Clinical trials: Eye Change
Humoral Rejection, Guillain-Barre Syndrome
Changes in Haemostasis After Therapeutic Plasmapheresis With Citrate Anticoagulation
Plasma exchange procedures remove procoagulant and anticoagulant factors. Every procedure increases the risk of bleeding and repeated procedures increase the risk of bleeding mostly because lower fibrinogen levels.
- Conditions
- Humoral Rejection, Guillain-Barre Syndrome, Miller Fisher Syndrome, CIDP
- Trial name
- NCT03801135
- Testing
- Fibrinogen concentrate, Fresh Frozen Plasma
- Where
- Slovenia
- Volunteers
- 20 people
- Sponsor
- University Medical Centre Ljubljana
Cataract
Comparative Study on Changes in Anterior Chamber Cytokines, Oxidative Stress, and Pupil Size After LenSx and Z8 Femtosecond Lasers
Femtosecond laser-assisted cataract surgery is rapidly gaining popularity. Among the 5 femtosecond laser platforms available at present for cataract surgery, the Femto LDV Z8 (Ziemer Ophthalmic Systems AG) is a high-frequency…
- Trial name
- NCT06649799
- Testing
- LenSx, Z8
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Brain Tumor, Central Nervous System Tumors
Cyproheptadine and Megestrol in Preventing Weight Loss in Children With Cachexia Caused By Cancer or Cancer Treatment
RATIONALE: Cyproheptadine and megestrol may improve appetite and help prevent weight loss in children with cancer. PURPOSE: This phase II trial is studying how well cyproheptadine and megestrol work in improving appetite and…
- Conditions
- Brain Tumor, Central Nervous System Tumors, Cachexia, Leukemia
- Trial name
- NCT00066248
- Testing
- cyproheptadine hydrochloride, megestrol acetate
- Where
- 43 sites in United States, Canada and 1 more
- Volunteers
- 70 people
- Sponsor
- University of South Florida
Eyelid Diseases
Functional Changes After Upper Blepharoplasty
Upper blepharoplasty is a common eyelid procedure. It associated with visual, cosmetic and functional changes .Investigator will evaluate outcome of this procedure.
- Trial name
- NCT04201925
- Testing
- upper blepharoplasty
- Where
- United Arab Emirates
- Volunteers
- 50 people
- Sponsor
- Benha University
Alcohol Use Disorder
Effect of CBT Microinterventions on Mechanisms of Behavior Change Among Adults With AUD
This proposed R21, Effect of CBT Microinterventions on Mechanisms of Behavior Change among Adults with AUD: Using Eye Tracking to Measure Pre-Post Cognitive Control, uses a translational team science approach to isolate and…
- Trial name
- NCT03661853
- Testing
- Control, Functional Analysis, Cognitive Restructuring
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- University of Massachusetts, Worcester
Presbyopia
Safety and Effectiveness of the AcuFocus Corneal Inlay ACI7000PDT in Presbyopes
The purpose of this study is to determine if the AcuFocus Corneal Inlay ACI 7000PDT will provide an effective method of for the correction of presbyopia in patients who have normal distance vision but need correction such as…
- Trial name
- NCT01352442
- Testing
- AcuFocus Corneal Inlay ACI 7000PDT
- Where
- 11 sites in Australia, Austria and 8 more
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- AcuFocus, Inc.
Age Related Macular Degeneration (AMD)
A 16 Week Evaluation of the Novartis Health Management Tool (HMT) in Age Related Macular Degeneration (AMD)
This is a prospective pilot study to evaluate the usability and applicability of a self monitoring test of visual function with the handheld Health Management Tool (HMT) to remotely monitor neovascular Age Related Macular…
- Trial name
- NCT01542866
- Testing
- Health Management Tool (HMT)
- Where
- 23 sites in United States
- Volunteers
- 160 people
- Sponsor
- Novartis Pharmaceuticals
Dry Eye, Vision Disorders
Visual Quality Change of Eyes Implanted With Diffractive Multifocal Intraocular Lens After Cataract Surgery
In this study, the investigators examined the subjective visual quality including LogMAR uncorrected distance visual acuity (UCDVA), best corrected distance visual acuity (BCDVA),uncorrected intermediate visual acuity (UCIVA)…
- Conditions
- Dry Eye, Vision Disorders, Quality of Life
- Trial name
- NCT02234635
- Testing
- Diffractive multifocal IOLs group
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Wenzhou Medical University
Glaucoma
The Effects of Changing Light Levels on Contrast Sensitivity in Patients With Glaucoma
The study is a prospective observational study where participants will be recruited from the Ophthalmology department (Outpatient department, Eye Casualty). Only one research visit will be required.
- Trial name
- ENLIGHTEN (NCT04061343)
- Where
- United Kingdom
- Volunteers
- 115 people
- Sponsor
- Portsmouth Hospitals NHS Trust
Non-arteritic Ischemic Optic Neuropathy
Peripapillary and Macular Vascular Changes of Unilateral Anterior Ischemic Optic Neuropathy: An Optical Coherence Tomography Angiography Study
This series aims at studying the peripapillary and macular vascular changes in subjects with unilateral anterior ischemic optic neuropathy via Optical Coherence Tomography Angiography (OCTA).
