Clinical trials: Extracorporeal Membrane Oxygenation Complication, open to volunteers
Compartment Syndrome of Leg, Extracorporeal Membrane Oxygenation Complication
Continuous Compartment Pressure Monitoring for Compartment Syndrome in VA-ECMO Patients
Acute compartment syndrome (ACS) is a surgical emergency that can develop in patients on extracorporeal membrane oxygenation (ECMO).
- Conditions
- Compartment Syndrome of Leg, Extracorporeal Membrane Oxygenation Complication, Limb Ischemia, Limb Ischemia, Critical
- Trial name
- VA-ECMO (NCT05830721)
- Testing
- MY01 + Standard of Care, 14-Gauge Slit Catheter + Standard of Care, Standard of Care
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Johns Hopkins University
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Mechanical Ventilation Complication, Hypoxemia
Trial of Venovenous ECMO to De-Sedate, Extubate and Mobilise in Hypoxic Respiratory Failure
To determine whether a strategy of adding venovenous ECMO to mechanical ventilation, as compared to mechanical ventilation alone, increases the number of intensive care free days at day 60, in patients with moderate to severe…
- Conditions
- Mechanical Ventilation Complication, Hypoxemia, Acute Respiratory Distress Syndrome Due to COVID-19, COVID-19 Respiratory Infection
- Trial name
- REDEEM (NCT05562505)
- Testing
- Venovenous ECMO
- Where
- 7 sites in Australia, Germany
- Volunteers
- 140 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Extracorporeal Membrane Oxygenation Complication
Distal Perfusion Timing, Early or Conservative, to Prevent Limb Ischemia During Peripheral VA-ECMO
Peripheral VA-ECMO is widely used in refractory cardiogenic shock patients as a salvage therapy. In most cases, the femoral artery and vein are used for the vascular approach.
- Trial name
- DECIDE-ECMO (NCT05698628)
- Testing
- Distal perfusion catheterization
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Min-Seok Kim
Cardiogenic Shock, Extracorporeal Membrane Oxygenation
Individualized or Conventional Transfusion Strategies During Peripheral VA-ECMO
This multicenter randomized controlled trial compare two transfusion strategies of red blood cells transfusion in patients supported by veno-arterial extracorporeal membrane oxygenation for refractory cardiogenic shock.
- Conditions
- Cardiogenic Shock, Extracorporeal Membrane Oxygenation, Transfusion Related Complication, Anemia
- Trial name
- ICONE (NCT05699005)
- Testing
- Packed Red Blood Cells (PRBCs)
- Where
- 4 sites in France
- Volunteers
- 236 people
- Sponsor
- University Hospital, Lille
Septic Shock, Extracorporeal Membrane Oxygenation Complication
Study on the Efficacy and Timing of ECMO Therapy in Children With Refractory Septic Shock
Severe sepsis and septic shock remain the leading causes of child mortality worldwide. Sepsis is a complex process that ultimately leads to circulation disorders, organ perfusion abnormalities, capillary leakage, tissue hypoxia…
- Trial name
- NCT03948048
- Testing
- ECMO
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Children's Hospital of Fudan University
ExtraCorporeal Membrane Oxygenation (ECMO), Wound Complications
Closed Incision NPWT to Prevent Wound Complications Post-ECMO
Patients undergoing extracorporeal membrane oxygenation (ECMO) are at increased risk of wound complications at the vascular access site after decannulation. These complications may delay recovery and increase healthcare burden.
- Conditions
- ExtraCorporeal Membrane Oxygenation (ECMO), Wound Complications, Surgical Site Infection (SSI)
- Trial name
- PREVENT-ECMO (NCT07709546)
- Testing
- Prophylactic Closed-Incision Negative Pressure Wound Therapy, Standard Wound Dressing
- Volunteers
- 144 people
- Sponsor
- St. Antonius Hospital
Out-of-hospital Cardiac Arrest (OHCA), ECMO Treatment
Hypothermia Versus Normothermia After Extracorporeal Cardiopulmonary Resuscitation for Out-of-hospital Cardiac Arrest
The SAVE-J NEUROTHERM trial is a cluster randomized trial that evaluated and compared the mortality risk, neurological outcomes, and adverse events between patients who underwent hypothermia and those who underwent normothermia…
- Conditions
- Out-of-hospital Cardiac Arrest (OHCA), ECMO Treatment, Temperature, Post Cardiac Arrest Syndrome
- Trial name
- J-NEURO (NCT06776549)
- Testing
- Temperature control
- Where
- 29 sites in Japan
- Volunteers
- 468 people
- Sponsor
- Kagawa University
Cardiogenic Shock, Extracorporeal Life Support
Post-Surgery Extracorporeal Life Support
Extracorporeal Life Support (ECLS) may provide pulmonary and circulatory support for patients with acute heart failure refractory to conventional medical therapy.
- Conditions
- Cardiogenic Shock, Extracorporeal Life Support, Extracorporeal Membrane Oxygenation Complication, Post Cardiac Arrest Syndrome
- Trial name
- PC-ECLS (NCT04330651)
- Testing
- ECLS
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- University of Florence
Venoarterial Extracorporeal Membrane Oxygenation, Renal Replacement Therapy
Evaluation of Integrated Versus Parallel Connection for Renal Replacement Therapy in ECMO Patients
Extracorporeal membrane oxygenation (ECMO) is an extra-corporeal assistance used in case of respiratory or circulatory failure. In case of circulatory failure, ECMO is in the veno-arterial configuration (VA-ECMO).
- Conditions
- Venoarterial Extracorporeal Membrane Oxygenation, Renal Replacement Therapy, Acute Kidney Injury
- Trial name
- EPIC-ECMO (NCT06038162)
- Testing
- Parallel connection, Integrated connection
- Where
- 12 sites in France
- Volunteers
- 158 people
- Sponsor
- Hospices Civils de Lyon
Extracorporeal Membrane Oxygenation, Child, Only
ECMO Treatment of Children in China in the Past 10 Years
It is a cross-sectional study to summarize the extracorporeal membrane oxygenation （ECMO）treatment in children in China.
- Trial name
- NCT04709432
- Testing
- ECMO
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Children's Hospital of Fudan University
Extracorporeal Membrane Oxygenation Complication
Anticoagulation-free VV ECMO for Acute Respiratory Failure
Currently international experts recommend therapeutic anticoagulation for veno-venous extracorporeal membrane oxygenation (VV-ECMO).
- Trial name
- A-FREE ECMO (NCT04273607)
- Testing
- Subcutaneous Heparin
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Damian Ratano
Extracorporeal Membrane Oxygenation Complication
EUROSETS ECMO Study in Clinical Extracorporeal Life Support Applications
This is a prospective single-center study designed for evaluation of safety and performance of the Conformitè Europëenne (CE)-marked EUROSETS ECMOLIFE SYSTEM, composed by: ECMOLIFE console, ECMO TUBING SET, ECMO OXYGENATOR and…
- Trial name
- NCT05163925
- Testing
- Eurosets ECMO Life System
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Eurosets S.r.l.
Lung Transplantation, Extracorporeal Membrane Oxygenation (ECMO)
Prospective Observational Pilot Study of LMWH Versus UFH as ECMO Anticoagulation in Lung Transplantation
The aim of this observational pilot study is to evaluate the effectiveness and safety of low-molecular-weight heparin (LMWH) compared to unfractionated heparin (UFH) as anticoagulation in perioperative ECMO during bilateral lung…
- Conditions
- Lung Transplantation, Extracorporeal Membrane Oxygenation (ECMO), Anticoagulants and Bleeding Disorders
- Trial name
- LUX-ET-LT (NCT06868823)
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- University Hospital, Motol
Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation Complication
"Continuous Positive Airway Pressure on Venovenous extracorporeaL Membrane Oxygenation for Acute respIratory Distress syndrOme"
The CALMDOWN trial is a prospective, open-label, multicenter, comparative, controlled trial randomizing patients who received near apneic ventilation vs usual care on ECMO (ultra-protective lung ventilation).
- Trial name
- CALMDOWN (NCT06814340)
- Testing
- ECMO + near apneic ventilation, ECMO + ultra-protective lung ventilation
- Where
- 11 sites in France
- Volunteers
- 280 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
ExtraCorporeal Life Support (ECLS), Wound Infection
Investigating the Impact of Cold Atmospheric Plasma Treatment on Wound Healing at Cannulation Sites in Patients Following Extracorporeal Life Support
This study aims to evaluate a new wound treatment called cold atmospheric plasma (CAP) for patients receiving extracorporeal life support (ECLS).
- Conditions
- ExtraCorporeal Life Support (ECLS), Wound Infection, Surgical Site Infection, Delayed Wound Healing
- Trial name
- NCT07501897
- Testing
- Cold Atmospheric Plasma (CAP) Therapy, Standard wound care
- Where
- Taiwan
- Volunteers
- 65 people
- Sponsor
- National Taiwan University Hospital
Cardiogenic Shock, Post-cardiac Surgery
Pharmacokinetics and Modelling of Beta-Lactam in ECMO-VA Patients
The use of antibiotic therapy is common in intensive care units and primarily involves beta-lactams. Its optimal implementation is made difficult by the pharmacokinetic changes inherent in critically ill patients.
- Conditions
- Cardiogenic Shock, Post-cardiac Surgery, Cardiac Arrest, Extracorporeal Membrane Oxygenation Complication
- Trial name
- KAMELOT (NCT06338345)
- Testing
- Therapeutic drug monitoring of beta-lactam
- Where
- 5 sites in France
- Volunteers
- 225 people
- Sponsor
- University Hospital, Grenoble
Acute Kidney Injury
The AminoECMO Pilot Trial
Acute kidney injury (AKI) is a serious problem for patients in intensive care, especially those on life-support machines like ECMO (which helps the heart and lungs).
- Trial name
- AminoECMO (NCT07438262)
- Testing
- Synthamin-17 (10% amino acid solution)
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Cardiogenic Shock, Extracorporeal Membrane Oxygenation Complication
Cangrelor on Top of anticoagUlation in Patients With myocaRdial Infarction-related Cardiogenic Shock/Cardiac Arrest receiVIng VA-ECMO
The SURVIVE trial aims to test whether using an anti-thrombotic regimen involving cangrelor can reduce bleeding risk while maintaining effective antithrombotic effects in patients on VA-ECMO due to cardiogenic shock (CS)/ cardiac…
- Conditions
- Cardiogenic Shock, Extracorporeal Membrane Oxygenation Complication, Platelet Dysfunction
- Trial name
- SURVIVE (NCT06792643)
- Testing
- Cangrelor
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS San Raffaele
Extracorporeal Membrane Oxygenation Complication
Use of Nafamostat Mesilate for Anticoagulation in Patients With ECMO
The purpose of this study is to evaluate the effectiveness and safety of nafamostat mesilate compared with unfractionated heparin for anticoagulation in patients with ECMO after cardiac surgery.
- Trial name
- NCT06276010
- Testing
- nafamostat mesilate, unfractionated heparin group
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Xiaotong Hou