Clinical trials: Extubation, open to volunteers
Postoperative Respiratory Failure, Extubation Failure
Assessment of Reintubation Risk Using Multiple Parameters in Postoperative Intensive Care Unit Patients
This prospective, non-interventional observational study will evaluate the risk of reintubation in adult postoperative patients admitted to the intensive care unit after major surgery.
- Conditions
- Postoperative Respiratory Failure, Extubation Failure, Lung Ultrasonography Score, Diaphragm Thickness
- Trial name
- NCT07672106
- Where
- Turkey (Türkiye)
- Volunteers
- 600 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Congenital Heart Disease
HFNC vs NIPPV Following Extubation
This study has the goal to determine the best method of respiratory support following extubation after cardiac surgery (CS). After cardiac surgery for Congenital Heart Disease (CHD), patients remain intubated until the cardiac…
- Trial name
- NCT05869825
- Testing
- High Flow Nasal Canula following extubation, Non-Invasive Positive Pressure Ventilation following extubation
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Emory University
Ventilator Weaning
Instrumental Respiratory Physiotherapy in Difficult-to-wean ICU Patients
Difficult ventilatory weaning is associated with a 20% mortality rate. 40% of these patients will develop intensive care unit (ICU)-acquired neuromyopathy, associated with reduced cough strength and a 4-fold increase in the risk…
- Trial name
- PHYSIO WEAN (NCT06499389)
- Testing
- Systematic and early intensive instrumental respiratory physiotherapy for patients undergoing difficult ventilatory weaning, Protocolized standard-of-care respiratory physiotherapy
- Where
- 3 sites in France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Premature, Respiratory Distress Syndrome
Post-extubation Use RAM Cannula Versus Short Binasal Prong Interfaces in Preterm Infants
Nowadays, the use of non-invasive ventilation for preterm infants in the NICU has increased to avoid complications associated with prolonged endotracheal intubation.
- Conditions
- Premature, Respiratory Distress Syndrome, Extubation
- Trial name
- NCT07113535
- Testing
- RAM cannula, Short binasal prong
- Where
- Saudi Arabia
- Volunteers
- 90 people
- Sponsor
- Ministry of Health, Saudi Arabia
Positive Pressure Extubation Techniques, Negative Pressure Extubation Techniques
Positive- vs Negative-Pressure Extubation in High-Risk Patients
In the intensive care unit (ICU), weaning from mechanical ventilation and extubation are critical clinical goals. Successful extubation not only significantly shortens mechanical ventilation duration but also reduces the…
- Conditions
- Positive Pressure Extubation Techniques, Negative Pressure Extubation Techniques, High-risk Patients Prone to Extubation Failure
- Trial name
- NCT07829627
- Testing
- Positive-pressure extubation, Negative-pressure extubation
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Shanghai Zhongshan Hospital
Respiratory Distress Syndrome (RDS), PreTerm Neonate
Breathing Patterns in Infants Before and After Extubation
The primary objective of this study is to compare work of breathing indices before and after extubation in intubated premature infants admitted to the Christiana Care Neonatal Intensive Care Unit.
- Trial name
- NCT07542301
- Testing
- Observation
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Christiana Care Health Services
Tracheal Extubation, Cough
Remifentanil Versus Remifentanil-Lidocaine for Tracheal Extubation After Thyroidectomy
This randomized, double-blind clinical trial will compare the effects of remifentanil alone and remifentanil combined with intravenous lidocaine on the quality of tracheal extubation in adult patients undergoing elective…
- Trial name
- NCT07857356
- Testing
- remifentanil, Lidocaine %2 ampoule
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Pamukkale University
Airway Extubation, Weaning Mechanical Ventilation
One-Hour Positive Pressure Ventilation After a Pressure Support Spontaneous Breathing Trial
This is a randomized, open, multicenter, pragmatic, adaptive clinical trial with intention-to-treat analysis. The study will compare two weaning strategies from mechanical ventilation in critically ill patients admitted to…
- Conditions
- Airway Extubation, Weaning Mechanical Ventilation, Extubation Failure
- Trial name
- NCT07324460
- Testing
- One-hour positive pressure ventilation, Immediate extubation
- Volunteers
- 4,000 people
- Sponsor
- Hospital do Coracao
Systolic Heart Failure, Respiratory Failure
A Trial Comparing High-Flow Nasal Cannula Versus Noninvasive Ventilation on Reintubation and Post-Extubation Respiratory Failure in High-Risk Patients With Systolic Heart Failure
This prospective, open-label randomized controlled pilot trial will enroll participants at the Yale New Haven Hospital. Patients with systolic heart failure, defined as an ejection fraction ≤40%, who require invasive mechanical…
- Trial name
- EXTUBATE-HF (NCT06671015)
- Testing
- Airvo 3
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Yale University
Heart Defects, Congenital, Intensive Care Units, Pediatric
High-Flow Nasal Cannula vs. NIV After Extubation in Children Undergoing Heart Surgery
High-Flow Nasal Cannula vs. NIV After Extubation in Children Undergoing Heart Surgery
- Conditions
- Heart Defects, Congenital, Intensive Care Units, Pediatric, Respiration, Artificial, Extubation
- Trial name
- NCT07059689
- Testing
- High Flow Nasal Cannula (HFNC), Non-Invasive Ventilation (NIV)
- Where
- Indonesia
- Volunteers
- 114 people
- Sponsor
- Universitas Indonesia