- Trial name
- NCT06031350
- Testing
- Optical Coherence Tomography Angiography
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Omar Said
Endothelial Cell Loss, Corneal
Endothelial Changes in Pseudoexfoliation Syndrome
this study aimed to evaluate the corneal endothelial cell changes before and after phacoemulsification in pseudoexfoliative patients relative to healthy adults.
- Trial name
- PEX (NCT05194891)
- Testing
- Specular Microscopy
- Volunteers
- 100 people
- Sponsor
- Assiut University
Age-Related Macular Degeneration
Visual Function Change in Wet Age-related Macular Degeneration Patients With Better Baseline Visual Acuity
Although the number of wet AMD patients with the better visual acuity is increasing, the visual improvement in patients with the better vision may not be so significant after anti-vascular endothelial growth factor (VEGF)…
- Trial name
- NCT06330220
- Testing
- Aflibercept Injection [Eylea]
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- Seoul National University Hospital
Cataract Bilateral, Astigmatism Bilateral
Vision and Balance Changes After Bilateral Implantation of Toric IOLs
Cataracts are the major cause of blindness in the world. Cataract surgery, being the most performed surgery in the world today, provide correction by extracting the natural lens from its capsular bag and replaced by an artificial…
- Trial name
- NCT05629078
- Testing
- Toric intraocular lens Zeiss AT TORBI
- Where
- United Kingdom
- Volunteers
- 140 people
- Sponsor
- University of Plymouth
Postoperative Cognitive Dysfunction
Ketamine and Changes of the Short Portable Mental Status Questionnaire
Cognitive changes are related to aging, affecting the performance of older patients in the solution of problems and the execution of tasks.
- Trial name
- SPMSQ-E (NCT02049411)
- Testing
- Ketamine, physiological solution
- Where
- Mexico
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Instituto Mexicano del Seguro Social
Mild Ptosis, Moderate Ptosis
A Newly Modified Technique for Levator Muscle Tucking in Blepharoptosis Surgery: An Egyptian Tertiary Center Study
Mild to moderate blepharoptosis with good levator function is usually corrected by levator muscle resection or advancement with their modifications with high success rate.
- Trial name
- Lidtucking (NCT04883853)
- Testing
- Mild _moderate Ptosis tucking
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Ain Shams University
Diabetic Retinopathy
Assessment of Retinal Microvascular Changes by OCT Angiography in Diabetic Retinopathy
This observational cross-sectional study aims to assess retinal microvascular changes using optical coherence tomography angiography (OCTA) in patients with diabetic retinopathy.
- Trial name
- NCT07747428
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Idiopathic Intracranial Hypertension, Intracranial Pressure
The Effect of an Anti-obesity Drug, Semaglutide, as Treatment in New-onset Idiopathic Intracranial Hypertension (IIH) Compared to Standard Weight Management (Dietician) With Regards to Change in Weight and Intracranial Pressure
50 patients with verified new-onset Idiopathic Intracranial Hypertension are randomly allocated to standard weight management (dietician counselling) or trial intervention consisting of subcutaneous injections with Semaglutide…
- Conditions
- Idiopathic Intracranial Hypertension, Intracranial Pressure, Obesity, Pseudotumor Cerebri Syndrome
- Trial name
- IIH:DUAL (NCT06027567)
- Testing
- Semaglutide, Very Low Calorie Diet, Dietician counselling
- Where
- 2 sites in Denmark
- Volunteers
- 38 people
- Sponsor
- Rigmor Højland Jensen
Diabetic Retinopathy (DR), Retinal Microvascular Changes
Relation Between Glycemic Control and Retinal Microvascular Changes in Diabetic Patients Using OCTA
An observational cross-sectional comparative study which will be conducted in the Department of Ophthalmology, Sohag University Hospital, Egypt to detect the relation between glycemic control and retinal microvascular changes in…
- Trial name
- Retinopathy (NCT07726381)
- Volunteers
- 50 people
- Sponsor
- Sohag University
Glaucoma
Cyclophotocoagulation in Glaucoma
Transscleral cyclophotocoagulation of the ciliary body is an effective technique to reduce intraocular pressure in case of glaucoma.
- Trial name
- NCT02875158
- Testing
- Cyclophotocoagulation protocol, Conventional cyclophotocoagulation, Modified cyclophotocoagulation
- Where
- Canada
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Dry Eye Disease
In Vivo Confocal Microscopic Analysis of Corneal Nerve Changes After ProKera Slim® for Dry Eye
Prospective controlled pilot study to compare the outcome of ProKera® (PK) and conventional treatment in patients with moderate to severe Dry Eye Disease (DED)
- Trial name
- NCT02764814
- Testing
- Cryopreserved amniotic membrane
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- BioTissue Holdings, Inc