Clinical trials: Extracorporeal Membrane Oxygenation Complication
Extracorporeal Membrane Oxygenation Complication
Bivalirudin vs Heparin in ECMO Patients
This is an open label, randomized study comparing the clinical outcomes of unfractionated Heparin and Bivalirudin for anticoagulation in adult subjects requiring ECMO support.
- Trial name
- NCT03707418
- Testing
- Heparin Sodium, Bivalirudin Injection [Angiomax]
- Where
- United States
- Sponsor
- Johns Hopkins University
Cardiogenic Shock, Renal Replacement Therapy
REnal reCOVery After ECMO for Cardiogenic Shock (RECOVECMO)
This retrospective study assesses long term renal outcome in patients having suffered medical or post cardiotomy refractory cardiogenic shock requiring renal replacement therapy (RRT) concomitant with veno-arterial extracorporeal…
- Conditions
- Cardiogenic Shock, Renal Replacement Therapy, Venoarterial Extracorporeal Membrane Oxygenation
- Trial name
- RECOVECMO (NCT05788211)
- Testing
- standard of care
- Where
- France
- Volunteers
- 93 people
- Sponsor
- University Hospital, Bordeaux
Mechanical Ventilation Complication, Severe Acute Respiratory Infection
The REDEEM Pilot Study: A Feasibility RCT of Early ECMO in Severe Acute Respiratory Infection, Including COVID-19, WHO
Patients who are critically ill in intensive care with moderate to severe acute respiratory infection often require mechanical ventilation.
- Conditions
- Mechanical Ventilation Complication, Severe Acute Respiratory Infection, Covid19
- Trial name
- REDEEM (NCT04708457)
- Testing
- VV-ECMO
- Where
- 2 sites in Australia, Germany
- Volunteers
- 6 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Acute Brain Injury, Extracorporeal Membrane Oxygenation Complication
ECMO ABI Detection With Hyperfine
The primary objective is to characterize the prevalence and type of ABI following cannulation for pediatric patients who require ECMO support.
- Conditions
- Acute Brain Injury, Extracorporeal Membrane Oxygenation Complication, Hypoxia-Ischemia, Brain, Stroke, Acute
- Trial name
- NCT06469801
- Testing
- Hyperfine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Mercy Hospital Kansas City
Shock, Cardiogenic, Cardiac Arrest
Hemodynamic Comparison of Peripheral and Central VA ECMO.
The goal of this clinical trial is to monitor hemodynamic differences between central veno-arterial extracorporeal membrane oxygenation (VA ECMO) and peripheral VA ECMO.
- Conditions
- Shock, Cardiogenic, Cardiac Arrest, Extracorporeal Circulation; Complications, Hemodynamics Instability
- Trial name
- RECOVERY (NCT05669183)
- Testing
- Veno-arterial extracorporeal membrane oxygenation
- Where
- China
- Volunteers
- 136 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Lung Transplantation, Extracorporeal Membrane Oxygenation (ECMO)
Prospective Observational Pilot Study of LMWH Versus UFH as ECMO Anticoagulation in Lung Transplantation
The aim of this observational pilot study is to evaluate the effectiveness and safety of low-molecular-weight heparin (LMWH) compared to unfractionated heparin (UFH) as anticoagulation in perioperative ECMO during bilateral lung…
- Conditions
- Lung Transplantation, Extracorporeal Membrane Oxygenation (ECMO), Anticoagulants and Bleeding Disorders
- Trial name
- LUX-ET-LT (NCT06868823)
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- University Hospital, Motol
Cardiac Failure, Extracorporeal Membrane Oxygenation Complication
Echocardiographic Assessment of Function During ECMO Support
The purpose of this study is to evaluate echocardiographic markers of cardiac function to assess the ability of patients to successfully end VA-ECMO support.
- Trial name
- NCT01551849
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Nationwide Children's Hospital
Acute Kidney Injury
Renal Biomarkers to Predict Recovery Following Venoarterial Extracorporeal Membrane Oxygenation
The investigators objective is to assess the utility of renal biomarkers in predicting renal recovery following institution of Venoarterial Extracorporeal Membrane Oxygenation (VA-ECMO).
- Trial name
- NCT02978378
- Testing
- biomarker levels
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Milton S. Hershey Medical Center
Diaphragm, Extracorporeal Membrane Oxygenation Complication
Evolution of Diaphragm Thickness Under Veno-arterial ECMO
The main objective is to evaluate the evolution of the thickness of the diaphragm (during the first week of treatment) by VA ECMO in the resuscitation patients.
