Clinical trials: Extraction, Tooth
Alveolar Bone Loss
Ridge Preservation Following Tooth Extraction Using Two Mineralized Cancellous Bone Allografts
The study is a 2-arm, parallel-design, randomized, prospective clinical trial designed to examine histologic wound healing following ridge preservation using bone allograft that has been prepared by either freeze-drying or via a…
- Trial name
- NCT02515058
- Testing
- PUROS (Ridge Preservation bone grafting surgery), FDBA (Ridge Preservation bone grafting surgery)
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Jaw, Edentulous, Partially
Multicenter Study to Evaluate the Clinical Outcome of PrimeTaper EV Implant in Single Tooth Restorations
The purpose of this study is to evaluate the clinical outcome of implant survival of the PrimeTaper EV implant in single tooth restorations 1 year after permanent restoration.
- Trial name
- NCT05315414
- Testing
- PrimeTaper EV implant
- Where
- 5 sites in United States, Belgium and 3 more
- Volunteers
- 138 people
- Sponsor
- Dentsply Sirona Implants and Consumables
Oral Hygiene
Clinical Study to Investigate the Tooth Stain Removal Efficacy of Two Experimental Toothpastes Compared to a Standard Toothpaste When Used Twice Daily for 8 Weeks
The aim of this study is to investigate the stain removal efficacy of 2 experimental anti-dentin hypersensitivity (DH) dentifrices with four and eight weeks twice daily use.
- Trial name
- NCT05459558
- Testing
- Experimental Dentifrice 1, Experimental Dentifrice 2, Reference Dentifrice
- Where
- United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- HALEON
Tooth Loss
Bone Tissue Engineering Using Autologous Bone Repair Cell (BRC) Therapy for Sinus Floor Bone Augmentation
The purpose of this research is to determine if one's own bone marrow tissue can help regenerate (grow) bone in the area of the jaw where an implant will be placed.
- Trial name
- NCT00980278
- Testing
- Sinus lift augmentation and dental implant, Aastrom BRCs
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Michigan
Impacted Third Molar Tooth, Temporomandibular Disorder
Assessing a New Jaw Support Device During Third Molar Extractions
During mandibular 3rd molar (wisdom tooth) extractions, when a downward force is placed on the patient's jaw, the patient must tense his/her jaw muscles to oppose it.
- Trial name
- NCT03975920
- Testing
- The Restful Jaw Device
- Where
- 4 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Malocclusion
Effect of Cyclic Loading (Vibration) on Orthodontic Tooth Movement
To gather data indicating whether or not the OrthoAccel device speeds tooth movement in people who use orthodontics (braces).
- Trial name
- NCT00830947
- Testing
- OrthoAccel Device
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- OrthoAccel Technologies Inc.
Alveolar Ridge Preservation, Tooth Extraction
A 14 Weeks Longitudinal Study to Investigate the Effect of Leukocyte- Platelet Rich Fibrin Plug on the Quality of the Newly Formed Bone in Ridge Preservation Procedure Following a Tooth Extraction. It is a Clinical, Radiographic and Histomorphometric Study.
This 14 weeks longitudinal study will be conducted from March 2018 to June 2020, with a 40 participants. No subjects has received placebo medication at any point in the research procedures.
- Trial name
- NCT03487718
- Testing
- Leukocyte platelet rich fibrin plug + d-PTFE membrane, d-PTFE membrane
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Firas Al Yafi
Alveolar Bone Loss
Treatment of Alveolar Bone Defects Using Aastrom Biosciences Autologous Tissue Repair Cell Therapy
The purpose of this research is to determine if a subject's own bone marrow tissue can help regenerate bone in the area of his/her jaw where a tooth has been removed using Tissue Repair Cell (TRC) Therapy.
- Trial name
- NCT00755911
- Testing
- Tissue Repair Cells (TRC), Control
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Michigan
Acute Pain
A Study to Assess Efficacy and Tolerability of Ketoprofen 40 mg Granules vs Placebo
Primary objective: To assess the efficacy of OKITASK® 40 mg granules versus Placebo in patients with acute pain syndrome after removal of one molar tooth by comparing AUC0-6h of posttreatment pain profile measured by VAS.
- Trial name
- KSL0117 (NCT03836807)
- Testing
- OKITASK®
- Where
- 3 sites in Russia
- Volunteers
- 70 people
- Sponsor
- Dompé Farmaceutici S.p.A
Tooth Extraction
De-Implementing Opioids for Dental Extractions
The overarching goal of this project is to de-implement the reliance on opioid analgesics and to implement reliance on non-opioid analgesics to manage postoperative pain following dental extractions.
- Trial name
- DIODE (NCT03584789)
- Testing
- Clinical Decision Support, Patient education
- Where
- United States
- Volunteers
- 5,722 people
- Sponsor
- HealthPartners Institute
Tooth Loss
Healing Dynamics in Human Extraction Sockets Grafted With Bio-Oss Collagen®
The purpose of this study is to clinically, radiographically and histologically evaluate the healing sequence of post-extraction sockets grafted with Bio-Oss Collagen® at 3, 6 and 9 months following tooth extraction in…
- Trial name
- NCT03659617
- Testing
- xenograft (BioOss Collagen)
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Pain
Analgesic Effect of Different Combinations of Dexketoprofen Trometamol With Tramadol Hydrochloride in a Model of Moderate to Severe Pain
The purpose of this study is to evaluate the analgesic efficacy of Dexketoprofen Trometamol and Tramadol Hydrochloride given in combinations and the analgesic efficacy of each single component in comparison to placebo on moderate…
- Trial name
- DEX-TRA 02 (NCT01307020)
- Testing
- Dexketoprofen Trometamol, Tramadol Hydrochloride, Ibuprofen
- Where
- 16 sites in Germany, Hungary and 4 more
- Volunteers
- 745 people
- Sponsor
- Menarini Group
Acute Pain
Tramadol/Diclofenac Fixed-dose Combination Phase III Trial in Acute Pain After Third Molar Extraction
This study evaluated a new drug fixed-dose combination tablet (FDC) called tramadol/diclofenac at two different strengths (fixed doses of 25 milligrams [mg] of tramadol and of diclofenac or of 50 mg each).
- Trial name
- NCT03714672
- Testing
- Tramadol/Diclofenac 50/50, Tramadol/Diclofenac 25/25, Tramadol 50
- Where
- 8 sites in Mexico
- Volunteers
- 1,151 people
- Sponsor
- Grünenthal GmbH
Alveolar Bone Loss
Ridge Preservation Following Tooth Extraction Using Porcine and Bovine Xenograft Materials
The study is a two-arm, parallel-design, randomized, prospective clinical trial designed to examine histologic wound healing following ridge preservation using bovine xenograft and porcine xenograft materials.This protocol…
- Trial name
- NCT02802319
- Testing
- Porcine Xenograft (Zcore), Bovine Xenograft (Bio-Oss)
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Dental Anxiety
Augmented Reality Distraction for Reducing Pain in Pediatric Dental Procedures
This randomized controlled trial evaluates the effectiveness of augmented reality (AR) as a distraction technique to reduce procedural pain and anxiety in children aged 6-10 undergoing primary tooth extraction.
- Trial name
- AR (NCT06954883)
- Testing
- Augmented Reality Distraction, Standard Care (Tell-Show-Do Technique)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Tooth Extraction
Histological Comparison of Ridge Preservation Using Mineralized FDBA Alone Versus a Combined Mineralized-Demineralized Freeze Dried Bone Allograft
This entire protocol involves procedures that are standard care. The purpose of the research is to evaluate whether there are any differences in new bone formation following tooth extraction and grafting of the extraction socket…
- Trial name
- NCT01924390
- Testing
- Mineralized freeze-dried bone allograft alone, Combination of Mineralized and demineralized freeze-dried bone allograft alone
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Jaw, Edentulous, Partially
Study to Compare Survival for ASTRA TECH Implant System, OsseoSpeed™ Implants Following Immediate Loading in Extraction Sockets Versus Immediate Loading in Healed Ridges
The purpose of this study is to evaluate survival for ASTRA TECH Implant System, OsseoSpeed™ implants following immediate loading in extraction sockets versus immediate loading in healed ridges.
- Trial name
- NCT00710944
- Testing
- ASTRA TECH Implant System, OsseoSpeed™
- Where
- 4 sites in United States, Belgium and 2 more
- Volunteers
- 132 people
- Sponsor
- Dentsply Sirona Implants and Consumables
Gingivitis, Dental Plaque
A Clinical Study Investigating the Effects of a Dentifrice Containing 67% Sodium Bicarbonate When Used Twice Daily for 12 Weeks on Gingivitis Treatment and Plaque Removal
The main goal of this study is to evaluate and compare the efficacy of an on-market dentifrice containing 67 percent (%) sodium bicarbonate and 0.31% sodium fluoride to a reference regular fluoride dentifrice on treating gingival…
- Trial name
- NCT05654662
- Testing
- Corsodyl Original Dentifrice, Colgate Cavity Protection Dentifrice
- Where
- United Kingdom
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- HALEON
Dry Socket
Impact of Treatment With ALVEOGYL in Patients With Post-extraction Dry Socket
Alveogyl (Septodont, Saint-Maur-des-Fossés - France) is a Medical Device used as dressing in case of dry socket. ALVE study is a clinical investigation measuring Alveogyl performance and safety in patients with post-extraction…
- Trial name
- NCT05536115
- Testing
- Alveogyl
- Where
- 16 sites in France, India
- Volunteers
- 120 people
- Sponsor
- Septodont
Loss of Teeth Due to Extraction
Evaluation of Healing at Molar Extraction Sites With and Without Ridge Preservation
Following tooth extraction ridge preservation procedure have been suggested to limit bone resorptive dimensional changes to facilitate prospective implant placement.
- Trial name
- NCT02543398
- Testing
- Ridge preservation
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio