Clinical trials: Eye Diseases, Hereditary
Retinal Degeneration, Genetic Disease
Saffron Supplementation in Stargardt's Disease
The general area of research in which this project has been designed is that of retinal degeneration related to mutations in the ABCR gene, responsible of Stargardt disease/fundus flavimaculatus retinal dystrophy (STD/FF).
- Conditions
- Retinal Degeneration, Genetic Disease, Single-Gene Defects, Macular Dystrophy
- Trial name
- STARSAF02 (NCT01278277)
- Testing
- Saffron supplementation
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Catholic University of the Sacred Heart
Takayasu Arteritis, Behcet Disease
Turkish Adaptation of the VascuQoL-6 Quality of Life Scale
Study type: Observational study Primary objective: The aim of this study was to examine the validity and reliability of the Vascular Quality of Life Questionnaire-6 (VascuQoL-6) in Turkish in individuals diagnosed with Takayasu…
- Conditions
- Takayasu Arteritis, Behcet Disease, Quality of Life
- Trial name
- NCT06979245
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 37 people
- Sponsor
- Uşak University
Behçet Disease, Uveitis
Interferon α2a Versus Cyclosporine for Refractory Behçet's Disease Uveitis
Brief summary: This study compares the long-term efficacy and safety of interferon (IFN) α2a and cyclosporine (cyclosporin A, CsA) following suppression of acute attack by high-dose oral glucocorticosteroid in patients with…
- Trial name
- NCT03209219
- Testing
- Interferon Alfa-2A, Cyclosporine Pill
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Peking Union Medical College Hospital
Childhood Soft Tissue Sarcoma, Childhood Liver Cancer
Liposomal Doxorubicin in Treating Children With Refractory Solid Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of liposomal doxorubicin in treating children who have…
- Conditions
- Childhood Soft Tissue Sarcoma, Childhood Liver Cancer, Bone Cancer, Brain Tumor
- Trial name
- NCT00019630
- Testing
- doxorubicin HCl liposome
- Where
- 2 sites in United States
- Sponsor
- National Cancer Institute (NCI)
Bardet-Biedl Syndrome, Orphan Diseases
Bardet-Biedl Syndrome Study: Clinical and Genetic Epidemiology Study in Adults
This study is based on the study of the natural history of a rare disorder: the Bardet-Biedl syndrome (BBS) (which is associated with retinitis pigmentosa, polydactyly, cognitive impairment, obesity, and kidney failure).
- Trial name
- NCT00213811
- Testing
- clinical, biological, and radiological
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Strasbourg, France
Retinoblastoma
A Clinical Study on the Efficacy and Safety of VEC Intravenous Chemotherapy Combined With Conbercept Intravitreal Injection in the Treatment of Retinoblastoma
This prospective, multi-center, open single-arm Phase II clinical trial is designed to investigate the efficacy and safety of intravenous chemotherapy combined with Conbercept intravitreal injection in the treatment of…
- Trial name
- NCT04990271
- Testing
- Conbercept ophthalmic injection
- Where
- 5 sites in China
- Volunteers
- 92 people
- Sponsor
- Chengdu Kanghong Biotech Co., Ltd.
Thyroid Associated Ophthalmopathies
Evaluation of the Efficacy and Safety Observation of IBI311 Treatment in Patients With Inactive TAO
Thyroid-associated ophthalmopathy (TAO) is an organ-specific autoimmune disease closely related to thyroid disease, which leads the incidence of orbital disease in adults and is the most common cause of diffuse toxic goiter…
- Trial name
- NCT07152392
- Testing
- IBI311, Follew-up
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai Changzheng Hospital
Incomplete Spinal Cord Injury, Spasticity, Muscle
Activating Spinal Circuits to Improve Walking, Balance, Strength, and Reduce Spasticity
For many people with spinal cord injury (SCI), the goal of walking is a high priority. There are many approaches available to restore walking function after SCI; however, these approaches often involve extensive rehabilitation…
- Trial name
- NCT05429736
- Testing
- Motor Skill Training (MST), Transcutaneous Spinal Stimulation (TSS)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Shepherd Center, Atlanta GA
Retinal Degeneration
Safety Study of RPE65 Gene Therapy to Treat Leber Congenital Amaurosis
The purpose of the study is to determine whether gene therapy is safe and effective for the treatment of severe childhood blindness caused by mutations in RPE65.
- Trial name
- NCT00643747
- Testing
- tgAAG76 (rAAV 2/2.hRPE65p.hRPE65)
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University College, London
Cytomegalovirus Retinitis, HIV Infections
A Study of the Safety and Tolerance of Long-Term Therapy With Intravenous Cytovene (Ganciclovir Sodium) for Cytomegalovirus Retinitis in Persons With AIDS
To evaluate the safety and tolerance of long-term ganciclovir (DHPG) therapy for newly diagnosed macular threatening Cytomegalovirus (CMV) retinitis in AIDS patients.