- Trial name
- ATROPHY-ECMO (NCT04052230)
- Testing
- ultrasound measure
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Grenoble
ARDS, COVID-19
Monitoring Anticoagulation in Patients on ECMO for Severe Lung Failure
A monocentric observational study evaluates the accuracy of anticoagulation monitoring in critically ill patients on ECLS (extracorporeal life support) using new markers of the effect of direct thrombin inhibitors and also the…
- Trial name
- NCT06038682
- Testing
- Argatroban Injection, Heparin
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- University Hospital Ostrava
Respiratory Insufficiency, Extracorporeal Membrane Oxygenation Complication
Platform of Randomized Adaptive Clinical Trials in Critical Illness
PRACTICAL is a randomized multifactorial adaptive platform trial for acute hypoxemic respiratory failure (AHRF). This platform trial will evaluate novel interventions for patients with AHRF across a range of severity states…
- Conditions
- Respiratory Insufficiency, Extracorporeal Membrane Oxygenation Complication, Mechanical Ventilation Pressure High
- Trial name
- PRACTICAL (NCT05440851)
- Testing
- Ultra-Protective Ventilation Facilitated by Extracorporeal Support, Lung-Protective Ventilation (LPV), Driving Pressure-Limited Ventilation (DPL)
- Where
- 103 sites in United States, Australia and 8 more
- Volunteers
- 6,250 people
- Sponsor
- University Health Network, Toronto
Brain Injuries, Congenital Heart Disease
Protecting Brains and Saving Futures - the PBSF Protocol
Background: Multiple neonatal disorders are associated with risks of neurological injury. Thus, management of these infants should involve a coordinated approach to permit early diagnosis with improved clinical care.
- Conditions
- Brain Injuries, Congenital Heart Disease, Newborn Morbidity, Intraventricular Hemorrhage
- Trial name
- PBSF (NCT03786497)
- Where
- 2 sites in Brazil
- Volunteers
- 2,268 people
- Sponsor
- Protecting Brains Saving Futures
Extracorporeal Membrane Oxygenation Complication
Early Rehabilitation in Patients on Extracorporeal Membrane Oxygenation
Critically ill patients who require extracorporeal membrane oxygenation (ECMO) are the sickest in the hospital. More patients are surviving but survivors have compromised functional recovery for months or years.
- Trial name
- ECMO-Rehab (NCT05003609)
- Testing
- Early Rehabilitation
- Where
- 7 sites in Australia, Canada
- Volunteers
- 100 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
ARDS, Human, Extracorporeal Membrane Oxygenation Complication
Predictors of Intracranial Hemorrhage in ARDS Patients on ECMO
Intracranial hemorrhage is is a rare, but critical incident in patients with acute lung failure undergoing ECMO therapy. Predictors of intracranial hemorrhage are yet to be defined to identify patients at (high) risk.
- Trial name
- NCT04142775
- Testing
- complication versus no complication
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Charite University, Berlin, Germany
Cardiogenic Shock, Extracorporeal Membrane Oxygenation Complication
Efficacy and Clinical Outcomes of Levosimendan in E-CPR
Treatment of refractory cardiac arrest requiring cardiopulmonary resuscitation (CPR) may be augmented with Extracorporeal membrane oxygenation (ECMO) to re-establish perfusion in the absence of return of spontaneous circulation.
- Trial name
- ECPR (NCT05730907)
- Testing
- Levosimendan
- Where
- Qatar
- Volunteers
- 100 people
- Sponsor
- Hamad Medical Corporation
Extracorporeal Membrane Oxygenation Complication, Cardiopulmonary Arrest
Registry Study of Extracorporeal Cardiopulmonary Resuscitation (eCPR) in China
The data of patients undergo extracorporeal cardiopulmonary resuscitation (eCPR) will be collected and analyzed. This study will provide useful information about the indication, the start time and others to improve the outcome of…
- Trial name
- ECPR-China (NCT04956497)
- Testing
- extracorporeal membrane oxygenation (ECMO)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Peking Union Medical College Hospital
Extracorporeal Membrane Oxygenation Complication
Application of Early Physical Therapy Regimens in Patients With Veno-venos Extracorporeal Membrane Oxygenation
Promote early recovery through the application of early physiotherapy programs for VV-ECMO patients
- Trial name
- VV-ECMO (NCT04918498)
- Testing
- early physiotherapy programs, routine treatment
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Extracorporeal Membrane Oxygenation Complication, Coagulation Factor Deficiency
Evaluation of Coagulation Factors and Point-of-care Devices During Veno-venous ECMO Therapy
Hemorrhagic and thromboembolic complications are common in Veno-venous ECMO therapy. The aim of this study is to provide a detailed analysis of the activity of different coagulation factors and changes in functional coagulation…
- Trial name
- NCT03754868
- Testing
- Detailed coagulation monitoring
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Goettingen
Complication of Extracorporeal Membrane Oxygenation, Cerebral Microembolism
Cerebral Microemboli in Venoarterial ECMO Patients
Extracorporeal membrane oxygenation (ECMO) is progressively used in critically ill patients with cardiac or respiratory failure as a bridging option for potential organ recovery.
- Conditions
- Complication of Extracorporeal Membrane Oxygenation, Cerebral Microembolism, Cerebral Perfusion
- Trial name
- NCT02020759
- Testing
- Transcranial Doppler Ultrasound
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Critical Illness, Extracorporeal Membrane Oxygenation Complication
Does Extra-Corporeal Membrane Oxygenation Alter Antiinfectives Therapy Pharmacokinetics in Critically Ill Patients
Observational study Primary Objective: To study whether ECMO alters the PK of anti-infectives including voriconazole, posaconazole and caspofungin in critically ill patients on ECMO Secondary Objectives: Develop Population PK…
- Conditions
- Critical Illness, Extracorporeal Membrane Oxygenation Complication, Infection
- Trial name
- EAT-PK (NCT04674657)
- Testing
- blood drug concentration
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust