Clinical trials: Exosome
Premature Ovarian Insufficiency, Diminished Ovarian Reserve
A Proof of Concept Study to Evaluate Exosomes From Human Mesenchymal Stem Cells in Women With Premature Ovarian Insufficiency (POI)
The VL-POI-01 study is designed to evaluate the safety and efficacy of human placental mesenchymal stem cell derived exosome treatment in patients with premature ovarian insufficiency (POI) and diminished ovarian reserve.
- Trial name
- VL-POI-01 (NCT06072794)
- Testing
- VL-PX10
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Vitti Labs, LLC
Colon Cancer
Study Investigating the Ability of Plant Exosomes to Deliver Curcumin to Normal and Colon Cancer Tissue
This clinical trial will investigate the ability of plant exosomes to more effectively deliver curcumin to normal colon tissue and colon tumors.
- Trial name
- NCT01294072
- Testing
- curcumin, Curcumin conjugated with plant exosomes, No intervention
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Louisville
Multiple Organ Failure
Exosome of Mesenchymal Stem Cells for Multiple Organ Dysfuntion Syndrome After Surgical Repaire of Acute Type A Aortic Dissection
Multiple organ dysfunction syndrome (MODS) after surgical repaired for acute type A aortic dissection (ATAAD) is a life-threatening condition.
- Trial name
- NCT04356300
- Testing
- Exosome of MSC
- Volunteers
- 60 people
- Sponsor
- Fujian Medical University
Safety
Purified Exosome Product (PEP) Injected Into the Hypodermis
This clinical trial aims to characterize the safety, tolerability, and histological profile of PEP (Purified Exosome Product) when injected into the hypodermis of healthy adults.
- Trial name
- PEP (NCT06429033)
- Testing
- PEP (Purified Exosome Product)
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Clinical Testing of Beverly Hills
Acute Respiratory Distress Syndrome
A Clinical Study of Mesenchymal Stem Cell Exosomes Nebulizer for the Treatment of ARDS
To evaluate allogeneic human mesenchymal stem cell exosomes (hMSC-Exos) in the treatment of acute respiratory distress syndrome (ARDS)
- Trial name
- NCT04602104
- Testing
- low dose hMSC-Exos, medium dose hMSC-Exos, high dose hMSC-Exos
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Ruijin Hospital
COVID-19 Acute Respiratory Distress Syndrome, Respiratory Distress Syndrome
Safety and Effectiveness of Placental Derived Exosomes and Umbilical Cord Mesenchymal Stem Cells in Moderate to Severe Acute Respiratory Distress Syndrome (ARDS) Associated With the Novel Corona Virus Infection (COVID-19)
Recent advances have been made in prevention of the viral infection via vaccines but there is still need for effective treatment options for patients. Novel therapies need to be developed to further improve clinical outcomes.
- Trial name
- NCT05387278
- Testing
- EV-Pure™ and WJ-Pure™
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vitti Labs, LLC
Oral Submucous Fibrosis
Fibrosis-Modulating Effects of Metformin and Pirfenidone in Oral Submucous Fibrosis
The goal of this clinical trial is to learn if metformin and antifibrotic drugs (pirfenidone) can modulate fibrosis and improve treatment outcomes in patients with oral submucous fibrosis (OSF).
- Trial name
- "FIBR-MET-PF" (NCT06871904)
- Testing
- Metformin Hydrochloride 500Mg Tablet, Pirfenidone (PFD), Beclomaethasone and Vitamin E
- Where
- Pakistan
- Volunteers
- 45 people
- Sponsor
- Ziauddin University
Irritable Bowel Disease
Plant Exosomes +/- Curcumin to Abrogate Symptoms of Inflammatory Bowel Disease
The trial will test the hypothesis that edible structures within plant cells (ginger) will have clinically important anti-inflammatory effects on the gut lining of patients with inflammable bowel disease.
- Trial name
- NCT04879810
- Testing
- Sigmoidoscopy and biopsy, blood work
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Louisville
Colorectal Cancer, Colorectal Neoplasms
Early Detection of Advanced Adenomas and Colorectal Cancer
This study aims to develop a highly sensitive, specific, and cost-effective blood assay for early detection of colorectal adenomas and cancer, using advanced machine learning and state-of-the-art biological analyses.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Polyp, Colorectal Adenocarcinoma
- Trial name
- AACRC (NCT06342440)
- Testing
- DENEB
- Where
- 6 sites in United States, China and 3 more
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Skin Aging
Effects on Facial Skin Aging After Topical Application of Exosomes With a Microneedling Device
In this study, we evaluated the extent of reversal of facial dermal aging signs using topical lyophilized exosomes with a microneedling device
- Trial name
- EFSATAEMD (NCT07372001)
- Testing
- Topical lyophilized exosomes application
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Frailty Syndrome, Aging
Safety and Preliminary Efficacy of Adipose-Derived Stem Cell Secretome in Frailty (VinVital)
This is a Phase I, open-label, non-randomized clinical trial to evaluate the safety and preliminary efficacy of adipose-derived mesenchymal stem cell secretome capsules (VinVital) in patients with frailty syndrome.
- Trial name
- VinVital (NCT07856602)
- Testing
- VinVital
- Volunteers
- 20 people
- Sponsor
- Vinmec Research Institute of Stem Cell and Gene Technology
Untreated Advanced NSCLC Patients, FISH Identified ALK Fusion Positive or Negative
The Study of Exosome EML4-ALK Fusion in NSCLC Clinical Diagnosis and Dynamic Monitoring
The application of ALK inhibitors in the first-line cancer treatment can significantly increase the PFS and ORR of patients those with EML4-ALK fusion.
- Trial name
- NCT04499794
- Testing
- ALK inhibitor
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Chinese Academy of Medical Sciences
Cortical Visual Impairment, Visual Function
Exosomes Effect on Visual Function in CVI
The goal of this observational study is to learn about the effects of nazally applied exosome treatment on visual functions in children with Phase 1 Cerebral visual impairment (CVİ).
- Trial name
- NCT07492966
- Testing
- Molecularly matched therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Hatice Semrin Timlioglu İper
Schizophrenia
Study on the Role and Mechanism of Plasma Exosome microRNAs in Cognitive Impairment in First-episode Schizophrenia
Schizophrenia is a severe mental illness characterised by positive symptoms, negative symptoms, and cognitive symptoms. In recent years, an increasing number of doctors and scholars have focused on cognitive symptoms; however…
- Trial name
- NCT07139171
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tianjin Anding Hospital
KRAS NP_004976.2:p.G12D, Metastatic Pancreatic Adenocarcinoma
iExosomes in Treating Participants With Metastatic Pancreas Cancer With KrasG12D Mutation
This phase I trial studies the best dose and side effects of mesenchymal stromal cells-derived exosomes with KrasG12D siRNA (iExosomes) in treating participants with pancreatic cancer with KrasG12D mutation that has spread to…
- Conditions
- KRAS NP_004976.2:p.G12D, Metastatic Pancreatic Adenocarcinoma, Pancreatic Ductal Adenocarcinoma, Stage IV Pancreatic Cancer AJCC v8
- Trial name
- NCT03608631
- Testing
- Mesenchymal Stromal Cells-derived Exosomes with KRAS G12D siRNA
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- M.D. Anderson Cancer Center
Parkinson's Disease
LRRK2 and Other Novel Exosome Proteins in Parkinson's Disease
This proposal seeks to 1) determine whether there are biomarkers associated with Parkinson's disease (PD) susceptibility and/or progression in exosome-proteomes derived from PD patients versus controls, and 2) to determine if…
- Trial name
- NCT01860118
- Where
- United States
- Volunteers
- 601 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Endothelial Dysfunction
Circulating Exosomes and Endothelial Dysfunction in Patients With Obstructive Sleep Apneas Hypopneas Syndrome
Evaluation of miRNA contained in exosomes in obese and OSA patients with endothelial dysfunction evaluated by digital plethysmography (ENDOPAT) compared to obese and OSA patients without endothelial dysfunction.
- Trial name
- EXODYS (NCT04459182)
- Testing
- ENDOPAT
- Where
- France
- Volunteers
- 99 people
- Sponsor
- University Hospital, Angers
Healthy
Exosome Proteomics to Detect EPO
The role of exosomes in cell signalling has only recently been appreciated and is a hugely exciting and rapidly growing area, and combined with LC-MS/MS proteomics, can overcome traditional barriers to proteomics in doping…
- Trial name
- NCT03700515
- Testing
- Erythropoietin
- Where
- Denmark
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Morten Hostrup, PhD
Covid19, Corona Virus Infection
Expanded Access to Zofin for Patients With COVID-19
This expanded access protocol will provide access to the investigational product Zofin for patients in outpatient facilities infected with SARS-CoV-2 who have mild to moderate COVID-19, or who are judged by a healthcare provider…
- Conditions
- Covid19, Corona Virus Infection, SARS (Severe Acute Respiratory Syndrome), Acute Respiratory Distress Syndrome
- Trial name
- NCT04657406
- Testing
- Zofin
- Sponsor
- ZEO ScientifiX, Inc.
Pancreatic Cancer, Benign Pancreatic Disease
Interrogation of Exosome-mediated Intercellular Signaling in Patients With Pancreatic Cancer
The purpose of this study is to isolate and analyze exosomes, which are tiny carriers of important proteins and nucleic acids that serve as messenger systems in the blood and tissue.
- Trial name
- NCT02393703
- Where
- United States
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center