Clinical trials: Exosome
Preeclampsia, Postpartum
MSC Exosome Therapy for Post-Preeclampsia Endothelial Dysfunction
--- Why Is This Study Being Done? Women who have preeclampsia during pregnancy face a much higher risk of heart disease later in life.
- Conditions
- Preeclampsia, Postpartum, Endothelial Injury, Exosome Multiomics
- Trial name
- EXITPE (NCT07183384)
- Testing
- Mesenchymal Stem Cell-Derived Exosomes
- Where
- Indonesia
- Volunteers
- 80 people
- Sponsor
- Universitas Padjadjaran
Aging
Evaluation of Electroencephalographic Biomarkers in Physiological Aging
Aging is the inevitable biological process that results in a progressive structural and functional decline from the cellular level to whole body function.
- Trial name
- AGE-MARK (NCT06824285)
- Where
- Italy
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma
Diabetic Retinopathy
Study on Exosome Changes in Patients With Proliferative Diabetic Retinopathy
Diabetic retinopathy is a common complication of diabetes and one of the leading causes of low vision and blindness in adults. In recent years, the prevalence of diabetes and the incidence of diabetic retinopathy have increased…
- Trial name
- NCT06198543
- Volunteers
- 60 people
- Sponsor
- Xuanwu Hospital, Beijing
COVID-19, Critical Illness
Immune Modulation by Exosomes in COVID-19
Following whole blood stimulation with mesenchymal stem cell derived exosomes, immune phenotype, cytokine release and mRNA expression patterns from critically ill patients with COVID-19 will be determined.
- Conditions
- COVID-19, Critical Illness, Hypercytokinemia, Lung Fibrosis
- Trial name
- IMECOV19 (NCT05191381)
- Testing
- Application of exosomes in a whole blood assay
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Bone Loss, Osteoclastic, Bone Loss, Alveolar
Autogenous Mesenchymal Stem Cell Culture-Derived Signalling Molecules as Enhancers of Bone Formation in Bone Grafting
This study aims to evaluate bone formation in grafts in terms of its quality (density), quantity (volume) and maturation obtained with the application of a tissue-engineered bone grafting compound containing concentrated…
- Conditions
- Bone Loss, Osteoclastic, Bone Loss, Alveolar, Alveolar Bone Loss, Alveolar Bone Atrophy
- Trial name
- NCT04998058
- Testing
- Maxillary sinus floor elevation grafting with synthetic bone substitute.
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidade Católica do Rio Grande do Sul
Sudden Cardiac Death, Exosome Multiomics
Early Evaluation of Exosome Multiomics and Clinical Prognosis in Patients With Sudden Death
Acute coronary syndrome (ACS) is one of the main causes of death. Worldwide, tens of millions of patients are hospitalized for coronary heart disease and ACS every year.
- Conditions
- Sudden Cardiac Death, Exosome Multiomics, Clinical Prognosis
- Trial name
- NCT06856993
- Testing
- standardized medical care of cardiac arrest
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Prehypertension
When the Kidney Reacts to Nutritional Changes
Hypertension is one of the leading causes of morbidity and mortality in the industrialized world, attributed mostly to modifiable lifestyle factors.
- Trial name
- NCT04142138
- Testing
- DASH
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Rockefeller University
Coronavirus
A Pilot Clinical Study on Inhalation of Mesenchymal Stem Cells Exosomes Treating Severe Novel Coronavirus Pneumonia
In December 2019, a novel coronavirus infectious disease characterized by acute respiratory impairment due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) broke out in Wuhan city of Hubei province in China.
- Trial name
- NCT04276987
- Testing
- MSCs-derived exosomes
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Ruijin Hospital
Myocardial Infarction, Myocardial Ischemia
Co-transplantation of Mesenchymal Stem Cell Derived Exosomes and Autologous Mitochondria for Patients Candidate for CABG Surgery
Heart failure (HF) and acute myocardial infarction that often follows are among the main causes of disability and death worldwide.
- Conditions
- Myocardial Infarction, Myocardial Ischemia, Myocardial Stunning
- Trial name
- NCT05669144
- Testing
- mitochondria and MSC-derived exosomes
- Where
- Iran
- Volunteers
- 20 people
- Sponsor
- Tehran University of Medical Sciences
Diabetes Mellitus Type 1
Effect of Microvesicles and Exosomes Therapy on β-cell Mass in Type I Diabetes Mellitus (T1DM)
Type 1 diabetes mellitus is strictly autoimmune mediated disease destructing the islets β-cell of the pancreas. Mesenchymal stem cells and its microvesicles are reported as an anti-inflammatory agents.
- Trial name
- NCT02138331
- Testing
- MSC exosomes.
- Where
- 3 sites in Egypt
- Volunteers
- 20 people
- Sponsor
- General Committee of Teaching Hospitals and Institutes, Egypt
Exosome, Post-stroke Dementia
The Role of Acupuncture-induced Exosome in Treating Post-stroke Dementia
Stroke is the main cause of disability and the second main cause of dementia. Approximately 21.5% of patients develop dementia within 4 years after stroke.
- Conditions
- Exosome, Post-stroke Dementia, Acupuncture
- Trial name
- NCT05326724
- Testing
- Acupuncture
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- China Medical University Hospital
Bipolar Affective Disorder, Major Depressive Disorder
Exosome for Early Diagnosis of Bipolar Affective Disorder
Objectives: Bipolar disorder (BD) is a chronic and recurrent mental illness characterized by depressive episodes and manic or hypomanic episodes, leading to severe functional impairment and cognitive damage.
- Trial name
- NCT05915312
- Where
- China
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Tianjin Anding Hospital
Gastric Cancer, Esophagus Cancer
Exosome-based Liquid Biopsies for Upper Gastrointestinal Cancers Diagnosis
This study constitutes a case-control investigation employing a retrospective approach. Plasma samples from individuals with esophageal cancer, benign esophageal diseases, gastric cancer, benign gastric diseases, and a healthy…
- Trial name
- NCT06278064
- Testing
- Gastric Cancer, Esophagus Cancer
- Where
- 3 sites in China
- Volunteers
- 562 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
Pilonidal Sinus, Pilonidal Disease
The Role of Mesenchymal Stem Cell and Exosome in Treating Pilonidal Sinus Disease in Children
Chronic wounds that fail to heal over extended periods pose a significant financial burden on the healthcare system, underscoring the urgent need to enhance clinical treatments.
- Trial name
- NCT06391307
- Testing
- Crystallized phenol, Crystallized phenol + Exosome, Crystallized phenol + Stem Cell
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Mustafa Azizoğlu
Decompensated Liver Cirrhosis
Effect of Mesenchymal Stem Cells-derived Exosomes in Decompensated Liver Cirrhosis
Decompensated liver cirrhosis (LC), a life-threatening complication of chronic liver disease, is one of the major indications for liver transplantation.
- Trial name
- NCT05871463
- Testing
- MSC-derived exosomes
- Where
- Iran
- Volunteers
- 15 people
- Sponsor
- Research Institute for Gastroenterology and Liver Diseases (RIGLD)
Long COVID-19 Syndrome
Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Exosomes in Treating Chronic Cough After COVID-19
This clinical trial aims to evaluate the safety and effectiveness of umbilical cord mesenchymal stem cell (UCMSC)-derived extracellular vesicle nebulization inhalation therapy for the treatment of chronic cough after COVID-19…
- Trial name
- NCT05808400
- Testing
- MSC-derived exosomes
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Huazhong University of Science and Technology
Obesity, Insulin Resistance
Small Extracellular Vesicles and Insulin Action
The goals of this research study are to: 1) understand why some people with obesity are protected from developing conditions such as type 2 diabetes and cardiovascular disease while others are more likely to develop…
- Conditions
- Obesity, Insulin Resistance, Metabolically Healthy Obesity, Obesity, Metabolically Benign
- Trial name
- SEV (NCT05933707)
- Testing
- People with Metabolically Unhealthy Obesity - Low Calorie Diet
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Familial Pancreatic Cancer, Familial Pancreatic Carcinoma
A Liquid Biopsy for Pancreatic Cancer Early-detection and Disease Monitoring
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy characterized by an asymptomatic early phase, late diagnosis, and poor survival, particularly in individuals who develop disease outside the context of…
- Conditions
- Familial Pancreatic Cancer, Familial Pancreatic Carcinoma, Hereditary Pancreatic Cancer, Hereditary Pancreatitis
- Trial name
- PANXEON (NCT07700992)
- Testing
- PANXEON
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Università Vita-Salute San Raffaele
Gastric Cancer, Gastric Adenocarcinoma
Stomach Cancer Exosome-based Detection
Gastric cancer continues to have a poor prognosis primarily due to the inability to detect it in its early stages. This study will develop and validate a blood assay to facilitate the non-invasive detection of gastric cancer.
- Conditions
- Gastric Cancer, Gastric Adenocarcinoma, Gastric Cancer Stage, Gastric Neoplasm
- Trial name
- DESTINEX (NCT06342427)
- Testing
- DESTINEX
- Where
- 3 sites in United States, Japan
- Volunteers
- 809 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
COVID-19
Treatment of SARS-CoV-2 Virus Disease (COVID-19) in Humans With Hemopurifier® Device
This is an Early Feasibility Study (EFS) investigating the use of the Hemopurifier® in the treatment of SARS-CoV-2 Virus Disease (COVID-19).
- Trial name
- NCT04595903
- Testing
- Hemopurifier
- Where
- 9 sites in United States
- Volunteers
- 1 people
- Sponsor
- Aethlon Medical Inc.