Clinical trials: Eye Disorders
Myopia, High Myopia
Clinical Results of Small Incision Lenticule Extraction (SMILE) for the Correction of High Myopia
Small Incision Lenticule Extraction (SMILE) was introduced in 2011 using the VISUMAX femtosecond laser (Carl Zeiss Meditec, Jena, Germany). It is designed for correction of myopia and myopic astigmatism.
- Trial name
- NCT04110067
- Testing
- Small Incision Lenticule Extraction (SMILE) with Visumax (Carl Zeiss Meditec, Jena)
- Where
- Germany
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Suphi Taneri
Primary Open Angle Glaucoma, Intraocular Pressure
Effects of Forskolin on Intraocular Pressure in Glaucomatous Patients Under Treatment With Either Beta-blockers or Prostaglandins Eye Drops
Elevated intraocular pressure is still the main risk factor for development and progression of glaucoma. Several drugs exist on the market that may decrease IOP in glaucomatous patients.
- Trial name
- NCT00863811
- Where
- Italy
- Sponsor
- Sooft Italia
Cataract
Predicting Lens Tilt Using Optical Coherence Tomography and Partial Least Squares Regression Modelling
Misalignment of IOLs can cause severe loss of visual quality. Different types of misalignment are known. Tilt is one type of misalignment that is thought to play a negative role for the optical performance in eyes with IOL…
- Trial name
- Tilt (NCT05915429)
- Where
- Austria
- Volunteers
- 110 people
- Sponsor
- Johannes Kepler University of Linz
Corneal Ulcer, Corneal Disease
Treatment of Patients With Inflammatory-dystrophic Diseases of the Cornea Using Autologous Stem Cells
Treatment of patients with inflammatory-dystrophic diseases of the cornea using autologous limbal stem cells (corneal epithelial stem cells) or adipose-derived mesenchymal stem cells
- Conditions
- Corneal Ulcer, Corneal Disease, Corneal Dystrophy
- Trial name
- NCT04484402
- Testing
- mesenchymal stem cells, limbal stem cells, standard treatment
- Where
- Belarus
- Volunteers
- 25 people
- Sponsor
- Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus
Presbyopia
Comparison of Two Soft Bifocal Contact Lenses
The purpose of the study is to compare the visual performance of two soft bifocal contact lenses.
- Trial name
- NCT00724945
- Testing
- balafilcon A, senofilcon A
- Where
- 6 sites in United States
- Volunteers
- 113 people
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Refractive Errors
Bifocal & Atropine in Myopia (BAM) Study
This study will test whether the combined treatment of 0.01% atropine and soft bifocal contact lens wear produces slower myopia progression and axial elongation compared to soft bifocal contact lenses alone in children ages 7 to…
- Trial name
- BAM (NCT03312257)
- Testing
- Multifocal D +2.50 add & 0.01% atropine
- Volunteers
- 49 people
- Sponsor
- Jenny Jones
Pseudophakia, Hypermetropia
Treatment of Residual Hypermetropic Refraction on Pseudophakic Patients Using Allogenic Fresh Myopic Lenticule
The residual hypermetropic refraction on pseudophakic(Trifocal IOL) patients is difficult to treat surgically. In addition, there are not many suitable options to offer such patients presenting with this condition.
- Conditions
- Pseudophakia, Hypermetropia, Myopia
- Trial name
- ReLex-Smile (NCT04692012)
- Testing
- FRESH CORNEAL MYOPIC LENTICULE IMPLANTATION
- Where
- Kosovo
- Volunteers
- 34 people
- Sponsor
- Eye Hospital Pristina Kosovo
Behçet Disease
Efficacy and Safety of Ustekinumab, a Human Monoclonal Anti-IL-12/IL-23 Antibody, in Patients With Behçet Disease
The purpose of this study is to evaluate the proof of concept of efficacy of ustekinumab in subjects with Behçet disease, including patients with oral ulcers (STELABEC-1) and patients with active posterior uveitis or panuveitis…
- Trial name
- STELABEC (NCT02648581)
- Testing
- Subcutaneous Ustekinumab
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hemianopia, Homonymous
Comparative Efficacy of Saccadic and Biofeedback Training in Homonymous Hemianopia
This pilot study aims to understand how eye movements change in people with vision loss from stroke after completing one of two types of training.
- Trial name
- NCT06638619
- Testing
- Biofeedback Fixation Training, Saccadic Reading Training
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Alabama at Birmingham
Retinal Artery Occlusion
Long-term Clinical Outcomes After Retinal Artery Occlusion
Retinal artery occlusion (RAO) is a rare but vision-threatening vascular disorder that is commonly caused by embolic events originating from the heart or carotid arteries.
- Trial name
- CVO-RAO (NCT07482228)
- Testing
- retinal artery occlusion
- Where
- South Korea
- Volunteers
- 15,000 people
- Sponsor
- Chonnam National University Hospital
Primary Open-Angle Glaucoma (POAG), Cataract
Aqueous Humor and Ocular Tissue Analysis in Glaucoma and Cataract
This observational study will compare proteomic and elemental profiles of aqueous humor and ocular tissues in patients with primary open-angle glaucoma (POAG) and cataract versus cataract controls without glaucoma.
- Trial name
- NCT07462000
- Testing
- Phacoemulsification With Intraocular Lens Implantation and Deep Sclerectomy, Phacoemulsification With Intraocular Lens Implantation
- Where
- 2 sites in Poland
- Volunteers
- 40 people
- Sponsor
- Military Institute od Medicine National Research Institute
Diabetic Macular Edema
Efficacy Study of Triamcinolone and Bevacizumab Intravitreal for Treatment of Diabetic Macular Edema
Triamcinolone and Bevacizumab Intravitreal for Treatment of Diabetic Macular Edema
- Trial name
- ATEMD (NCT00737971)
- Testing
- Bevacizumab intravitreal, Triamcinolone, Triamcinolone + Bevacizumab
- Where
- Brazil
- Volunteers
- 142 people
- Sponsor
- Rubens Belfort Jr.
Cataract
Visual and Refractive Outcomes After Implantation of Aspheric IOLs With Different Dioptric Increments and Manufacturing
This study compares two intraocular lenses, the Softec HD and the Tecnis Z9002, used to replace the natural crystalline lens after cataract extraction.
- Trial name
- NCT01249144
- Testing
- Intraocular Lens (IOL)
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Lenstec Incorporated
Retinitis Pigmentosa
RETINA IMPLANT Alpha AMS in Blind Patients With Retinitis Pigmentosa
The goal of this study is to transfer the surgical implantation technique and evaluate the safety and effectiveness of the RETINA IMPLANT Alpha AMS to restore limited visual function and functional vision in blind Retinitis…
- Trial name
- NCT03629899
- Testing
- RETINA IMPLANT Alpha AMS
- Where
- United States
- Sponsor
- Wills Eye
Neovascular Glaucoma
Comparison of Efficacy Between Silicone Ahmed Glaucoma Valves With and Without Intravitreal Triamcinolone Injection
The management of neovascular glaucoma (NVG) is a challenge for the ophthalmologist and surgery is frequently needed to control IOP. The success rates of a drainage device is usually lower in NVG than in other forms of glaucoma.
- Trial name
- NCT00491712
- Testing
- Glaucoma drainage implant with/without triamcinolone
- Where
- Brazil
- Volunteers
- 49 people
- Sponsor
- Federal University of São Paulo
Brain and Central Nervous System Tumors, Carcinoma of Unknown Primary
Topotecan in Treating Young Patients With Neoplastic Meningitis Due to Leukemia, Lymphoma, or Solid Tumors
RATIONALE: Drugs used in chemotherapy, such as topotecan, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Brain and Central Nervous System Tumors, Carcinoma of Unknown Primary, Leukemia, Lymphoma
- Trial name
- NCT00112619
- Testing
- topotecan hydrochloride
- Where
- 11 sites in United States
- Volunteers
- 19 people
- Sponsor
- Pediatric Brain Tumor Consortium
Glaucoma, Healthy
Cause of Pigment Dispersion Syndrome
The purpose of this study is to learn how pigment is released from the iris (the colored part of the eye) in patients with pigment dispersion syndrome.
- Conditions
- Glaucoma, Healthy, Pigment Dispersion Syndrome
- Trial name
- NCT00005919
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Diabetes Mellitus
Clinical Usefulness of a Magnifier for Insulin Pen
Insulin treatment is crucial for glucose control. Many patients with type 2 diabetes exhibit inadequate glycemic control in spite of combination of oral antidiabetic drugs and eventually need insulin therapy.
- Trial name
- NCT01563419
- Testing
- Indicator magnifying window (Izumi Planning Co.)
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Mental Health Issue
Delivery Format of Cognitive Behavioral Therapy Materials on Engagement and Outcomes: AI-Enabled App vs PDF Workbook
The goal of this clinical trial is to compare two different ways of delivering cognitive behavioral therapy (CBT) materials to people with symptoms of anxiety and depression. The main questions it aims to answer are: 1.
- Trial name
- NCT06459128
- Testing
- Limbic Care, Digital Workbook
- Where
- United Kingdom
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Limbic Limited
Cataracts
A Clinical Outcome Study of Two Multifocal Intraocular Lenses (IOL) in Cataract Patients
The purpose of this study is to compare AcrySof® IQ ReSTOR® +2.5 D Multifocal IOL in both eyes (bilateral implantation) to AcrySof® IQ ReSTOR® +2.5 D Multifocal IOL in the dominant eye with AcrySof® IQ ReSTOR® +3.0 D Multifocal…
- Trial name
- NCT01684007
- Testing
- AcrySof® IQ ReSTOR® +2.5 D Multifocal IOL Model SN6AD2 [SV25T0], AcrySof® IQ ReSTOR® +3.0 D Multifocal IOL Model SN6AD1
- Volunteers
- 112 people
- Sponsor
- Alcon Research