Clinical trials: Extracorporeal Membrane Oxygenation Support
Drug Effect
Pharmacokinetics of Antibiotics During Extracorporeal Membrane Oxygenation (ECMO) Support
This study will measure plasma concentrations of piperacillin-tazobactam and cefazolin in pediatric patients supported with extracorporeal membrane oxygenation (ECMO) aiming to better understand the pharmacokinetics of these…
- Trial name
- NCT03922451
- Testing
- piperacillin-tazobactam, Cefazolin
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Boston Children's Hospital
COVID-19 Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation Complication
Correlation Between PaCO2 and Respiratory Effort in Patients With COVID-19 With Extracorporeal Membrane Oxygenation
Excessive respiratory effort may cause self-inflicted lung injury (SILI) and inspiratory muscle injuries , stimulate desynchronization between the patient and ventilator , and worsen the perfusion of extrapulmonary organs .
- Conditions
- COVID-19 Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation Complication, Respiratory Effort-Related Arousal
- Trial name
- NCT05882474
- Testing
- PaCO2
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Peking Union Medical College Hospital
Cardiogenic Shock, Renal Replacement Therapy
REnal reCOVery After ECMO for Cardiogenic Shock (RECOVECMO)
This retrospective study assesses long term renal outcome in patients having suffered medical or post cardiotomy refractory cardiogenic shock requiring renal replacement therapy (RRT) concomitant with veno-arterial extracorporeal…
- Conditions
- Cardiogenic Shock, Renal Replacement Therapy, Venoarterial Extracorporeal Membrane Oxygenation
- Trial name
- RECOVECMO (NCT05788211)
- Testing
- standard of care
- Where
- France
- Volunteers
- 93 people
- Sponsor
- University Hospital, Bordeaux
Cardiogenic Shock, End-stage Heart Failure
ECLS Versus IMPELLA™ as Bridge to LVAD (ECI-BLAD)
In this retrospective observational multicenter study the authors tested the hypothesis that the use of IMPELLA™ pump as bridge to bridge, by giving the opportunity of active rehabilitation, should improve patient's outcomes…
- Trial name
- ECI-BLAD (NCT04480151)
- Testing
- standard of care
- Where
- 5 sites in France
- Volunteers
- 92 people
- Sponsor
- University Hospital, Bordeaux
ARDS, Multi-organ Failure
Biomarker of Lung Injury in ARDS Patients Receiving ECMO Support
The goal of this project is to find a marker expression that the investigators can use to trace symptom progression and develop a more efficient therapy to enhance ARDS patient survival rate and better post-ICU life quality.
- Trial name
- ARDS (NCT01967602)
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- National Taiwan University Hospital
Invasive Candidiasis
Pharmacokinetics of Micafungin in Children on Extracorporeal Membrane Oxygenation
Determine proper dosing of micafungin in children supported with extracorporeal membrane oxygenation (ECMO).
- Trial name
- NCT01666769
- Testing
- Micafungin
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Kevin Watt
Out-of-hospital Cardiac Arrest (OHCA)
Emergency Total ECLS vs Standard ACLS With ECMO Bailout for Survival in Refractory OHCA
The goal of the clinical trial is to learn if early extracorporeal life support ( ECLS ) will save more out-of-hospital cardiac arrest ( OHCA ) patients with good neurological outcome.
- Trial name
- ECLS-OHCA (NCT06692075)
- Testing
- extracorporeal life support, standard ACLS
- Where
- Taiwan
- Volunteers
- 332 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Acute Coronary Syndrome, Cardiogenic Shock
Left Ventricular Physiological Effects of Veno-Arterial Extracorporeal Membrane Oxygenation Support During Cardiogenic Shock
A Clinical Events Committee (CEC) will include Cardiac Surgery Professor and chief of cardiac surgery Rose Kelly MD, Professor of Medicine Ganesh Raveendran MD at the University of Minnesota who is the direction of Interventional…
- Trial name
- NCT05426083
- Testing
- Physiological Assessment
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Minnesota
Cardiac Arrest
Emergency Cardiopulmonary Bypass for Cardiac Arrest
Cardiac arrest ist associated with a very poor prognosis. Even though resuscitation algorithms and postcardiac arrest care have been improved there is an urgent need for measures leading to a higher survival rate.
- Trial name
- ECPB4OHCA (NCT01605409)
- Testing
- Emergency cardiopulmonary bypass under ongoing CPR, Standard ACLS
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Vienna
Drug Monitoring of Antiinfectives in Critically Ill Patients Receiving Extracorporeal Life Support
Drug Monitoring in Critically Ill Patients During Extracorporeal Life Support
About 70% of critically ill patients require antiinfective therapy. Optimal antibiotic dosing is key to improve patient survival, reduce toxic effects and minimise the emergence of bacterial resistance.
- Trial name
- NCT04127305
- Testing
- No Intervention
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Goethe University
COVID-19 Pneumonia, Extracorporeal Membrane Oxygenation Complication
Safety and Feasibility of Percutaneous Dilatational Tracheostomy in Patients With Severe COVID-19 Supported by ECMO
COVID-19 pandemic has presented the global health care systems with unprecedented and unexpected challenges. The clinical spectrum of COVID-19 disease varies from mild, at times asymptomatic, to severe life-threatening multiple…
- Conditions
- COVID-19 Pneumonia, Extracorporeal Membrane Oxygenation Complication, Tracheostomy Complication, Respiratory Failure
- Trial name
- NCT05045885
- Where
- Qatar
- Volunteers
- 32 people
- Sponsor
- Hamad Medical Corporation
Brain-injured Patients on Extracorporeal Life Support
Multimodal Assessment of the Neurological Prognosis of Patients With Brain Lesions on ExtraCorporeal Life Support
It seems of the greatest importance to evaluate the neurological prognosis of patients with brain lesions after cardiorespiratory arrest or circulatory failure requiring circulatory assistance.
- Trial name
- NeuroECMO (NCT03633981)
- Testing
- clinical examinations, neurological assessment when a neurological event occurs, mortality assessment
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Cardiogenic Shock, Extracorporeal Membrane Oxygenation Complication
Cangrelor on Top of anticoagUlation in Patients With myocaRdial Infarction-related Cardiogenic Shock/Cardiac Arrest receiVIng VA-ECMO
The SURVIVE trial aims to test whether using an anti-thrombotic regimen involving cangrelor can reduce bleeding risk while maintaining effective antithrombotic effects in patients on VA-ECMO due to cardiogenic shock (CS)/ cardiac…
- Conditions
- Cardiogenic Shock, Extracorporeal Membrane Oxygenation Complication, Platelet Dysfunction
- Trial name
- SURVIVE (NCT06792643)
- Testing
- Cangrelor
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS San Raffaele
Critically Ill, Acute Respiratory Failure
The EXCEL Registry of Patients Requiring ECMO
ECMO is associated with significant costs, risks and requires specialist training and expertise. EXCEL is a novel, high-quality, detailed prospective registry of patients requiring ECMO in Australia and New Zealand.
- Conditions
- Critically Ill, Acute Respiratory Failure, Acute Heart Failure, Cardiac Arrest
- Trial name
- NCT03793257
- Where
- 29 sites in Australia, New Zealand
- Volunteers
- 3,000 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Pulmonary Embolism and Thrombosis, Extracorporeal Membrane Oxygenation
Mechanical Respiratory/circulatory Support in Patients with Pulmonary Thrombectomy
Pulmonary embolism (PE) results from embolization of venous thrombi in the branches of the pulmonary arteries. Although anticoagulation is usually the preferred method of treatment, patients with high-risk and/or…
- Conditions
- Pulmonary Embolism and Thrombosis, Extracorporeal Membrane Oxygenation, Percutaneous Pulmonary Thrombectomy
- Trial name
- NCT06525480
- Testing
- Percutaneous pulmonary thrombectomy
- Where
- Spain
- Volunteers
- 77 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Cardiogenic Shock
Evaluation of Oxiris Membrane as a Treatment for Ischemia-reperfusion Syndrome in Cardiogenic Shock Treated With Extracorporeal Life Support (ECMO/ECLS): A Randomized Pilot Study ECMORIX
The Oxiris membrane is an AN-69 membrane whose surface is treated with polyethyleneimine (PEI) grafted with heparin. This property allows the removal of lipopolysaccharide and cytokines from the blood.
- Trial name
- ECMORIX (NCT04886180)
- Testing
- Oxiris membrane, Prismaflex membrane, Blood tests
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
VA-ECMO for Postcardiotomy Cardiogenic Shock
Timing of VA-ECMO Support During or After Cardiac Surgery
Some patients develop severe heart failure during or after cardiac surgery and require temporary support for circulation and oxygenation.
- Trial name
- NCT07873034
- Where
- Slovakia
- Volunteers
- 128 people
- Sponsor
- National Institute of Cardiovascular Diseases, Slovakia
Cardiogenic Shock
Pharmacokinetic Modelling of Levosimendan in Adults
In the light of current knowledge of the PK of levosimendan and its use in ECMO weaning, deciphering the mechanisms of inter-individual variability in exposure and response to levosimendan appears essential in order to better…
- Trial name
- MILADECMO (NCT06993584)
- Testing
- Adult patients in cardiogenic shock
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Rouen
Coronary Artery Disease, Heart Failure
PIONEER Trial:Hemodynamic Support With ECMO and IABP in Elective Complex High-risk PCI
To determine whether hemodynamic support combining VA-ECMO with IABP could mitigate the rates of Major Adverse Cardiovascular and Cerebrovascular Events (MACCEs), compared with IABP support alone, in patients undergoing elective…
- Trial name
- NCT04045873
- Testing
- extracorporeal membrane oxygenation
- Volunteers
- 306 people
- Sponsor
- Xijing Hospital