Clinical trials: Extubation Failure
Extubation Failure
Validation of an Effort-Based Cough Peak Flow Algorithm to Predict Extubation Outcomes
This study aims to prospectively validate the diagnostic accuracy of an effort-stratified Cough Peak Flow (CPF) decision algorithm for predicting extubation failure, maintaining strict blinding of the clinical team.
- Trial name
- NCT07737483
- Testing
- Observational measurement of Cough Peak Flow and Tidal Volume
- Volunteers
- 150 people
- Sponsor
- Hospital H+ Queretaro
Prematurity, Mechanical Ventilation
Comparison of Two Flow Rates of HHHFNC to Prevent Extubation Failure in Preterm Infants
This is a randomized controlled trial (RCT) to evaluate the influence of two flow rates (6 liter/min versus 3 liter/min) of Heated-Humidified High-Flow-Nasal-Cannula (HHHFNC) on rates of extubation failure in mechanically…
- Trial name
- NCT02681315
- Testing
- HHHFNC 6 liter minute, HHHFNC 3 liters/min
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Mansoura University Children Hospital
Mechanical Ventilation, Weaning From Mechanical Ventilation
Temporal Change in Parasternal Thickening Fraction as a Predictor for Weaning
optimal time to liberate from mechanical ventilation is highly prioritized since improper extubation time lead to serious consequences
- Conditions
- Mechanical Ventilation, Weaning From Mechanical Ventilation, Weaning Failure
- Trial name
- NCT07083128
- Testing
- Parasternal intercostal thickening
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Cairo University
Weaning From Mechanical Ventilation
Physiological Effects of Non-invasive Mechanical Ventilation Versus High-flow Nasal Cannula in Critically Ill Patients at High Risk of Extubation Failure
Weaning is one of the most complex challenges in mechanically ventilated patients. Increased work of breathing after extubation would play a central role in weaning failure.
- Trial name
- NCT05012696
- Testing
- Non-invasive ventilation (NIV), High-flow nasal cannula
- Where
- Chile
- Volunteers
- 22 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Ventilated Patient in Intensive Care, Failure of Extubation
The Rapid Shallow Breathing Index (RSBI) is a Widely Used Predictor for Weaning Patients From Mechanical Ventilation This Study Aims to Determine the Predictive Value of RSBI Measurements for Extubation Success in Mechanically Ventilated ICU Patients
Early extubation in ICU patients is crucial for reducing complications of prolonged ventilation, including morbidity and mortality.
- Trial name
- NCT07467265
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Respiratory Insufficiency
Incidence and Risk Factors of Extubation Failure in Pediatric Resuscitation
The failure of extubation in pediatric resuscitation is most often described as the need for reintubation within 48 hours after extubation.
- Trial name
- NCT03129802
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Strasbourg, France
Mechanical Ventilation
Prediction of Extubation Failure: A Multicenter Prospective Observational Study
The investigators intend to collect several variables to predict extubation failure among patients who successfully complete a spontaneous breathing trial, and then develop a scale using simple bedside indicators to predict…
- Trial name
- NCT05069441
- Where
- China
- Volunteers
- 2,604 people
- Sponsor
- Chongqing Medical University
Muscle Weakness, Renal Failure
Predictors of Respiratory Failure Following Extubation in the SICU
Respiratory failure following extubation causes significant morbidity and increases mortality in teh surgical intensive care unit (SICU). However the causes of respiratory failure following extubation remain poorly understood.
- Conditions
- Muscle Weakness, Renal Failure, Respiratory Comorbidities
- Trial name
- NCT01967056
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- Massachusetts General Hospital
Extubation Failure in Neonates
Noninvasive High Frequency Oscillatory Ventilation Versus Nasal Intermittent Mandatory Ventilation After Extubation in Neonates
The goal of this clinical trial is to learn which breathing support works better after removing a newborn's breathing tube. Researchers will study newborns born at 26 weeks of gestation or later.
- Trial name
- NOV-A (NCT07836166)
- Testing
- Noninvasive High Frequency Oscillatory Ventilation, Nasal Intermittent Mandatory Ventilation
- Where
- Pakistan
- Volunteers
- 172 people
- Sponsor
- Aga Khan University
Mechanical Ventilation Complication, Acute Respiratory Failure
Non-invasive Respiratory Monitoring During SBT
Spontaneous breathing trials (SBTs) assess readiness for extubation, yet the use of conventional parameters used to establish weaning success may be elusive, especially in high-risk patients.
- Conditions
- Mechanical Ventilation Complication, Acute Respiratory Failure, Re-intubation Rate
- Trial name
- NCT05295186
- Where
- 2 sites in Italy
- Volunteers
- 238 people
- Sponsor
- University of Bari
Mechanical Ventilation Complication, Weaning Failure
NIV Versus HFO Versus Standard Therapy Immediately After Weaning From Mechanical Ventilation in ARDS Patients
The weaning failure is a paramount challenge when aggressive discontinuation of respiratory support in ARDS. The aim of the study is to improve weaning safety and efficacy by a transient postextubation non-invasive respiratory…
- Conditions
- Mechanical Ventilation Complication, Weaning Failure, Acute Respiratory Distress Syndrome, High-flow Oxygenation
- Trial name
- NCT06332768
- Testing
- Respiratory support
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Northern State Medical University
Central Nervous System Diseases, Acute Respiratory Failure
Clinical Evaluation of Swallowing Disorders as a Predictor of Extubation Failure
Patients with failed extubation stay significantly longer in an intensive care unit (ICU) and have a higher mortality rate, than those intubated successfully.
- Conditions
- Central Nervous System Diseases, Acute Respiratory Failure, Shock, Heart Failure
- Trial name
- EVAKIN (NCT00780078)
- Testing
- extubation
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Mechanical Ventilator Weaning, Predictive Value of Tests
ICU Predictive Score of WEaning Success in Patients At Risk of Extubation Failure
Observational study in two medical-surgical intensive care units of the Clermont-Ferrand University Hospital to develop a composite score for prediction of 72h-extubation failure in patients at risk of extubation failure.
- Conditions
- Mechanical Ventilator Weaning, Predictive Value of Tests, Ventilator Weaning, Airway Extubation
- Trial name
- I-SWEAR (NCT05114551)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Clermont-Ferrand
Post Extubation Stridor, Upper Airway Ultrasonography
Role of Upper Airway Ultrasound in Predicting Weaning Outcomes in Mechanically Ventilated Patients
The goal of the study is to know the role of upper airway ultrasound in predicting weaning outcomes in mechanically ventilated patients , and the question is ,Is it the best to use or the conventional criteria of weaning
- Conditions
- Post Extubation Stridor, Upper Airway Ultrasonography, Upper Airway Edema
- Trial name
- NCT07580742
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Fayoum University
Dexmedetomidine, Midazolam
Prospective, Randomized, Open Label Controlled Trial To Evaluate The Safety And Efficacy Of Dexmedetomidine Use Beyond 24 Hours Compared With Midazolam In Children Admitted To Pediatric Intensive Care Unit at King Abdullah Specialist Children Hospital- Ministry of National Guard Health Affairs.
Study will be conducted in Pediatric Intensive Care Unit (PICU) in King Abdullah Specialist Children Hospital (KASCH), National Guard Health Affairs, Riyadh, Saudi Arabia.
- Conditions
- Dexmedetomidine, Midazolam, Withdrawal Symptoms, Failure of Extubation
- Trial name
- PROMISE (NCT05485519)
- Testing
- Dexmedetomidine, Midazolam
- Where
- Saudi Arabia
- Volunteers
- 430 people
- Sponsor
- King Abdullah International Medical Research Center
Acute Respiratory Failure, Ventilator Weaning Assessment
Electrical Impedance Tomography-derived Flow Index During Spontaneous Breathing Trial Stratifies the Risk of Reintubation Within 48 h After Extubation
Accurate prediction of readiness to liberate patients from mechanical ventilation remains challenging. Conventional indices such as the rapid shallow breathing index (RSBI) and maximal inspiratory pressure (MIP) often miss early…
- Trial name
- EIT-FI Weaning (NCT06876792)
- Testing
- electrical impedance tomography
- Where
- 3 sites in China
- Volunteers
- 150 people
- Sponsor
- Ruijin Hospital
Ventilatory Failure, Hypoxemic Respiratory Failure
PREdicting Failure of Non-inVasIve Ventilatory Support Using Non-invaSIve mONitoring in Non-intubated Patients With Acute Hypoxemic Respiratory Failure or Post-extubation Failure. The PREVISION Study
The goal of this observational study is to assess the potential non-invasive tools (e.g. regional ventilation, respiratory muscle response, lung mechanic's parameters) to identify the risk of failure when using high flow nasal…
- Conditions
- Ventilatory Failure, Hypoxemic Respiratory Failure, Weaning Failure, Respiratory
- Trial name
- PREVISION (NCT06716463)
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Unity Health Toronto
Infant,Premature, Respiratory Failure
Nasal High-frequency Jet Ventilation (nHFJV) Following Extubation in Preterm Infants
Very low birth weight infants are at increased risk of requiring prolonged duration of mechanical ventilation and multiple intubations, both of which are risk factors for ventilator-induced lung injury and BPD.
- Conditions
- Infant,Premature, Respiratory Failure, Respiratory Insufficiency, Respiratory Distress Syndrome in Premature Infant
- Trial name
- NCT03558737
- Testing
- Nasal high-frequency jet ventilation (nHFJV), Nasal intermittent positive pressure ventilation (NIPPV)
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- University of Utah
Premature Birth, Respiration Failure
Predictors of Prolonged Mechanical Ventilation in Preterm Infants
This prospective cohort study aims to identify the independent predictors of prolonged mechanical ventilation in preterm infants admitted to the Neonatal Intensive Care Unit of Assiut University Children Hospital.
- Conditions
- Premature Birth, Respiration Failure, Bronchopulmonary Dysplasia
- Trial name
- NCT07821632
- Volunteers
- 100 people
- Sponsor
- Assiut University
Respiratory Failure
Noninvasive Ventilation After Extubation in Hypercapnic Patients
The purpose of this study is to assess the efficacy of noninvasive ventilation (NIV) in the prevention of extubation failure and mortality in patients with either chronic respiratory disorders or hypercapnic respiratory failure…
- Trial name
- VHYPER (NCT01047852)
- Testing
- Noninvasive ventilation
- Where
- 6 sites in France
- Volunteers
- 144 people
- Sponsor
- University Hospital, Bordeaux