- Trial name
- NCT00002034
- Testing
- Zidovudine, Ganciclovir
- Where
- 9 sites in United States, Canada
- Volunteers
- 100 people
- Sponsor
- Hoffmann-La Roche
Healthy Volunteer, Rheumatoid Arthritis
Phenomics in Autoimmune and Inflammatory Diseases
The family of inflammatory/autoimmune systemic diseases (IAD) form a continuum from pure inflammatory diseases to pure autoimmune diseases, encompassing a large panel of inflammatory diseases with some autoimmune components, and…
- Conditions
- Healthy Volunteer, Rheumatoid Arthritis, Ankylosing Spondylitis, Systemic Lupus Erythematosus/Antiphospholipid Syndrome
- Trial name
- TRANSIMMUNOM (NCT02466217)
- Testing
- 1: AID groups, 2: Control groups
- Where
- 2 sites in France
- Volunteers
- 537 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Retinoblastoma, Extraocular
Intrathecal Chemotherapy for Central Nervous System Metastasis in Retinoblastoma
Retinoblastoma is the most common intraocular malignancy in infancy and childhood. The overall survival rate of retinoblastoma was reported to exceed 95% when children were early diagnosed with localized intraocular phase.
- Trial name
- NCT04903678
- Testing
- Melphalan
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Allergic Rhinitis, Asthma
The Significance of Ambrosia in Allergic Rhinitis and Asthma in Israel
Ambrosia is known for its allergenicity in the USA causing hay fever and asthma. Israel has always been considered "clean" of Ambrosia but over the past years growth of Ambrosia plants has been detected in several locations in…
- Conditions
- Allergic Rhinitis, Asthma, Allergic Conjunctivitis, Atopic Dermatitis
- Trial name
- NCT01686048
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Hereditary Eye Disease
Evaluation and Treatment of Patients With Inherited Eye Diseases
This study offers evaluation and treatment for patients with inherited (genetic) eye diseases. The protocol is not designed to test new treatments; rather, patients will receive current standard of care treatments.
- Trial name
- NCT00011817
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- National Eye Institute (NEI)
Leber Hereditary Optic Neuropathy (LHON)
Gene Therapy Clinical Trial for the Treatment of Leber's Hereditary Optic Neuropathy Associated With ND4 Mutations
The objective of this clinical study is to evaluate the safety and efficacy of NR082 in the treatment of LHON caused by mitochondrial ND4 gene mutation.
- Trial name
- NCT05293626
- Testing
- NR082 Injection, Injection needle
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- Neurophth Therapeutics Inc
Color Vision Defects, Color Blindness
Performance of Red Tinted Contact Lenses on Colour Defects
This study aimed to relate and compare the performance of 4 types of red-tinted contact lenses (CL) with the Total Error Score (TES) from the Farnsworth-Munsell 100 Hue test on colour deficient subjects.
- Trial name
- CL (NCT05643222)
- Testing
- red tint contact lenses
- Where
- Malaysia
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Retinopathy of Prematurity (ROP)
Comparing Alternative Ranibizumab Dosages for Safety and Efficacy in Retinopathy of Prematurity
This study is designed as an exploratory study to assess safety and efficacy of two different doses of the anti-VEGF agent ranibizumab (0.12 mg vs. 0.20 mg) in the treatment of infants with retinopathy of prematurity.
- Trial name
- CARE-ROP (NCT02134457)
- Testing
- ranibizumab
- Where
- 9 sites in Germany
- Volunteers
- 19 people
- Sponsor
- University Hospital Freiburg
Retinitis Pigmentosa
Safety and Efficacy of Subretinal Transplantation of Clinical Human Embryonic Stem Cell Derived Retinal Pigment Epitheliums in Treatment of Retinitis Pigmentosa
This project intends to transplant a clinical level human embryonic stem cells derived retinal pigment epithelium into subretinal space to treat eetinitis pigmentosa(RP) diseases.
- Trial name
- NCT03944239
- Testing
- Retinal pigment epitheliums transplantation
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Qi Zhou
Fuchs' Endothelial Corneal Dystrophy
Study to Investigate the Safety and Efficacy of K-321 in Patients With Fuchs Endothelial Corneal Dystrophy (FECD) Following Descemetorhexis
The objective of this study is to investigate the effect of K-321 in patients with Fuchs endothelial corneal dystrophy (FECD) after descemetorhexis.
- Trial name
- NCT04250207
- Testing
- K-321 Solution
- Where
- 29 sites in United States, Australia and 3 more
- Volunteers
- 65 people
- Sponsor
- Kowa Research Institute, Inc.
Behçet's Syndrome
Withdrawal of Colchicine in Behçet Syndrome
Behçet's syndrome is a multisystem variable vessel vasculitis. Clinical features include mucocutaneous manifestions such as oral ulcers, genital ulcers, papulopustular lesions and nodular lesions, musculoskeletal manifestations…
- Trial name
- NCT06146192
- Testing
- Colchicine
- Volunteers
- 130 people
- Sponsor
- Istanbul University - Cerrahpasa
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