Clinical trials: Extracellular Vesicles
Ovarian Cancer
EARLY Study: Evaluating the Specificity and Feasibility of the EARLY Biomarker Panel for Ovarian Cancer Detection
The overall aim of the EARLY study is to systematically evaluate the impact of blood collection protocols, storage temperatures, transport conditions, and time to processing on the stability of extracellular vesicle (EV)…
- Trial name
- NCT07491081
- Testing
- Intervention 1, Intervention 2
- Where
- 2 sites in Australia
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Queensland Centre for Gynaecological Cancer
Metastatic Colorectal Cancer
Circulating Tumor Extracellular Vesicles for Non-Invasive Monitoring of Metastatic Colorectal Cancer
Metastatic colorectal cancer (mCRC) remains a major clinical challenge due to heterogeneous treatment responses and the development of therapeutic resistance.
- Trial name
- EVA26 (NCT07754513)
- Testing
- Blood sample
- Volunteers
- 290 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Breast Cancer
Clinical Study of Glycosylated Extracellular Vesicles for Early Diagnosis of Breast Cancer
This is a prospective, single-center, non-randomized, cohort study designed to evaluate the clinical diagnostic performance of glycosylated extracellular vesicles and their contents for early detection of breast cancer.
- Trial name
- NCT05417048
- Testing
- Blood Sample
- Where
- China
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Peking University
Impaired Glucose Tolerance
Preliminary Safety and Efficacy Study of Extracellular Vesicle Infusion in the Intervention of Age-related Phenotypes With Impaired Glucose Tolerance.
The objective of this exploratory study was to evaluate the initial safety of human mesenchymal stem cell-derived extracellular vesicle infusion in an age-related phenotype with impaired glucose tolerance
- Trial name
- NCT06495437
- Testing
- Intravenous infusion of extracellular vesicle preparation derived from Wharton's jelly mesenchymal stem cells.
- Volunteers
- 20 people
- Sponsor
- BEAUTECH
Dry Eye Disease, Umbilical Cord Mesenchymal Stem Cell-derived Small Extracellular Vesicles
Human Umbilical Cord Mesenchymal Stem Cell-derived Small Extracellular Vesicles for the Treatment of Dry Eye Disease
This clinical trial aims to preliminarily evaluate the safety and efficacy of human umbilical cord mesenchymal stem cell small extracellular vesicle eye drops in patients with dry eye disease. 1.
- Trial name
- NCT07623382
- Testing
- Human umbilical cord mesenchymal stem cell-derived small extracellular vesicle (sEV) eye drops.
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Parkinson's Disease (PD), GBA1 Parkinson Disease
Understanding Alpha-Synuclein Spread in Parkinson's Disease Through Blood Biomarkers and Neuroimaging
The project aims to investigate how abnormal accumulation of alpha synuclein and its interaction with tau influence brain function across the Parkinson's disease (PD) spectrum, with particular focus on individuals carrying GBA1…
- Conditions
- Parkinson's Disease (PD), GBA1 Parkinson Disease, REM Sleep Behavior Disorder (iRBD)
- Trial name
- SYNchronPD (NCT07474779)
- Testing
- brain imaging, blood draw, Skin biopsy
- Where
- 2 sites in Italy
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Pavia
Obesity & Overweight
Impact of Exercise-derived Extracellular Vesicle in Blood and Physical Fitness Data in Overweight/Obesity Individuals
This project aims to study the effect of exercise in the obesity/overweight on the changes of physical fitness and blood components.
- Trial name
- Exercise (NCT07312344)
- Testing
- High-intensity interval training exercise on treadmill
- Where
- Thailand
- Volunteers
- 20 people
- Sponsor
- Mahidol University
Knee Osteoarthrosis
Use of Extracellular Vesicles (EV) for Knee Osteoarthrosis
Extracellular vesicles (EV) will be injected in patients diagnosed with Knee osteoarthrosis
- Trial name
- NCT06937528
- Testing
- Extracellular vesicles
- Where
- Jordan
- Volunteers
- 50 people
- Sponsor
- University of Jordan
Advanced Gastric Adenocarcinoma, Immunotherapy
Prospectively Predict the Efficacy of Treatment of Gastrointestinal Tumors Based on Peripheral Multi-omics Liquid Biopsy
To vertify the function of EV-score on predicting \& monitoring immunotherapeutic outcomes of GC
- Trial name
- NCT04993378
- Testing
- EV-array
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shen Lin
Breast Cancer
Role of Tumor Microbiota in the Response to Neoadjuvant Therapy in Patients Affected by Triple Negative Breast Cancer
Triple-negative breast cancer (TNBC) is an aggressive subtype of cancer characterized by substantial heterogeneity in treatment response.
- Trial name
- NCT07808086
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Lymphangioleiomyomatosis (LAM), Extracellular Vesicles; Generation and Function
Role of Extracellular Vesicles as Biomarkers of Pulmonary Involvement in Patients With Lymphangioleiomyomatosis and Tuberous Sclerosis Complex
Lymphangioleiomyomatosis (LAM) is a rare lung disease, linked to Tuberous Sclerosis Complex (TSC) or occurring sporadically, and involves abnormal mTORC1 activation.
- Trial name
- NCT07304856
- Testing
- Pulmonary Function Test, Analysis of Extracellular Vesicles
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Milan
Immune Effector Cell Associated Neurotoxicity Syndrome
Temporal Characterization of Extracellular Vesicles During Cellular Therapy Using CAR-T Cells and During the Occurrence of Immune Effector Cell-Associated Neurotoxicity Syndrome
Immune effector Cell-Associated Neurotoxicity Syndrome (ICANS) is a common and serious neurological complication associated with the use of CAR-T cells.
- Trial name
- VESICANS (NCT06706102)
- Testing
- Biological tests, MRI, Neuropsychological tests
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Joint Disease
Extracellular Vesicles in Fibrin Gel for Cartilage Repair
This project aims to produce and study in vitro/ex vivo a platelet rich plasma (PRP)-derived fibrin gel loaded with mesenchymal stromal cells (MSC)-extracellular vesicles (EVs), to combine the positive results on cartilage growth…
- Trial name
- GelVex (NCT06713902)
- Where
- Italy
- Volunteers
- 51 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Segmental Fracture - Bone Loss
Treatment of Patients With Bone Tissue Defects Using Mesenchymal Stem Cells Enriched by Extracellular Vesicles
Treatment of patients with segmental bone tissue defects using mesenchymal stem cells enriched by extracellular vesicles
- Trial name
- NCT05520125
- Testing
- Mesenchymal stem cells enriched by extracellular vesicles, Standard treatment of bone defects
- Where
- Belarus
- Volunteers
- 20 people
- Sponsor
- Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus
Schizophrenia Disorder, Schizophreniform Disorder
MicroRNAs as Biomarkers in First Episode Schizophrenia
This study investigates whether tiny molecules called microRNAs (miRNAs), found in special brain-derived "packages" (neural-derived extracellular vesicles, or NDEs) that travel from the brain into the blood, can serve as helpful…
- Conditions
- Schizophrenia Disorder, Schizophreniform Disorder, Schizoaffective Disorder, Psychosis Not Otherwise Specified (NOS)
- Trial name
- MIRFEST (NCT07703670)
- Testing
- Plasma NDE miRNA Sequencing, Whole Genome Sequencing
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Heart Failure With Reduced Ejection Fraction
Treatment of Non-ischemic Cardiomyopathies by Intravenous Extracellular Vesicles of Cardiovascular Progenitor Cells
The goal of this clinical trial is to assess the safety and efficacy of three intravenous injections of the extracellulat vesicle-enriched secretome of cardiovascular progenitor cells in severely symptomatic patients with…
- Trial name
- SECRET-HF (NCT05774509)
- Testing
- Extracellular vesicle-enriched secretome of cardiovascular progenitor cells differentiated from induced pluripotent stem cells
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Gastric Cancer, Esophagus Cancer
Exosome-based Liquid Biopsies for Upper Gastrointestinal Cancers Diagnosis
This study constitutes a case-control investigation employing a retrospective approach. Plasma samples from individuals with esophageal cancer, benign esophageal diseases, gastric cancer, benign gastric diseases, and a healthy…
- Trial name
- NCT06278064
- Testing
- Gastric Cancer, Esophagus Cancer
- Where
- 3 sites in China
- Volunteers
- 562 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
Mild Cognitive Impairment
Curcumin and Yoga Therapy for Those at Risk for Alzheimer's Disease
Physical exercise has proven to improve memory including in the elderly. Drugs developed to stop the underlying disease processes that cause Alzheimer's disease may succeed only with multimodal efforts to stimulate brain…
- Trial name
- NCT01811381
- Testing
- Curcumin, aerobic yoga, non aerobic yoga
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- VA Office of Research and Development
COVID-19
Extracellular Vesicles Infusion Treatment for Mild-to-Moderate COVID-19
Early Mild Outpatient infusion Therapy with ExoFloTM for COVID-19 (EMOTE COVID-19) To evaluate the safety and efficacy of intravenous (IV) administration of bone marrow mesenchymal stem cell derived extracellular vesicles…
- Trial name
- NCT05125562
- Testing
- ExoFlo
- Sponsor
- Direct Biologics, LLC
Severe Acute Respiratory Syndrome (SARS), Acute Respiratory Distress Syndrome (ARDS)
Extracellular Vesicles From Mesenchymal Cells in the Treatment of Acute Respiratory Failure
This is a phase I/II, randomized, double-blind, placebo-controlled clinical trial that will evaluate the safety and potential efficacy of therapy with extracellular vesicles (EVs) obtained from mesenchymal stromal cells (MSCs)…
- Conditions
- Severe Acute Respiratory Syndrome (SARS), Acute Respiratory Distress Syndrome (ARDS), Pneumonia
- Trial name
- NCT06002841
- Testing
- intravenous treatment with EVs
- Where
- Brazil
- Volunteers
- 15 people
- Sponsor
- D'Or Institute for Research and Education