Clinical trials: Exosomes
Ulcer
Effect of Plasma Derived Exosomes on Cutaneous Wound Healing
This study is an open prospective clinical trial. The objective is to evaluate the effect of autologous exosomes rich plasma on cutaneous wound healing. The participants are patients with intractable cutaneous ulcers (e.g.
- Trial name
- NCT02565264
- Testing
- plasma-derived exosomes
- Where
- Japan
- Volunteers
- 5 people
- Sponsor
- Kumamoto University
Acute Ischemic Stroke
A Phase 1b Study to Assess the Safety and Tolerability of AB126 Neural Exosomes in Patients With Moderate to Severe Acute Ischemic Stroke
The goal of this clinical trial is to learn if AB126, an investigational treatment made from neural exosomes, is safe and well tolerated when given to adults with moderate to severe acute ischemic stroke (AIS) who have undergone…
- Trial name
- NEXIS (NCT07813130)
- Testing
- AB126 Neural Exosomes Intravenous Injection
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Aruna Bio, Inc.
Alopecia Androgenica
Exosome Treatment and Hair Growth
This study investigates a novel exosome-based plant formulation for treating male pattern baldness (androgenetic alopecia), a condition that affects self-esteem and well-being.
- Trial name
- exosome (NCT06930326)
- Testing
- intradermal exosome, 0.9 % NaCl
- Where
- Malaysia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- COSMEDICIAN AP SDN BHD
Premature Birth, Extreme Prematurity
The Pilot Experimental Study of the Neuroprotective Effects of Exosomes in Extremely Low Birth Weight Infants
To study the safety and efficacy of intranasal administration of exosomes derived from mesenchymal stromal cells on long-term neurodevelopmental outcome in extremely low birth weight infants born at gestational age 25/0-27/6…
- Conditions
- Premature Birth, Extreme Prematurity, Preterm Intraventricular Hemorrhage, Hypoxia-Ischemia, Cerebral
- Trial name
- NCT05490173
- Testing
- Exosomes derived from mesenchymal stromal cells (MSCs)
- Where
- Russia
- Volunteers
- 10 people
- Sponsor
- Federal State Budget Institution Research Center for Obstetrics, Gynecology and Perinatology Ministry of Healthcare
Alzheimer Disease
the Safety and the Efficacy Evaluation of Allogenic Adipose MSC-Exos in Patients With Alzheimer's Disease
Evaluate the Safety and Efficacy of Exosomes Derived from Allogenic Adipose Mesenchymal Stem Cells（MSCs-Exos）in Subjects with Alzheimer's disease.
- Trial name
- NCT04388982
- Testing
- low dosage MSCs-Exos administrated for nasal drip, mild dosage MSCs-Exos administrated for nasal drip, high dosage MSCs-Exos administrated for nasal drip
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Ruijin Hospital
Autism Spectrum Disorder
Combined Photo-Biomodulation At Acupuncture Points, Autologous PRP, and Umbilical Cord-Derived Exosome Therapy in Autism Spectrum Disorder
This randomized controlled trial aims to evaluate the efficacy of a combination of photo-biomodulation at acupuncture points, autologous platelet-rich plasma (PRP), and umbilical cord-derived exosome therapy in children with…
- Trial name
- Biomodulation (NCT06600529)
- Testing
- Photo-Biomodulation, Autologous PRP, Exosome Therapy
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Iffat Anwar Medical Complex
Prehypertension
When the Kidney Reacts to Nutritional Changes
Hypertension is one of the leading causes of morbidity and mortality in the industrialized world, attributed mostly to modifiable lifestyle factors.
- Trial name
- NCT04142138
- Testing
- DASH
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Rockefeller University
Cholangiocarcinoma, Benign Biliary Stricture
ncRNAs in Exosomes of Cholangiocarcinoma
Exosomes are part of extracellular vesicles(EVs), and can be secreted into the environment by many types of cells. It has been demonstrated that the content and function of exosomes depends on the originating cell and the…
- Trial name
- NCT03102268
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Pulmonary Nodules
Clinical Study of ctDNA and Exosome Combined Detection to Identify Benign and Malignant Pulmonary Nodules
This study through the detection of EGFR、ALK、ROS1、KRAS、HER2、BARF、NTRG1 seven ctDNA and exosome RNA in the blood and alveolar lavage of lung nodules patients and heavy smoking healthy population.
- Trial name
- ctDNA (NCT04182893)
- Testing
- ctDNA and Exosome Combined Detection
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Shanghai Chest Hospital
Neonatal Jaundice From Other Specified Causes, ABO Incompatibility
The Role of Breastmilk and Serum Exosomes in Neonatal Jaundice Due to ABO Incompatibility
Neonatal jaundice is a major global health issue that can lead to serious complications and even death if not promptly treated. ABO incompatibility is a common cause of pathological neonatal jaundice, but there are currently no…
- Conditions
- Neonatal Jaundice From Other Specified Causes, ABO Incompatibility, ABO Hemolytic Disease
- Trial name
- NCT06502847
- Testing
- Exosome profile study
- Where
- Turkey (Türkiye)
- Volunteers
- 338 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Corona Virus Infection, COVID-19
Zofin (Organicell Flow) for Patients With COVID-19
The purpose of this research study is to evaluate the safety and potential efficacy of Intravenous Infusion of Zofin for treatment of moderate to severe Acute Respiratory Syndrome (SARS) related to COVID-19 infection vs Placebo.
- Conditions
- Corona Virus Infection, COVID-19, SARS, Acute Respiratory Distress Syndrome
- Trial name
- NCT04384445
- Testing
- Zofin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- ZEO ScientifiX, Inc.
Type 2 Diabetes Mellitus
Mesenchymal Stromal/Stem Cells-Derived Exosomes (MSC-Exos) Therapy for Type 2 Diabetes Mellitus Patients
This is an open-label randomized controlled trial with a pre-and-post-test control group design to evaluate the effect of Mesenchymal Stromal/Stem Cells-Derived Exosomes (MSC-Exos) as an adjunctive therapy on glycemic control and…
- Trial name
- NCT07144241
- Testing
- Mesenchymal Stromal/Stem Cells-Derived Exosomes (Exo-HWS + 1 vial Exo-HUVEC) Therapy, Mesenchymal Stromal/Stem Cells-Derived Exosomes (Exo-HWS ) Therapy
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- Universitas Indonesia
Heart Transplant Rejection
Research on Patients With Heart Transplantation
This trial was a single-center, prospective cohort study.The purpose of this clinical research is to evaluate the accuracy of combining multimodality MR Imaging with circulating exosomal miRNA expression to diagnose acute…
- Trial name
- NCT04921774
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Guangdong Provincial People's Hospital
Radiation-induced Esophagitis
Spirulina Derivative for Radiation Esophagitis
To evaluate the efficacy and safety of a Spirulina-derived product in preventing and treating radiation-induced esophagitis in esophageal cancer patients undergoing intensity-modulated radiotherapy (IMRT).
- Trial name
- NCT07324018
- Testing
- Hydrogel of spirulina-derived exosomes., Radiotherapy
- Where
- China
- Volunteers
- 70 people
- Sponsor
- West China Hospital
Pilonidal Sinus, Pilonidal Disease
The Role of Mesenchymal Stem Cell and Exosome in Treating Pilonidal Sinus Disease in Children
Chronic wounds that fail to heal over extended periods pose a significant financial burden on the healthcare system, underscoring the urgent need to enhance clinical treatments.
- Trial name
- NCT06391307
- Testing
- Crystallized phenol, Crystallized phenol + Exosome, Crystallized phenol + Stem Cell
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Mustafa Azizoğlu
Lung Cancer, Exosomes
Molecular Profiling of Exosomes in Tumor-draining Vein of Early-staged Lung Cancer
This is an observational prospective single-center study of 30 patients operated for early-staged non-small cell lung cancer. The main aim is the analysis of molecular profiling of exosome with a sample in tumor-draining vein in…
- Conditions
- Lung Cancer, Exosomes, Non Small Cell Lung Cancer
- Trial name
- ExOnSite-Pro (NCT04939324)
- Testing
- Blood samples at 2 sites: peripheral vein and tumor-draining vein
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Limoges
Bipolar Affective Disorder, Major Depressive Disorder
Exosome for Early Diagnosis of Bipolar Affective Disorder
Objectives: Bipolar disorder (BD) is a chronic and recurrent mental illness characterized by depressive episodes and manic or hypomanic episodes, leading to severe functional impairment and cognitive damage.
- Trial name
- NCT05915312
- Where
- China
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Tianjin Anding Hospital
Erectile Dysfunction With Diabetes Mellitus
Mesenchymal Stem Cell and Exosome Therapy for Diabetic Erectile Dysfunction
The goal of this prospective randomized controlled clinical study is to evaluate the effectiveness and safety of intracavernosal injections of umbilical cord-derived mesenchymal stem cells (MSCs) and umbilical cord-derived…
- Trial name
- NCT07480161
- Testing
- Umbilical Cord-Derived Mesenchymal Stem Cells, Umblical Cord-Derived Mesenchymal Stem Cell-Derived Exosomes
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Ankara City Hospital Bilkent
Ulcerative Colitis (UC)
hucMSCs Exosomes for the Treatment of Active Ulcerative Colitis
To evaluate the safety and efficacy of hUC-MSCs-Exos in the treatment of ulcerative colitis.
- Trial name
- NCT06853522
- Testing
- exosomes derived from human umbilical cord mesenchymal stem cells, saline +5% albumin
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanghai East Hospital
Diabetic Keratopathy
Effect of PAE Hydrogel Loaded With tRF-ASO-Exo on Patients With Diabetic Ocular Surface Diseases
The purpose of this study is to determine whether poly（β-amino ester）(PAE)hydrogel loaded with tRNA-derived fragments-antisense oligonucleotides-exosomes(tRF-ASO-Exo) could alleviate symptoms in patients with diabetic ocular…
- Trial name
- NCT07382453
- Testing
- Exosomes, tRNA-derived fragments-antisense oligonucleotides-exosomes, poly（β-amino ester）hydrogel loaded with tRNA-derived fragments-antisense oligonucleotides-exosomes
- Volunteers
- 30 people
- Sponsor
- Affiliated Hospital of Nantong University