Clinical trials: Exosome
Osteo Arthritis Knee
Intra-articular Injection of UC-MSC Exosome in Knee Osteoarthritis
The study aim to evaluate safety of exosomes (sEVs) from allogeneic mesenchymal stromal cells delivered by an intra-articular injection in the knee of patients with mild to moderate symptomatic osteoarthritis.
- Trial name
- EXO-OA01 (NCT06431152)
- Testing
- UC-MSC sEV
- Where
- Chile
- Volunteers
- 12 people
- Sponsor
- Universidad de los Andes, Chile
Bone Metastases
Identification and Characterization of Predictive Factors of Onset of Bone Metastases in Cancer Patients
The aim of the present study is to identify deregulated miRNAs in oncological patients with bone metastases present within the circulating exosomes and responsible for the biological mechanisms involved in the process of bone…
- Trial name
- PreMetOn (NCT03895216)
- Where
- Italy
- Volunteers
- 34 people
- Sponsor
- Istituto Ortopedico Rizzoli
Fistula Perianal
Human Placenta Mesenchymal Stem Cells Derived Exosomes Injection for Treatment of Complex Anal Fistula
The goal of this clinical trial is to learn if human placenta mesenchymal stem cells (MSC)-derived exosomes work to treat complex perianal fistula in adults without Crohn's disease.
- Trial name
- NCT06568653
- Testing
- exosome, routine conventional fistulotomy
- Volunteers
- 40 people
- Sponsor
- Tehran University of Medical Sciences
Myocardial Infarction
Differential Expression and Analysis of Peripheral Plasma Exosome miRNA in Patients With Myocardial Infarction
The aim of this study is to determine the miRNA expression profile in peripheral blood exosomes of patients with myocardial infarction and to investigate its relationship with myocardial infarction.
- Trial name
- NCT04127591
- Testing
- exosome
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Allergic Asthma, Severe Eosinophilic Asthma
Non-coding RNAs Analysis of Eosinophil Subtypes in Asthma
Chronic airway inflammation rich in eosinophils is an important feature seen in asthma. Airway and blood eosinophilia is associated with increased rates of asthma exacerbations and more intense treatment.
- Trial name
- NCT04542902
- Testing
- Dermatophagoides pteronyssinus allergen, Blood sampling, Bronchial challenge with allergen
- Where
- Lithuania
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
Acute Ischemic Stroke AIS
The STem Cell-derived Extracellular Vesicle Therapy In Acute Ischemic Stroke (STEVIA)
This is a multicenter open-label, single-arm, dose escalation phase I clinical trial to evaluate the safety and tolerability of SNE-101 in patients with acute ischemic stroke
- Trial name
- STEVIA (NCT06995625)
- Testing
- SNE-101
- Where
- 3 sites in South Korea
- Volunteers
- 18 people
- Sponsor
- S&Ebio Co. Ltd.
Covid19, SARS-CoV-2 PNEUMONIA
Evaluation of Safety and Efficiency of Method of Exosome Inhalation in SARS-CoV-2 Associated Pneumonia.
Coronavirus is an acute viral disease with prevailing upper respiratory tract infections caused by the RNA-containing virus of the genus Betacoronavirus of the Coronaviridae family.
- Conditions
- Covid19, SARS-CoV-2 PNEUMONIA, COVID-19
- Trial name
- COVID-19EXO (NCT04491240)
- Testing
- EXO 1 inhalation, EXO 2 inhalation
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- State-Financed Health Facility "Samara Regional Medical Center Dinasty"
Hypospadias
USC-Exos in Corpus Spongiosum Reconstruction for Hypospadias
Hypospadias is one of the common congenital malformation disorders in male children, with a ratio of about 1 to 300 in newborn boys.
- Trial name
- NCT07495176
- Testing
- Exsome
- Where
- China
- Volunteers
- 82 people
- Sponsor
- Shanghai Children's Hospital
Colorectal Cancer
Identification of New Diagnostic Protein Markers for Colorectal Cancer
The search for biochemical markers in patient's blood for non-invasive colorectal cancer diagnostic has not yielded satisfactory results to date.
- Trial name
- EXOSCOL01 (NCT04394572)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 80 people
- Sponsor
- CHU de Reims
Oropharyngeal Cancer
Exosome Testing as a Screening Modality for Human Papillomavirus-Positive Oropharyngeal Squamous Cell Carcinoma
Cancer of the oropharynx (middle, side and back walls of the throat; back of the tongue; soft palate, and tonsils), or oropharyngeal squamous cell carcinoma (OPSCC), has been on the rise in the United States.
- Trial name
- NCT02147418
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- New Mexico Cancer Research Alliance
NSCLC Patients
Prediction of Immunotherapeutic Effect of Advanced Non-small Cell Lung Cancer
To detect the difference of PD-L1 and miRNA expression profiles of exosomes in NSCLC patients before and after immunotherapy, and to explore the potential of plasma exosomes PD-L1 and miRNAs as biomarkers to predict the…
- Trial name
- NCT04427475
- Testing
- pabolizumab, nafulizumab
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Fudan University
Gastric Cancer
Circulating Exosomes As Potential Prognostic And Predictive Biomarkers In Advanced Gastric Cancer Patients ("EXO-PPP Study")
Exosomes are formed by inward budding of late endosomes, producing multivesicular bodies (MVBs), and are released into the environment by fusion of the MVBs with the plasma membrane.
- Trial name
- EXO-PPP (NCT01779583)
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hospital Miguel Servet
Osteoarthritis, Knee
Intra-articular Injection of MSC-derived Exosomes in Knee Osteoarthritis (ExoOA-1)
The study aim to evaluate safety of exosomes (sEVs) from allogeneic mesenchymal stromal cells delivered by an intra-articular injection in the knee of patients with mild to moderate symptomatic osteoarthritis.
- Trial name
- ExoOA-1 (NCT05060107)
- Testing
- Exosomes (sEVs)
- Volunteers
- 10 people
- Sponsor
- Francisco Espinoza
Oral Health
Egyptian Dental Professionals' Perspectives on the Oral Microbiome and Exosomes
This study employs a structured, validated questionnaire as the index test to objectively assess dental professionals' knowledge of the oral microbiome and exosomes, alongside attitudes, readiness, and perceived barriers.
- Trial name
- NCT07374575
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Cairo University
Refractory Focal Epilepsy
Induced Pluripotent Stem Cell Derived Exosomes Nasal Drops for the Treatment of Refractory Focal Epilepsy
Evaluate the safety, tolerability, and preliminary efficacy of GD-iEXo-002 nasal drops in the treatment of focal refractory epilepsy
- Trial name
- NCT05886205
- Testing
- iPSC-Exos
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Peking Union Medical College Hospital
Non Small Cell Lung Cancer
Olmutinib Trial in T790M (+) NSCLC Patients Detected by Liquid Biopsy Using BALF Extracellular Vesicular DNA
The purpose of this study is to evaluate the efficacy of Olmutinib(Olita®) in patients with T790M-positive non-small cell lung cancer (NSCLC) confirmed using DNA extracted from extracellular vesicles of bronchoalveolar lavage…
- Trial name
- NCT03228277
- Testing
- Olmutinib
- Where
- South Korea
- Volunteers
- 25 people
- Sponsor
- Konkuk University Medical Center
Autism Spectrum Disorder
Combined Photo-Biomodulation At Acupuncture Points, Autologous PRP, and Umbilical Cord-Derived Exosome Therapy in Autism Spectrum Disorder
This randomized controlled trial aims to evaluate the efficacy of a combination of photo-biomodulation at acupuncture points, autologous platelet-rich plasma (PRP), and umbilical cord-derived exosome therapy in children with…
- Trial name
- Biomodulation (NCT06600529)
- Testing
- Photo-Biomodulation, Autologous PRP, Exosome Therapy
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Iffat Anwar Medical Complex
Acute Ischemic Stroke
Safety and Efficacy of Human Adipose-Derived Stem Cell Exosomes in Acute Ischemic Stroke
This is a Phase I/II, randomized, double-blind, placebo-controlled, single/multiple ascending dose clinical study (Investigator-Initiated Trial, IIT) evaluating the safety and efficacy of Human Adipose-Derived Stem Cell Exosomes…
- Trial name
- NCT07398612
- Testing
- Human Adipose-Derived Stem Cell Exosomes
- Volunteers
- 60 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Postoperative Delirium, General Anesthesia
The Disorder of Circadian Clock Gene and Early Cognitive Dysfunction After General Anesthesia
Postoperative cognitive dysfunction (POCD) is a common postoperative complication in patients aged 65 and over, which refers to cognitive function changes such as memory decline and attention deficit after anesthesia and surgery.
- Conditions
- Postoperative Delirium, General Anesthesia, Exosomes, Clock Gene
- Trial name
- NCT04421872
- Testing
- receiving general anesthesia
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Shengjing Hospital
Alzheimer Disease (AD)
Study of Neural Stem Cell-Derived Exosomes in Moderate-to-Severe Early-Onset Alzheimer's Disease
This is an open-label, single-center, phase I clinical study in patients with moderate-to-severe early-onset Alzheimer's disease.
- Trial name
- NCT07554872
- Testing
- Neural Stem Cell-Derived Exosomes
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Shanghai Mental Health Center