results have been reported concerning the association of pseudoexfoliation syndrome (PXF) and abdominal aortic aneurysms (AAA). Schumacher et al.
- Conditions
- Abdominal Aortic Aneurysms, Pseudoexfoliation Syndrome, Hypertension
- Trial name
- NCT00546013
- Where
- France
- Volunteers
- 208 people
- Sponsor
- European Georges Pompidou Hospital
Open Angle Glaucoma, Primary Open Angle Glaucoma
Topical Insulin for Glaucoma (TING2)
This study evaluates the safety and preliminary efficacy of topical sterile human insulin eye drops (EYED-002) in patients with open-angle glaucoma.
- Conditions
- Open Angle Glaucoma, Primary Open Angle Glaucoma, Low Tension Glaucoma, Pigmentary Glaucoma
- Trial name
- NCT07619482
- Testing
- EYED-002 Low Dose (721 U/mL topical insulin), EYED-002 High Dose (1442 U/mL topical insulin), EYED-002 (highest tolerated dose, 12-month)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Stanford University
Primary Open Angle Glaucoma, Secondary Open Angle Glaucoma Due to PEX
Contrast Sensitivity in Glaucoma
The primary aim of the Erlangen´s Glaucoma Contrast Sensitivity-Study (EGCS-Study) is the evaluation of the diagnostic and prognostic validity of a diagnostic procedure, measuring contrast sensitivity.
- Trial name
- NCT00947869
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg
Pseudoexfoliation Syndrome
The Possible Association Between Pseudoexfoliation Syndrome And Corneal Endothelial Cell Changes
The study aims to compare the endothelial cell count in patients with pseudoexfoliation syndrome to the the endothelial cell count in normal patients above the age of 50.
- Trial name
- NCT05156138
- Testing
- no interventions as it is a case control observational study
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Endothelial Cell Loss, Corneal
Endothelial Changes in Pseudoexfoliation Syndrome
this study aimed to evaluate the corneal endothelial cell changes before and after phacoemulsification in pseudoexfoliative patients relative to healthy adults.
- Trial name
- PEX (NCT05194891)
- Testing
- Specular Microscopy
- Volunteers
- 100 people
- Sponsor
- Assiut University