Clinical trials: Eye Manifestations
Type 1 Diabetes, Visual Impairment
Pancreatic Islet Transplantation to the Anterior Chamber of the Eye
This is a phase II prospective, interventional, open-labeled, proof-of-concept study. 2 years per participant, 2 years 6 months in total Total n=6 The primary objective is to assess the safety of human pancreatic islet…
- Trial name
- EYELETS (NCT04198350)
- Testing
- Islet implantation
- Where
- United Kingdom
- Sponsor
- Imperial College London
Neglect, Hemispatial, Stroke
Immersive Virtual REality for Treatment of Unilateral Spatial NEglect Via Eye-tracking Biofeedback
The purpose of this study is to evaluate the effects of a treatment using virtual reality on the recovery of unilateral spatial neglect.
- Trial name
- IRENE (NCT06264713)
- Testing
- Immersive Virtual Reality
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Progressive Supranuclear Palsy, Motor and Cognitive Symptoms
Efficacy and Safety of Transcranial dIrect Current stiMulation (tDCS) in Progressive Supranuclear Palsy (PSP) (STIM-PSP)
This is a double-blind, randomized, sham-controlled clinical trial that aim to verify the safety and the efficacy of anodal transcranial direct current stimulation (tDCS) on cognitive and motor symptoms in Progressive…
- Trial name
- STIM-PSP (NCT04655079)
- Testing
- Anodal transcranial direct current stimulation (a-tDCS)
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- University of Salerno
Amblyopia, VEP
Possible Beneficial Effects Of Combined Fluoxetine And Occlusion Therapy In Improving And Maintaining Vision In Amblyopia Using Optical Coherence Tomography Angiography (OCTA) And Visual Evoked Potential (VEP). The Aim Of The Study Is To Evaluate Possible Beneficial Effects For Different Age Groups.
Amblyopia is described as a limitation of the visual function of one or both eyes with no pathological cause, with a prevalence of about 1-5% of the total world population.
- Trial name
- VA; OCTA; VEP; (NCT07417046)
- Testing
- Flouxetine, Patching therapy
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Minia University
Cervical Dystonia, Primary, Blepharospasm
Analysis of Gait Before and After Botulinum Toxin Treatment in Patients With Focal Dystonia
Efficient gait requires effective postural control, both static and dynamic. Hence, postural disorders may affect gait. Yet, very little is known about the specific effects of focal postural disorders such as cervical dystonia…
- Trial name
- GAIT-TOX (NCT03938363)
- Testing
- Treadmill, Botulinum Toxin injection, Severity scale of the disease
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Progressive Supranuclear Palsy
A Study to Test the Safety and Tolerability of UCB0107 in Study Participants With Progressive Supranuclear Palsy (PSP)
The purpose of the study is to assess the safety and tolerability of UCB0107 in study participants with Progressive Supranuclear Palsy (PSP).
- Trial name
- NCT04185415
- Testing
- bepranemab
- Where
- 13 sites in Belgium, Germany and 2 more
- Volunteers
- 25 people
- Sponsor
- UCB Biopharma SRL
Amblyopia
Proof of Concept Study of Binocular Videogames Versus Patching for Amblyopia
The purpose of this PoC study was to evaluate the potential therapeutic efficacy of binocular video games played on a tablet and to compare the efficacy of binocular video games versus patching in amblyopic patients 4 to 7 years…
- Trial name
- NCT04784390
- Testing
- Binocular video games, Patching of the sound eye
- Where
- 8 sites in United States, Australia and 1 more
- Volunteers
- 27 people
- Sponsor
- Novartis Pharmaceuticals
Dry Eye Syndromes, Keratoconjunctivitis Sicca
Safety and Efficacy of KPI-121 in Subjects With Dry Eye Disease
The primary purpose of this study is to determine the efficacy and safety of KPI-121 0.25% ophthalmic suspension compared to vehicle (placebo) in subjects who have a documented clinical diagnosis of dry eye disease.
- Trial name
- Kauai (NCT02188160)
- Testing
- KPI-121
- Where
- 11 sites in United States
- Volunteers
- 150 people
- Sponsor
- Kala Pharmaceuticals, Inc.
Benign Prostatic Hyperplasia, Pupil Anomaly
The Effects of α-adrenergic Receptor Antagonists on Choroid and Pupil
It was aimed to evaluate and investigate the effects of tamsulosin hydrochloride, has preferential selectivity for the α1A receptor in the prostat versus the α1B receptor in the blood vessels, and alfuzosin hydrochloride on…
- Conditions
- Benign Prostatic Hyperplasia, Pupil Anomaly, Choroid Disease
- Trial name
- NCT03144596
- Testing
- Alfuzosin Hydrochloride 10 MG, Tamsulosin Hydrochloride 0.4 MG
- Volunteers
- 63 people
- Sponsor
- Kocatepe University
Dementia, Alzheimer Disease
The Swedish BioFINDER 2 Study
The Swedish BioFINDER 2 study is a new study that will launch in 2017 and extends the previous cohorts of BioFINDER 1 study (www.biofinder.se). BioFINDER 1 is used e.g.
- Conditions
- Dementia, Alzheimer Disease, Parkinson Disease, Lewy Body Disease
- Trial name
- BioFINDER2 (NCT03174938)
- Testing
- Flutemetamol F18 Injection, [18F]-RO6958948, Elecsys (Roche) Abeta42, Ttau and Ptau
- Where
- 2 sites in Sweden
- Volunteers
- 2,950 people, healthy volunteers welcome
- Sponsor
- Skane University Hospital
Corneal Abrasions
Proparacaine vs Placebo for Corneal Injuries
Introduction: Traumatic injuries to the outer covering of the eye (the cornea) are a common emergency department complaint. They cause significant patient distress including pain, loss of sleep and missed work days.
- Trial name
- Dogma (NCT00620997)
- Testing
- Proparacaine drops 0.05%, saline drops
- Where
- Canada
- Volunteers
- 43 people
- Sponsor
- London Health Sciences Centre
Blepharospasm, Dystonia
Exploratory Study of Dipraglurant (ADX48621) for the Treatment of Patients With Blepharospasm
This study is designed to assess the safety and tolerability of dipraglurant in patients with blepharospasm (BSP) (randomized 1:1:1 to receive dipraglurant 50 mg, 100 mg or placebo) and explore the efficacy of 50 mg and 100 mg…
- Trial name
- NCT05027997
- Testing
- Dipraglurant
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Addex Pharma S.A.
Diplopia, Monocular
VisionApp - Ghosting
Recent Android mobile device technology is available which allows user-measured refractive error and reading add power. This technology could be quite useful to the clinical and research community.
- Trial name
- NCT07571538
- Testing
- Proclear 1 Day Contact Lens, MyDay Contact Lens, NaturalVue Contact Lens
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Indiana University
Blindness, Spinal Cord Injury
Use of "Smart Wheelchairs" to Provide Independent Mobility to Visual and Mobility Impairments
The goal of this project is to evaluate the Smart Wheelchair Component System (SWCS) for power wheelchairs and the Smart Power Assistance Module (SPAM) for manual wheelchairs in realistic indoor environments with target users…
- Trial name
- NCT00333762
- Testing
- Smart Power Assistance Module (SPAM), Smart Wheelchair Component System (SWCS)
- Where
- 2 sites in United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Blindness
The Impact of Rehabilitation on Quality of Life in Visually Impaired
The project has four primary objectives: 1) Determine if blind rehabilitation improves the quality of life of legally blind veterans; 2) Determine the relationship between quality of life and visual function; 3) Determine if…
- Trial name
- NCT00013403
- Testing
- Blindness
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- US Department of Veterans Affairs
Visual Impairment
Prospective Pilot Study of Multi-actor Tolerance Evaluation Using the VIRARE Device (VIrtual Reality Assisted Rehabilitation) in Visually Impaired Patients
Our study aims to validate the relevance of a virtual reality tool (VIRARE: VIrtual REality Assisted Rehabilitation) in the assessment and rehabilitation of visually impaired subjects.
- Trial name
- VIRARE (NCT03646786)
- Testing
- Virtual reality tests
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Anxiety, Pain
Evaluation of Anxiolysis and Pain Associated With Retrobulbar Eye Block for Cataract Surgery : Melatonin Versus Gabapentin
Principle goals of sedation for eye surgery are to provide patient comfort and to allow the patient to stay calm during both retrobulbar injection and surgery.
- Trial name
- NCT01200641
- Testing
- Melatonin, Gabapentin
- Where
- Iran
- Volunteers
- 90 people
- Sponsor
- Qazvin University Of Medical Sciences
Retinitis Pigmentosa
Stress and Vision Fluctuations in Retinitis Pigmentosa
Retinitis pigmentosa (RP) patients experience a slowly progressive, unpredictable loss of vision which eventually leads to bare or no light perception, posing a continuous threat to patients' independence.
- Trial name
- NCT00475254
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Johns Hopkins University
Pupillary Function, Abnormal, Cerebral Aneurysm
Impact of Acute Cerebral Diseases on the Autonomous Nervous System: Progression and Correlation to Therapy and Outcome
The pupilometer determines the alteration of the pupil diameter after a defined light stimulus. In this study data is collected from pupilometer measurements of patients with an acute cerebral disease.
- Trial name
- Pupillometry (NCT02999659)
- Testing
- Pupilometer
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- RWTH Aachen University
Hemianopia, Homonymous, Hemianopsia, Homonymous
VR System for Cross-modal Rehabilitation of Hemianopia
The purpose of this research study is to investigate the effectiveness of a new rehabilitation for visual hemianopia. The study team believes a cross-modal rehabilitation technique delivered by a virtual reality system can help…
- Trial name
- NCT04230486
- Testing
- Cross-model Visual Auditory Rehabilitation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Wake Forest University Health Sciences
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