Clinical trials: Exhaled Breath Condensate
Chronic Obstructive Pulmonary Disease
Exhaled Breath Condensate (EBC) Assessment in Acute Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)
This study aimed to assess airway inflammation in patients during the course of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) by serial analyses of their exhaled breath condensates (EBC).
- Trial name
- NCT00448500
- Where
- Hong Kong
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Cystic Fibrosis
Non-Invasive Biomarkers in Cystic Fibrosis
Background Chronic airway inflammation is present in cystic fibrosis. Non-invasive inflammometry may be useful in disease management.
- Trial name
- NCT00413140
- Where
- 4 sites in Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Respiratory Disease
Investigation of Inflammacheck to Measure Exhaled Breath Condensate Hydrogen Peroxide in Respiratory Conditions
People with lung conditions can suffer significantly with their symptoms and often require multiple trips to their GP or secondary care before a diagnosis is made.
- Trial name
- VICTORY (NCT04467190)
- Where
- United Kingdom
- Volunteers
- 425 people
- Sponsor
- Portsmouth Hospitals NHS Trust
Lung Cancer (Diagnosis), Lung Cancer (Suspected or Confirmed)
A Study Measuring Markers of Airway Inflammation in Breath Samples From People With Respiratory Diseases and Healthy Volunteers.
Lung cancer remains the leading cause of cancer-related death in the UK, with over 35,000 deaths annually and most cases diagnosed at a late stage.
- Conditions
- Lung Cancer (Diagnosis), Lung Cancer (Suspected or Confirmed), Healthy, Pneumonia
- Trial name
- VICTORY 2 (NCT07426718)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Portsmouth Hospitals NHS Trust
Combined Allergic Rhinitis and Asthma Syndrome
Exhaled Breath Condensate Biomarkers in CARAS
To explore the differences in the expression of biomarkers in different sample types between the healthy population and different subgroups of the disease, and to screen for potential biomarkers in a more simple, direct and…
- Trial name
- NCT06573450
- Testing
- questionnaire survey
- Where
- China
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Henan University of Traditional Chinese Medicine
Smoking
Young Smokers Have Impaired Airway Defense
Background: Smoking is a key factor for development and progression of chronic obstructive pulmonary disease (COPD). Although persons with COPD often have concomitant nasal disease, there are few studies that report physiological…
- Trial name
- NCT01877291
- Where
- Brazil
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Asthma
Exhaled Breath Condensate as a Measure of Airway Inflammation in Children With Asthma
This study will evaluate the usefulness of a new procedure for evaluating asthma in children. The method measures the pH (a measure of acidity and alkalinity) of exhaled breath condensate (water vapor created by the lungs).
- Trial name
- NCT00078208
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Inflammatory Response, Immunological Abnormality
Measurment of Interleuukin-6 at Exhaled Breath Condensate of Covid-19 Patients and Post Covid-19 Patients With Lung Fibrosis Randomized Controlled Study
COVID-19 has emerged as a global pandemic. It is mainly manifested as pneumonia which may deteriorate into severe respiratory failure.
- Conditions
- Inflammatory Response, Immunological Abnormality, COVID-19
- Trial name
- NCT05157204
- Testing
- measurment of interleukin-6 at exhaled condensate
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Saudi Arabia
Asthma, Cystic Fibrosis
FLAME: Airway Inflammation Monitoring in Asthma and Cystic Fibrosis
Background By means of measurements of series of non-invasive inflammatory markers in exhaled breath (condensate), a reflection of inflammatory processes and oxidative stress, can be obtained.
- Trial name
- NCT00404859
- Where
- 4 sites in Netherlands
- Volunteers
- 70 people
- Sponsor
- Maastricht University Medical Center
Lung Cancer
Metabolomic Characteristics of Patients With Non-small Cell Lung Cancer in Plasma, Tissue and Exhaled Breath Condensate
Investigators collected tissue and plasma samples from patients with benign pulmonary nodules and non-small cell lung cancer (NSCLC).
- Trial name
- NCT07532447
- Where
- China
- Volunteers
- 74 people
- Sponsor
- People's Hospital of Xinjiang Uygur Autonomous Region
Respiratory Distress Syndrome, Adult, Respiratory Syncytial Virus Infections
Continuous Exhaled Breath Condensate pH in Mechanically Ventilated Patients
Given the possible prognostic relationship between exhaled breath condensate pH and clinical symptoms, it is quite plausible that exhaled breath condensate pH can prove useful in the intensive care unit.
- Conditions
- Respiratory Distress Syndrome, Adult, Respiratory Syncytial Virus Infections, Pneumonia, Acute Lung Injury
- Trial name
- NCT00429637
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Virginia
Healthy
A Pilot Feasibility Study of Detection of IL-11 and Other Cytokines in the Exhaled Breath Condensate (EBC) and Blood of Healthy Volunteers
IL-11 is a receptor previously proven to be highly expressed in human lungs with idiopathic lung fibrosis, and in animal model, IL-11 receptor neutralizing antibody has been shown to prevent the process of fibrosis in…
- Trial name
- NCT05536375
- Testing
- Exhaled breath condensate collection and blood draw
- Where
- Singapore
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Heart Centre Singapore
Asthma, Chronic Obstructive Pulmonary Disease
EXhaled Hydrogen Peroxide As a Marker of Lung diseasE (EXHALE) Pilot Study.
This Pilot study evaluates the use of a new device called Inflammacheck and whether it can consistently measure hydrogen peroxide levels in exhaled breath condensate.
- Trial name
- EXHALE Pilot (NCT03055923)
- Testing
- The Inflammacheck Device
- Where
- United Kingdom
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Portsmouth Hospitals NHS Trust
Cystic Fibrosis
Breath Condensate Study in Patients With Cystic Fibrosis.
There is an urgent need for a noninvasive method to diagnose bronchial infections and exacerbations in patients with Cystic Fibrosis (CF).
- Trial name
- NCT02056132
- Testing
- Exhaled Breath Condensate
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Florida
Asthma, COPD Exacerbation
Study to Explore the Relationship Between the Level of Exhaled Breath Condensate Hydrogen Peroxide (EBC H2O2) as Measured Using a New Device Against Existing Measures of Lung Disease
A cross-sectional, observational study of EBC H2O2 levels, as measured by a novel device, 'Inflammacheck™', and other markers of disease severity and symptom control in patients with Asthma and COPD and volunteers with no history…
- Trial name
- EXHALE 1A (NCT04061291)
- Where
- United Kingdom
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Portsmouth Hospitals NHS Trust
Exhaled Breath Condensate, Athlete
Small RNA Profiling in EBC in Athletes
Background: Exhaled breath condensate (EBC) is a non-invasively collected biofluid containing volatile and non-volatile compounds, including small RNAs.
- Conditions
- Exhaled Breath Condensate, Athlete, RNA Profile, Cardio-pulmonary Function
- Trial name
- AirBiopsy (NCT07324252)
- Where
- Poland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Bronchial Asthma
Inhaled Apocynin Decreases Reactive Oxygen Species Concentrations in Exhaled Breath Condensate in Mild Asthmatics
The aim of the study is to investigate the effect of inhaled apocynin on ROS (reactive oxygen species) and NOS (reactive nitrogen species) synthesis in 10 nonsmoking mild asthmatics.
- Trial name
- NCT00992667
- Testing
- Apocynin nebulization
- Where
- Poland
- Volunteers
- 10 people
- Sponsor
- Medical University of Lodz
Lung Disease
Non-invasive Ways to Evaluate Lung Disease After Treatment With Xolair
The purpose of this study is to study the effects of Xolair using non-invasive techniques from the expired gas of patients with moderate to severe allergic asthma.
- Trial name
- NCT00139152
- Testing
- Xolair
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- Creighton University
Ventilator Associated Pneumonia (VAP)
Serial, Non-invasive Analysis of Exhaled Breath Condensate in Ventilated Trauma Patients
To determine if the analysis of exhaled breath condensate correlates with the development \& resolution of pneumonia.
- Trial name
- NCT02652247
- Testing
- molecular analysis of exhaled breath condensate, molecular analysis of mini-bronchoalveolar lavage (BAL) aspirate, molecular analysis of bronchoalveolar lavage (BAL) aspirate
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Vanderbilt University Medical Center
Acute Pulmonary Insufficiency Following Thoracic Surgery, Ventilator-associated Lung Injury
Metabolomic Study in Exhaled Breath Condensate of Thoracic Surgical Patients
Acute lung injury (ALI) following thoracic surgery remains a major source of morbidity and mortality after lung resection. One-lung ventilation (OLV) is usually required in thoracic surgery.
- Trial name
- NCT02583984
- Testing
- Thoracic Surgery with Lung Resection, Thoracic Surgery without Lung Resection
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital