Clinical trials: Extensive Disease Small Cell Lung Cancer
Small-cell Lung Cancer, Small Cell Lung Carcinoma
KRT-232 in Subjects With Relapsed or Refractory Small Cell Lung Cancer
This study evaluates KRT-232, a novel oral small molecule inhibitor of MDM2, for the treatment of patients with relapsed or refractory small cell lung cancer. This study will be conducted in 2 parts.
- Conditions
- Small-cell Lung Cancer, Small Cell Lung Carcinoma, Small Cell Lung Cancer Extensive Stage, Small Cell Lung Cancer Recurrent
- Trial name
- NCT05027867
- Testing
- KRT-232
- Where
- 33 sites in United States, Australia and 5 more
- Volunteers
- 3 people
- Sponsor
- Kartos Therapeutics, Inc.
Depression, Lung Cancer
Depression Screening in Patients With Lung Cancer
RATIONALE: Screening tests may help doctors find depression in patients with lung cancer, allow doctors to recommend treatment for depression, and improve the patient's quality of life.
- Trial name
- NCT00404365
- Testing
- counseling intervention, screening questionnaire administration, study of socioeconomic and demographic variables
- Where
- 2 sites in United States
- Volunteers
- 241 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Extensive-stage Small-cell Lung Cancer
Safety and Efficacy of BNT327, an Investigational Therapy in Combination With Chemotherapy for Patients With Untreated Small-cell Lung Cancer
This is a Phase III, multisite, randomized, double-blinded study to investigate pumitamig (BNT327) combined with chemotherapy (etoposide/carboplatin) compared to atezolizumab combined with chemotherapy (etoposide/carboplatin) for…
- Trial name
- NCT06712355
- Testing
- Pumitamig, Atezolizumab, Etoposide
- Where
- 225 sites in United States, Australia and 12 more
- Volunteers
- 621 people
- Sponsor
- BioNTech SE
Lung Cancer
Radiation Therapy to Prevent Brain Metastases in Patients With Previously Treated Extensive-Stage Small Cell Lung Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Radiation therapy to the brain may be effective in preventing brain metastases.
- Trial name
- NCT00016211
- Testing
- radiation therapy
- Where
- 49 sites in Belgium, Cyprus and 10 more
- Volunteers
- 287 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
SCLC, Extensive Stage
Lomustine Combined With Anlotinib as Interventional Therapy for Extensive-stage Small Cell Lung Cancer Resistant to Second-line and Above Treatment
This single-arm phase II study aims to evaluate the efficacy and safety of lomustine combined with anlotinib in patients with extensive-stage small cell lung cancer resistant to second-line and above systemic treatment.
- Trial name
- Aurora003 (NCT07632209)
- Testing
- Lomustine, Anlotinib
- Volunteers
- 46 people
- Sponsor
- Yayi He
Extensive Stage Small Cell Lung Cancer
Tumor Microenvironment Surveillance on Simultaneous Liver Metastases Extensive Stage Small Cell Lung Cancer
The purpose of the trial is to detect tumor microenvironment on Extensive Stage Small Cell Lung Cancer with simultaneous liver metastases who Treated with Atezolizumab plus Etoposide and Platinum Based Chemotherapy.
- Trial name
- NCT05055999
- Testing
- First line EC/EP+Atezolizumab
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Hunan Province Tumor Hospital
Extensive Stage Lung Small Cell Carcinoma, Limited Stage Lung Small Cell Carcinoma
Bomedemstat and Maintenance Immunotherapy for Treatment of Newly Diagnosed Extensive Stage Small Cell Lung Cancer
This phase I/II trial studies the side effects of bomedemstat and maintenance immunotherapy with atezolizumab and to see how well they work in treating patients with newly diagnosed extensive stage small cell lung cancer.
- Trial name
- NCT05191797
- Testing
- Bomedemstat, Atezolizumab
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Washington
Extensive Stage Small Cell Lung Carcinoma
Tumor-Treating Fields Therapy in Preventing Brain Tumors in Participants With Extensive-Stage Small Cell Lung Cancer
This trial studies how well tumor-treating fields therapy works in preventing brain tumors in participants with small cell lung cancer that has spread to other places in the body.
- Trial name
- NCT03607682
- Testing
- Tumor Treating Fields (TTF) Therapy, NovoTTF-200A Device, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
SCLC, Extensive-stage Small Cell Lung Cancer
Medical Access Program for Ifinatamab Deruxtecan in 3L+ Pretreated Extensive-stage Small Cell Lung Cancer
The purpose of this Medical Access Program (also referred to as an Expanded Access Program in the USA) is to provide access to I-DXd for eligible patients with extensive-stage small cell lung cancer (ES-SCLC) after two or more…
- Trial name
- NCT07535359
- Testing
- Ifinatamab Deruxtecan
- Where
- 5 sites in United States
- Sponsor
- Daiichi Sankyo
Extensive Stage Small Cell Lung Cancer, Recurrent Small Cell Lung Cancer
Topotecan Hydrochloride or Cyclodextrin-Based Polymer-Camptothecin CRLX101 in Treating Patients With Recurrent Small Cell Lung Cancer
This randomized phase II trial studies how well giving topotecan hydrochloride or cyclodextrin-based polymer-camptothecin CRLX101 works in treating patients with recurrent small cell lung cancer.
- Trial name
- NCT01803269
- Testing
- topotecan hydrochloride, cyclodextrin-based polymer-camptothecin CRLX101
- Where
- 5 sites in United States
- Volunteers
- 29 people
- Sponsor
- University of Chicago
Extensive-Stage Small-Cell Lung Cancer
Chemotherapy and Immunotherapy in Extensive-Stage Small-Cell Lung Cancer With Thoracic Radiotherapy
This is a prospective, multi-centre, single arm, phase 2, open label clinical trial of patients with untreated extensive-stage small-cell lung cancer (ES-SCLC) suitable for first-line platinum-based chemotherapy.
- Trial name
- CHEST RT (NCT05796089)
- Testing
- Thoracic Radiotherapy, Etoposide with Carboplatin or Cisplatin, Durvalumab
- Where
- 8 sites in Australia
- Volunteers
- 35 people
- Sponsor
- Trans Tasman Radiation Oncology Group
Brain and Central Nervous System Tumors, Breast Cancer
Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma
RATIONALE: Giving antibiotics may be effective in preventing or controlling early infection in patients receiving chemotherapy for solid tumors or lymphoma.
- Conditions
- Brain and Central Nervous System Tumors, Breast Cancer, Extragonadal Germ Cell Tumor, Infection
- Trial name
- NCT00005590
- Testing
- levofloxacin
- Where
- United Kingdom
- Sponsor
- Cancer Research Campaign Clinical Trials Centre
Lung Cancer, Targeted Therapy
AZD9291, an Irreversible EGFR-TKI, in Relapsed EGFR-mutated Non-small Cell Lung Cancer Patients Previously Treated With an EGFR-TKI, Coupled to Extensive Translational Studies
Phase II, single-arm study to assess the safety and efficacy of AZD9291 (80 mg, orally, once daily) in second-line (or later) patients with EGFR mutation-positive, locally advanced or metastatic NSCLC, who have progressed…
- Trial name
- TREM (NCT02504346)
- Testing
- AZD9291
- Where
- 7 sites in Denmark, Finland and 3 more
- Volunteers
- 200 people
- Sponsor
- Oslo University Hospital
Small Cell Lung Cancer
Efficacy and Biomarker Explanation of IBI-322 Plus Lenvatinib on Extensive Stage Small Cell Lung Cancer
This study aimed to explore the efficacy and biomarker explanation of IBI-322 Plus Lenvatinib on extensive stage small cell lung cancer who failed from first line PD-(L)1 inhibitors.
- Trial name
- NCT05296603
- Testing
- IBI-322 Plus Lenvatinib
- Where
- China
- Volunteers
- 83 people
- Sponsor
- Hunan Province Tumor Hospital
Small Cell Lung Cancer, Large Cell Neuroendocrine (NE) Tumors
Genomic and Methylation Markers in SCLC and LCNEC for Chemo-Immunotherapy Resistance Prediction (STRATUS)
The goal of this observational study is to understand how genomic and epigenetic factors contribute to resistance against chemo-immunotherapy in adults diagnosed with extensive-stage small cell lung cancer (ES-SCLC) or metastatic…
- Conditions
- Small Cell Lung Cancer, Large Cell Neuroendocrine (NE) Tumors, Treatment Failure, Biomarkers / Blood
- Trial name
- STRATUS (NCT06717243)
- Testing
- Carboplatin/Cisplatin -Etoposide - Atezolizumab
- Where
- 2 sites in United States, Greece
- Volunteers
- 111 people
- Sponsor
- Oncology Center of Biochemical Education And Research
Breast Cancer, Kidney Cancer
Genistein in Treating Patients Undergoing External-Beam Radiation Therapy for Bone Metastases
RATIONALE: Genistein may increase the effectiveness of radiation therapy in treating pain caused by bone metastases. PURPOSE: This phase I/II trial is studying the side effects of genistein and to see how well it works in…
- Conditions
- Breast Cancer, Kidney Cancer, Lung Cancer, Melanoma
- Trial name
- NCT00769990
- Testing
- genistein, radiation therapy
- Sponsor
- Masonic Cancer Center, University of Minnesota
Extensive-stage Small-cell Lung Cancer
Low-dose Radiotherapy Combined With Concurrent Chemotherapy, Toripalimab and Tifcemalimab in the Treatment of ES-SCLC
To evaluate the tolerability and safety of Low-dose radiotherapy combined with concurrent Chemotherapy, Toripalimab and Tifcemalimab in first-line treatment of Extensive-Stage Small Cell Lung Cancer, and to determine the RP2D.
- Trial name
- NCT06732258
- Testing
- Low-dose radiotherapy, Tifcemalimab injection, Toripalimab
- Sponsor
- Sichuan University
Small Cell Lung Carcinoma
Two Different Dosages of Irinotecan Combined With Cisplatin Scheme in Extensive Disease-Small Cell Lung Cancer
As the gene polymorphism of uridine diphosphate glucuronosyl transferase 1A1(UGT1A1)is related to the side effect of diarrhea induced by irinotecan.
- Trial name
- TDICC (NCT01977235)
- Testing
- Irinotecan, Cisplatin
- Where
- 3 sites in China
- Volunteers
- 110 people
- Sponsor
- Third Military Medical University
Extensive Stage Lung Small Cell Carcinoma, Limited Stage Lung Small Cell Carcinoma
Tumor Treating Fields (TTFields) Therapy to Manage Brain Metastases in Small Cell Lung Cancer
This phase II single-arm pilot study will evaluate the safety and preliminary efficacy of Optune-Tumor Treating Fields (TTFields) therapy as a prophylactic approach to reducing small cell lung cancer (SCLC) that has spread to the…
- Conditions
- Extensive Stage Lung Small Cell Carcinoma, Limited Stage Lung Small Cell Carcinoma, Stage I Lung Cancer AJCC v8, Stage IA1 Lung Cancer AJCC v8
- Trial name
- NCT03995667
- Testing
- Questionnaire Administration, Tumor Treating Fields Therapy
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- OHSU Knight Cancer Institute
Extensive-stage Small Cell Lung Cancer
Benmelstobart, Anlotinib and Chemotherapy as First-line Treatment for Extensive-stage Small-cell Lung Cancer
The goal of this clinical trial is to evaluate the efficacy and safety of benmelstobart in combination with anlotinib and chemotherapy sequential benmelstobart in combination with anlotinib for the first-line treatment of…
- Trial name
- NCT06931145
- Testing
- Benmelstobart, Anlotinib, Carboplatin or cisplatin
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking Union Medical College Hospital