Clinical trials: Eye Hemorrhage
Lymphoma
Revlimid® Capsules Drug Use-results Surveillance (Relapsed or Refractory ATLL)
To understand the safety and efficacy of Revlimid® Capsules 2.5 mg and 5 mg (hereinafter referred to as Revlimid) under actual conditions of use in patients with relapsed or refractory adult T-cell leukemia lymphoma (hereinafter…
- Trial name
- NCT03098589
- Testing
- Revlimid
- Where
- Japan
- Volunteers
- 1,149 people
- Sponsor
- Celgene
Proliferative Diabetic Retinopathy, Diabetic Retinopathy
Continuous Delivery of Ranibizumab Via the Port Delivery System for Proliferative Diabetic Retinopathy-related Vitreous Hemorrhage With Pars Plana Vitrectomy and Limited PRP.
In prolifertive diabetic retinopathy (PDR) eyes with bleeding known as vitreous hemorrhage (VH) requiring a surgical procedure to remove the vitreous, called a vitrectomy, we will determine if the benefit and safety of adding a…
- Conditions
- Proliferative Diabetic Retinopathy, Diabetic Retinopathy, Diabetes
- Trial name
- 4 PORT (NCT07864480)
- Testing
- PDS Implant filled with 100 mg/mL Ranibizumab, Ranibizumab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Southeast Retina Center, Georgia
Proliferative Diabetic Retinopathy, Vitreous Hemorrhage
Cryoapplication Versus Anti-VEGF Before Diabetic Vitrectomy
Pars-plana vitrectomy (PPV) is the cornerstone of surgical treatment for eyes with complicated proliferative diabetic retinopathy. Anti-VEGF intravitreal injection before PPV has shown a good effect on surgical outcomes.
- Conditions
- Proliferative Diabetic Retinopathy, Vitreous Hemorrhage, Tractional Retinal Detachment
- Trial name
- NCT05514925
- Testing
- Bevacizumab Injection [Avastin], Peripheral Retinal Cryoapplication
- Where
- Tunisia
- Volunteers
- 60 people
- Sponsor
- Khairallah Moncef
Vision-Threatening Retinal Lesions, Urgent Referral Retinal Findings
Artificial Intelligence-Assisted Lesion-Based Urgent Referral Triage of Ultra-Widefield Retinal Images
his study evaluates the clinical utility of an artificial intelligence (AI)-assisted lesion-based urgent referral triage system for ultra-widefield (UWF) retinal images.
- Conditions
- Vision-Threatening Retinal Lesions, Urgent Referral Retinal Findings, Retinal Detachment, Pre-retinal Hemorrhage
- Trial name
- ALERT-UWF (NCT07643129)
- Testing
- AI-Assisted UWF Lesion-Based Triage System, Unassisted Interpretation
- Where
- China
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Xiamen Ophthalmology Center Affiliated to Xiamen University
Diabetic Retinopathy
Intravitreal Bevacizumab for Management of Active Progressive Proliferative Diabetic Retinopathy (PDR)
To evaluate the effect of intravitreal bevacizumab on the course of diabetic retinopathy in cases with the signs of active progressive PDR
- Trial name
- NCT00370721
- Testing
- bevacizumab
- Where
- Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences
Retinopathy of Prematurity (ROP), Intraventricular Hemorrhage
Safety and Efficacy Outcomes Following Previously Administered Short-Term Treatment With SHP607 in Extremely Premature Infants
The purpose of this study is to evaluate long-term safety and efficacy outcomes following previously administered short-term exposure to SHP607, as compared to a standard neonatal care group.
- Conditions
- Retinopathy of Prematurity (ROP), Intraventricular Hemorrhage, Bronchopulmonary Dysplasia, Chronic Lung Disease of Prematurity
- Trial name
- NCT04506619
- Testing
- No Intervention
- Where
- 8 sites in United States, Italy and 1 more
- Volunteers
- 26 people
- Sponsor
- Oak Hill Bio Ltd
Diabetic Retinopathy
Effect of Intravitreal Bevacizumab on Early Post-Vitrectomy Hemorrhage in Diabetic Patients
The purpose of this study is to determine whether bevacizumab 1-2 weeks before vitrectomy is effective in lowering the rate of early post-vitrectomy vitreous hemorrhage in diabetic patients.
- Trial name
- NCT00524875
- Testing
- Bevacizumab
- Where
- Iran
- Volunteers
- 80 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Purpura, Thrombocytopaenic, Idiopathic
LENS - Long-term Eltrombopag Observational Study
A long term observational ocular safety study in adults who have received study medication (either active drug or placebo) in a phase II or III clinical study evaluating eltrombopag.
- Trial name
- LENS (NCT00643929)
- Testing
- Eltrombopag
- Where
- 71 sites in United States, Australia and 19 more
- Volunteers
- 164 people
- Sponsor
- GlaxoSmithKline
Post Vitrectomy State, Recurrent Diabetic Vitreous Hemorrhage
Efficacy and Safety of Intravitreal Triamcinolone Acetonide in Eyes With Post Vitrectomy Diabetic Vitreous Hemorrhage
The Purpose of this study is compare the efficacy of intravitreal triamcinolone in clearing recurrent post-vitrectomy diabetic hemorrhage with conventional treatment, air-fluid exchange.
- Trial name
- NCT00300014
- Testing
- Intravitreal triamcinolone injection, Air-fluid exchange
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Asan Medical Center
Proliferative Diabetic Retinopathy, Diabetic Traction Retinal Detachment
Prospective Randomized Controlled Study of Intravitreal Injection of Bevacizumab for Proliferative Diabetic Retinopathy
We hypothesized that to reduce the adverse effects of intravitreal bevacizumab on ocular tissue and whole body, intravitreal injection of a low concentration of bevacizumab and conducting vitrectomy shortly after the injection is…
- Conditions
- Proliferative Diabetic Retinopathy, Diabetic Traction Retinal Detachment, Vitreous Hemorrhage
- Trial name
- NCT01854593
- Testing
- Bevacizumab, Vitrectomy
- Where
- Japan
- Volunteers
- 69 people
- Sponsor
- Nihon University
Senile Cataract, Epiretinal Membrane
Clareon Intraocular Lens Stability in Vitrectomy Patients: CLOVE Study
This prospective randomized controlled trial will be conducted to investigate Clareon intraocular lens (IOL) stability in vitrectomy patients. The investigator plans to target the patients undergoing cataract surgery.
- Conditions
- Senile Cataract, Epiretinal Membrane, Vitreous Hemorrhage
- Trial name
- NCT06383754
- Testing
- Clareon, Tecnis 1
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- The University of Hong Kong
Diabetic Retinopathy, Postoperative Recurrent Vitreous Hemorrhage
A Prospective Study of Ranibizumab in the Treatment of Postoperative Recurrent Vitreous Haemorrhage of Diabetic Retinopathy
Diabetic retinopathy (DR) is one of the main complications in diabetes, the proliferative diabetic retinopathy (PDR) is the most important one of the reasons leading to decreased vision, PDR is the stage of clinical intervention.
- Conditions
- Diabetic Retinopathy, Postoperative Recurrent Vitreous Hemorrhage, Pars Plana Vitrectomy, Ranibizumab
- Trial name
- NCT05248334
- Testing
- Ranibizumab Injection, PPV
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Tianjin Medical University Eye Hospital
Hypertension, Heart Failure
LSFG-SKIN, Laser Speckle Flowgraphy
The purpose of this project is to quantify normal and abnormal skin blood flow regionally in different areas of the body(face, extremities, over burns and wounds) at baseline and over time in response to treatment or…
- Conditions
- Hypertension, Heart Failure, Vascular Ischemia, Burns
- Trial name
- NCT03660618
- Testing
- laser speckle flowgraphy
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Randy Kardon
Diabetic Retinopathy, Vitreous Hemorrhage
IVB for Post-vitrectomy Hemorrhage in Diabetic Eyes
Recurrent vitreous hemorrhage following pars plana vitrectomy (PPV) for proliferative diabetic retinopathy remains a significant complication with reported incidence ranging from 11 to 75%.
