Clinical trials: Extubation Failures, active
Extubation Success, Extubation Failure
Combined RSBI, TOF, and BIS for Prediction of Extubation Success
This prospective observational study aims to evaluate the predictive value of the combined use of the rapid shallow breathing index, train-of-four ratio, and bispectral index for extubation success after general anesthesia.
- Conditions
- Extubation Success, Extubation Failure, Postoperative Respiratory Complications
- Trial name
- NCT07577453
- Testing
- Combined pre-extubation assessment using RSBI, TOF ratio, and BIS
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Gaziantep City Hospital
Extubation Failures, Extubation
Comparison of Acute Airway/Respiratory Complications and Intervention Requirements in Extubations Performed During On-Hours Versus Off-Hours
Perioperative airway/respiratory complications are a major driver of morbidity and mortality. While UK audits NAP4 and NAP7 extensively examined major critical events (e.g., cardiac arrest), prospective standardized data on…
- Conditions
- Extubation Failures, Extubation, Airway Complication of Anaesthesia
- Trial name
- NCT07752173
- Testing
- Extubation, Survey/Questionnaire Administration
- Where
- Turkey (Türkiye)
- Volunteers
- 2,640 people
- Sponsor
- Kocaeli City Hospital
Weaning From Mechanical Ventilation, Weaning Failure
Characterization of Weaning Practices in ICUs of Global South Countries
This is a prospective observational study to be conducted in intensive care units of Global South countries. Patients on mechanical ventilation for more than 12 hours who have initiated the weaning process and for whom the…
- Conditions
- Weaning From Mechanical Ventilation, Weaning Failure, Weaning From Mechanical Ventilation, Extubation
- Trial name
- NCT07337408
- Where
- Brazil
- Volunteers
- 900 people
- Sponsor
- Hospital do Coracao
Extubation Failure in Neonates
Noninvasive High Frequency Oscillatory Ventilation Versus Nasal Intermittent Mandatory Ventilation After Extubation in Neonates
The goal of this clinical trial is to learn which breathing support works better after removing a newborn's breathing tube. Researchers will study newborns born at 26 weeks of gestation or later.
- Trial name
- NOV-A (NCT07836166)
- Testing
- Noninvasive High Frequency Oscillatory Ventilation, Nasal Intermittent Mandatory Ventilation
- Where
- Pakistan
- Volunteers
- 172 people
- Sponsor
- Aga Khan University
Airway Extubation, Extubation Failure
One-Hour Positive Pressure Ventilation After a T-Piece Spontaneous Breathing Trial
This is a randomized, open, multicenter, pragmatic, adaptive clinical trial with intention-to-treat analysis. The study will compare two weaning strategies from mechanical ventilation in critically ill patients admitted to…
- Conditions
- Airway Extubation, Extubation Failure, Weaning Mechanical Ventilation
- Trial name
- GS-Wean Tpiece (NCT07324382)
- Testing
- One-hour positive pressure ventilation, Immediate extubation
- Volunteers
- 4,000 people
- Sponsor
- Hospital do Coracao
Airway Extubation, Weaning Mechanical Ventilation
One-Hour Positive Pressure Ventilation After a Pressure Support Spontaneous Breathing Trial
This is a randomized, open, multicenter, pragmatic, adaptive clinical trial with intention-to-treat analysis. The study will compare two weaning strategies from mechanical ventilation in critically ill patients admitted to…
- Conditions
- Airway Extubation, Weaning Mechanical Ventilation, Extubation Failure
- Trial name
- NCT07324460
- Testing
- One-hour positive pressure ventilation, Immediate extubation
- Volunteers
- 4,000 people
- Sponsor
- Hospital do Coracao
Positive Pressure Extubation Techniques, Negative Pressure Extubation Techniques
Positive- vs Negative-Pressure Extubation in High-Risk Patients
In the intensive care unit (ICU), weaning from mechanical ventilation and extubation are critical clinical goals. Successful extubation not only significantly shortens mechanical ventilation duration but also reduces the…
- Conditions
- Positive Pressure Extubation Techniques, Negative Pressure Extubation Techniques, High-risk Patients Prone to Extubation Failure
- Trial name
- NCT07829627
- Testing
- Positive-pressure extubation, Negative-pressure extubation
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Shanghai Zhongshan Hospital
Mechanical Ventilation, Pulmonary Rehabilitation
Rehabilitation Practices in Critically Ill Patients Receiving Invasive Mechanical Ventilation in the Intensive Care Unit.
This international, multicenter, observational study aims to describe rehabilitation practices in Intensive Care Units (ICUs) worldwide.
- Conditions
- Mechanical Ventilation, Pulmonary Rehabilitation, Intensive Care Units (ICUs), Quality of Life (QOL)
- Trial name
- REPOrt (NCT07093125)
- Where
- Italy
- Volunteers
- 2,400 people
- Sponsor
- Universita degli Studi di Genova
Extubation Failure, Neonates
Predictors of Extubation Failure in Ventilated Neonates
This protocol proposes a prospective observational study to develop and validate such a model, directly addressing a critical evidence gap identified by recent systematic reviews.
- Conditions
- Extubation Failure, Neonates, NICU
- Trial name
- Neonates (NCT07764575)
- Volunteers
- 124 people
- Sponsor
- Assiut University
Postoperative Respiratory Failure, Extubation Failure
Assessment of Reintubation Risk Using Multiple Parameters in Postoperative Intensive Care Unit Patients
This prospective, non-interventional observational study will evaluate the risk of reintubation in adult postoperative patients admitted to the intensive care unit after major surgery.
- Conditions
- Postoperative Respiratory Failure, Extubation Failure, Lung Ultrasonography Score, Diaphragm Thickness
- Trial name
- NCT07672106
- Where
- Turkey (Türkiye)
- Volunteers
- 600 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Obesity, Morbid, Extubation Failure
Postextubation Use of Noninvasive Respiratory Support in Severely Obese Patients
Around 20% of the obese patients with higher body mass index (BMI) who are taken off the breathing tube and breathing machine (ventilator) end up needing it back to support breathing.
- Trial name
- NCT05918575
- Testing
- Noninvasive ventilation alternating with high flow nasal cannula, High flow nasal cannula
- Where
- 5 sites in United States, Mexico
- Volunteers
- 250 people
- Sponsor
- Rush University Medical Center
Extubation Failure
Validation of an Effort-Based Cough Peak Flow Algorithm to Predict Extubation Outcomes
This study aims to prospectively validate the diagnostic accuracy of an effort-stratified Cough Peak Flow (CPF) decision algorithm for predicting extubation failure, maintaining strict blinding of the clinical team.
- Trial name
- NCT07737483
- Testing
- Observational measurement of Cough Peak Flow and Tidal Volume
- Volunteers
- 150 people
- Sponsor
- Hospital H+ Queretaro
Respiratory Failure, Extubation Failure
Impact of Biphasic Cuirass Ventilation Compared to Non Invasive Ventilation in High Risk Extubations
subjects on mechanical ventilator who are about to be extubated to Non invasive ventilation because the physician thinks they are high risk for failure will be approached and consented for our study.
- Trial name
- NCT07067502
- Testing
- Biphasic cuirass ventilator which is a type of negative pressure ventilator will be applied to patients on the intervention arm
- Volunteers
- 50 people
- Sponsor
- University of Missouri-Columbia
Extubation Readiness, Respiratory Failure With Hypoxia
Identifying the Best Flow Setting Strategy for High-Flow Nasal Cannula
The goal of this randomized trial is to compare four different flow-setting approaches for post-extubation use of high-flow nasal cannula (HFNC).
- Trial name
- NCT07007715
- Testing
- Flow of 40L/min, Peak tidal inspiratory flow (PTIF) guided, PaO2/FiO2 ratio guided
- Where
- Taiwan
- Volunteers
- 480 people
- Sponsor
- National Taiwan University Hospital
Study of Predictors of Successful Extubation in Preterm Infants, Extubation Succeeded
Neonatal Diaphragmatic Activity-Linked Extubation Conditions and Timing
The objective of this study is to evaluate the role of diaphragmatic electrical activity monitoring (collected by esophageal probe) around extubation of preterm patients in order to consider its use as a standardized objective…
- Conditions
- Study of Predictors of Successful Extubation in Preterm Infants, Extubation Succeeded, Extubation Failure, Preterm
- Trial name
- NEODIALECT (NCT07709988)
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Extubation Failure, Bronchopulmonary Dysplasia
The Diaphragmatic Initiated Ventilatory Assist (DIVA) Trial
DIVA is a pragmatic randomized clinical trial (RCT) to determine: among (P) preterm infants born 23 0/7-28 6/7 weeks gestation undergoing extubation from mechanical ventilation, whether (I) Non-invasive neurally adjusted…
- Conditions
- Extubation Failure, Bronchopulmonary Dysplasia, Death
- Trial name
- DIVA (NCT05446272)
- Testing
- NIV-NAVA, NS-NIPPV
- Where
- 20 sites in United States, Canada
- Volunteers
- 478 people
- Sponsor
- University of Pennsylvania
Mechanical Ventilation Weaning From Mechanical Ventilation Extubation Failure Critical Illness
Delta Pocc During Spontaneous Breathing Trial to Predict Extubation Failure in Mechanically Ventilated Adults (DELTA-EXT)
This prospective observational single-center study will evaluate whether dynamic respiratory stress estimated by delta airway occlusion pressure deflection (Delta Pocc) during a standardized spontaneous breathing trial can…
- Trial name
- DELTA-EXT (NCT07634783)
- Testing
- Delta Pocc Measurement During Spontaneous Breathing Trial
- Where
- Argentina
- Volunteers
- 120 people
- Sponsor
- Sanatorio Parque, Argentina
Extubation Failure, Mechanical Ventilation
Swallowing Assessment for Predicting Extubation Failure in Critically Ill Patients
Extubation failure, defined as the need for reintubation after planned removal of the endotracheal tube, occurs in up to 20% of critically ill patients and is associated with prolonged mechanical ventilation, longer intensive…
- Conditions
- Extubation Failure, Mechanical Ventilation, Critical Illness
- Trial name
- APEX (NCT07659275)
- Where
- Brazil
- Volunteers
- 800 people
- Sponsor
- Universidade Federal de Pernambuco
Post Extubation Respiratory Failure
Non-Invasive Ventilation Versus High-flow Nasal Oxygen in Intensive Care Units
In intensive care units (ICUs), around 20% of patients experience respiratory failure after planned extubation. Nearly 40-50% of them eventually require reintubation with subsequently high mortality rates reaching 30-40%.
- Trial name
- VENTILO (NCT05686850)
- Testing
- High-Flow Oxygen, Non invasive ventilation
- Where
- 47 sites in Belgium, France and 3 more
- Volunteers
- 670 people
- Sponsor
- Poitiers University Hospital
Ventilator Weaning, Respiration, Artificial
A New Tool for Extubation Readiness in Mechanically Ventilated Patients: Readiness for EXtubation Score
Liberation from mechanical ventilation involves three steps: weaning, readiness assessment, and extubation. Readiness is determined using clinical criteria such as improvement of the underlying condition, hemodynamic stability…
- Conditions
- Ventilator Weaning, Respiration, Artificial, Respiratory Failure, Extubation Readiness
- Trial name
- REXs (NCT07098611)
- Where
- 7 sites in Chile, Egypt and 4 more
- Volunteers
- 470 people
- Sponsor
- Medipol University