Clinical trials: Eye Diseases, Hereditary
Pain, Retinopathy of Prematurity
Reducing Pain and Increasing Comfort During a Retinopathy of Prematurity Examination
The aim of this study is to investigate the effect of baby massage applied to babies with retinopathy of prematurity on the pain and comfort of the newborn.
- Conditions
- Pain, Retinopathy of Prematurity, Premature Baby 26 to 32 Weeks, Premature Baby 33 to 36 Weeks
- Trial name
- NCT06348641
- Testing
- baby massage
- Volunteers
- 60 people
- Sponsor
- Nurgül Tekin
Rheumatoid Arthritis, Spondylitis, Ankylosing
Recombinant Herpes Zoster Vaccine in Patients With Autoimmune Rheumatic Diseases
Introduction: Patients with autoimmune rheumatic diseases (ARDs), rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), psoriatic arthritis (PAs), ankylosing spondylitis (AS), systemic lupus erythematosus (SLE), primary…
- Conditions
- Rheumatoid Arthritis, Spondylitis, Ankylosing, Spondyloarthritis, Systemic Lupus Erythematosus
- Trial name
- RZVRheum (NCT05879419)
- Testing
- Recombinant Herpes Zoster Vaccine (RZV), MTX Discontinuation, MMF Discontinuation
- Where
- Brazil
- Volunteers
- 2,005 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Normal Eyes, Eye Abnormalities
The Heidelberg Engineering BI US Evaluation Study
Evaluation of defined parameters measured in pathological and non-pathological eyes with the Heidelberg BI
- Trial name
- NCT03578302
- Testing
- BI Anterior Segment Mode, BI Anterior Segment and IOL Biometry Mode
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Heidelberg Engineering GmbH
Cataract, Down Syndrome
Evaluation of Ocular Lens Proteins in Cataract From Individuals With Down Syndrome
This study involves the collection ocular lens tissue from individuals with Down syndrome and age-matched controls at the time of cataract surgery.
- Trial name
- NCT03778528
- Testing
- cataract surgery
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Colorado, Denver
Retinopathy of Prematurity
a Prospective Cohort Study for Propranolol Treatment in Retinopathy of Prematurity
The purpose of this study is to evaluate the safety and efficacy of oral/local propranolol in preterm newborns who diagnosed as early phase of retinopathy of prematurity (ROP).
- Trial name
- NCT03038295
- Testing
- Propranolol
- Volunteers
- 100 people
- Sponsor
- Guangdong Women and Children Hospital
Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders
Studying Fentanyl in Patients With Cancer
RATIONALE: Studying blood samples from cancer patients undergoing pain treatment in the laboratory may help doctors learn more about how pain drugs work in the body.
- Conditions
- Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders, Leukemia, Lymphoma
- Trial name
- NCT00899951
- Testing
- fentanyl citrate, pharmacological study
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Retinitis Pigmentosa
Safety and Efficacy of Subretinal Transplantation of Clinical Human Embryonic Stem Cell Derived Retinal Pigment Epitheliums in Treatment of Retinitis Pigmentosa
This project intends to transplant a clinical level human embryonic stem cells derived retinal pigment epithelium into subretinal space to treat eetinitis pigmentosa(RP) diseases.
- Trial name
- NCT03944239
- Testing
- Retinal pigment epitheliums transplantation
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Qi Zhou
Extensive Macular Atrophy With Pseudodrusen (EMAP), Retinitis Pigmentosa (RP)
Subtenon Autologous Platelet-Rich Plasma in Inherited and Degenerative Retinal Diseases
his prospective, comparative pilot study investigates the safety and functional outcomes of subtenon autologous platelet-rich plasma (PRP) in patients with Retinitis Pigmentosa (RP) and Extensive Macular Atrophy with…
- Trial name
- RETINA-PRP (NCT07341919)
- Testing
- Subtenon Injection of Autologous Platelet-Rich Plasma
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Rubens Camargo Siqueira
Retinopathy of Prematurity
Improve Screening Criteria for Retinopathy of Prematurity in Two French Center
The aim of the study is to assess whether a delay of the first examination can be safely considered in French population. Secondary objectives are to describe retinopathy of prematurity (ROP) in a population of premature from two…
- Trial name
- DEREP3 (NCT05152862)
- Testing
- Laser, Anti VEGF
- Where
- France
- Volunteers
- 886 people
- Sponsor
- Centre Hospitalier Sud Francilien
Intellectual Disability, Neurodevelopmental Disorders
Physical Activity and Community EmPOWERment Project
Purpose: Conduct a wait-list randomized controlled trial (RCT) of an inclusive physical activity program called PACE for adults with intellectual disability (ID) who are not yet showing signs of Alzheimer's Disease…
- Conditions
- Intellectual Disability, Neurodevelopmental Disorders, Autism Spectrum Disorder, Down Syndrome
- Trial name
- PACE (NCT06740162)
- Testing
- PACE Program
- Where
- 2 sites in United States
- Volunteers
- 376 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Behcet Syndrome
Assessment of Disease Activity in Behcet by Complete Blood Count
To determine platelet to lymphocyte ratio (PLR), lymphocytes to monocytes ratio (LMR), mean platelet volume (MPV) and neutrophile lymphocyte ratio (NLR), levels in Behçet's disease (BD) To investigate their correlation with…
- Trial name
- NCT03747354
- Testing
- blood samples
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
Retinitis Pigmentosa (RP)
Phase I/II Open-Label Trial of UGX202 for Advanced Retinitis Pigmentosa
This is a single-arm, open-label study employing a 3+3 dose escalation design to evaluate two UGX202 dose groups: the low-dose group (1.2×10¹¹ vg/eye) and the high-dose group (3.5×10¹¹ vg/eye).
- Trial name
- UGX202 (NCT07847723)
- Testing
- UGX202 Injection
- Volunteers
- 12 people
- Sponsor
- Suzhou UgeneX Therapeutics Co., Ltd.
Behcet Syndrome
Randomized Controlled Multicenter Study Comparing Steroid Therapy Plus Anticoagulants to Steroid Therapy Alone in Deep Venous Thrombosis of Behçet's Syndrome
In patients with Behçet's syndrome (BS), deep venous thrombosis (DVT) is thought to result from inflammation of the vessel wall rather than hyper coagulability.
- Trial name
- ACTOR (NCT06780462)
- Testing
- Corticosteroids + Rivaroxaban, Corticosteroids alone
- Where
- 17 sites in France
- Volunteers
- 134 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Mucopolysaccharidosis, Fabry Disease
Non-invasive Assessment of Intraocular Pressure in MPS by Use of the Ocular Response Analyzer.
The aim of the present study is to compare intraocular pressure (IOP) values assessed with Ocular Response Analyzer to the classical gold standard of IOP measurement, to Goldmann applanation tonometry by mucopolysacchyridosis…
- Trial name
- MPSORA (NCT01695161)
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Johannes Gutenberg University Mainz
CHARGE Syndrome
Neurovisual Function in CHARGE Syndrome
The rationale of the study is to analyze visual function and correlate them with adaptive functions in patients with CHARGE syndrome in order to identify a pattern of specific indicators to enable better patient care
- Trial name
- NCT05764980
- Testing
- visual function evaluation
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Vitiligo, Piebaldism
Evaluation of Non-cultured Epidermal Cellular Grafting vs Hyaluronic Acid for Repigmenting Vitiligo and Piebaldism
The purpose of this study is to assess the efficacy of autologous epidermal cells suspension grafting using a newly developed device named VITICELL® compared to placebo.
- Trial name
- NCT02156427
- Testing
- VITICELL
- Where
- 5 sites in Belgium, France and 1 more
- Volunteers
- 38 people
- Sponsor
- Laboratoires Genévrier
Retinopathy of Prematurity (ROP)
ROP Check Database Premature Infant Outcomes
The goal of this observation of multi-centered care of infants covered by ROP Check cloud-based database is to compare demographic and clinical risk factors to evaluate and improve vision-protecting guidelines.
- Trial name
- NCT07312669
- Where
- United States
- Volunteers
- 7,070 people
- Sponsor
- Alaska Blind Child Discovery
Choroideremia
A Safety Study of Retinal Gene Therapy for Choroideremia With Administration of BIIB111
The objective of the study is to evaluate the safety of bilateral, sequential sub-retinal administration of a single dose of BIIB111 in adult male participants with Choroideremia (CHM).
- Trial name
- GEMINI (NCT03507686)
- Testing
- BIIB111
- Where
- 6 sites in United States, France and 1 more
- Volunteers
- 66 people
- Sponsor
- Biogen
Corneal Transplantation, Descemet Stripping Automated Endothelial Keratoplasty
DSAEK- Postoperative Positioning and Transplant Dislocation
Corneal transplant is a surgical procedure where a damaged or diseased cornea is replaced by donated corneal tissue (the graft) in its entirety (penetrating keratoplasty) or in part (lamellar keratoplasty).
- Conditions
- Corneal Transplantation, Descemet Stripping Automated Endothelial Keratoplasty, Fuchs' Endothelial Dystrophy, Corneal Dystrophies, Hereditary
- Trial name
- NCT01206127
- Testing
- Postoperative positioning: Bed rest, Postoperative positioning: Sitting up
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- Oslo University Hospital
Retinitis Pigmentosa
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases
Retinitis Pigmentosa (RP) is the most common form of hereditary retinal degeneration, with a worldwide prevalence of 1:3500. It is one of the most genetically heterogenous conditions in humans, with over 100 causative genes and…
- Trial name
- NCT02309866
- Testing
- Genetic testing
- Volunteers
- 100 people
- Sponsor
- Hillel Yaffe Medical Center
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