- Trial name
- NCT06559488
- Testing
- Bevacizumab Injection [Avastin], Pars Plana Vitrectomy
- Where
- Indonesia
- Volunteers
- 18 people
- Sponsor
- Universitas Padjadjaran
Neurological Disorder, Nursing Caries
Effects of Cold Application and Heparinoid on Periorbital Edema and Ecchymosis
During surgery, blood leaking from damaged blood vessels spread to the periorbital area may cause periorbital edema and ecchymosis after anterior craniotomy.
- Conditions
- Neurological Disorder, Nursing Caries, Periorbital Edema, Ecchymosis
- Trial name
- NCT04119297
- Testing
- Routine care, Cold gel pack, Heparinoids Topical Cream
- Volunteers
- 90 people
- Sponsor
- Necmettin Erbakan University
Traumatic Brain Injury, Cerebral Hemorrhage
TCD Detection of Ophthalmic Artery Blood Flow Velocity Prediction Feasibility Study of Intracranial Pressure
Increased intracranial pressure is a cause of disease progression in patients with brain disease, a common cause of poor prognosis.
- Conditions
- Traumatic Brain Injury, Cerebral Hemorrhage, Increased Intracranial Pressure
- Trial name
- NCT02240394
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Anti-VEGF, Branch Retinal Vein Occlusion
Anti-VEGF Instead of Intraoperative Fan-shaped Photocoagulation in BRVO Combined With Vitreous Hemorrhage
To evaluate the efficacy and safety of Anti-VEGF instead of intraoperative fan-shaped photocoagulation in BRVO combined with vitreous hemorrhage.
- Conditions
- Anti-VEGF, Branch Retinal Vein Occlusion, Vitrectomy
- Trial name
- NCT03637283
- Testing
- anti-VEGF, fan-shaped photocoagulation
- Volunteers
- 100 people
- Sponsor
- Wenzhou Medical University
Autoimmune Diseases, Lupus Erythematosus, Systemic
Comparative Autoantibody and Immunologic Cell Marker Study
The purpose of this study is to compare immune phenotype, function, and specificity of B lymphocytes from different developmental stages in autoimmune patients to B cells from infectious disease patients and healthy controls.
- Conditions
- Autoimmune Diseases, Lupus Erythematosus, Systemic, Communicable Diseases
- Trial name
- NCT02422875
- Where
- 3 sites in United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Emory University
Antiphospholipid Syndrome (APS), Bullous Pemphigoid (BP)
Phase 1b Trial of RAY121 in Immunological Diseases (RAINBOW Trial)
This Phase 1b basket trial will investigate the safety, tolerability, pharmacokinetics, pharmacodynamics, immunogenicity and preliminary efficacy of RAY121, a inhibitor of classical complement pathway, after multiple dose…
- Conditions
- Antiphospholipid Syndrome (APS), Bullous Pemphigoid (BP), Behçet's Syndrome (BS), Dermatomyositis (DM)
- Trial name
- NCT06371417
- Testing
- RAY121
- Where
- 77 sites in United States, Australia and 18 more
- Volunteers
- 144 people
- Sponsor
- Chugai Pharmaceutical
Epiretinal Membrane, Macular Hole
UNITY VCS Vitreoretinal Surgery
This purpose of this study is to compare the safety and effectiveness of two eye surgery systems-UNITY VCS and CONSTELLATION-in treating adults with vitreoretinal diseases or disorders.
- Conditions
- Epiretinal Membrane, Macular Hole, Visually Significant Vitreous Floater, Vitreomacular Traction
- Trial name
- NCT07054281
- Testing
- UNITY Vitreoretinal Cataract System (VCS), CONSTELLATION Vision System, Vitreoretinal ophthalmic surgery
- Where
- 8 sites in United States
- Sponsor
- Alcon Research