Clinical trials: Exosome
Spinocerebellar Ataxia - All Sub-types
Evaluation of the Safety and Preliminary Efficacy of Neuroinduced Mesenchymal Stem Cells and Exosome Therapy in Patients With Spinocerebellar Palsy
This clinical study aims to evaluate the safety and preliminary therapeutic potential of mesenchymal stem cell-derived therapies in patients diagnosed with spinocerebellar palsy.
- Trial name
- NEURO-SCP (NCT07467733)
- Testing
- Intrathecal infusion, Intranasal infusion
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Biocells Medical
Alzheimer Disease
Combined Aerobic Exercise and Cognitive Training in Seniors at Increased Risk for Alzheimer's Disease
The study aims to investigate the effect of a long-term combined aerobic exercise and cognitive training program on cognitive function and blood exosomal synaptic protein levels in seniors at increased risk for Alzheimer's…
- Trial name
- NCT05163626
- Testing
- Combined aerobic exercise and cognitive training program
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xuanwu Hospital, Beijing
Non-Small Cell Lung Cancer
Exosomes Detection for the Prediction of the Efficacy and Adverse Reactions of Anlotinib in Patients With Advanced NSCLC
Exosomes detection for the prediction of the efficacy and adverse reactions of Anlotinib in patients with advanced NSCLC
- Trial name
- NCT05218759
- Testing
- Anlotinib
- Volunteers
- 30 people
- Sponsor
- Shanghai Chest Hospital
Atrophic Acne Scars
Pilot Study of Combination Treatment With Subcision, Human Adipose Tissue-Derived Exosomes and Powdered Polydioxanone for Atrophic Acne Scars
This pilot study compared two treatments for depressed acne scars: subcision alone and subcision followed by injections containing exosomes derived from human fat-derived stem cells and powdered polydioxanone (PDO).
- Trial name
- NCT07914322
- Testing
- Subcision, Human Adipose-Derived Stem Cell Exosomes and Powdered Polydioxanone
- Where
- Malaysia
- Volunteers
- 12 people
- Sponsor
- COSMEDICIAN AP SDN BHD
Androgenetic Alopecia
Evaluation of Exosomes Injection in Treatment of Male Androgenetic Alopecia: Clinical and Immunohistochemical Study
Intradermal injection of exosomes in treatment of male androgenetic alopecia, clinically and using a immunohistochemical marker
- Trial name
- NCT07112586
- Testing
- Plasma derived exosomes
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Ain Shams University
Parkinson Disease
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Exosomes for Parkinson's Disease
This trial will study the safety and efficacy of intranasal instillation of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell exosomes for the treatment of Parkinson's Disease
- Trial name
- NCT05152394
- Testing
- cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell exosomes
- Where
- 2 sites in United States, Greece
- Volunteers
- 20 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Stable Vitiligo
Induced Pluripotent Stem Cell Derived Exosomes Nasal Drops for the Treatment of Stable Vitiligo
Evaluate the efficacy of induced pluripotent stem cell-derived exosomes (iPSC-Exos) for the treatment of stable vitiligo
- Trial name
- NCT06810869
- Testing
- human induced pluripotent stem cell derived exosomes （GD-iExo-003）
- Where
- China
- Volunteers
- 29 people
- Sponsor
- Second Affiliated Hospital of Wannan Medical College
Pneumonitis, Interstitial, Immune Checkpoint Inhibitors (ICIs)
Exploratory Study on the Efficacy and Safety of Nebulized hUC-MSC-Derived Exosomes for Non-Acute CIP
Study Objectives The primary objective of Phase II is to evaluate the percentage of lesion resolution on high-resolution computed tomography (HRCT) as assessed by independent blinded reviewers.
- Conditions
- Pneumonitis, Interstitial, Immune Checkpoint Inhibitors (ICIs), Mesenchymal Stem Cells, Exosomes
- Trial name
- NCT07599111
- Testing
- Nebulized hUCMSC-Exos, Nebulized normal saline
- Volunteers
- 40 people
- Sponsor
- Zhou Chengzhi
Lung Neoplasm, Squamous Cell Carcinoma
Serum Exosomal miRNA Predicting the Therapeutic Efficiency in Lung Squamous Carcinoma
This is an observational prospective bi-center study of 50 patients operated on advanced squamous cell carcinoma. The main aim is to investigate the efficacy of serum exosomal miRNA as a biomarker for predicting the therapeutic…
- Conditions
- Lung Neoplasm, Squamous Cell Carcinoma, Exosomes
- Trial name
- NCT05854030
- Testing
- collect plasma samples and clinical features
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Intra-Bony Defects in Periodontitis Patients
The Efficacy of Exosomes Combined With Synthetic Bone Graft for the Treatment of Periodontal Intra-bony Defects
The aim of this study will be to evaluate clinically, radiographically and biochemically the efficacy of exosomes combined with synthetic bone graft for the treatment of periodontal intra-bony defects.
- Trial name
- NCT07897292
- Testing
- single flap approach, single flap approach combined with nanocrystalline hydroxyapatite bone substitute, Exosomes
- Where
- 2 sites in Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Khoshoe Al-mokhtar Mohammed
Ulcer
Effect of Plasma Derived Exosomes on Cutaneous Wound Healing
This study is an open prospective clinical trial. The objective is to evaluate the effect of autologous exosomes rich plasma on cutaneous wound healing. The participants are patients with intractable cutaneous ulcers (e.g.
- Trial name
- NCT02565264
- Testing
- plasma-derived exosomes
- Where
- Japan
- Volunteers
- 5 people
- Sponsor
- Kumamoto University
Skin Graft
PEP on a Skin Graft Donor Site Wound
The purpose of this study is to determine the safety of a biological therapeutic PEP in participants who have skin graft donor site wounds.
- Trial name
- NCT04664738
- Testing
- 10% PEP, TISSEEL, 20% PEP
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Rion Inc.
Ulcerative Colitis (UC)
hucMSCs Exosomes for the Treatment of Active Ulcerative Colitis
To evaluate the safety and efficacy of hUC-MSCs-Exos in the treatment of ulcerative colitis.
- Trial name
- NCT06853522
- Testing
- exosomes derived from human umbilical cord mesenchymal stem cells, saline +5% albumin
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanghai East Hospital
Familial Hypercholesterolemia
Exosome-based Nanoplatform for Ldlr mRNA Delivery in FH
mRNA therapy is a highly promising gene therapeutic strategy in the treatment of Homozygous Familial Hypercholesterolemia (HoFH).
- Trial name
- ENDFH (NCT05043181)
- Testing
- Low Density Lipoprotein Receptor mRNA Exosomes
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Tang-Du Hospital
Exosomes, Newborn
Exosome microRNAs as Potential Biomarkers of Metabolic Bone Disease of Prematurity
Metabolic bone disease of prematurity (MBDP) is caused by insufficient content of calcium, phosphorus, and organic protein matrix in preterm infants or bone metabolism disorder, which is one of the complications affecting the…
- Conditions
- Exosomes, Newborn, Bone Diseases, Metabolic
- Trial name
- NCT06368154
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hunan Children's Hospital
Androgenic Alopecia
A Study on the Treatment of Androgenetic Alopecia in Young Men With Umbilical Cord Mesenchymal Stem Cell Exosomes
This clinical trial aims to determine the efficacy of human umbilical cord mesenchymal stem cell exosomes (hUCMSC-sEV) in treating androgenic alopecia in young men. It will also investigate the safety of hUCMSC-sEV.
- Trial name
- MSCs treatment (NCT07203599)
- Testing
- Human umbilical cord mesenchymal stem cell exosomes, Minoxidil 5% Topical Solution
- Where
- China
- Volunteers
- 59 people
- Sponsor
- Shenzhen People's Hospital
Radiation-induced Oral Mucositis
Spirulina-Derived Product Alleviates Oral Mucositis in Patients Undergoing Radiotherapy for Malignant Head and Neck Tumors
To evaluate the efficacy and safety of Spirulina-Derived Product for prevention and treatment of oral mucositis in patients undergoing radiotherapy for malignant head and neck tumors.
- Trial name
- NCT07040969
- Testing
- Spray of spirulina derivatives, Radiotherapy
- Where
- China
- Volunteers
- 70 people
- Sponsor
- West China Hospital
Erectile Dysfunction With Diabetes Mellitus
Mesenchymal Stem Cell and Exosome Therapy for Diabetic Erectile Dysfunction
The goal of this prospective randomized controlled clinical study is to evaluate the effectiveness and safety of intracavernosal injections of umbilical cord-derived mesenchymal stem cells (MSCs) and umbilical cord-derived…
- Trial name
- NCT07480161
- Testing
- Umbilical Cord-Derived Mesenchymal Stem Cells, Umblical Cord-Derived Mesenchymal Stem Cell-Derived Exosomes
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Ankara City Hospital Bilkent
STEMI
ExosoMe as Integrative Tool for pRognostic Stratification of Adverse Cardiac remodeLing in stEmi Patients: the MIRACLE Study
This is a multicenter observational prospective study aimed to assess whether plasma exosomes can help identify, at an early stage, patients at high risk of adverse remodeling after STEMI (ST-elevation myocardial infarction) …
- Trial name
- MIRACLE (NCT06070974)
- Testing
- CMR and blood collection
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Centro Cardiologico Monzino
Thyroid Cancer, Follicular Thyroid Cancer
Correlation Between Various Urinary Exosomal Protein Biomarkers and Pathological Manifestation in Thyroid Follicular Neoplasm: Early and Pre-operative Diagnosis of Follicular Thyroid Cancer
Thyroid cancer is the most common endocrine malignancy in the world. Generally, thyroid cancer could be divided into well-differentiated and poorly-differentiated.
- Trial name
- NCT05463107
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital