Clinical trials: Exposure to Polluted Air
Exposure to Pollution, Heart Failure
Effects of Air Pollution Exposure Reduction by Filter Mask on Heart Failure
Exposure to air pollution is associated with increase in cardiovascular morbidity and mortality. Controlled human exposure studies have demonstrated impaired vascular function and heart rate variability on healthy volunteers.
- Trial name
- NCT01960920
- Testing
- Filtered diesel exhaust, Unfiltered diesel exhaust, Clean air
- Where
- Brazil
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- InCor Heart Institute
Lung Function, Heart Rate Variability
Effects of Exposure to Biomass-burning Air Pollution on Lung Function, Heart Rate Variability and Inflammatory Markers in Sugarcane Workers
Introduction: Non-mechanized sugar cane harvesting preceded by burning, an important and prevalent professional activity of agribusiness segment of the Brazilian economy, exposes workers and people of neighboring towns to high…
- Conditions
- Lung Function, Heart Rate Variability, Oxidative Stress, Systemic Inflammatory Response
- Trial name
- NCT01371188
- Where
- Brazil
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- InCor Heart Institute
Heat Strain
Mitigation of Health Effects in Outdoor Workers by Reducing Exposure to Heat and Air Pollution
The goal of this clinical trial is to assess the effectiveness of an intervention (combination of behavioural recommendations and technical measures) in reducing personal exposure to heat and air pollution and related health…
- Trial name
- ISMED-CLIM OW (NCT07634952)
- Testing
- Heat intervention, Heat and air pollution mitigation intervention
- Where
- 2 sites in Greece, Spain
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Cyprus
Interstitial Lung Disease Due to Systemic Disease (Disorder), Interstitial Lung Disease Due to Systemic Disease (Telomere Biology Disorder)
Occupational and Environmental Exposures Analysis in Interstitial Lung Diseases.
The OCEAN-ILD study is designed to prospectively evaluate the prevalence and clinical relevance of environmental and occupational exposures in a large Italian cohort of patients affected by any ILD, using a standardised exposure…
- Conditions
- Interstitial Lung Disease Due to Systemic Disease (Disorder), Interstitial Lung Disease Due to Systemic Disease (Telomere Biology Disorder), Exposure Occupational, Occupational Exposure
- Trial name
- OCEAN-ILD (NCT07577115)
- Testing
- standard interview
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Istituto Clinico Humanitas
Exposure to Environmental Pollution, Non-occupational
Interaction Effects of Temperature and Ozone
Purpose: The purpose of this protocol is to understand how individuals respond to the air pollutant ozone at elevated temperatures.
- Trial name
- TROPICOZ (NCT01981135)
- Testing
- Clean Air, Ozone
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Environmental Protection Agency (EPA)
Environmental Exposure, Nasal Inflammation
Human Biological Responses to Low Level Ozone
To investigate if low level ozone exposure will cause measurable inflammation in nasal cells.
- Trial name
- SNOZ (NCT02857283)
- Testing
- Ozone, Filtered Air, Health and Exposure Tracker (HET)
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Exposure to Environmental Pollution, Non-occupational
The Interaction of Social Factors With Air Pollution
Purpose: The purpose of this protocol is to understand how social factors such as psychosocial stress may modify how people respond to air pollution.
- Trial name
- SOZIAL (NCT02206750)
- Testing
- Clean Air, Ozone
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Environmental Protection Agency (EPA)
Lung Carcinoma
Educational Intervention for the Promotion of Knowledge and Preventive Health Behaviors Related to Personal Air Pollution Exposure, The Air Study
This clinical trial will conduct an educational intervention to promote knowledge of and preventive health behaviors related to personal air pollution exposure.
- Trial name
- NCT04922697
- Testing
- Educational Intervention, Questionnaire Administration
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Air Pollution Exposure, Oxidative Stress
Savannah Environmental Nutrition Study (SENS): Nutrition Intervention to Reduce Air Pollution-Related Airway Inflammation and Oxidative Stress
This pilot clinical trial will evaluate the feasibility and potential health effects of a nutrition-based intervention among adults living in communities affected by air pollution near the Port of Savannah, Georgia.
- Conditions
- Air Pollution Exposure, Oxidative Stress, Airway Inflammation
- Trial name
- NCT07797413
- Testing
- Antioxidant- and Nutrient-Rich Food-Based Nutrition Intervention
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Georgia Southern University
Air Pollution
The Effect of Juice Types on the Responses to Air Pollution
The study hypothesis is that drinking different juices will affect the body's responses to air pollution. Subjects will be exposed to air pollution during a 2-hour car ride on the NJ (New Jersey) Turnpike.
- Trial name
- NCT02027415
- Testing
- Beet juice, Orange juice
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Allergies
Effects of Co-Exposure to Air Pollution and Allergen
The investigators are investigating the effects of combined exposures to diesel exhaust and allergens on lung function and on the immune system.
- Trial name
- NCT01792232
- Testing
- Allergen, Saline
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Mild Hypertension, Air Pollution Exposure
Reducing Air Pollution to Lower Blood Pressure
Fine particulate matter <2.5 μm (PM2.5) air pollution is the fifth leading risk factor for global mortality. Mitigating the clinically significant blood pressure (BP) elevation from air pollution by reducing PM2.5 exposure will…
- Trial name
- AIR PRESSURE (NCT04908917)
- Testing
- Portable Air Cleaner with a HEPA Filter, Portable Air Cleaner without a HEPA Filter
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Asthma
Asthma & Exposure to Peaks in Particulate Air Pollution
We are testing the following two hypotheses: 1) Peaks in hourly exposures to airborne particulate matter (PM) of outdoor origin will be more closely associated with acute asthmatic responses to particles than 24-hour average…
- Trial name
- NCT00013728
- Volunteers
- 24 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Asthma in Children, Pollution; Exposure
AIM to Improve Asthma: Airflow Improvements During Meal-Prep
The investigators propose a pilot trial of kitchen ventilation in the homes of children using a youth engaged research strategy.
- Trial name
- AIM (NCT04464720)
- Testing
- Cooking Ventilation Intervention
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of California, Berkeley
Environmental Exposure, Ozone
Lung Mucus Hypersecretion and NQO1
The research plan proposes translational studies in relevant animal models and human subjects in order to identify host (genetic) susceptibility factors that confer vulnerability to the prototypal air pollutant, ozone.
- Conditions
- Environmental Exposure, Ozone, Air Pollution, Genetic Susceptibility
- Trial name
- NCT00729352
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Healthy Adults
Statins Against Bushfire Smoke
The goal of this clinical trial is to test whether statins can protect the heart and brain from the biological stress and inflammatory responses caused by breathing bushfire smoke in healthy adult volunteers aged 18-64 years.
- Trial name
- SABS (NCT07462715)
- Testing
- Atorvastatin
- Where
- Australia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Menzies Institute for Medical Research
Heart Failure
Project 4: ACHIEVE PATHFINDER
ACHIEVE-P4: PATHFINDER is a randomized, blinded clinical trial of portable air cleaners (PAC) provided at the time of hospital discharge to Heart Failure (HF) patients. It will be carried out at Henry Ford Hospitals.
- Trial name
- PATHFINDER (NCT06070428)
- Testing
- PAC provision at hospital discharge, Control non-intervention; PAC without filter
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Henry Ford Health System
Tobacco Use, Pollution; Exposure
FRESHAIR4Life: Building the Case for Action
The goal of this observational study is to understand the burden and determinants of tobacco use and air pollution (AP) exposure among mid- to late adolescents in Greece, the Kyrgyz Republic, Pakistan, Romania, and Uganda.
- Conditions
- Tobacco Use, Pollution; Exposure, Non-communicable Disease
- Trial name
- NCT06074939
- Volunteers
- 1,750 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Blood Pressure
Reducing AIR Pollution Exposure to Lower Blood PRESSURE Among New York City Public Housing Residents
Fine particulate matter <2.5 µm (PM2.5) air pollution is the fifth leading risk factor for global mortality, with the largest portion of deaths due to cardiovascular disease (CVD).
- Trial name
- AirPressureNYC (NCT05874479)
- Testing
- Active PAC
- Where
- United States
- Volunteers
- 440 people
- Sponsor
- NYU Langone Health
Lung Diseases
Assessment of Exposures of the Mother-infant Pair to the Air Pollution of São Paulo
A single group of pregnant women who was analyzed in the first and in the third trimesters of pregnancy
- Trial name
- NCT02807038
- Testing
- Lung function test
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital