Clinical trials: External Validation
Cardiac Disease
External Validation of Artificial Intelligence-enabled Electrocardiography (AI-ECG) for the Detection of Left Ventricular Dysfunction (LVD)
This is a multi-center, retrospective study evaluating the performance of an artificial intelligence-enabled electrocardiography (AI-ECG) algorithm in detecting reduced left ventricular ejection fraction (LVEF ≤ 40%).
- Trial name
- NCT07038018
- Testing
- AI-ECG Algorithm
- Where
- 13 sites in Taiwan
- Volunteers
- 12,500 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Acute Kidney Injury
External Validation of IRRIV Test Relationship With Renal Functional Reserve
The assessment of renal functional reserve (RFR) has been proposed for the risk stratification of patients undergoing potentially nephrotoxic procedures.
- Trial name
- IRRIV-RFR (NCT03756402)
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Ospedale San Bortolo di Vicenza
Prostate Cancer
External Validation of Prostate MRI QCAD/Lyon
Multiparametric magnetic resonance imaging (mpMRI) of the prostate combines T2-weighted imaging, diffusion-weighted imaging and dynamic contrast-enhanced imaging.
- Trial name
- DIJON-CAD (NCT03687918)
- Testing
- Assessment of the performances of QCAD/Lyon in characterizing Gleason ≥7 cancers among contoured lesions
- Where
- 7 sites in France
- Volunteers
- 80 people
- Sponsor
- Hospices Civils de Lyon
Reliability in the Detection of ACL Injuries in Emergency Departments
Evaluation of the External Validity of the Knee SFA Score
A screening score for ACL (anterior cruciate ligament) injuries based on questioning has been developed by the Société Francophone d'Arthroscopie to provide better guidance for post-trauma patients.
- Trial name
- SCORESFA (NCT06960681)
- Testing
- External validity of the SFA score
- Where
- 3 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Rouen
External Effectiveness Validation of Model
Evaluation of U-AKIpredTM for Predicting AKI in Critically Ill Patients Within 12 Hours: a Multicenter Prospective Cohort Study
The goal of our study is to evaluate U-AKIpredTM for predicting AKI in critically ill patients within 12 h by the multicenter prospective cohorts. AKI was diagnosed by Kidney Disease Improving Global Outcomes (KDIGO) criteria.
- Trial name
- NCT06496555
- Where
- China
- Volunteers
- 2,100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Postoperative Pain
Prospective External Validation of an Early Prediction Model for Adverse Postoperative Pain Trajectories After Orthopedic Surgery
This prospective observational study will externally validate a previously developed and locked prediction model for identifying adult patients at risk of adverse postoperative pain trajectories after elective orthopedic surgery.
- Trial name
- NCT07846878
- Testing
- Elective Orthopedic Surgery
- Where
- China
- Volunteers
- 400 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Shoulder Pain
Reliability and Validity of Goniometric iPhone Applications
The purpose of this study is to determine the test-retest and inter-rater reliability and concurrent validity of two iPhone goniometric applications in the measurement of active shoulder external rotation as compared to a…
- Trial name
- NCT01629641
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Texas Woman's University
Postoperative Infection, Geriatrics
Postoperative Infectious Complications Calculator for Elderly Patients
The investigators established a first-ever convenient scoring system for clinicians to assess the risk of Postoperative infectious complications (PICs) for elderly patients.
- Conditions
- Postoperative Infection, Geriatrics, Prediction
- Trial name
- NCT06265493
- Where
- China
- Volunteers
- 37,230 people
- Sponsor
- Weidong Mi
Ovarian Cancer, Ovarian Tumor
AI Analysis of CT Scans to Classify Ovarian Tumours as Benign, Borderline or Malignant Before Surgery
The goal of this observational study is to learn if a computer program can tell what type of ovarian tumour a person has from a CT scan taken before surgery. The program uses artificial intelligence (AI).
- Conditions
- Ovarian Cancer, Ovarian Tumor, Borderline Ovarian Tumor
- Trial name
- OvaClass (NCT07883551)
- Where
- 7 sites in Belgium, Netherlands
- Volunteers
- 1,300 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Pulmonary Embolism
External Validation of a Deep Learning Based Model for Pulmonary Embolism Detection on Chest CT Scans
The scope of this study is the external validation of an explainable deep learning-based classifier for the diagnosis and detection of pulmonary embolism in computed tomography pulmonary angiography (CTPA) and contrast enhanced…
- Trial name
- NCT05333042
- Where
- Belgium
- Volunteers
- 5,000 people
- Sponsor
- OncoRadiomics
Venous Thromboembolism
Construction and External Validation of a Predictive Clinico-biological Score of the Risk of Venous Thrombosis in Women Under Combined Oral Contraceptives
the investigators hypothesize that some of these polymorphisms contribute to VTE risk in women using COC, and that their screening could to help assess individual risk of VTE before COC prescription.
- Trial name
- PILGRIM (NCT03309293)
- Testing
- blood samples
- Where
- France
- Volunteers
- 1,454 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Ventricular Dysfunction, Left, Ventricular Function, Left
Federated Learning for Point-of-Care Cardiac Ultrasound
This prospective, multicenter study will evaluate a federated machine-learning system designed to analyze focused cardiac point-of-care ultrasound examinations.
- Conditions
- Ventricular Dysfunction, Left, Ventricular Function, Left, Echocardiography, Ultrasonography
- Trial name
- FL-POCUS (NCT07800962)
- Testing
- Focused Cardiac Point-of-Care Ultrasonography, FL-POCUS Federated Machine-Learning Analysis System
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- Truway Health, Inc.
Acute Respiratory Failure, Oxygen Inhalation Therapy
External Validation of the BREF Models
Introduction High-flow oxygen therapy is increasingly used to treat acute respiratory failure (ARF). It can reduce intubation rates without increasing mortality.
- Conditions
- Acute Respiratory Failure, Oxygen Inhalation Therapy, Respiratory Distress
- Trial name
- BREF2 (NCT06669312)
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Istituto Clinico Humanitas
ABPA, Allergic Bronchopulmonary Aspergillosis
ML-Based ABPA Recurrence Prediction and Clinical Utility
This multicenter bidirectional cohort study aims to develop and externally validate a machine learning model for predicting the risk of acute exacerbation within 1 year in patients with allergic bronchopulmonary aspergillosis…
- Conditions
- ABPA, Allergic Bronchopulmonary Aspergillosis, Allergic Bronchopulmonary Aspergillosis (ABPA), Acute Exacerbation
- Trial name
- ABPA-ML (NCT07714863)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Qianfoshan Hospital
Acute Coronary Syndromes, Chest Pain
AI-ECG Detection of Occlusion Myocardial Infarction at Emergency Department Triage (TRIACS)
Chest pain is among the most common reasons people attend an emergency department, and the electrocardiogram (ECG) recorded at triage is the first test used to decide who needs urgent treatment for a blocked coronary artery.
- Conditions
- Acute Coronary Syndromes, Chest Pain, Myocardial Infarction (MI), NSTEMI - Non-ST Segment Elevation MI
- Trial name
- TRIACS-MB (NCT07882849)
- Where
- Slovenia
- Volunteers
- 1,000 people
- Sponsor
- University Medical Centre Maribor
Constriction, Pathologic, Spine Degeneration
Strategic Use of Big Data in Spine Surgery - Testing Digital Prediction of Outcome in Clinical Praxis
The goal of this prospective, multicenter clinical trial is to determine if the use of the postoperative outcome prediction model the Dialogue Support tool can alter postoperative patient-reported outcome and satisfaction…
- Conditions
- Constriction, Pathologic, Spine Degeneration, Surgery, Radiculopathy
- Trial name
- NCT05817747
- Testing
- Dialogue support tool
- Where
- 10 sites in Sweden
- Volunteers
- 900 people
- Sponsor
- Sahlgrenska University Hospital
Cardiac Surgery Associated - Acute Kidney Injury, CKD (Chronic Kidney Disease) Stage 5D
Incidence and Prognostic of Cardiac Surgery-Associated Acute Kidney Injury: A Spanish Multicenter Study (SCARS-AKI)
To predict the renal damage caused by cardiac surgery in patients to try to mitigate it as soon as possible
- Conditions
- Cardiac Surgery Associated - Acute Kidney Injury, CKD (Chronic Kidney Disease) Stage 5D, Acute Kidney Injury, Acute Kidney Disease
- Trial name
- SCARS-AKI (NCT07370831)
- Testing
- CARDIAC SURGERY
- Where
- Spain
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Universidad de Oviedo
Healthy Individuals
Study for Cognitive and Genetic Characterization of a 45-65 Years Old Population
Before Alzheimer's disease (AD) clinical symptoms appear, there is a long period when changes in the brain occur. In this long asymptomatic period or preclinical phase, studies with populations at risk of developing AD have shown…
- Trial name
- NCT01835717
- Where
- Spain
- Volunteers
- 2,743 people, healthy volunteers welcome
- Sponsor
- Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
Upper Gastrointestinal Bleeding (UGIB), Glasgow-Blatchford Score
External Validation of the Glasgow-Blatchford Bleeding Score in a Tunisian Population
This study aims to externally validate the Glasgow-Blatchford Score (GBS) in a Tunisian population presenting with non-traumatic upper gastrointestinal bleeding.
- Trial name
- NCT07089277
- Where
- Tunisia
- Volunteers
- 250 people
- Sponsor
- Hôpital Universitaire Sahloul
ICU
External Validation of the FedHist Dynamic Early Warning Model for Mortality Risk in Critically Ill Patients: A Prospective Multicenter Study
The purpose of this study is to assess how accurately FedHist, an artificial intelligence model, predicts the risk of death in critically ill patients. Patients in intensive care units (ICUs) can become worse quickly.
- Trial name
- NCT07825012
- Testing
- Risk of mortality
- Volunteers
- 23,579 people
- Sponsor
- Southeast University, China