Clinical trials: Exogenous Ketosis
Heart Failure With Reduced Ejection Fraction
Effects of 2-week Ketosis on the Heart's Ketone Body Consumption, Utilization, and Energetic Efficiency in Patients With Chronic Heart Failure
Heart Failure (HF) is a significant health concern, affecting around 1-2% of people in Western countries. The risk of developing HF during a lifetime is about 20%.
- Trial name
- KETO-CHF PET (NCT06398964)
- Testing
- 3-hydroxybutyrat
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Aarhus University Hospital
Exercise, Ketones
The Effects of Exogenous Ketones on Exercise Performance in Young Healthy Adults
The ketone body beta-hydroxybutyrate is produced during prolonged fasting or exercise and can be used as an alternative fuel source.
- Conditions
- Exercise, Ketones, Dietary Supplements
- Trial name
- NCT02825823
- Testing
- Ketone Salt
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
PTSD, Ketosis
Ketone Supplementation in Individuals With PTSD
The purpose of this study is to determine if a 6-week period of ketone salt supplementation affects physiological, emotional, cognitive, and/or behavioral health markers in individuals with PTSD.
- Trial name
- NCT04083352
- Testing
- Pruvit Ketomax Ketone Salt
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Augusta University
Obstructive Sleep Apnea, Sleep
Impact of Exogenous Ketones on Sleep Disruption in Vulnerable Populations
Obstructive Sleep Apnea (OSA) is a common medical disorder that is associated with reduced quality of life and higher risk of cardiovascular disease. Treatments for OSA and limited and not well tolerated.
- Trial name
- KETO-SLEEP 1 (NCT06655649)
- Testing
- Ketone-IQ (1,3 Butanediol)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Ketosis, Hypoxia
Intermittent Exogenous Ketosis (IEK) at High Altitude
Altitude-related hypoxia decreases human functional capacity, especially during exercise. Even with prolonged acclimatization, the physiological adaptations are insufficient to preserve exercise capacity, especially at higher…
- Trial name
- NCT06097754
- Testing
- Ketone ester
- Where
- 2 sites in Belgium, Slovenia
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Jozef Stefan Institute
Ketonemia, Ketosis
Exogenous Ketone Supplementation and Exercise Performance
20 healthy recreationally active men and woman aged 18-35 will participate in the study. There will be three treatments involved: Caffeinated ketone supplements, non-caffeinated ketone supplement and water-placebo.
- Trial name
- NCT03895892
- Testing
- 20 km time trial, Wingate test, Ketone/Caffeine
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Healthy Young Adults
Effects of Exogenous Ketones in Healthy Young Adults
Exogenous ketone supplements in the form of beta-hydroxybutyrate can be utilized as an alternate energy source (in place of glucose) for all cells except red blood cells.
- Trial name
- NCT03452761
- Testing
- Ketone Salts
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Augusta University
Ketosis
Markers of Appetite Regulation During Exogenous Ketosis
The aim of this study is to investigate the relationship, if any, between markers of satiety, desire to eat, hunger, and metabolic markers of the regulation hereof during ketosis as compared with a Glucose-containing and a…
- Trial name
- MARK (NCT04156477)
- Testing
- Ketone ester, Glucose, Tap water
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Central Jutland Regional Hospital
Type 1 Diabetes Mellitus, Diabetic Ketoacidosis
Metabolic Effects of Exogenous 3-hydroxybutyrate in Patients With Type 1 Diabetes and Healthy Controls
The main objective of this clinical trial is to study the metabolic effects of intravenous infusion of the ketone body, 3-hydroxybutyrate (3-OHB), in patients with type 1 diabetes and healthy control subjects.
- Trial name
- NCT04656236
- Testing
- 3-hydroxybutyrate
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Ketonemia, Mental Fatigue
Exogenous Ketone Supplementation and Cognitive Function During Exercise
15 healthy trained males will volunteer to participate in this study. there will be 2 treatments: Ketone esters supplementation and iso-caloric carbohydrate.
- Conditions
- Ketonemia, Mental Fatigue, Ketosis
- Trial name
- NCT04576026
- Testing
- mental fatiguing task, 45 - minute simulated soccer game, cognitive function
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Heart Failure With Reduced Ejection Fraction, Ketosis
Comparison Between Endogenous and Exogenous Ketosis in Patients With Non-ischemic Chronic Heart Failure With Reduced Ejection Fraction
This randomized controlled trial will evaluate the effect of a ketogenic diet and/or exogenous administration of ketone bodies vs conventional diet on the ejection fraction of patients with non-ischemic chronic heart failure…
- Trial name
- NCT04921293
- Testing
- Ketogenic diet, Exogenous ketones
- Where
- Mexico
- Volunteers
- 18 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Exogenous Ketosis, Endurance Cycling Performance
The Effects of Exogenous Ketosis on Ultra-endurance Recovery and Performance
The study aims to investigate the effects of post-exercise and pre-sleep ketosis via oral ketone ester supplementation on physical and mental recovery during a multi-day cycling stage race.
- Conditions
- Exogenous Ketosis, Endurance Cycling Performance, Fatigue; Muscle, Heart, Fatigue, Mental
- Trial name
- NCT06965491
- Testing
- Ketone ester supplement
- Where
- Belgium
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Exercise Adaptations
Role of Intermittent Exogenous Ketosis in the Physiological and Muscular Adaptive Response to Endurance Training
In a recent study (Poffé et al., 2019), we demonstrated that increasing the concentration of ketone bodies in the blood through the ingestion of a ketone ester (KE) post-exercise and just before sleeping time during a 3-week…
- Trial name
- NCT05932420
- Testing
- Ketone ester
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Renal Insufficiency, Chronic, Polycystic Kidney Diseases
Effects of Exogenous Ketosis on Proteinuria and Renal Function
A randomized, placebo-controlled, double-blinded crossover study will be conducted. Fourteen patients with polycystic kidney disease (PKD) and 29 patients with proteinuric kidney disease will receive ketone bodies (Ketone-IQ) and…
- Conditions
- Renal Insufficiency, Chronic, Polycystic Kidney Diseases, Proteinuria, Ketosis
- Trial name
- KETO-CKD (NCT06867471)
- Testing
- Ketone Diol, R-1,3-butanediol (Ketone-IQ)
- Where
- Denmark
- Volunteers
- 45 people
- Sponsor
- Gødstrup Hospital
Exogenous Ketosis
Evaluation of the Safety and Tolerability of Exogenous Ketosis Induced by Free Beta-hydroxybutyrate.
The goal of this clinical trial is to evaluate the safety and tolerability of free beta-hydroxybutyrate induced ketosis in healthy individuals.
- Trial name
- NCT05584371
- Testing
- Free Beta-hydroxybutyrate
- Where
- Mexico
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Behavior
Exogenous Ketones and Behavior
The study will examine the effect of exogenous ketone ester on behavior and metabolism using Virtual Reality and computerizes behavioral tasks.
- Trial name
- ExoKet (NCT06515717)
- Testing
- ketone ester
- Where
- Germany
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
ICU Delirium, Critical Illness
Exogenous Ketone Supplementation in ICU Delirium
Delirium is a common syndrome in intensive care unit (ICU) patients. Those experiencing delirium may suddenly feel confused, have trouble thinking clearly, struggle to pay attention, or see and hear things that are not real.
- Trial name
- KETONES-ICU (NCT07364162)
- Testing
- Ketone monoester
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center
Diabetes Mellitus, Ketosis
The Effect of a Ketone Drink on Liver Glucose Production in People With Type 2 Diabetes
What is the effect of a ketone drink on liver glucose production, and postprandial glycemia, in people with type 2 diabetes.
- Trial name
- KES2 (NCT05518448)
- Testing
- Ketone - beta-hydroxybutyrate (β-OHB)
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University of Exeter
PCOS (Polycystic Ovary Syndrome)
Symptoms of Polycystic Ovarian Syndrome Ameliorated by Keto-Adaptation Pilot
The SPARK- Pilot study (Symptoms of PCOS Ameliorated by Responses to Keto-adaptation) is a 12-week clinical trial at The Ohio State University designed to explore how different ways of achieving ketosis may improve reproductive…
- Trial name
- (SPARK-Pilot) (NCT07227363)
- Testing
- Ketogenic diet, Exogenous Ketone Supplement
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Ohio State University
Hypoxia, Exogenous Ketosis
The Effects of Ketone Ester Supplementation During a 5 Week Live High, Train Low Altitude Training Camp
This study aims to investigate the effects of post-exercise and pre-sleep exogenous ketosis via oral ketone ester supplementation during a 5 week simulated altitude training camp.
- Trial name
- NCT06596083
- Testing
- Ketone ester supplement
- Where
- Belgium
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- KU Leuven