Clinical trials: Exfoliation Syndrome
Pseudoexfoliation, Pseudoexfoliation Syndrome
Cataract Surgery in Patients With Pseudoexfoliation and Pseudoexfoliation Glaucoma
The study aims to document the effect cataract surgery has on the pseudoexfoliation and pseudoexfoliation glaucoma eye. Details such has patient history, history of possible glaucoma, intraocular pressure, status of the eye…
- Conditions
- Pseudoexfoliation, Pseudoexfoliation Syndrome, Pseudoexfoliation Glaucoma, Cataract
- Trial name
- PHACOPXG (NCT04590651)
- Testing
- Cataract surgery, Cataract surgery with extra anterior chamber angle aspiration
- Where
- Finland
- Volunteers
- 150 people
- Sponsor
- Peeter Kuddu
Pseudoexfoliation Syndrome, Carpal Tunnel Syndrome (CTS)
Pseudoexfoliation and Carpal Tunnel Study
This prospective, single-center case-control study aimed to investigate the association between pseudoexfoliation syndrome (PES) and carpal tunnel syndrome (CTS) using biochemical markers.
- Trial name
- NCT06946030
- Where
- Turkey (Türkiye)
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Ankara Training and Research Hospital
Down Syndrome
Non-drug Study to Assess the Suitability of Assessment Scales in Japanese Individuals With Down Syndrome Aged 6-30
To evaluate the suitability (i.e. number of tests completed and number of participants completing the tests, variance estimate of baseline and of the change from baseline values) of neurocognitive tests and functioning scales in…
- Trial name
- NCT02431117
- Where
- 7 sites in Japan
- Volunteers
- 43 people
- Sponsor
- Chugai Pharmaceutical
Primary Open Angle Glaucoma, Primary Angle Closure Glaucoma
Patch Graft Material Safety and Effectiveness in Covering Glaucoma Drainage Device Tube
The investigators hypothesize that KeraSys is a safe as Tutoplast to cover the tube of the Molteno 3 glaucoma drainage device during surgery
- Conditions
- Primary Open Angle Glaucoma, Primary Angle Closure Glaucoma, Pseudoexfoliation Glaucoma, Pigmentary Glaucoma
- Trial name
- NCT01301378
- Testing
- Molteno 3 glaucoma drainage shunt
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Wills Eye
Frail Elderly Syndrome
Implementing, Evaluating, and Scaling Up of the Strengthening a Palliative Approach in Long Term Care (SPA-LTC) Program
This study will evaluate the implementation of the Strengthening a Palliative Approach in Long-Term Care (SPA-LTC) program using a cross-jurisdictional, effectiveness-implementation type II hybrid design (dual testing of clinical…
- Trial name
- NCT03935997
- Testing
- Strengthening a Palliative Approach in Long-Term Care (SPA-LTC) Program
- Where
- 4 sites in Canada
- Volunteers
- 594 people
- Sponsor
- McMaster University
Sturge-Weber Syndrome
Biomarker Development in Sturge-Weber Syndrome
This is a study of 40 individuals with Sturge-Weber Syndrome (SWS) brain and/or eye involvement. It will examine the test-retest reliability of the following clinical tests: 1. Quantitative EEG 2. Transcranial Doppler 3.
- Trial name
- Pilot (NCT01345305)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Corneal Endothelial Cell Loss, Pseudoexfoliation Syndrome
Corneal Endothelium After Phacoemulsification in Pseudo Exfoliation Syndrome
To study corneal endothelial cells changes after phacoemulsification in patients with senile cataract and pseudoexfoliation syndrome (PEX) compared with control patients with senile cataract using specular microscope.
- Trial name
- NCT05447130
- Testing
- phacoemulsification
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Minia University
Endothelial Cell Loss, Corneal
Endothelial Changes in Pseudoexfoliation Syndrome
this study aimed to evaluate the corneal endothelial cell changes before and after phacoemulsification in pseudoexfoliative patients relative to healthy adults.
- Trial name
- PEX (NCT05194891)
- Testing
- Specular Microscopy
- Volunteers
- 100 people
- Sponsor
- Assiut University
Gingivitis, PCOS
Effect of EE/NETA With Scaling on Periodontium and hsCRP in PCOS Women With Gingivitis
As gingivitis is known to add to the systemic inflammatory burden and may consequently contribute to progression of PCOS and vice-versa, So, controlling local and systemic inflammatory burden by scaling g and medical treatment…
- Trial name
- NCT05129878
- Testing
- scaling and OHI, oral Hygiene instructions, Scaling and oral hygiene instruction
- Where
- 2 sites in India
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Pseudoexfoliation Syndrome, Biomechanical Parameters
Corneal Biomechanics, Optical Properties and Anterior Segment Structural Features in Patients With Pseudoexfoliation
The purpose of this study is to assess the effect of pseudoexfoliation syndrome on corneal biomechanics, optical clarity of the cornea, and anterior segment structural features.
- Conditions
- Pseudoexfoliation Syndrome, Biomechanical Parameters, Corneal Densitometry
- Trial name
- CorPEX (NCT06731530)
- Testing
- Pentacam-AXL, HD Analyzer, Corvis ST
- Where
- Greece
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Glaucoma, Open-Angle, Suprachoroidal Space
Safety and Efficacy of Suprachoroidal Tube Shunt in Patients With Primary Open and Pseudoexfoliation Glaucomas
To assess safety and efficacy of a novel suprachoroidal silicone tube (SST) shunt for the treatment of primary open angle and exfoliative glaucomas.
- Conditions
- Glaucoma, Open-Angle, Suprachoroidal Space, Pseudo Exfoliation Syndrome
- Trial name
- NCT06154330
- Where
- Georgia
- Volunteers
- 91 people
- Sponsor
- Davinci LTD
Hiv
PrEPARE-SCALE: Scaling up Integrated PrEP Delivery in Kenyan Maternal and Child Health Clinics
This project aims to develop a community of practice; then test a combination of community of practice, quality improvement, and a training toolkit, to enhance implementation and clinical outcomes; and identify patterns…
- Trial name
- NCT06526507
- Testing
- Implementation strategy package
- Where
- 5 sites in Kenya
- Volunteers
- 17,000 people
- Sponsor
- University of Washington
Exfoliation Syndrome, Glaucoma
The International Collaborative Exfoliation Syndrome Treatment Study
Purpose: To determine the efficacy of treatment with latanoprost in combination with pilocarpine versus timolol or timolol/dorzolamide fixed combination (Timoptic or Cosopt) in eyes with XFS and elevated intraocular pressure…
- Conditions
- Exfoliation Syndrome, Glaucoma, Ocular Hypertension
- Trial name
- NCT00804115
- Testing
- Latanoprost with Pilocarpine vs Timolol or Cosopt
- Where
- United States
- Volunteers
- 277 people, healthy volunteers welcome
- Sponsor
- The New York Eye & Ear Infirmary
Glaucoma, Open Angle Glaucoma (OAG)
Long-term Safety and Efficacy of a Modified Suprachoroidal Silicone Tube (SST) Shunt
The goal of this observational study is to evaluate the long-term safety and efficacy of a modified suprachoroidal silicone tube (SST) shunt in treating patients with primary open-angle glaucoma (POAG) and pseudo-exfoliative…
- Conditions
- Glaucoma, Open Angle Glaucoma (OAG), POAG, Ocular Hypertension
- Trial name
- NCT06691555
- Testing
- Suprachoroidal silicone tube (SST) shunt
- Where
- Georgia
- Volunteers
- 66 people
- Sponsor
- Davinci LTD
Cataract, Phacoemulsification
Intracameral Mydriasis Versus Topical Mydriasis in Cataract Surgery
The purpose is to determine if an intracameral solution of 0.2% tropicamide and 2% phenylephrine can dilate the pupil for cataract surgery as well as pre-operative topical 1% tropicamide and 5% phenylephrine.
- Conditions
- Cataract, Phacoemulsification, Mydriasis, Pseudoexfoliation Syndrome
- Trial name
- NCT00690222
- Testing
- Intracameral injection of mydriatic agent
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Nova Scotia Health Authority
Glaucoma, Primary Open Angle Glaucoma
Changes in Ocular Rigidity After Trabeculectomy in Patients With POAG
It has been hypothesized that the biomechanical properties of the optic nerve head and/or sclera play a role in the development of glaucoma.
- Conditions
- Glaucoma, Primary Open Angle Glaucoma, Pseudoexfoliation Glaucoma
- Trial name
- NCT02544646
- Testing
- Changes in Ocular rigidity
- Where
- Austria
- Volunteers
- 53 people
- Sponsor
- Medical University of Vienna
Down Syndrome
Efficacy and Safety of Memantine Hydrochloride in Enhancing the Cognitive Abilities of Young Adults With Down Syndrome
The purpose of this 16-week research study is to determine whether a drug called memantine hydrochloride (memantine) has the potential to help improve memory and other cognitive abilities of young adults with Down syndrome (DS).
- Trial name
- NCT01112683
- Testing
- Memantine
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Colorado, Denver
Cataract, Diabetes
Aqueous Flare of a Hydrophobic Acrylic Single-piece Open-loop IOL With Modified Material Surface Properties
Modern phacoemulsification techniques have made cataract surgery safe and efficient over the past several decades. Although the phacoemulsification procedure has improved greatly, cataract surgery still involves trauma.
- Conditions
- Cataract, Diabetes, Pseudoexfoliation Syndrome
- Trial name
- POL (NCT01767012)
- Testing
- Polylens EC-HY10-PAL (coated), Polylens EC-Y10-PAL (uncoated)
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Glaucoma Eye, Open-angle Glaucoma
Quality of Life After Glaucoma Surgery: Evaluating the Patient Perspective Across Surgical Options
Glaucoma surgery currently relies on a wide therapeutic arsenal, ranging from conventional filtering surgeries to minimally invasive glaucoma surgery (MIGS).
- Conditions
- Glaucoma Eye, Open-angle Glaucoma, Closed-Angle Glaucoma, Pseudo Exfoliative Syndrome
- Trial name
- G-SCOPE (NCT07303257)
- Testing
- NEI-VFQ-25 (National Eye Institute Visual Function Questionnaire-25).
- Where
- France
- Volunteers
- 132 people
- Sponsor
- Hospices Civils de Lyon
Marfan's Syndrome With Ocular Manifestations, Pseudoexfoliation Syndrome
The Oscillation of Crystalline and Intraocular Lenses
The crystalline lens of the human eye helps to sharpen vision. There can be issues with the support/stability of the lens. This could be seen with the naked eye of an external observer or with the use of a slit lamp.
- Conditions
- Marfan's Syndrome With Ocular Manifestations, Pseudoexfoliation Syndrome, Cataract, Phakodonesis
- Trial name
- NCT04274634
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Anglia Ruskin University