Clinical trials: Exosome
Stable COPD Patients
Study on the Mechanism of Yifei Moxibustion Improving Immune Function in COPD Based on Plasma Exosome miRNAs
This study adopted a randomized controlled design, enrolling 90 patients and 30 healthy volunteers. The patients were randomly divided into the Yifei Moxibustion group, the conventional Western medicine treatment group, and the…
- Trial name
- NCT07131020
- Testing
- Yifei moxibustion, Conventional Western medicine treatment, TCM syndrome differentiation treatment
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Henan University of Traditional Chinese Medicine
Atopic Dermatitis (AD)
Topical Chinese Medicine and Exosome Mechanisms for Atopic Dermatitis
The goal of this clinical trial is to learn if menthol works to relieve pruritus in atopic dermatitis. The primary objectives are to evaluate the safety and clinical efficacy of menthol-containing gloves and foot-covers…
- Trial name
- NCT07693400
- Testing
- menthol-based hand and foot gloves
- Where
- Taiwan
- Volunteers
- 44 people
- Sponsor
- Taiwan Municipal An-Nan Hospital-China Medical University
Prostate Cancer
Plasma Exosome RNA to Diagnose Prostate Cancer
The aim of the present study is to investigate a RNA combination to diagnose prostate cancer.
- Trial name
- exo-PRECISE (NCT06604130)
- Testing
- Prostate cancer screening decision
- Where
- 9 sites in China
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Colo-rectal Cancer, Colorectal Cancer Recurrent
Exosome-based Detection of Molecular Residual Disease in Stage II-III Colorectal Cancer
This study aims to establish an exosome-based liquid biopsy signature to detect molecular residual disease (MRD) in stage II-III colorectal cancer (CRC) patients.
- Trial name
- NCT06654622
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- City of Hope Medical Center
Acute Ischemic Stroke
A Phase 1b Study to Assess the Safety and Tolerability of AB126 Neural Exosomes in Patients With Moderate to Severe Acute Ischemic Stroke
The goal of this clinical trial is to learn if AB126, an investigational treatment made from neural exosomes, is safe and well tolerated when given to adults with moderate to severe acute ischemic stroke (AIS) who have undergone…
- Trial name
- NEXIS (NCT07813130)
- Testing
- AB126 Neural Exosomes Intravenous Injection
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Aruna Bio, Inc.
Peritoneal Dysfunction
The Therapeutic Potential of Mesenchymal Stem Cell-derived Exosomes in Peritoneal Dysfunction
The goal of this clinical trial is to learn if a single intraperitoneal infusion of mesenchymal stem cell-derived exosomes (MSC-Exos) is safe and tolerable in adults with peritoneal dialysis-related peritoneal failure.
- Trial name
- NCT07791667
- Testing
- MSC-Exos
- Volunteers
- 12 people
- Sponsor
- Zhujiang Hospital
Lung Adenocarcinoma, EGFR Activating Mutation
Plasma Exosomes Reveal the Efficacy of Targeted Therapy in Patients With EGFR Mutation in Lung Adenocarcinoma
The objective of this observational study is to explore the therapeutic trajectory of targeted therapy in lung adenocarcinoma patients with epidermal growth factor receptor (EGFR) mutations.
- Trial name
- NCT06730477
- Testing
- observational study
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Skin Aging, Skin Quality
AnteAGE Exosomes and PEARL Multiplier With Microneedling for Facial Skin Quality
This exploratory clinical study evaluated changes in facial skin quality following a series of mechanical microneedling treatments combined with topical AnteAGE Exosomes and PEARL Multiplier and a standardized AnteAGE homecare…
- Trial name
- NCT07849205
- Testing
- Mechanical microneedling, AnteAGE Exosomes and PEARL Multiplier, AnteAGE Homecare Regimen
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cellese Inc.
Ulcerative Colitis, Inflammatory Bowel Disease
Whey Protein Milk-Derived Exosomes
This Phase 1B open-label, uncontrolled multicenter trial evaluates the safety, tolerability, and potential efficacy of WPMDE2, a whey protein milk-derived exosome supplement, in adult patients with mild to severe ulcerative…
- Trial name
- NCT06755021
- Testing
- Whey Protein Milk-Derived Exosomes
- Where
- 4 sites in Israel
- Volunteers
- 31 people
- Sponsor
- Exosomm Ltd.
Intrauterine Adhesions, Exosomes
Clinical Study on the Effect of Umbilical Cord Mesenchymal Stem Cell Exosomes on Endometrial Repair of Intrauterine Adhesions
Intrauterine adhesions (IUA) is a group of diseases caused by endometrial injury leading to occlusion of the uterine cavity and serious abnormality of the uterine cavity morphology, which causes primary or secondary infertility…
- Trial name
- NCT07416578
- Testing
- Exosmoes, HRT
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Healthy
The Influence of High and Low Salt on Exosomes in the Urine
The hypothesis is that changes in the epithelial sodium channel (ENaC) in the kidney is reflected in urinary exosomes and that the amount of ENaC as well as the cleavage degree is upregulated in conditions with low salt.
- Trial name
- NCT02823613
- Testing
- High salt diet followed by low salt diet, Low salt diet followed by high salt diet
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Renal Cell Carcinoma
A Companion Diagnostic Study to Develop Circulating Exosomes as Predictive Biomarkers for the Response to Immunotherapy in Renal Cell Carcinoma
Immune checkpoint inhibitors targeting PD-1 or PD-L1 have been developed and clinical trials showning better response in unselected patients with metastatic renal cell carcinoma (RCC).
- Trial name
- NCT05705583
- Testing
- Other: Blood and Urine Collection
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhejiang Cancer Hospital
Erectile Dysfunction Following Radical Prostatectomy
Intracavernosal Exosomes vs. Rectal Ozone for Post-RARP Erectile Dysfunction
This prospective, randomized, controlled trial aims to evaluate and compare the therapeutic efficacy of intracavernosal urine-derived exosomes and systemic rectal ozone therapy in patients experiencing erectile dysfunction (ED)…
- Trial name
- REHAB-RARP (NCT07707505)
- Testing
- Urine-Derived Exosomes (USC-Exos), Rectal Medical Ozone Insufflation, Daily Phosphodiesterase type 5 (PDE5) Inhibitor
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Medipol University
Sjögren's Syndrome
Exosomes in Patients With Ocular Involvement of Sjögren's Syndrome
This study is a single-center, multiple-dosing, prospective, nonrandom, single-arm trial.
- Trial name
- NCT07192666
- Testing
- Exosome Preparation
- Volunteers
- 12 people
- Sponsor
- Guangdong ProCapZoom Biosciences Co., Ltd.
Prostate Cancer
ExoDx Prostate Evaluation in Prior Negative Prostate Biopsy Setting
The study is designed to confirm the performance of the ExoDx Prostate test in prior negative biopsy patients now presenting for a repeat prostate biopsy.
- Trial name
- NCT04357717
- Testing
- ExoDx Prostate
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Exosome Diagnostics, Inc.
Anti-MDA5 Positive Dermatomyositis-Associated RP-ILD, Rapidly Progressive Interstitial Lung Disease
Nebulized MSC-Exos for Anti-MDA5+ RP-ILD: Safety and Efficacy Trial
Objective: To assess the safety, tolerability, and efficacy of nebulized MSC-exos-P1 in patients with anti-MDA5 positive dermatomyositis-associated rapidly progressive interstitial lung disease (RP-ILD).
- Trial name
- NCT06919380
- Testing
- MSC-exos Nebulization Therapy
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Li Shiyue
Knee; Injury, Meniscus (Lateral) (Medial), Meniscus Tear
Clinical Efficacy of Exosome in Degenerative Meniscal Injury
Comparison of intra-articular administration of synovial fluid-derived mesenchymal stem cells-derived exosomes with synovial fluid-derived mesenchymal stem cells on the same patient.
- Conditions
- Knee; Injury, Meniscus (Lateral) (Medial), Meniscus Tear, Meniscus Lesion, Meniscus; Degeneration
- Trial name
- KNEEXO (NCT05261360)
- Testing
- SF-MSC-EX, SF-MSC
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Eskisehir Osmangazi University
Thin Endometrial Lining, Female Infertility
Evaluating Mechanically Engineered Stem Cell Exosomes for Treating Endometrial Injury: A Clinical Study
The goal of this clinical trial is to evaluate if engineered mechanically umbilical cord-derived stem cell exosomes, or conventional umbilical cord -derived stem cell exosomes, can improve endometrial thickness in women with thin…
- Conditions
- Thin Endometrial Lining, Female Infertility, Intrauterine Adhesions
- Trial name
- NCT06896747
- Testing
- Mechanically Engineered Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes, Umbilical cord mesenchymal stem cell-derived exosomes, platelet-rich plasma
- Where
- 2 sites in China
- Volunteers
- 90 people
- Sponsor
- Tang-Du Hospital
Healthy Subjects, Exosome
A Study to Investigate HLA-G Targeted Exosome (SOB100) in Healthy Subjects
The investigational drug, SOB100, is an HLA-G targeted exosome equipped with a nanobody namely anti-HLA-G VHH on the exosome membrane.
- Conditions
- Healthy Subjects, Exosome, Targeted Therapy
- Trial name
- αHLA-G Exo-01 (NCT07219940)
- Testing
- SOB100
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Shine-On Biomedical Co., Ltd.
Peripheral Neuropathy, Trigeminal Neuralgia
Safety of Cultured Allogeneic Adult Umbilical Cordor Placental Derived Stem Cells Exosomes for Trigeminal Neuralgia
This trial will study the safety and efficacy of instillation of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell exosomes for the treatment of Trigeminal Neuralgia.
- Trial name
- NCT05152368
- Testing
- cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell exosomes
- Where
- 2 sites in United States, Greece
- Volunteers
- 20 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine